Recent Advances In Inorganic Chemistry Research Articles

Metal Complexes in Biology and Medicine: The System Cadmium ((II))/ Iron ((II))/ Zinc ((II)) - α - Aminobutenoic Acid

Metal ions play an important role in biological system. The importance of metal ions to essential functions of living systems and for wellbeing of living organisms is well known. Metal ions are fundamental elements for the maintenance of life spans of the human, animals, and plants. Recent advances in inorganic chemistry have made possible formation of number of transition metal complexes with organic ligand of interest, which can be used as therapeutic agent. In coordination compounds studies, knowledge of the stability constants of complexes is necessary for preliminary quantitative treatment. The present technique involving the use of paper electrophoresis is described for the study of equilibria in binary complex systems in solution. The method is based on the movement of a spot of a metal ion in an electric field at various pH’s of background electrolyte. A graph of pH versus mobility was used to obtained information in the binary complexes and to calculate its stability constants. Using this method , the stability constants of binary complexes metal (II) – α – aminobutenoic acid have been determined to be ( 3.78 ± 0.01, 2.48 ± 0.03 ); ( 3.27 ± 0.04, 2.33 ± 0.07 ); and (4.45 ± 0.02, 2.66 ± 0.05); (logarithm stability constant values) for cadmium (II), iron (II) and zinc (II) complexes, respectively, at ionic strength 0.01 Mol / L and a temperature of 35º C.

Implicatons of Metal Complexes in Biology and Medicine the System Cadmium (II)/ Iron (II)/ Zinc (II)-Hydroxyproline

The importance of metal ions to essential functions of living systems and for the well being of living organisms is known. Metal ions are fundamental elements for the maintenance of the life spans of the human, animals and plants. The stability constants of Cd2+, Fe2+ and Zn2+ complexes with hydroxyproline were determined by Paper Electrophoretic Technique (PET). This method is based on the movement of a spot of metal ion in an electric field at various pH of background electrolyte. A graph of pH against mobility gives information about the formation of binary complexes and permit to calculate their stability constants. The stability constant of the ML and ML2 complexes of Cd (II) – hydroxyproline, Fe (II) – hydroxyproline and Zn (II) – hydroxyproline, have been found to be (4.41 ± 0.01; 2.95 ± 0.06) (4.11 ± 0.01; 2.81 ± 0.11 and (4.83 ± 0.02; 3.28 ± 0.07) ( logarithm stability constant values), respectively at ionic strength 0.1 mole L-1 (per chloric acid as background electrolyte) and a temperature of 35 0C, The first and second stability constants of metal complexes follow the order Zn (II) > Cd (II) > Fe (II). Metal complexes can offer their action such as anti-inflammatory, antibiotic, anti-thyroid and anticancer compounds. Metal based drugs bioactivity can be increased by metal chelation, which in turn increase their absorbance and stability. Recent advances in inorganic chemistry have made possible formation of a number of metal complexes with organic ligands of interest which can be use as therapeutic agents.

Metal Complexes in Medicine: An Overview and Update from Drug Design Perspective

Metals are essential cellular components selected by nature to function in several indispensable biochemical processes for living organisms. Transition metal complexes are important in catalysis, materials synthesis, photochemistry, and biological systems. Medicinal inorganic chemistry can exploit the unique properties of metal ions for the design of new drugs. The use of metals and their salts for medicinal purposes has been present throughout history. With the advancement in the field of inorganic chemistry the role of transition metal complexes as therapeutic compounds is becoming increasingly important. Recent advances in inorganic chemistry have made possible formation of number of transition metal complexes with organic ligand of interest, which can be used as therapeutic agent. This review illustrates the role of metals and the recent progress in the field of medicinal bioinorganic chemistry with new approaches to the design of innovative metal-based drugs and their application.

Recent advances in inorganic chemistry: Introduction

Introduces a series of papers presented at an ACS sponsored symposium entitled Recent Advances in Inorganic Chemistry.

Recent Advances in Inorganic Chemistry

Recent Advances in Inorganic Chemistry