Recipient Of Grant Research Articles

P186 Impact of glucocorticoids on appearance and sense of self in rheumatic diseases

Abstract Background/Aims To explore patients’ perspectives on the impact of appearance changes attributed to glucocorticoid treatment. Methods We conducted a secondary analysis of semi-structured interviews with patients with rheumatic conditions receiving glucocorticoids in the UK, USA, and Australia. Interview data were analysed inductively to develop preliminary individual and overarching themes. Results 60 patient interviews were analysed. Patients ranged from 26-84 years, and 39 (65%) were female. Patients had diagnoses of systemic vasculitis (n = 19), inflammatory arthritis (n = 14), crystal arthropathy (n = 2), connective tissue disorders (n = 16), or other/multiple (n = 9). Interviews contained rich data on how appearance changes impacted health-related quality of life. Three preliminary overarching themes were identified. i) Societal influences: participants reported pressure to conform to cultural and societal ideals: “I think with the weight gain it was more of an emotional response. [⋯] There's a part of you that's thin is better. So, I think that impacted me the most, just because of that aspect of what others thought of me…” (Female [Mixed/Multiple ethnicity] aged 27, granulomatosis with polyangiitis [Australia]) and “…within a week my dad had seen me and said, “Gosh you’ve put on a lot of weight”. Obviously, that’s not what I want to hear [⋯] but I think it was just pure shock." (White female aged 40, eosinophilic granulomatosis with polyangiitis [UK])”.ii)?Impact on mental health and sense of self: glucocorticoids were often described as making participants ‘not look like’ themselves, associated with changes in mood, self-confidence, and reluctance to socialise: “It makes you feel down. It makes you feel depressed. You don't want to socialise because you're not you.” (White male aged 65, inflammatory myositis [Australia]) and “Yeah, that’s it and it will hopefully look nice, which is a really vain thing to think about isn’t it, but it does really affect [⋯] how you feel and kind of your state of mind and things…” (White female aged 39, Takayasu arteritis [UK]). iii) Burden of adjustments included dieting, purchasing additional clothing sizes, working from home, discontinuing hobbies, and postponing key life events: "I have a wardrobe right now that goes four different sizes as my weight goes up and down and up and down." (White female aged 55, systemic lupus erythematosus [USA]) and "Well, with the high dose of prednisone since I gained weight, I get really tired if I try to do like exercise or something. And I used to be very sporty, so that just completely changed." (Hispanic female aged 29, systemic lupus erythematosus [USA]). Conclusion Patients attribute a variety of impacts on their health-related quality of life to glucocorticoid-related appearance changes and report a burden of adjustments above management of their chronic rheumatic condition. Further work is required to establish ways to mitigate these through improved information provision and support. Disclosure S.J. Lax: Grants/research support; post funded by National Institute for Health and Care Research Advanced Fellowship [grant number NIHR300863]. E. Dures: Grants/research support; recipient of grants from Above & Beyond Bristol Hospitals Charity, UWE Bristol, Vifor Pharma, National Institute for Health and Care Research (Research for Patient Benefit) and Sanofi. S. Bridgewater: None. C. Silverthorne: None. V. Lowndes: None. P. Richards: None. J. Dawson: None. C. Hill: Grants/research support; recipient of an Australian Rheumatology Association Project Grant, administered by Arthritis Australia. S. Goodman: None. S.L. Mackie: None. M.E. Ndosi: None. F.A. Pearce: Grants/research support; recipient of a National Institute for Health and Care Research Advanced Fellowship [grant number NIHR300863] and a grant from Vifor pharma. J. Robson: Consultancies; consultancy and speaking fees from Vifor Pharma. Grants/research support; recipient of grants from Above & Beyond Bristol Hospitals Charity, UWE Bristol, Vifor Pharma, National Institute for Health and Care Research (Research for Patient Benefit) and Sanofi.

Literature and reading under the light of intermedial and multimodality studies

Professor Grzegorz Maziarczyk specialises in contemporary English and American literature and culture as well as transmedial narrative theory. His main research interests include textual materiality, intermediality, relations between literature and new media, multimodal storytelling, utopia and dystopia. He has been a recipient of fellowships and research grants from the University of Notre Dame, Katholieke Universiteit Leuven and European Society for the Study of English. He is the author of two monographs – The Narratee in Contemporary British Fiction (2005) and The Novel as Book: Textual Materiality in Contemporary Fiction in English (2013) – and the co-editor of five collections of essays, including (Im)perfection Subverted, Reloaded and Networked: Utopian Discourse across Media (2015) and Explorations of Consciousness in Contemporary Fiction (2017). He has published widely in edited collections and peer-reviewed journals, including Word & Image, Journal of Narrative Theory, Utopian Studies, Interfaces: Image, Texte, Language and Slavia amongst others. Since 2019 he has been Director of the Institute of Literary Studies at the John Paul II Catholic University of Lublin

RE-VISITING ACT EAST POLICY AND NORTHEAST INDIA: A VIEW FROM THE PERIPHERY

Northeast India's geo-strategic location and natural resources make it an important factor in India's Act East (AEP). The region extensive international border connects with neighbouring countries in South and Southeast Asia, and this has potential for a thriving border trade. Moreover, ethnically and culturally, the region enjoys close affinity with Southeast Asian countries. These cross-cultural affinities as well as the geo-strategic location of the region provide a rich incentive for India to strengthen close ties with Southeast Asian nations. However, the region has been deliberated upon in various ways, both through academic and non-academic prisms. Some perceive it as a volatile region with internecine ethnic conflicts and insurgency movements that shape the region’s socio-political landscape, while others perceive it as a region endowed with high potential for economic development. Of late, the region has been a recipient of generous financial grants disbursed by the central government, but nevertheless, it remains one of the most backward regions in the country, marked by acute unemployment and poverty despite being potentially rich in natural resources.

Maternal tobacco smoking and childhood obesity in South Africa: A cohort study.

Tobacco use and obesity are major public health problems and part of the leading causes of preventable disease and death worldwide. The prevalence of overweight children has escalated over the years; making the weight gain in children a critical issue for health professionals and academics alike. This study examines the association between maternal tobacco use and body weight abnormalities among South African children. The study uses data from the National Income Dynamics Study (NIDS), conducted from 2008 to 2017. The survey is available in five waves which have been merged into a panel dataset of 211,718 children aged between 0 to 5 years old, drawn from a nationally representative sample of households followed across time. Thus, the subgroup of children aged between 6 and 15 years old was excluded from the analysis. The empirical investigation employs a logistic regression model to estimate the marginal effect of maternal smoking on childhood overweight prevalence measured by three anthropometric based proxies, namely risk of child overweight, child overweight and child obesity. This framework assumes unobserved child characteristics to be uncorrelated with independent variables (random effect assumption); hence allowing to control for time-invariant sociodemographic factors which are likely to affect child nutritional health. In addition to sociodemographic and health characteristics of mothers, empirical findings suggest that maternal smoking exhibits a significant odds and/ or probability of weight abnormalities in children. Notably, children of smoking mothers are likely to be obese, overweight, or at risk of becoming overweight with a possible coexistence of mother-child overweight. Similarly, weight irregularities in children are likely to increase with mother's age. Conversely, married mothers although associated with increased odds of children having high BMI, display a reduced probability of children being abnormally weighted. Finally, child support grant has the potential to improve children nutritional health as children whose mothers are recipient of such grant have a negative probability of having high BMI. Overall, maternal smoking contributes to child overweight and/or obesity in south Africa; suggesting that maternal healthy lifestyle could be an alternative strategic tool to fight against overweight in children. However, mothers' inability to remain and/or follow a healthy life style is plausible as age increases, with spillover effect on child care. Thus, policymakers should prioritize programs to reduce smoking, especially amongst pregnant women and caregivers, to minimise the risk of overweight in children. Promoting the consumption of healthy foods accompanied by physical activity may reduce mothers' stress levels and their incentive to self-medicate using tobacco substances. In addition, comprehensive action programs including child support grant and recommendations for treatment plans that address the problems of children who are already suffering from overweight, remain essential.

PetSavers interview

Professor Clare Rusbridge of Wear Referrals and the University of Surrey has been a recipient of many PetSavers grants. Her most recent was for the undergraduate project Cytological and MRI evaluation of the soft palate and tonsils in Cavalier King Charles Spaniels with Chiari-like malformation.

Editorial introductions.

Current Opinion in Lipidology was launched in 1990. It is part of a successful series of review journals whose unique format is designed to provide a systematic and critical assessment of the literature as presented in the many primary journals. The field of lipidology is divided into six sections that are reviewed once a year. Each section is assigned a Section Editor, a leading authority in the area, who identifies the most important topics at that time. Here we are pleased to introduce the Section Editor for this issue. SECTION EDITOR Erik StroesErik StroesErik S. G. Stroes is Chair of the Department of Vascular Medicine at the Academic Medical Center, Amsterdam, The Netherlands. After gaining his Doctor of Medicine degree from Erasmus University, Rotterdam, The Netherlands, he then specialized in internal medicine at University Medical Center, Utrecht, The Netherlands, and later in vascular medicine at the Academic Medical Center, Amsterdam. Professor Stroes’ research interests include the role of the vessel wall in atherosclerosis development and lipid disorders in relation to atherogenesis. He has been an investigator in numerous lipid-lowering trials using various surrogate markers, such as intima-media thickness and flow-mediated dilation, and more recently 3T magnetic resonance imaging as a surrogate marker for vascular disease progression. He has also been involved in the development of novel therapeutic moieties for dyslipidemia, such as lipoprotein lipase gene therapy, antisense oligonucleotide inhibition of apolipoprotein B synthesis, and reconstituted high-density lipoprotein infusion. He has been the recipient of numerous research grants and several awards. Professor Stroes is Chair of the Dutch Atherosclerosis Society, member of the Vascular Biology Working Group, member of the American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology, and former Chair of the Dutch Internist Vascular Society. He has published more than 300 papers in various peer-reviewed journals and authored several book chapters in the field. Gerald F WattsGerald F WattsGerald F Watts (DSc DM PhD FRCP FRACP) trained at Imperial College (St Mary's Hospital) and King's College (St Thomas’ Hospital) in the University of London. He is a consultant physician, specializing in lipid disorders and cardiovascular medicine, within the department of cardiology at Royal Perth Hospital, as well as Winthrop Professor of Cardiometabolic Medicine in the University of Western Australia. He is Chair of The Familial Hypercholesterolaemia (FH)-Australasia Network and executive board member of the International Atherosclerosis Society. His research interests include lipid disorders and cardiovascular prevention, with clinical interest focusing on delivering improved health care for patients and families with FH. Professor Watts is actively involved in undergraduate medical education and supervisors PhD students and post-doctoral fellows. He has authored over 500 published works, including scientific articles, reviews, book chapters and monographs, and is associate editor of Atherosclerosis, Journal Clinical Lipidology and Metabolism.

The Piano

The Piano Lea Nagy (bio) Translation from the French Click for larger view View full resolution Click for larger view View full resolution In your living room wasa bone-colored piano.In boredom we presseda key.We even sang.Do you remember?You know, just sosomething fills yourrented apartment in Buda,and recovers its moldy silence.At the time we wereboth still beautiful.It was fall.I saw you lessand less.I could not sleep.Still can't. [End Page 17] Lea Nagy Lea Nagy is the recipient of an NKA grant (National Cultural Fund of Hungary). She has published two poetry collections, Kōhullás / Whirlwind and Légörvény / Stone Fall, with Editions Napkút in Budapest. She won the prize for Best Young Hungarian Poet in 2018. A French collection, Le chaos en spectacle, just came out from Éditions du Cygne in Paris. Hélène Cardona Hélène Cardona received her MA in American literature from the Sorbonne and has authored five translations and three collections. Her awards include the Independent Press and International Book Awards. She worked as a translator for the Canadian Embassy, taught at Hamilton College and Loyola Marymount University, and received the Royal Society of Arts Translation Diploma (Cambridge). Copyright © 2022 World Literature Today and the Board of Regents of the University of Oklahoma

Second generation drug eluting stent: The longer, the better?

Carlo Di Mario has received institutional research grants from AMGEN, Abbott Vascular, Behring, Boston Scientific, Chiesi Pharmaceuticals, Daiichi-Sankyo, Edwards Lifescience, Medtronic, Shockwave Medical, Volcano Philips. Selcuk Kucukseymen is the recipient of the clinical fellowship grant from the European Association of Percutaneous Cardiovascular Interventions (EAPCI).

Immunogenicity and clinical efficacy of anti‐SARS‐CoV‐2 vaccination in patients with hematological malignancies: Results of a prospective cohort study of 365 patients

Immunogenicity and clinical efficacy of anti‐SARS‐CoV‐2 vaccination in patients with hematological malignancies: Results of a prospective cohort study of 365 patients

Chitin-Glucan Supplementation Altered Gut Microbiota and Improved Postprandial Metabolism in Subjects at Cardiometabolic Risk

ObjectivesIn this exploratory study, we aimed at characterizing the impact of chitin-glucan (CG), an insoluble dietary fiber, on gut microbiota composition and functions as well as on the cardiometabolic profile in subjects at cardiometabolic risk. MethodsFifteen subjects were included in this double-blind, randomized, twice 3-week cross-over study and consumed 4.5g of CG or maltodextrin (control) as a supplement daily. Before and after the intervention phases, fasting and postprandial metabolic parameters and exhaled gases (hydrogen [H2] and methane [CH4]) were evaluated. Gut microbiota composition (16S next generation sequencing), fecal concentrations of bile acids, long- and short-chain fatty acids (LCFA, SCFA), zonulin, calprotectin and lipopolysaccharide binding protein (LBP) were analyzed. ResultsCompared to control, CG supplementation increased exhaled H2 following an enriched-fiber breakfast ingestion and decreased postprandial glycemia and triglyceridemia response to a standardized test meal challenge served at lunch. Of note, the decrease in postprandial glycemia was only observed in subjects with higher exhaled H2, assessed upon lactulose breath test performed at inclusion. CG decreased a family belonging to Actinobacteria phylum and increased 3 bacterial taxa: Erysipelotrichaceae UCG.003, Ruminococcaceae UCG.005 and Eubacterium ventriosum group. Fecal metabolites, inflammatory and intestinal permeability markers did not differ between groups. ConclusionsWe showed that CG supplementation modified the gut microbiota composition and improved postprandial glycemic response, an early determinant of cardiometabolic risk. Our results also suggest breath H2 production as a non-invasive parameter of interest for predicting the effectiveness of dietary fiber intervention. Funding SourcesThe FiberTAG project was initiated from a European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL). This study was supported by the Service Public de Wallonie. NMD is a recipient of a grant from Belgium National Scientific Research Fund and from UCLouvain. GGM is a recipient of a FSR grant from the UCLouvain.

Artificial intelligence for disease diagnosis: the criterion standard challenge

Artificial intelligence for disease diagnosis: the criterion standard challenge

Thresholds Revisited: Disentangling Public Space: Social Media and Internet Activism

April 01 2022 Thresholds Revisited: Disentangling Public Space: Social Media and Internet Activism T.F. Tierney, T.F. Tierney T.F. Tierney is founding director of URL: Urban Research Lab and Emerita Professor at the University of Illinois Urbana Champaign. She is a 2021 recipient of a Graham Foundation research grant that focuses on critical urbanism and the impact of policy-making on socioeconomic inclusion. Recent publications include “Intelligent Infrastructure: Zipcars, Invisible Networks and Urban Transformation” and “The Public Space of Social Media: Connected Cultures of Network Society,” which was a finalist for the Jane Jacobs Award. Search for other works by this author on: This Site Google Scholar Mariam Elnozahy Mariam Elnozahy Mariam Elnozahy is a curator, writer, and researcher based between Cairo, Egypt and Cambridge, Massachusetts, where she is currently completing her Masters degree in the Aga Khan Program for Islamic Architecture at the Massachusetts Institute of Technology. She has curated exhibitions in Cairo, Jeddah, London, Basel, and Amsterdam. Her project titled “Whose Open Society? Understanding Neoliberalism and the Economics of Artistic Production in the Middle East and former Eastern bloc” was presented at the Kunsthalle Wien, the Warsaw Biennale, UJazdowski, the Matter of Art Biennale, and Tranzit in Prague. Search for other works by this author on: This Site Google Scholar Author and Article Information T.F. Tierney T.F. Tierney is founding director of URL: Urban Research Lab and Emerita Professor at the University of Illinois Urbana Champaign. She is a 2021 recipient of a Graham Foundation research grant that focuses on critical urbanism and the impact of policy-making on socioeconomic inclusion. Recent publications include “Intelligent Infrastructure: Zipcars, Invisible Networks and Urban Transformation” and “The Public Space of Social Media: Connected Cultures of Network Society,” which was a finalist for the Jane Jacobs Award. Mariam Elnozahy Mariam Elnozahy is a curator, writer, and researcher based between Cairo, Egypt and Cambridge, Massachusetts, where she is currently completing her Masters degree in the Aga Khan Program for Islamic Architecture at the Massachusetts Institute of Technology. She has curated exhibitions in Cairo, Jeddah, London, Basel, and Amsterdam. Her project titled “Whose Open Society? Understanding Neoliberalism and the Economics of Artistic Production in the Middle East and former Eastern bloc” was presented at the Kunsthalle Wien, the Warsaw Biennale, UJazdowski, the Matter of Art Biennale, and Tranzit in Prague. Online Issn: 2572-7338 Print Issn: 1091-711X © 2022 T.F. Tierney and Mariam Elnozahy2022T.F. Tierney and Mariam Elnozahy Thresholds (2022) (50): 67–80. https://doi.org/10.1162/thld_a_00755 Cite Icon Cite Permissions Share Icon Share MailTo Twitter LinkedIn Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Search Site Citation T.F. Tierney, Mariam Elnozahy; Thresholds Revisited: Disentangling Public Space: Social Media and Internet Activism. Thresholds 2022; (50): 67–80. doi: https://doi.org/10.1162/thld_a_00755 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsThresholds Search Advanced Search This content is only available as a PDF. © 2022 T.F. Tierney and Mariam Elnozahy2022T.F. Tierney and Mariam Elnozahy Article PDF first page preview Close Modal You do not currently have access to this content.

Leonard Norman Primiano (1957–2021)

Leonard Norman Primiano (1957–2021)

Protocol for developing a core outcome set for male infertility research: an international consensus development study.

STUDY QUESTIONWe aim to develop, disseminate and implement a minimum data set, known as a core outcome set, for future male infertility research.WHAT IS KNOWN ALREADYResearch into male infertility can be challenging to design, conduct and report. Evidence from randomized trials can be difficult to interpret and of limited ability to inform clinical practice for numerous reasons. These may include complex issues, such as variation in outcome measures and outcome reporting bias, as well as failure to consider the perspectives of men and their partners with lived experience of fertility problems. Previously, the Core Outcome Measure for Infertility Trials (COMMIT) initiative, an international consortium of researchers, healthcare professionals and people with fertility problems, has developed a core outcome set for general infertility research. Now, a bespoke core outcome set for male infertility is required to address the unique challenges pertinent to male infertility research.STUDY DESIGN, SIZE, DURATIONStakeholders, including healthcare professionals, allied healthcare professionals, scientists, researchers and people with fertility problems, will be invited to participate. Formal consensus science methods will be used, including the modified Delphi method, modified Nominal Group Technique and the National Institutes of Health’s consensus development conference.PARTICIPANTS/MATERIALS, SETTING, METHODSAn international steering group, including the relevant stakeholders outlined above, has been established to guide the development of this core outcome set. Possible core outcomes will be identified by undertaking a systematic review of randomized controlled trials evaluating potential treatments for male factor infertility. These outcomes will be entered into a modified Delphi method. Repeated reflection and re-scoring should promote convergence towards consensus outcomes, which will be prioritized during a consensus development meeting to identify a final core outcome set. We will establish standardized definitions and recommend high-quality measurement instruments for individual core outcomes.STUDY FUNDING/COMPETING INTEREST(S)This work has been supported by the Urology Foundation small project award, 2021. C.L.R.B. is the recipient of a BMGF grant and received consultancy fees from Exscentia and Exceed sperm testing, paid to the University of Dundee and speaking fees or honoraria paid personally by Ferring, Copper Surgical and RBMO. S.B. received royalties from Cambridge University Press, Speaker honoraria for Obstetrical and Gynaecological Society of Singapore, Merk SMART Masterclass and Merk FERRING Forum, paid to the University of Aberdeen. Payment for leadership roles within NHS Grampian, previously paid to self, now paid to University of Aberdeen. An Honorarium is received as Editor in Chief of Human Reproduction Open. M.L.E. is an advisor to the companies Hannah and Ro. B.W.M. received an investigator grant from the NHMRC, No: GNT1176437 is a paid consultant for ObsEva and has received research funding from Ferring and Merck. R.R.H. received royalties from Elsevier for a book, consultancy fees from Glyciome, and presentation fees from GryNumber Health and Aytu Bioscience. Aytu Bioscience also funded MiOXYS systems and sensors. Attendance at Fertility 2020 and Roadshow South Africa by Ralf Henkel was funded by LogixX Pharma Ltd. R.R.H. is also Editor in Chief of Andrologia and has been an employee of LogixX Pharma Ltd. since 2020. M.S.K. is an associate editor with Human Reproduction Open. K.Mc.E. received an honoraria for lectures from Bayer and Pharmasure in 2019 and payment for an ESHRE grant review in 2019. His attendance at ESHRE 2019 and AUA 2019 was sponsored by Pharmasure and Bayer, respectively. The remaining authors declare no competing interests.TRIAL REGISTRATION NUMBERCore Outcome Measures in Effectiveness Trials (COMET) initiative registration No: 1586. Available at www.comet-initiative.org/Studies/Details/1586.TRIAL REGISTRATION DATEN/A.DATE OF FIRST PATIENT’S ENROLMENTN/A.

PetSavers interview

Dr Penny Watson has been the recipient of several BSAVA PetSavers grants for undergraduate student projects and clinical research projects. Her most recent funds a Master’s student in a project entitled An investigation of novel immunohistochemical markers and serum auto-antibodies in cats with chronic biliary tract disease.

Editorial introductions

Current Opinion in Ophthalmology was launched in 1990. It is one of a successful series of review journals whose unique format is designed to provide a systematic and critical assessment of the literature as presented in the many primary journals. The field of Ophthalmology is divided into nine sections that are reviewed once a year. Each section is assigned a Section Editor, a leading authority in the area, who identifies the most important topics at that time. Here we are pleased to introduce the Journal's Editor and Section Editor for this issue. EDITOR Allen C. HoAllen C. HoDr Allen C. Ho is an Attending Surgeon of the Retina Service and Director of Retina Research of Wills Eye Hospital, USA. He is Professor of Ophthalmology at Thomas Jefferson University School of Medicine, USA. Dr Ho is a founding member of Mid Atlantic Retina. He is author of multiple textbooks including Age Related Macular Degeneration Diagnosis and Treatment, The Wills Eye Hospital Color Atlas and Synopsis of Retinal Disease and is Editor-in-Chief of Current Opinion in Ophthalmology and Chief Medical Editor of Retina Today, a global publication that features new therapies for retinal disease. He is a member of the Scientific Editorial Boards of Retina Cases and Brief Reports, Ophthalmic Surgery, Lasers and Imaging, Retinal Physician, and Ocular Surgery News. Dr Ho has been an invited lecturer at numerous national and international ophthalmic meetings around the world. He is a recipient of multiple clinical research grants investigating new treatments for macular diseases sponsored by the National Eye Institute and received the American Academy of Ophthalmology's Achievement Award and Senior Achievement Award and the American Society of Retina Specialists Crystal Apple Award. Dr Ho is Principal Investigator at Wills Eye Institute of several collaborative clinical trials evaluating new treatments for age-related macular degeneration, surgical retina and diabetic retinopathy. He maintains special interests in macular diseases, diabetic retinopathy, surgical retinal diseases and clinical trials investigating new treatments for vitreoretinal diseases. SECTION EDITOR Natalie A. AfshariNatalie A. AfshariNatalie A. Afshari is Stuart I. Brown MD Chair in Ophthalmology in Memory of Donald P. Shiley, Chief of Cornea and Refractive Surgery, Vice Chair of Education, and Professor of Ophthalmology at the Shiley Eye Institute, University of California, San Diego. Prior to this, she was Professor of Ophthalmology and Director of Centers of Excellence at the Duke University Eye Center. She received her medical degree from Stanford University and her residency training at Harvard University, Massachusetts Eye and Ear Infirmary. She then completed a two-year fellowship in cornea and refractive surgery at Harvard University. Dr Afshari is the recipient of the Senior Achievement Award and the Secretariat Award by the American Academy of Ophthalmology and has been named a Gold Fellow of the Association for Research in Vision and Ophthalmology. She has received the inaugural Top Ten Women in Medicine award by Triangle News, Women Who Mean Business award by San Diego Business Journal, and the Teacher of the Year award at the Duke University Eye Center. She has also been recognized in the Best Doctors in America in each listing for the past decade, and was named in the U.S. News & World Report's Top Doctors List. Dr Afshari is the co-editor of a new two-volume cornea book called “Principles and Practice of Cornea”. She is also on the editorial boards of Investigative Ophthalmology and Visual Science and American Journal of Ophthalmology. She has previously served on the EyeNet editorial board, BCSC Cornea text book committee, and the American Academy of Ophthalmology council representing the American Society of Cataract and Refractive Surgery. She was co-chair of the cornea program committee for the Association for Research in Vision and Ophthalmology and co-director of Cornea Subspecialty Day for the American Academy of Ophthalmology. She is currently the chair of the American Society of Cataract and Refractive Surgery FDA Committee. Her NIH research grant is on the study of Fuchs dystrophy, and she investigates the intricacies of endothelial keratoplasty and regeneration of cornea. When not researching or practicing, Dr Afshari donates her time and surgical expertise as an international volunteer. She has traveled to West Africa, Central America, and Mexico to help patients who might otherwise go untreated.

Does receiving a cash grant improve individual earnings in a war-torn country? Evidence from a randomized experiment in Afghanistan

Background: In this study, the effect of receiving a non-trivial cash grant and mentorship for business practice on individual earnings in Afghanistan was assessed. Methods: This randomized control trial (RCT) included 2177 individuals (n=2177), with the age range of 18-35 years. The amount of cash grant (500 USD) was approximately equal to the gross domestic product (GDP) per capita in the country. By a process of lottery, eligible applicants were equally divided into the group that received the grant (treatment group) and the group that did not (control group). Results: Almost two years after this study, the percentage of increased annual income to the size of this cash grant was approximately 173 % and 69 % for males and females, respectively. This result was much higher than the estimated percentage reported in previous literature assessing the effect of microfinance loans and cash grants in other countries. The treatment group had 7% higher probability of having an officially registered business than the control group. The treatment group also increased labor supply and employed additional workers, compared to the control group. The male treatment group bought more capital equipment (e.g., trike and commercial carts) than the male control group, while the female treatment group bought more domestic animals. Conclusion: A non-trivial cash grant has a strong positive effect on the earnings of the recipient of the cash grant in Afghanistan. If the state of increased income continues for the next few years, the sum of increased income will be more than the sum of the administration cost, the interest cost and the amount of cash grant given. This implies that the project passes the standard criteria to determine the appropriateness of government program. Additionally, we did not find any economically and statistically significant positive effect of mentorship on income.

Determinants of household over-indebtedness in South Africa

The proportion of household debt to disposable income is high in South Africa, signifying over-indebtedness which reduces the welfare of households. High debt leads to low savings, negatively impacting economic growth. This paper presents the determinants of household debt distress in South Africa and comes up with recommendations on how to manage household debt. The objectives are achieved through systematic literature review. Findings suggest that households are over-indebted because of several reasons. They lack necessary finance management skills and proper protection from predatory practices by lenders. Household indebtedness is also caused by the rising cost of living which leads to low household disposable income and savings, high interest rates, misfortunes and adverse trigger events and income inequalities. Education, age and being a recipient of a social grant all have positive and negative impacts on household indebtedness. Findings also suggest that female-headed households, renting households, large households, urban based households, households with a mortgage and households where the head is not working, is sick or disabled are more likely to be over-indebted. A framework is presented with recommendations on how household debt can be effectively managed in South Africa. Upskilling in finance management can help improve the way households manage their finances. Moneylending institutions should avoid predatory lending and disclose vital information affecting household borrowing decisions. A downward review of interest rates on debt is necessary with a balance between profitability and sustainability of loan repayments. Consumption insurance on loans is recommended to cushion debt distressed households.

Vocal learning in animals and humans.

Vocal learning in animals and humans.

Developing a framework for managing household debt The case of South Africa

The proportion of household debt to disposable income is very high in South Africa, signifying over-indebtedness which reduces the welfare of households and ultimately reduces economic growth. This paper presents the determinants of the household debt in South Africa and comes up with a framework of recommendations on how to manage household debt. The objectives are achieved through systematic literature review, document analysis and secondary data analysis. Our findings suggest that households are over-indebted because they lack the necessary finance management skills, lack proper protection from the predatory practices by lenders and fail to obtain disclosure of vital information pertaining credit which affects their decision to borrow. Household indebtedness is also caused by the rising cost of living and low household disposable income, low household savings, high interest rates, misfortunes or adverse trigger events and living in urban areas. Education, age and being a recipient of a social grant all have positive and negative impacts on household indebtedness. Findings also suggest that female-headed households, renting households, large households, households with a mortgage and households where head is not working, is sick or disabled are more likely to be over-indebted. We develop a framework with recommendations for managing household debt in South Africa. We recommend upskilling to help households to effectively manage their finances and take responsibility. Moneylending institutions are encouraged to disclose vital information pertaining credit which affects decision to borrow by households and to avoid predatory lending. We also recommend a review of interest rates on debt and availability of consumption insurance on all loans to cover for cases when the household faces unforeseen circumstances affecting repayment.