Rebound Rate Research Articles

Early Viral Dynamics Predict HIV Post-Treatment Control After Analytic Treatment Interruption

Abstract Background A key research priority for developing an HIV cure strategy is to define the viral dynamics and biomarkers associated with sustained post-treatment control. The ability to predict the likelihood of sustained post-treatment control or non-control could minimize the time off antiretroviral therapy (ART) for those destined to not control and anticipate longer periods off ART for those destined to control. Methods Mathematical modeling and machine learning were used to characterize virologic predictors of long-term virologic control using viral kinetics data from several studies in which participants interrupted ART. Predictors of post-ART outcomes were characterized using data accumulated from the time of treatment interruption, replicating real-time data collection in a clinical study, and classifying outcomes as either post-treatment control (plasma viremia ≤400 copies/mL at 2 of 3 time points for ≥24 weeks) or non-control. Results Potential predictors of virologic control were the time to rebound, the rate of initial rebound, and the peak plasma viremia. We found that people destined to be non-controllers could be identified within 3 weeks of rebound (prediction scores: accuracy, 80%; sensitivity, 82%; specificity, 71%). Conclusions Given the widespread use of analytic treatment interruption in cure-related trials, these predictors may be useful to increase the safety of analytic treatment interruption through the early identification of people who are unlikely to become post-treatment controllers.

Shotcreting with Cement–Sand Mixtures Under the Influence of an Electrostatic Field

One of the primary and still unresolved problems of shotcreting is the high rebound rate of the material, which reaches over 20% in “dry” shotcreting. There is a practical need to improve the very principle of shotcreting and methods for optimizing the movement of torch particles. Materials and Methods: The purpose of this study was to justify the use of the electrostatic treatment of cement–sand mortar in the process of performing shotcreting works using the dry method. It was proposed that the binder and then the finished mixture be ionized step-by-step (by passing it through a non-uniform electrostatic field formed by corona electrodes). As a result, the shotcrete will be held on the fence. Results: Analysis of the modeling results shows that the presence of an electrostatic field slows down the particle and reduces the kinetic energy of the rebound. After theoretical calculations, experiments were conducted, during which, the torch size and the plant productivity were changed, and the rebound mass was weighed. After application to the surface, prototypes were formed and subjected to strength tests. It was determined that gunning in a sharply non-uniform electric field demonstrates its practical and economic efficiency due to the uniform deposition of charged particles on the treated surface and low power consumption. Conclusions: It was established that the electrostatic treatment of a cement–sand mixture during application allows concrete particles to be retained on the shotcrete surface, the rebound of the material to be reduced and the strength of concrete to be increased.

Bonding performance and construction parameters of low-rebound shotcrete

Abstract Shotcrete has the advantages of short setting time, high early strength, simple process and flexible operation methods. It is mainly used as temporary support in domestic highway tunnels. This study investigates the development of low-rebound shotcrete for tunnel construction by adding silica fume and fly ash into the mixture. Sandstone and limestone were employed to simulate the surrounding rock. The workability and mechanical properties of the shotcrete were evaluated based on slump tests, rebound rates, compressive strength measurements, and bonding strength tests between the surrounding rock and the shotcrete. Furthermore, the research investigated construction techniques, with an emphasis on spraying distance, shrinkage angle, and wind pressure, and optimized these parameters for practical engineering uses. The outcomes demonstrate that the addition of silica fume enhances the mechanical properties of the shotcrete and reduces rebound. It was discovered that optimal spraying distance was between 1.2 m and 1.5 m, with the optimal wind pressure at 0.5 m, and the ideal shrinkage angle at 6°.Research on low rebound shotcrete is of great significance for improving construction quality, construction efficiency and engineering structural performance, and also meets the requirements of sustainable development.

Micro milling of WE43 magnesium alloy cardiovascular stent and its mechanical property enhancement by ultrasonic vibration assisted micro deburring

WE43 magnesium alloy cardiovascular stents have broad application prospects in the treatment of vascular diseases. In this article, Mg alloy cardiovascular stent was manufactured by applying micro milling method, and ultrasonic vibration assisted micro deburring technique was adopted for its surface deburring after micro milling. Results show that burrs on the outer wall of the stents can be fully removed after 30 min, without damaging the dimensions and structure. The average surface roughness Ra can be decreased by 24.4 %. The maximum radial pressure can be decreased by 10.2 %, and the radial rebound rate of the stent can be decreased by 13.8 %, when compressed or expanded to the same diameter of the stent after deburring. The stability of the mechanical properties was also validated This study provides a promising method for preparing high-quality micro milling Mg alloy vascular stents with excellent mechanical properties.

Data variables related to wins and losses of game in different scenarios in the WNBA 2023 season

ABSTRACT The research subarea of sports performance analysis on women’s basketball games is relatively scarce. Therefore, this study aims to explore the key variables that influence the game outcomes in the Women’s National Basketball Association (WNBA) during the 2023 season. Firstly, chi-square tests and k-means clustering to control variables were applied to categorise games into four groups (home balanced, home unbalanced, away balanced, and away unbalanced). Secondly, stepwise logistic regression was employed to identify key variables influencing game outcomes in each group. The game statistics variables that were significant in home and away balanced games were the field goals made (FG) (+) and attempted (FGA) (-), free throws made (FT) (+), total rebounds (TRB) (+), steals (STL) (+), turnovers (TOV) (-), and personal fouls (PF) (-). Additionally, 3-point field goals made (3P) were significant in home balanced games and assists (AST) (+) in the away balanced games. And FG (+), FGA (-), offensive rebounds (ORB) (+), STL (+), blocks (BLK) (+), and TOV (-) were significant in the home unbalanced games. In addition, in the away unbalanced group 4 variables included 3P (+), offensive rebound percentage (+), defensive rebound percentage (+), and total rebound percentage (+) were identified as key variables.

Tissue plasminogen activator for acute branch atheromatous disease exhibits transient improvement and worsening

BackgroundTissue plasminogen activator (tPA) is an effective treatment for acute ischemic stroke. Although initial improvement is observed when administered for branch atheromatous disease (BAD), some cases subsequently worsen. Clinical data on the characteristics of these patients is lacking, and the benefits of tPA are unclear. ObjectiveTo analyze rebound cases and elucidate the clinical characteristics and outcomes associated with tPA administration in BAD. MethodsThis multicenter retrospective study was conducted in Japan. Worsening after initial improvement of a condition is termed as rebound, and such cases were compared with other types of ischemic stroke in patients with and without rebound. The characteristics of patients with BAD who rebounded were examined. ResultsThe study included 93 patients. Among the patients who were administered tPA, the NIHSS scores at 24 h and 7 days post-tPA were significantly higher in patients with BAD than in patients with other types of infarcts. The group with BAD exhibited a significantly higher rate of rebound than other groups (37.5 % vs. 0 %, P < 0.001). However, no differences were observed in outcomes between patients who experienced rebound after tPA administration and those who did not. ConclusionsReevaluation and changing the strategy of tPA use in patients with BAD may be necessary. However, this study does not totally discourage its use, as specific patients can benefit.

Impact of alemtuzumab-mediated lymphocyte depletion on SIV reservoir establishment and persistence.

Persistence of the rebound-competent viral reservoir (RCVR) within the CD4+ T cell compartment of people living with HIV remains a major barrier to HIV cure. Here, we determined the effects of the pan-lymphocyte-depleting monoclonal antibody (mAb) alemtuzumab on the RCVR in SIVmac239-infected rhesus macaques (RM) receiving antiretroviral therapy (ART). Alemtuzumab administered during chronic ART or at the time of ART initiation induced >95% depletion of circulating CD4+ T cells in peripheral blood and substantial CD4+ T cell depletion in lymph nodes. However, treatment was followed by proliferation and reconstitution of CD4+ T cells in blood, and despite ongoing ART, levels of cell-associated SIV DNA in blood and lymphoid tissues were not substantially different between alemtuzumab-treated and control RM after immune cell reconstitution, irrespective of the time of alemtuzumab treatment. Upon ART cessation, 19 of 22 alemtuzumab-treated RM and 13 of 13 controls rebounded with no difference in the time to rebound between treatment groups. Time to rebound and reactivation rate was associated with plasma viral loads (pVLs) at time of ART initiation, suggesting lymphocyte depletion had no durable impact on the RCVR. However, 3 alemtuzumab-treated RM that had lowest levels of pre-ART viremia, failed to rebound after ART withdrawal, in contrast to controls with similar levels of SIV replication. These observations suggest that alemtuzumab therapy has little to no ability to reduce well-established RCVRs but may facilitate RCVR destabilization when pre-ART virus levels are particularly low.

Preparation and Properties of Elastic Mullite Fibrous Porous Materials with Excellent High-Temperature Resistance and Thermal Stability.

Mullite fiber felt is a promising material that may fulfill the demands of advanced flexible external thermal insulation blankets. However, research on the fabrication and performance of mullite fiber felt with high-temperature resistance and thermal stability is still lacking. In this work, mullite fibers were selected as raw materials for the fabrication of mullite fibrous porous materials with a three-dimensional net structure. Said materials' high-temperature resistance and thermal stability were investigated by assessing the effects of various heat treatment temperatures (1100 °C, 1300 °C, and 1500 °C) on the phase composition, microstructure, and performance of their products. When the heat treatment temperature was below 1300 °C, both the phase compositions and microstructures of products exhibited stability. The compressive rebound rate of the product before and after 1100 °C reached 92.9% and 84.5%, respectively. The backside temperature of the as-prepared products was 361.6 °C when tested at 1500 °C for 4000 s. The as-prepared mullite fibrous porous materials demonstrated excellent high-temperature resistance, thermal stability, thermal insulation performance, and compressive rebound capacity, thereby indicating the great potential of the as-prepared mullite fibrous porous materials in the form of mullite fiber felt within advanced flexible external thermal insulation blankets.

Development of Negative-Temperature Cement Emulsified Asphalt Spraying Materials Based on Spraying Performance and Rheological Parameters.

To develop a cement emulsified asphalt composite (CEAC) that can be sprayed under a plateau negative temperature environment, the effects of the water-solid ratio, calcium aluminate cement substitution rate, emulsified asphalt content, sand-binder ratio, and polyvinyl alcohol (PVA) fiber content on the spraying performance and rheological parameters of CEAC were explored through the controlled variable method. Additionally, the correlation between the spraying performance and rheological parameters of CEAC was established, and the optimal proportion of CEAC was determined. Then, the difference in frost resistance and pore structure between the cement slurry (CS) without emulsified asphalt and CEAC at the optimum proportion was analyzed. The results showed that the optimum proportions for sprayed CEAC were 0.14 water-solid ratio, 0.5 sand-binder ratio, 25% substitution of calcium aluminate cement, 5% emulsified asphalt content, and 1.5% PVA fiber volume mixing. The yield stress and plastic viscosity of CEAC were positively correlated with the build-up thickness, whereas the rebound rate and the latter showed a negative correlation. The spraying performance may be described by the rheological parameters; the ranges of yield stress and plastic viscosity of 2.37-3.95 Pa·s and 77.42-108.58 Pa, respectively, produced the best spray ability. After undergoing an equivalent number of freeze-thaw cycles, CEAC exhibited lower mass and strength loss rates compared to CS, thereby demonstrating superior frost resistance. In addition, the pore structure analysis showed that the difference in capillary and macropore contents was the main reason for the variability in frost resistance between CS and CEAC.

Experimental and numerical investigations of an auxetic support structure used for local repair of buried pipelines

Due to the ongoing disasters caused by local damage to underground pipelines in urban areas, a new method has been proposed for local trenchless rehabilitation of pipelines.This method utilizes the auxetic effect of an auxetic pipe structure to create support brackets inside the pipeline for repairing damaged sections, with the aim of reducing overall repair costs and improving efficiency. The main objectives of this study are to demonstrate the feasibility of using auxetic pipes for pipeline repairs and to enhance key parameters of auxetic support pipes. This paper presents a tube with auxetic support - the Surrounding Auxetic Tubular Structure (SATS). Using 3D printing technology, the preparation of SATS specimens was carried out, and the compressive properties of SATS were studied through finite element analysis and quasi-static compression test. The results show that the proposed SATS has a significant negative Poisson's ratio effect during the compression process and exhibits a high structural rebound rate after the load is removed. The size of the structure's boundary is the most influential factor on the auxetic effect. Additionally, the compression displacement of SATS increases with the increase of the elliptical short axis, and decreases with the increase of the elliptical long axis. The compressive load decreases with the increase of the short axis, and increases with the increase of the long axis. This demonstrates the excellent mechanical performance of the proposed auxetic support structure and lays the foundation for the feasibility of local repair work for trenchless rehabilitation.

Study of the Performance of Emulsified Asphalt Shotcrete in High-Altitude Permafrost Regions

To improve the performance of shotcrete in high-altitude and low-temperature environments, emulsified asphalt shotcrete (EASC), which can be used in negative-temperature environments, was prepared by using low-freezing-point emulsified asphalt, calcium aluminate cement, and sodium pyrophosphate as modified materials. The effect of emulsified asphalt on the performance of shotcrete was investigated through concrete spraying and indoor tests. Then, the modification mechanism of emulsified asphalt with respect to EASC was analyzed by combining scanning electron microscopy images and the pore structure characteristics of EASC. The results showed that in a negative-temperature environment, the incorporation of emulsified asphalt delayed the formation of the peak of the cement hydration exotherm, slowed the rate of the cement hydration exotherm, reduced the thermal perturbation of permafrost by EASC, increased the cohesion of the concrete, improved the bond strength between EASC and permafrost, and reduced the rate of rebound. The mechanical strength of the studied EASC decreased upon increasing the amount of emulsified asphalt in the admixture, and its resistance to cracking gradually improved. A content of less than 5% emulsified asphalt could improve the internal pore structure of EASC, thus improving its durability. Increasing the content of emulsified asphalt affected the hydration process of the cement, and the volume content of the capillary pores and macropores increased, which reduced the durability of the EASC.

Integrating high-efficiency thermal channel construction and structural wave absorption design within vertically oriented SiC-coated carbon fibers/silicone resin composites

To match the increasing miniaturization and integration of electronic devices, higher requirements are put forward for the electromagnetic wave absorption (EWA) and thermal conductivity (Tc) of heat conduction-microwave absorption integrated materials (HCMWAIMs) to overcome the problems of electromagnetic wave (EMW) pollution and heat accumulation. Herein, a simple and efficient shear force induction technique is used to construct a carbon/magnetic isolation network within the silicone resin matrix, where ferrite particles are well dispersed in vertically oriented SiC-coated carbon fibers array. Benefiting from the orderly interconnection of CFs@SiC in the array, the prepared composites have a high Tc of 7.86 W m−1 K−1. The introduction of magnetic ferrite particles within the CFs@SiC array can induce electrical-magnetic coupling, optimize impedance matching, and enhance EMW attenuation. This synergy of V-CFs@SiC/ferrite isolation network structure gives the composites an excellent effective absorption bandwidth (EAB) of 5.88 GHz and a minimal reflection loss (RLmin) of −47.5 dB at a thickness of 1.5 mm. Moreover, the as-prepared composites exhibit outstanding elastic compressibility of 43.2 % and rebound rate of 45.1 % under a pressure of 35psi. This strategy offers a distinguishing understanding of preparing high-performance HCMWAIMs in modern electronic devices.

SARS-CoV-2 infection rebound among patients receiving antiviral agents, convalescent plasma, or no treatment: a systematic review with meta-analysis.

There is some evidence showing rebound of COVID-19 infections in patients treated with nirmatrelvir-ritonavir between 2 and 8 days following cessation of the antiviral treatment. COVID-19 rebound is not unique to patients treated with nirmatrelvir-ritonavir, but is also observed in molnupiravir recipients, in patients who did not receive any antiviral treatment and in patients who received convalescent plasma (CP). This was a systematic review with meta-analysis of clinical trials evaluating rates of virologic and clinical rebound in COVID-19 patients receiving antiviral agents, CP or no treatment. Both randomized clinical trials and controlled cohort studies were considered. The methodological quality of trials was assessed using ROB-2 and ROBIN-1 checklists, and the GRADE approach. Data were available from 16 trials. The occurrence of virologic rebound was more commonly observed among nirmatrelvir recipients than among untreated patients (relative risk [RR]=2.12; 95% confidence interval [CI]: 1.38-3.28; p=0.0007). No differences were observed in the occurrence of virologic rebound between nirmatrelvir-ritonavir and molnupiravir recipients (RR=1.01; 95% CI: 0.71-1.43). Similar rates of virologic rebounds were observed in molnupiravir recipients and untreated patients (RR=1.14; 95% CI: 0.81-1.6). One study in the pre-omicron period compared rates of virologic rebound between patients receiving standard of care with or without CP: no differences were observed between groups (RR=1.04; 95% CI: 0.55-1.99). Rates of clinical rebound were reported in seven trials, five evaluating nirmatrelvir-ritonavir and untreated patients, and two evaluating nirmatrelvir-ritonavir and molnupiravir recipients. No statistically significant differences between groups were observed. For all these comparisons, the certainty of the available evidence was graded as low or moderate. Virologic rebound of COVID-19 infections appears to be mild and self-limited, and was observed more commonly in nirmatrelvir-ritonavir recipients than in untreated patients, but was also observed in patients treated with molnupiravir or CP.

Study on Phenol-Formaldehyde Resin-Montmorillonite Impregnation and Compression Modification of Chinese Fir.

In this study, a phenol-formaldehyde resin-montmorillonite intercalation composite solution was used as a modifier to treat Chinese fir via impregnation and compression. The basic characteristics and wettability of the PF (phenol-formaldehyde)-montmorillonite impregnation solution were analyzed. The effects of the solid content of PF, the quantity of montmorillonite, and the impregnation time on the impregnation weight gain of Chinese fir were studied through orthogonal experiments. The results showed that when the amount of montmorillonite was 1%, the wettability of the PF-montmorillonite impregnation solution performed the best, the curing time was short, and the curing strength was high. The optimal impregnation process consists of a PF solid content of 25%, an impregnation time of 120 min, and a montmorillonite ratio of 1%. Under these conditions, the modified Chinese fir was prepared via hot pressing. The effects of the addition of montmorillonite and different levels of compressibility on the physical and mechanical properties of modified wood were studied. The physical and mechanical properties were found to be better when the compression ratio was 33%: the density increased from 0.33 g/cm3 to 0.58 g/cm3; the surface hardness increased from 33.6 HD to 70.9 HD; the static bending strength increased from 60.4 MPa to 98.7 MPa; and the elastic modulus increased from 6 390 MPa to 11 498 MPa. After 30 days of release, the compression rebound rate was 3.97%. Meanwhile, the micromorphology and heat resistance of the impregnated compressed Chinese fir showed that the PF-montmorillonite impregnation solution entered into the cell cavity and intercellular space of the Chinese fir and formed a good composite, thus improving the water resistance, heat resistance, and physical and mechanical properties.

Viral SARS-CoV-2 Rebound Rates in Linked Commercial Pharmacy-Based Testing and Health Care Claims.

Viral SARS-CoV-2 rebound (viral RNA rebound) is challenging to characterize in large cohorts due to the logistics of collecting frequent and regular diagnostic test results. Pharmacy-based testing data provide an opportunity to study the phenomenon in a large population, also enabling subgroup analyses. The current real-world evidence approach complements approaches focused on smaller, prospective study designs. We linked real-time reverse transcription quantitative polymerase chain reaction test data from national pharmacy-based testing to health care claims data via tokenization to calculate the cumulative incidence of viral RNA rebound within 28 days following positive test results in nirmatrelvir/ritonavir (NMV-r)-treated and untreated individuals during the Omicron era (December 2021-November 2022) and prior to the Omicron era (October 2020-November 2021). Among 30 646 patients, the rate of viral RNA rebound was 3.5% (95% CI, 2.0%-5.7%) in NMV-r-treated infections as compared with 1.5% (95% CI, 1.3%-1.7%) in untreated infections during the Omicron era and 1.9% (95% CI, 1.7%-2.1%) prior to the Omicron era. Viral RNA rebound in patients who were vaccinated (n = 8151), high risk (n = 4411), or older (≥65 years, n = 4411) occurred at comparable rates to the overall cohort (range, 1.1%-4.8%). Viral rebounds to high RNA levels in NMV-r-treated infections occurred in 8% of viral rebounds as compared with 5% to 11% in untreated infections. Rates of hospitalization were comparable between patients with NMV-r-treated infections with viral RNA rebound (0%) and untreated patients with viral RNA rebound (0%-1.2%). Our findings suggest viral RNA rebound is rare (< 5%), with rates that were consistent with those from the EPIC-HR trial (Evaluation of Protease Inhibition for COVID-19 in High-Risk Patients). Most occurrences of viral RNA rebound were associated with low viral RNA levels, and viral RNA rebound progression to severe disease was not observed.

Ocean cavity regime shift reversed West Antarctic grounding line retreat in the late Holocene

Recent geologic and modeled evidence suggests that the grounding line of the Siple Coast of the West Antarctic Ice Sheet (WAIS) retreated hundreds of kilometers beyond its present position in the middle to late Holocene and readvanced within the past 1.7 ka. This grounding line reversal has been attributed to both changing rates of isostatic rebound and regional climate change. Here, we test these two hypotheses using a proxy-informed ensemble of ice sheet model simulations with varying ocean thermal forcing, global glacioisostatic adjustment (GIA) model simulations, and coupled ice sheet-GIA simulations that consider the interactions between these processes. Our results indicate that a warm to cold ocean cavity regime shift is the most likely cause of this grounding line reversal, but that GIA influences the rate of ice sheet response to oceanic changes. This implies that the grounding line here is sensitive to future changes in sub-ice shelf ocean circulation.

Changes in access to viral load testing, incidence rates of viral load suppression and rebound following the introduction of the 'universal test and treat' guidelines in Cameroon: A retrospective follow-up analysis.

Cameroon adopted and started implementing in 2016, the 'universal test and treat' (UTT) guidelines to fast-track progress towards the 95-95-95 ambitious targets to end the HIV epidemic. Achieving the third 95 (viral load suppression) is the most desirable target in HIV care. We aimed to evaluate the effectiveness of this novel approach on access to viral load testing (VLT), viral suppression (VLS), and viral load rebound (VLR). A retrospective cohort study was conducted at The Nkongsamba Regional Hospital to compare VLT outcomes between the pre-UTT (2002 to 2015) and the post-UTT (2016 to 2020) periods. We used a data extraction form to collect routine data on adult patients living with HIV. We measured uptake levels of the first and serial VLT and compared the incidence rates of VLS (VL<1000 copies/ml) and viral load rebound (VLR) before and after introducing the UTT approach using Kaplan Meier plots and log-rank tests. Cox regression was used to screen for factors independently associated with VLS and VLR events between the guideline periods. Access to initial VLT increased significantly from 6.11% to 25.56% at 6 months and from 12.00% to 73.75% at 12 months before and after introducing the UTT guidelines respectively. After a total observation time at risk of 17001.63 person-months, the UTT group achieved an incidence rate of 90.36 VLS per 1000 person-months, four-fold higher than the 21.71 VLS per 1000 person-months observed in the pre-UTT group (p<0.0001). After adjusting for confounding, the VLS rate was about 6-fold higher in the UTT group than in the pre-UTT group (adjusted Hazard Rate (aHR) = 5.81 (95% confidence interval (95%CI): 4.43-7.60). The incidence of VLR increased from 12.60 (95%CI: 9.50-16.72) to 19.11 (95%CI: 14.22-25.67) per 1000 person-months before and after the introduction of UTT guidelines respectively. After adjusting, VLR was more than twice as high in the UTT group than in the pre-UTT group (aHR = 2.32, 95%CI: 1.30-4.13). Increased access to initial VLT and higher rates of VLS have been observed but there are concerns that the suppressed viral load may not be durable since the introduction of the UTT policy in this setting.

Research on the rebound rule of a pit bottom caused by excavation of typical strata

In practical engineering, the magnitude of soil unloading rebound is closely related to the physical and mechanical properties of the soil. Therefore, there are significant differences in geological conditions among the different regions. As such, targeted research on the rebound law and calculation methods of foundation pits is needed. This article reports indoor experiments and numerical simulation methods which are used to study the trends and calculation methods of foundation pit rebound based on typical geological conditions in South China. Our findings are as follows. 1) At maximum consolidation stress ranging from 100 kPa to 400kPa, the maximum rebound rate of plain fill soil in typical soil layers is 0.0539–0.0704, the rebound rate of silty clay is 0.0373–0.0528, the rebound rate of coarse sand is 0.0296–0.0343, the rebound rate of gravelly cohesive soil is 0.0159–0.0305, the rebound rate of fully weathered granite is 0.0175–0.0344, and the rebound rate of strongly weathered granite is 0.0170–0.0379. 2) The rebound indices do not change with changes in the unloading ratio or initial consolidation stress. The rebound indices of the soil layer from top to bottom are 0.0143, 0.0119, 0.0077, 0.0096, 0.0083, and 0.0076, respectively, and a formula for calculating the rebound modulus of typical soil layers in South China was proposed. 3) The pore ratio of the soil after the end of the recompression process is lower than that which occurs after the first compression. The difference between the compression porosity ratio of the soil layer from top to bottom and the compression porosity ratio is 0.1, 0.08, 0.02, 0.06, 0.02, and 0.03, respectively. 4) The calculation of the depth of influence by the self-weight stress offset method is based on the theory of eliminating self-weight stress and unloading stress. The calculation depth is not affected by geological conditions, the formula for calculating the rebound modulus is consistent with the formula obtained from experimental research, and the calculation results are in good agreement with the numerical values.

The Effects of Different Doses of Sufentanil on Intraoperative Cardiovascular Response and Postoperative Recovery in Patients Undergoing Cardiac Surgery: A Retrospective Cohort Study.

To investigate the correlation between the amount of sufentanil used during anesthesia and intraoperative hemodynamic fluctuation and postoperative recovery in patients undergoing cardiopulmonary bypass (CPB). A retrospective analysis was performed on 454 patients undergoing elective heart surgery under CPB. Patients were divided into two groups according to the amount of sufentanil used during anesthesia: Group L (induced sufentanil 0.4-0.6 ug /kg, maintained sufentanil 0.01-0.02 ug/kg/min, n = 223) and Group H (induced sufentanil 4-6 ug/kg, maintained sufentanil 0.02-0.03 ug/kg/min, n = 231). Propensity score matching (PSM) was used at a 1:1 nearest-neighbor ratio to compare the two groups. Intraoperative use of vasoactive drugs, spontaneous heart rebound, secondary endotracheal intubation, postoperative mechanical ventilation time, the length of stay (LOS) in ICU, postoperative LOS in hospital, postoperative in-hospital mortality were analyzed. After matching, a total of 144 patients were included (72 patients in Group L, and 72 patients in Group H). Multivariate logistic regression analysis showed that the dosage of sufentanil during anesthesia was significantly correlated with the utilization rate of intraoperative vasoactive drugs (P < 0.001) and the success rate of spontaneous heart rebound (p = 0.001). The utilization rate of vasoactive drugs decreased significantly in Group H (OR, 0.062; 95% CI, 0.019-0.200) compared to that of Group L. The success rate of spontaneous heart rebound (OR, 0.187; 95% CI, 0.071-0.491) was higher in Group H. There were no differences on postoperative recovery outcomes between the two groups. On the basis of our data, the use of high-dose sufentanil is beneficial to keep the cardiovascular response of patients in a stable state, but there is no significant effect on the quality of early postoperative recovery.

Accurate estimation of concrete consumption in tunnel lining using terrestrial laser scanning

Accurate estimation of concrete (including shotcrete) consumption plays a crucial role in tunnel construction. A novel method has been introduced to accurately estimate concrete consumption with terrestrial laser scanning (TLS). The estimation needs to capture TLS data of tunnel surfaces at different stages of construction. Unrolling point clouds, a novel two-stage algorithm consisting of noise removal and hole filling has been used to generate resampled points. Furthermore, resampled points from two scans (before and after lining construction) ultimately generate an innovative computation model composed of multiple hexahedral elements, which is used for calculating volumes. The proposed technique was applied to the Tiantaishan highway tunnel and Da Fang Shan high-speed railway tunnel. The calculation relative error of the rebound rate is 0.19%, and the average relative error in predicting the demand for secondary lining concrete is 0.15%. Compared with 3D Delaunay with curve fitting, the proposed technique offers a more straightforward operation and higher accuracy. Considering factors such as tunnel geometry, support design, and concrete properties, a computational model will provide valuable insights into optimizing resource allocation and reducing material waste during construction.