As large-scale enterprises increasingly adopt cloud computing, the need for a structured framework to guide seamless cloud migration and optimize microservices architecture becomes critical. This review presents a comprehensive designed to address the challenges and opportunities associated with transitioning to cloud environments and optimizing microservices for performance, scalability, and security. The review begins with an assessment of the enterprise’s current infrastructure, emphasizing a phased approach to cloud migration. It outlines key strategies such as lift-and-shift, re-platforming, and re-architecting, each tailored to specific organizational needs. The selection of the appropriate cloud model (public, private, or hybrid) and the use of multi-cloud strategies are discussed to ensure flexibility and risk mitigation during migration. For microservices optimization, focuses on designing services that are loosely coupled and highly scalable. Key elements include the use of service discovery, load balancing, API gateways, and database management strategies to improve the efficiency and reliability of microservices. Additionally, this introduces security best practices, including identity and access management (IAM), encryption protocols, and microservices-specific security measures such as Zero Trust Architecture. The review also highlights optimization strategies involving containerization (Docker) and orchestration (Kubernetes), alongside the integration of Continuous Integration/Continuous Delivery (CI/CD) pipelines for streamlined development and deployment. Performance monitoring, real-time logging, and proactive maintenance are emphasized for sustained efficiency and cost control in cloud environments. Case studies demonstrate the successful implementation of cloud migration and microservices optimization in large enterprises, showcasing both the benefits and common challenges. The review concludes by exploring future trends, such as serverless computing and AI-driven optimization, that will continue to shape cloud migration and microservices architecture.