Recent Advances In Dermatology Research Articles

675 Top skin of color publications in dermatology

Recent advances in dermatology have aimed to be more inclusive of Skin of Color (SoC) to better serve the general public. This study compares the metrics and content of top publications regarding SoC in dermatology. Web of Science was utilized to measure an article’s citation count while Altmetrics was employed to measure the amount of online media attention surrounding published research papers by way of the Altmetric Attention Score (AAS), with a higher AAS denoting a greater amount of online attention.

334 Involvement of cathepsin S and protease-activated receptor-2 in ciguatoxin-induced substance P release: new promising targets to treat ciguatera pruritus

Ciguatera Fish Poisoning (CFP) is a widespread tropical intoxication consecutive to ciguatoxin (CTX) ingestion, which is characterized by persistent neuro-cutaneous disturbances, including an intense pruritus (itch). Currently, there is no specific treatment. The primary target of CTXs is the voltage dependent sodium channel (Nav), which is largely expressed in sensory nerves and, to a lesser extent, in keratinocytes. By activating Nav, CTXs induce neuronal hyper-excitability but the downstream molecular mechanisms leading to sensory disorders are poorly understood. Recent advances in dermatology reveal protease-activated receptor-2 (PAR-2) involvement in itch pathophysiology. Interestingly, this receptor is expressed in sensory neurons and keratinocytes. To better understand the pathophysiology of CFP pruritus, the purpose of the present study was to identify cellular and molecular actors involved in the substance P (SP) release elicited by P-CTX-2 from co-cultured sensory neurons and keratinocytes. First, P-CTX-2 is able to induce calcium signal in both sensory neurons and keratinocytes. We show that antagonism of PAR-2 significantly inhibited the P-CTX-2-evoked calcium signal in both cells. Then, our results demonstrate the synergistic role of keratinocytes in the SP release elicited by P-CTX-2 in the coculture. The P-CTX-2-induced SP was almost completely abolished by PAR-2 or cathepsin S (Cat S) antagonists, and Cat S activity was significantly increased after P-CTX-2 treatment. Finally, P-CTX-2 is able to internalise PAR-2 in keratinocytes. Taken together, this work reveals that keratinocytes, PAR-2 and Cat S are novel actors in the P-CTX-2-induced release of SP, suggesting those are promising pharmacological targets for specifically treating CFP neuro-cutaneous disorders.

Recent Advances: Dermatology

Recent advances in dermatology and related fields have brought new answers to some old questions and new treatment options for some traditionally vexing diseases of the skin. This review focuses on several important reports of the past year, including progress in the understanding of pathogenesis, prevention, diagnosis, and treatment of some of the most difficult dermatologic maladies. Since the discovery of its association with human immunodeficiency virus infection, Kaposi's sarcoma (1) has remained one of the most puzzling entities in the cutaneous repertoire of patients infected with HIV. An exhausting array of potential aetiological agents has been proposed.1 Until recently, even the basic categorisation of the condition (malignancy, reactive process, infection) has remained uncertain. Reports of Kaposi's sarcoma in homosexual men negative for HIV,2 coupled with the observation that among patients positive for HIV Kaposi's sarcoma was more common in homosexual men than in injecting drug users,3 led to the suspicion that the condition was sexually transmitted, presumably by a virus distinct from but often transmitted with HIV. Fig 1 HIV associated (epidemic) Kaposi's sarcoma During the past year, several reports have emerged documenting the discovery of herpesvirus-like DNA sequences within Kaposi's sarcoma lesions.4 5 6 The DNA sequences (sometimes referred to as KS330(233) or KSHV) have been identified by polymerase chain reaction and by Southern blot hybridisation. These bits of DNA have been discovered in tissue from the lesions of patients with epidemic (HIV associated) Kaposi's sarcoma as well as classic Kaposi's sarcoma (on the legs of immunocompetent elderly men of Mediterranean descent) and African endemic Kaposi's sarcoma.5 The additional finding of similar sequences in tissue from some lymphomas in patients infected with HIV7 and in Kaposi's sarcoma from homosexual men negative for HIV6 lends support to the hypothesis that a novel group of …

Recent Advances in Dermatology

THE past decade has witnessed important advances in the field of dermatology, several of which we have selected for review in this paper. Acne Vulgaris Acne vulgaris, the most common skin disease seen in dermatologic practice, affects approximately 17 million people in the United States.1 Its precise cause is unknown, although abnormal keratin production with obstruction of the follicular opening, increased production of sebum (lipids secreted by the androgen-sensitive sebaceous glands), and proliferation of Propionibacterium acnes (anaerobic follicular diphtheroids) leading to inflammation play a part.1 Topical treatments for mild and moderate cases of acne include comedolytic agents, such as tretinoin . . .

Recent Advances in Dermatology and Medicine (1989)

Recent Advances in Dermatology and Medicine (1989)

BOOK REVIEWS

Australasian Journal of DermatologyVolume 31, Issue 1 p. 8-8 BOOK REVIEWS First published: April 1990 https://doi.org/10.1111/j.1440-0960.1990.tb00641.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Book reviews in this article: Photosensitivity Disease. Principles of Diagnosis and Treatment. 2nd Ed. Leonard C. Harber and David R. Bickers. Recent Advances in Dermatology, Vol 8. R.H. Chapman and R.J. Pye (Eds). Volume31, Issue1April 1990Pages 8-8 RelatedInformation

Recent Advances in Dermatology, No. 7

Recent Advances in Dermatology, No. 7

Book Review

British Journal of DermatologyVolume 115, Issue 1 p. 119-121 Book Review First published: July 1986 https://doi.org/10.1111/j.1365-2133.1986.tb06230.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Abstract Recent Advances in Dermatology, Number 7. Edited by R.H.Champion (1986) Practical Psoriasis Therapy. N. J.Love (1986) Fundamentals of Skin Biopsy. June K.Robinson (1986) Fungal Dimorphism, with Emphasis on Fungi Pathogenics for Humans. Edited by P.J.Szanislo (1985) Advances of Dermatology. Volume 1. edited by J.P.Callen (1986) Book recieved Volume115, Issue1July 1986Pages 119-121 RelatedInformation

Significant Melanocytic Lesions in Infancy, Childhood, and Adolescence

Malignant melanoma is diagnosed yearly in approximately 300 persons under age 20 in the United States. Relatively recent advances in dermatology include the recognition of lesions felt to be potential precursors of malignant melanoma. Small congenital melanocytic nevi, present in 1 per cent of all newborn infants, may have a small but definite potential for developing malignant melanoma. Furthermore, despite inconclusive data, many leading dermatologists now advocate removal of these small congenital lesions. Giant congenital melanocytic nevi, with their strong predilection for undergoing malignant change, are removed surgically at an early age, often in multistaged procedures. Dermabrasion, once felt to have a role in the treatment of giant congenital nevi, does not remove the malignant potential of these lesions. The dysplastic nevus syndrome, recognized in 1976, identifies individuals at increased risk for developing melanoma. Adolescents who have the dysplastic nevus syndrome or who are members of families with the syndrome require close medical supervision and patient education. The benign Spitz nevus, with its histologic similarity to malignant melanoma, continues to challenge the dermatopathologist and clinician. These lesions--the Spitz nevus, dysplastic nevus, congenital melanocytic nevus, and malignant melanoma--must all be actively considered when regarding the many other benign melanocytic lesions found in infancy, childhood, and adolescence.

RECENT ADVANCES IN DERMATOLOGY: Skin diseases associated with auto‐immunity

RECENT ADVANCES IN DERMATOLOGY: Skin diseases associated with auto‐immunity

Recent Advances in Dermatology—Number 5

Recent Advances in Dermatology—Number 5

Book Review: Recent Advances in Dermatology

Book Review: Recent Advances in Dermatology

BOOK REVIEWS

Books reviewed in this article: Recent Advances in Dermatology (Number 4). Ed. Arthur Rook Comparative Biology of Skin. Zoo. Soc. Symposia Proc. Vol. 39. Ed. R. I. C. Spearman A Guide to Drug Eruptions. By W. Bruinsma Principles and Practice of Dermatology. By W. E. de Launey and W. A. Land

Recent Advances in Dermatology No. 4

Recent Advances in Dermatology No. 4

BOOK REVIEWS

Book reviewed in this article: THE PHYSIOLOGY AND PATHOPHYSIOLOGY OF THE SKIN. Volume 4 THE HAIR FOLLICLE. Edited by A. Jarrett. SKIN SURGERY. 4th Edition. Edited by Ervin Epstein M.D. and Ervin Epstein, Jr., M.D. MALIGNANT MELANOMA OF THE SKIN AND MUCOUS MEMBRANE. G. W. Milton with chapters by V. J. McGovern and Martin G. Lewis. RECENT ADVANCES IN DERMATOLOGY. Edited by Arthur Rook. DERMATOLOGY. R. Marks, M. B. B. Sc., and P. D. Samman, M.D. QUESTIONS AND ANSWERS ABOUT ACNE. John R. T. Reeves.

Book Review: Recent Advances in Dermatology, No. 4

Book Review: Recent Advances in Dermatology, No. 4

BOOK REVIEWS

Book reviewed in this article: RECENT ADVANCES IN DERMATOLOGY. Edited by Arthur Rook, M.A., M.D., F.R.C.P. FRONTIERS OF MATRIX BIOLOGY. Series Editor: Robert, L. (Creteil). Vol. 1: Aging of Connective Tissues‐Skin. Proceedings of the 11th International Colloquium of Dermo‐Chemistry of Aging of Skin, Paris 1972. Editors: Robert, L. and Robert, B. (Creteil).

Book Reviews

Book reviewed in this article:Recent Advances in Dermatology. Edited by Arthur Rook.The Diagnosis and Treatment of Fungal Infections. Edited by Harry M. Robinson.Hair Transplant Surgery. By O. T. Norwood.

Recent Advances in Dermatology

This collection of review articles, by an international group of experts, aims to summarize advances in dermatology during the past ten years, primarily in disease processes encountered by the average practitioner. The book covers the topics of cutaneous bacteriology, mycology, and viral diseases; contact dermatitis; atopic dermatitis; acne vulgaris; psoriasis; the photodermatoses; biology and immunology of vitiligo and malignant melanoma; immunofluorescence and electronmicroscopy of bullous diseases; genetically determined diseases; and recent advances in topical therapy. The presentations are fairly technical, presupposing some knowledge of dermatology. The authors' purpose is to discuss the basic mechanism of a particular disease process and to make practical application of this knowledge in treating disease. The chapter on therapy brings in the European point of view, slightly different than the American approach. Excellent references are provided in each chapter in case more detailed information is needed. In my opinion, this book is primarily for the

Recent advances in dermatology.

Recent advances in dermatology.