Abstract The purpose of this article is to provide an effective approach to evaluate slope stability in real-time in a reservoir area, which is significant for carrying out risk management for landslide disaster prevention in various engineering practices. A comprehensive idea for stability estimation of bank slope under the influence of rainfall or the reservoir water level is presented in this work. Slope stability analysis and back analysis of soil parameters are both included based on numerical simulation. The mechanical parameters of the bank slope were first back-analyzed using particle swarm optimization (PSO), and real-time stability analysis with high accuracy and efficiency was then established based on multiple continuously monitored displacements. Two case studies were carried out in this study. The results show that (1) based on the real-time monitored displacement and numerical simulation, the mechanical parameters of the slope can be reasonably retrieved through PSO; and (2) based on the inverse mechanical parameters, the safety factors of the slope can be numerically obtained, so that the real-time estimation of slope stability can be realized.