The paradigm shift toward the Internet of Things results in an increasing number of wireless applications being deployed. Since many of these applications contend for the same physical medium (i.e., the unlicensed ISM bands), there is a clear need for beyond-state-of-the-art solutions that coordinate medium access across heterogeneous wireless networks. Such solutions demand fine-grained control of each device and technology, which currently requires a substantial amount of effort given that the control APIs are different on each hardware platform, technology, and operating system. In this article an open architecture is proposed that overcomes this hurdle by providing unified programming interfaces (UPIs) for monitoring and controlling heterogeneous devices and wireless networks. The UPIs enable creation and testing of advanced coordination solutions while minimizing the complexity and implementation overhead. The availability of such interfaces is also crucial for the realization of emerging software-defined networking approaches for heterogeneous wireless networks. To illustrate the use of UPIs, a showcase is presented that simultaneously changes the MAC behavior of multiple wireless technologies in order to mitigate cross-technology interference taking advantage of the enhanced monitoring and control functionality. An open source implementation of the UPIs is available for wireless researchers and developers. It currently supports multiple widely used technologies (IEEE 802.11, IEEE 802.15.4, LTE), operating systems (Linux, Windows, Contiki), and radio platforms (Atheros, Broadcom, CC2520, Xylink Zynq, ), as well as advanced reconfigurable radio systems (IRIS, GNURadio, WMP, TAISC).