Recalcitrant Carpal Tunnel Syndrome Research Articles

Patient-Reported Outcomes Improve after Hypothenar Fat Flap for the Treatment of Recurrent Carpal Tunnel Syndrome.

Background: Recalcitrant carpal tunnel syndrome (CTS) can present with persistent or recurrent symptoms after carpal tunnel release (CTR). A common aetiology for recurrent CTS is the development of perineural adhesions due to excess scarring. The hypothenar fat pad flap (HFPF) has been described to decrease the amount of scarring formed after revision CTR. Herein, we present a prospective evaluation of these patients. Methods: A prospective series of consecutive patients by a single surgeon with recurrent CTS was conducted. All patients had at least 3 months follow-up. Patients received a revision open CTR with HFPF. The primary outcome was the Boston Carpal Tunnel Questionnaire (BCTQ). Secondary outcomes included pain and satisfaction on visual analogue scale, range of motion, grip strength, patient-reported outcomes and complications. Clinical outcomes were compared between preoperative and postoperative intervals using paired t-tests, with significance defined as p < 0.05. Results: Fifteen wrists (14 patients) were recruited for the study. Patients were predominantly male (n=9; 66%). Revision open CTR with HFPF was performed a median of 42 months (range: 4-300 months) post primary CTR. Patients demonstrated improved patient-reported outcomes with significantly improved BCTQ pain score (p<0.01), Patient-Rated Wrist and Hand Evaluation (p<0.01) and QuickDASH (p<0.001). Two patients in the series reported postoperative complications; however, there was no incidence of donor site morbidity recorded. Conclusions: Revision open CTR with hypothenar fat pad flap is associated with decreased pain, high patient satisfaction and improved functional measures compared to pre-operative status. Level of Evidence: Level IV (Therapeutic).

Standard incision and median nerve external neurolysis for recalcitrant carpal tunnel syndrome

Purpose: Failed carpal tunnel surgery poses a challenge for the attending surgeon(s). Numerous revision techniques have been reported in the literature, with evidence of long-term improvement. However, studies exploring how early could symptomatic improvement be detected are scarce. The objective of this study was to identify the speed of symptom(s) recovery after a repeated decompression technique using an open standard incision and median external nerve neurolysis with no supplemental procedures.Methods: Nine patients who underwent revision carpal tunnel surgery involving standard incision, external median neurolysis, and no supplemental techniques between June 2017 and June 2020, were included. Data regarding the preoperative Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) score, Disabilities of the Arm, Shoulder and Hand score, visual analogue score, and grip strength were collected and compared with evaluation results at 3 months postoperatively. Results: In all patients, severe adhesion of the median nerve with the surrounding soft tissue was confirmed intraoperatively. Compared with preoperative findings, 3-month evaluation of patients demonstrated a statistically significant improvement in the BCTQ symptoms score and pain score. All nine patients were satisfied with the procedure. Conclusion: Standard incision and median nerve external neurolysis can be a good option for recalcitrant carpal tunnel syndrome patient who has an adhesion of the median nerve with surrounding soft tissue.

Recalcitrant Carpal Tunnel Syndrome

Complications and failures after carpal tunnel release have been reported from 3% to 25%. And the revision surgeries usually show poorer outcomes than the primary surgeries. There are diverse etiologies causing neuropathic symptoms after the carpal tunnel release, which became a clinical challenge. Potential causes of the symptoms are categorized into three by those natures; persistent symptom, recurrent symptom, and new symptom. The decision of proper management should be based on the etiologies of reproduced symptoms. This article described an overview of the clinical presentation, etiologies, diagnosis, and treatments of the recalcitrant carpal tunnel syndrome.

Revision surgery for carpal tunnel syndrome: a retrospective study comparing the combination of Canaletto® and Dynavisc® gel versus Dynavisc® gel alone

The aim of this study was to assess the value of using a Canaletto® implant in combination with a gel composed of carboxymethylcellulose and polyethylene oxide in the surgical treatment of recurrent carpal tunnel syndrome (CTS). The case series included 31 patients with 32 hands operated for the second time for recurrent (22 cases) or recalcitrant (9 cases) CTS by neurolysis. The average patient age was 62 years. Dynavisc® gel alone was applied around the median nerve in the first 16 cases (Group I). The Canaletto® implant combined with Dynavisc® gel was used in the last 16 cases (group II). With an average follow up of 8 months (for group I) and 11 months (for group II), the pre/postoperative variation in pain assessed with a visual analog scale was 1.38/10 (group I) and 2.04/10 (group II), the QuickDASH score was 20.1/100 (Group I) and 20.48/100 (Group II), grip strength was 8% (Group I) and 20% (Group II), sensory nerve conduction speed was 23.20 m/s (group I) and 15.51 m/s (group II) and distal motor latency was 1.55 m/s (group I) and 1.21 m/s (group II). Ten patients recovered from hypoesthesia in both groups, 6 patients in group I and 2 patients in group II regained good trophicity of their superficial thenar muscles. Two patients from group II had not improved clinically although their electromyography had become normal. One patient from group II suffered a postoperative infection that required removal of the Canaletto® implant. He subsequently improved slightly. Our study found that for recurrent or recalcitrant CTS, the combination of Dynavisc® anti-adhesion gel around the median nerve and a Canaletto implant® after neurolysis results in outcomes that are as good as Dynavisc® alone, with a significant improvement of the QuickDASH score without the Canaletto®. In conclusion, the use of Dynavisc® gel alone around the median nerve after neurolysis seems to be as effective as other techniques described in literature but less invasive or time-consuming, and not associated with donor site morbidity such as the flexor tendon sheath.

Management of Recalcitrant Carpal Tunnel Syndrome.

Recalcitrant carpal tunnel syndrome presents a clinical challenge. Potential etiologies of persistent or recurrent symptoms after primary carpal tunnel release include incomplete nerve decompression, secondary sites of nerve compression, unrecognized anatomic variations, irreversible nerve pathology associated with chronic compression neuropathy, perineural adhesions, conditions associated with secondary nerve compression, iatrogenic nerve injury, or inaccurate preoperative diagnosis. Understanding the pertinent surgical anatomy and pathophysiology is essential toward developing an effective diagnostic and treatment strategy. A thorough clinical history and examination guide a comprehensive diagnostic evaluation that includes serial examinations, neurophysiologic testing, and imaging studies. Conservative treatment may provide symptomatic relief; however, surgical management involving revision neuroplasty, neurolysis, nerve reconstruction, and/or local soft-tissue flap augmentation may be indicated in refractory cases.

The Adipofascial Radial Artery Perforator Flap: A Versatile Reconstructive Option in Upper Limb Surgery.

Flaps have been used in upper limb surgery for varied indications including coverage of soft tissue defects, interposition and to provide a pliable bed for gliding structures among others. We report our use of the radial artery perforator based adipofascial flap in nine patients, five with rigid radioulnar synostosis, three with recalcitrant carpal tunnel syndrome and one with a soft tissue defect. All our patients with radioulnar synostosis regained good functional rotations of the forearm with no recurrence at follow up. The patients with recalcitrant carpal tunnel also had resolution of symptoms with no recurrence. The flap healed well in all the patients. We propose this flap as a viable, versatile reconstructive option for the hand and upper limb.

Pedicled hypothenar fat pad flap in recalcitrant carpal tunnel syndrome

The incidence of failure in open carpal canal tunnel decompression is underestimated. Recurrence is often the result of scarring of the median nerve. Conservative treatment or careful neurolysis are usually insufficient.

The Tenosynovial Flap for Recalcitrant Carpal Tunnel Syndrome

Operative intervention for recalcitrant carpal tunnel syndrome often utilizes local vascularized tissue to provide coverage of the median nerve in an attempt to limit scarring or adherence of the nerve to its surrounding structures. Although the hypothenar fat pad is the most commonly cited source of vascularized tissue, alternative options do exist. We review the technique of utilizing a pedicled tenosynovial flap as the source of local vascularized tissue for coverage of the median nerve in cases of recalcitrant carpal tunnel syndrome.

Surgical Options for Recalcitrant Carpal Tunnel Syndrome with Perineural Fibrosis

Surgical release of the transverse carpal ligament for the treatment of carpal tunnel syndrome (CTS) is, in general, a very successful procedure. Some patients, however, fail this standard release and have persistent or recurrent symptoms. Such recalcitrance may relate to incomplete release but more often relates to perineural or intraneural fibrosis of the median nerve. While there is no good treatment for intraneural fibrosis, numerous procedures have evolved in an attempt to treat perineural fibrosis which restricts nerve gliding. These include procedures to isolate the nerve from scar as well as procedures to bring neovascularization to the median nerve. This review describes the various surgical treatment options for recalcitrant CTS as well as their reported outcomes.

Microvascular Omental Transfer for the Treatment of Severe Recurrent Median Neuritis of the Wrist: A Long-Term Follow-Up

The results of reoperation for recurrent carpal tunnel syndrome have been quite disappointing. In addition to a secondary external or internal neurolysis, multiple tissues and procedures have been used to decrease scar adherence of the reoperated median nerve including muscle, fascial or fat flaps, and vein wrapping. However, each technique has certain limitations, especially in the carpal tunnel that has previously undergone multiple operations, with diffuse scar and adherence over an extended length of the median nerve. The purpose of this study was to evaluate the long-term functional and symptomatic outcome following microvascular omental transfer for severe recalcitrant median neuritis. Between 1989 and 1993, 10 extremities in seven patients underwent omental transfer for severe recurrent median neuritis at the wrist. Nine extremities in six women were available for personal evaluation at an average follow-up of 6.6 years (range, 4.5 to 8.75 years). All extremities had undergone a minimum of two previous surgical procedures, and since 1991, all patients also failed local pedicle tissue coverage. Each patient completed a physical examination, a questionnaire, and electrophysiologic studies. At surgery, all median nerves were encased in dense adherent scar, which often extended proximal to the wrist crease. There were seven neural abnormalities in six extremities, three patent median arteries, and one aberrant palmaris longus muscle. The Functional Status Index was 3.1 +/- 0.7 and the Symptom Severity Index was 3.1 +/- 0.9, with a range of 1 (best) to 5. Most symptoms were improved but not completely alleviated. Four of nine extremities exhibited improved two-point discrimination and five of seven improved sensitivity, according to the Semmes-Weinstein monofilament test. Grip strength increased an average of 73 percent in seven of nine extremities and pinch strength increased 101 percent in four of nine extremities. Five of six patients were satisfied with their results and reported improved quality of life. Preoperatively, five of seven patients were working on light duty; postoperatively, three of six patients attempted to return to work, but none were working at final follow-up. Electrophysiologic data did not correlate with the symptomatic or functional outcome. There were four complications; three were related to delayed wound healing, and one morbidly obese patient developed a ventral hernia. Wrapping the median nerve with vascularized omentum is a viable option for the treatment of severe recalcitrant carpal tunnel syndrome. Despite a high satisfaction rate and significant symptomatic improvement, many symptoms will persist, but to a lesser degree.

Neovascularization and other histopathologic findings in an autogenous saphenous vein wrap used for recalcitrant carpal tunnel syndrome: A case report

A patient suffering from recalcitrant carpal tunnel syndrome despite 4 surgical decompressions was treated successfully with revision carpal tunnel release, neurolysis, and autogenous saphenous vein wrapping of the median nerve. When he subsequently developed compression of the common digital nerve to the middle finger his carpal tunnel was re-explored and the previously applied vein graft underwent a biopsy examination. Histopathologic analysis of the biopsy specimen was remarkable for neovascularization of the vein graft and structural transformation of the vein endothelium, neither of which has been reported in vein wrapping of the upper extremity. (J Hand Surg 2003;28A:262-266. Copyright © 2003 by the American Society for Surgery of the Hand.)

The use of free fat grafts in recalcitrant carpal tunnel: a retrospective study

We present a retrospective study evaluating the proclaimed beneficial effect of the use of fat grafts in patients with recalcitrant carpal tunnel syndrome. Twenty-one re-decompression operations with fat grafting (group I) and 20 routine re-decompressions (group II) were assessed postoperatively with a questionnaire, physical examination, and nerve conduction studies. Both groups were improved by the operative intervention, but no significant differences were found between the two surgical techniques for postoperative severity of symptoms, threshold sensation, pain assessment, nerve conduction velocities, or patients' satisfaction with the postoperative result. Only the postoperative functional status score of the fat grafted patients revealed a trend to a significantly worse outcome. The fat grafted patients sustained more problems with a hypersensitive scar at the wrist level immediately after surgery, although on long-term review there was no significant difference in scar tenderness between the two groups. We concluded that implantation of free fat grafts has not proved to be of additional benefit in patients with recalcitrant carpal tunnel syndrome.

The hypothenar fat pad flap for management of recalcitrant carpal tunnel syndrome

The hypothenar fat pad flap interposes adipose tissue from the hypothenar eminence between the median nerve and overlying transverse carpal ligament and surgical scar. This retrospective study reviews 62 hands in 58 patients (46 non-workers' compensation and 16 workers' compensation) with recurrent symptoms after failed open carpal tunnel release who underwent revision carpal tunnel decompression and in whom a hypothenar fat pad flap was used. The follow-up period averaged 33 months. Patient satisfaction was 6 in the non-workers' compensation group and 4 in the workers' compensation group. Average time to return to work for the non-workers' compensation group was 12 weeks, compared to 37 weeks for the workers' compensation group. Study results indicate that the hypothenar fat pad flap produces excellent results in procedures designed to alleviate recalcitrant idiopathic carpal tunnel syndrome.

Treatment of recalcitrant carpal tunnel syndrome with the hypothenar fat flap

Treatment of recalcitrant carpal tunnel syndrome with the hypothenar fat flap