One of the most actual theological and cultural questions nowadays is the question of a harmonious relation between the scientific-technological paradigm of the understanding of man, the world and the universe and the paradigm of faith. This question does not just have relevance of a biblical, dogmatic or ethical-moral nature, but it also has the relevance of a theological-practical or pastoral nature as well. This theological-practical field of discernment of the relation that is pointed out above is the primary object of this article. Undertaking a discernment of this kind, it is possible to start with the problem of the so-called cosmic pessimism. This problem has immeasurable consequences in the cultural and practical area of life and many other problems are connected to it. On the theological side of the coin, many segments of understanding the faith with respect to the paradigm of science today do not always show an attempt at the harmonious fitting of the elements of the faith into the totality of the realization of life. There is the issue of developing theology in the modern and postmodern periods and the often lack of recognition of the scientific picture of the world. There are also some other theological elements which are very challenging regarding this entire debate, such as the question of the motives for genuine moral living, relations to people with different beliefs and worldviews, some practical issues regarding the models of evangelization, and practical actions of the parish and the other Church communities, etc.