Data-driven simulation (DDS) is fundamental to analytical and decision-support technologies in Industry 4.0 and smart manufacturing. This study investigates the potential of DDS for resource allocation (RA) in high-mix, low-volume smart manufacturing systems with mixed automation levels. A DDS-based decision support system (DDS-DSS) is developed by incorporating two RA strategies: simulation-based bottleneck analysis (SB-BA) and simulation-based multi-objective optimization (SB-MOO). To enhance the performance of SB-MOO, a unique meta-learning mechanism featuring memory, dynamic orthogonal array, and learning rate is integrated into the NSGA-II, resulting in a modified version of the NSGA-II with meta-learning (i.e., NSGA-II-ML). The proposed DSS also benefits from a post-optimality analysis that leverages a clustering algorithm to derive actionable insights. A real-life marine engine manufacturing application study is presented to demonstrate the applicability and exhibit efficacy of the proposed DSS and NSGA-II-ML. To this aim, NSGA-II-ML was tested against the original NSGA-II and differential evolution (DE) algorithm across a set of test problems. The results revealed that NSGA-II-ML surpassed the other two in terms of the number of non-dominated solutions and hypervolume, particularly in medium and large-sized problems. Furthermore, NSGA-II-ML achieved a 24% improvement in the best throughput found in the real case problem, outperforming SB-BA, NSGA-II, and DE. The post-optimality analysis led to the extraction of valuable knowledge about the key, influencing decision variables on the throughput.
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