In recent years, the desire to design, create and/or discover advanced functional nanomaterials has changed the way that faculty members and graduate students approach engineering research. Though materials can (and likely will) make a significant impact on most technologies, the truth is that in most disciplines, materials with highly complex structures remain on the fringes of realistic deployment. In some cases, even when so-called “advanced” materials are discovered there are significant difficulties in transitioning them from ex-situ tests to the real reacting environment. Therefore, we must be careful to understand that material chemistry and structure are only two variables in an extremely complex system and often times there are other fundamental (e.g. electronic mobility, thermodynamic barriers, diffusivity) and engineering (porosity, concentration, temperature) properties that drive behavior in such environments. Additionally, there are systems where materials are being sought without a clear understanding of what is truly limiting performance and durability or the properties that are required of a real engineered system to operate effectively.Anion exchange membrane fuel cells (AEMFCs) are an example system where the literature is littered with exotic materials that claim to improve activity and stability (presumed as performance and durability in real devices). However, it will be shown that for several years, such new materials had limited success (if any) in advancing performance and durability. This talk will summarize ~five years of work in AEMFCs where the performance and durability of AEMFCs were improved significantly without any new materials – just using traditional chemical engineering principles for reactor engineering. Only later – once device operation was well understood and controlled – were new materials helpful. On the operational side, the main discussion point will be the transport of water. On the materials side, new membranes and catalysts will be discussed. The talk will end with perspectives on transitioning AEMFCs to more realistic operating environments, including the mitigation of effects from CO2.