Reading Charts Research Articles

The Short-term Effect of Caffeine Consumption on Reading Performance

Objective: Caffeine, a widely consumed psychoactive substance, is recognized for its cognitive-enhancing effects, notably enhancing performance on tasks requiring narrative comprehension, where it has been shown to boost both acuity and speed. This study investigates the impact of caffeine intake on reading acuity and evaluates changes in reading speed post-caffeine consumption. Material and Methods: Employing a cross-sectional design, nineteen participants with distance best-corrected vision of 6/6 or better (equivalent to logMAR 0.00 or better) (mean age=22.5±1.00 years old) and near vision of 0.1 logMAR (N5) were recruited. Baseline measurements of reading acuity and speed were taken using the article sourced from Perpustakaan Tun Abdul Razak (PTAR) and Buari-Chen Malay Reading Chart (BCMRC) before coffee consumption, respectively. Participants consumed 200 mg of Nescafe Gold (caffeine) before the subsequent assessment. The time taken to read the reading materials was recorded, alongside any errors. Results: While reading speed significantly increased post-caffeine consumption (t=-7.536, p-value<0.001), reading acuity remained unaffected (t=-0.378, p-value=0.705). These results suggest a moderate dose of 200 mg of caffeine can enhance reading speed without compromising acuity in young adults.Conclusion: This indicates that caffeine mainly affects the rate of reading, while it does not alter the reading acuity of individuals.

Climb Performance Prediction in High Drag Configuration Middle-Class Transportation Aircraft: An Ensemble Learning Approach

This study addresses the application of machine learning and artificial neural network models for predicting the climb speed of the C-130H military transport aircraft. Random Forest, Neural Network, and Ensemble models were developed to overcome limitations of traditional chart reading and interpolation methods. Models were trained on flight manual data, considering factors such as gross weight, pressure altitude, drag index, temperature deviation, and engine efficiency. Comparative analysis revealed the Ensemble approach, combining Random Forest and Neural Network techniques, provided the highest accuracy (R² ≈ 0.4532), followed by Random Forest (R² ≈ 0.4303) and Neural Network (R² ≈ 0.3765) models. All significantly outperformed the traditional Young Method (R² = -1.2673). Feature importance analysis identified pressure altitude, gross weight, and engine efficiency as critical factors influencing climb speed. The ensemble approach demonstrated more reliable and accurate results in predicting C-130H climb rates, reducing risks associated with single-model reliance. This research highlights the potential of machine learning in aircraft performance prediction, offering possibilities for improving pre-flight preparation, reducing workload, and enhancing flight safety. Implications for the aviation industry and future research directions are discussed, emphasizing the role of advanced predictive models in shaping future flight operations and aircraft performance management.

Duration from start of antibiotic exposure to onset of Clostridioides difficile infection for different antibiotics in a non-outbreak setting

Background Antibiotic treatment is a well-known risk factor for Clostridioides difficile infection (CDI). The time from start of antibiotic exposure to onset of CDI for different antibiotics is sparsely studied. CDI with onset in the community is often treatable without in-hospital care while CDI patients treated in hospital need isolation, resulting in higher costs and infection control measures. Objectives To determine the time from start of antibiotic exposure to onset of healthcare facility-associated CDI for different antibiotics. Methods Time between antibiotic exposure and disease onset was evaluated retrospectively with chart reading in a two-centre Swedish setting. A case was attributed to an antibiotic group if this represented more than 2/3 of total antibiotic exposure 30 days before onset of CDI. Results Cephalosporins caused CDI faster (mean 7.6 days), and more often during ongoing antibiotic therapy (81% of the cases) than any other antibiotic group. All other common agents had between 2–3 times longer period between start of exposure to onset of CDI (quinolones more than 3 times). Conclusions The time gap between antibiotic exposure and onset of CDI is markedly different between different antibiotics. Decreased cephalosporin use could delay onset of healthcare facility-associated CDI and limit infections with onset within the hospital. This might decrease costs for inpatient care, need of infection control measures and shortage of beds in the hospital.

Investigating the impact of asymmetric macular sensitivity on visual acuity chart reading in choroideremia.

Degeneration in choroideremia, unlike typical centripetal photoreceptor degenerations, is centred temporal to the fovea. Once the fovea is affected, the nasal visual field (temporal retina) is relatively spared, and the preferred retinal locus shifts temporally. Therefore, when reading left to right, only the right eye reads into a scotoma. We investigate how this unique property affects the ability to read an eye chart. Standard- and low-luminance visual acuity (VA) for right and left eyes were measured with the Early Treatment of Diabetic Retinopathy Study (ETDRS) chart. Letters in each line were labelled by column position. The numbers of letter errors for each position across the whole chart were summed to produce total column error scores for each participant. Macular sensitivity was assessed using microperimetry. Central sensitivity asymmetry was determined by the temporal-versus-nasal central macular difference and subsequently correlated to a weighted ETDRS column error score. Healthy volunteers and participants with X-linked retinitis pigmentosa GTPase regulator associated retinitis pigmentosa (RPGR-RP) were used as controls. Thirty-nine choroideremia participants (median age 44.9 years [IQR 35.7-53.5]), 23 RPGR-RP participants (median age 30.8 years [IQR 26.5-40.5]) and 35 healthy controls (median age 23.8 years [IQR 20.3-29.0]) were examined. In choroideremia, standard VA in the right eye showed significantly greater ETDRS column errors on the temporal side compared with the nasal side (p = 0.002). This significantly correlated with greater asymmetry in temporal-versus-nasal central macular sensitivity (p = 0.04). No significant patterns in ETDRS column errors or central macular sensitivity were seen in the choroideremia left eyes, nor in RPGR-RP and control eyes. Difficulty in tracking across lines during ETDRS VA testing may cause excess errors independent of true VA. VA assessment with single-letter optotype systems may be more suitable, particularly for patients with choroideremia, and potentially other retinal diseases with asymmetric central macular sensitivity or large central scotomas including geographic atrophy.

Retinal OCT biomarkers associated with reading performance in patients with persistent vs. resolved diabetic macular edema.

Recent advancements in imaging technologies, particularly structural optical coherence tomography (OCT), have improved the understanding of diabetic macular edema (DME) pathophysiology and provided valuable biomarkers for disease progression and visual outcomes. This prospective study aimed to investigate the association between specific retinal biomarkers identified through OCT imaging and reading performance metrics in patients with previously treated persistent versus resolved DME and good visual acuity. Forty-nine eyes from 35 patients with a history of DME were enrolled. Reading performance was assessed using the Radner reading charts, which include standardized sentences with geometrically progressing print sizes. Structural alterations in the inner and outer retina, as well as the retinal pigment epithelium (RPE), were graded based on OCT images. Reading performance, measured as maximum reading speed, was associated with specific retinal biomarkers. The disruption of the ellipsoid zone (EZ) in the parafoveal region and the presence of disorganization of the inner retinal layers (DRIL) in the parafovea were correlated with reduced reading speed. These associations were independent of the presence of intraretinal or subretinal fluid. Understanding the relationship between retinal biomarkers and reading performance could contribute to a comprehensive evaluation of visual function and quality of life in patients with DME, leading to better management strategies and treatment outcomes.

Korean version of the MNREAD acuity chart

To investigate the efficacy of the Korean version of the Minnesota low vision reading chart. A Korean version consisting of 38 items was prepared based on the MNREAD acuity chart developed by the University of Minnesota. A linguist composed the representative sentences, each containing nine words from second and third grade levels of elementary school. Reading ability was measured for 20–35-year-old subjects with normal visual acuity (corrected visual acuity of logMAR 0.0 or better). The maximum reading speed (words per minute [wpm]) for healthy participants, reading acuity (smallest detectable font size), and critical print size (smallest font size without reduction of reading speed) were analyzed. The average age of the subjects was 28.3 ± 2.6 years (male:female ratio, 4:16). The average reading time for 38 sentences was 3.66 ± 0.69 s, with no differences in the average maximum reading speed between sentences (p = 0.836). The maximum reading speed was 174.2 ± 29.3 and 175.4 ± 27.8 in the right and left eye, respectively. Reading acuity was measured as logMAR 0.0 or better in 80% of the cases. All subjects showed a critical print size of 0.2 logMAR or better. The overall reading ability can be measured using the Korean version of the MNREAD acuity chart, thereby making it useful in measuring the reading ability of those with Korean as their native language.

Standardized Russian reading chart for assessing reading parameters

BACKGROUND: A number of charts based on checking reading parameters are increasingly being used to assess visual functions. These charts are standardized, translated into many languages. The development of a Russian chart based on international standards and the determination of age norms of clinical reading parameters will allow it to be used for a more accurate assessment of the dynamics of diseases and treatment results. AIM: The aim is to determine the normal reading parameters in patients of different age groups. MATERIALS AND METHODS: Based on international standards, two Russian charts have been developed to study reading parameters. Reading parameters were determined during one session in 135 subjects, divided into 3 groups: I — 18–39 years, II — 40–59 years, and III — 60–81 years. Three main parameters were studied: maximum reading speed, critical print size, and reading acuity (RA). RESULTS: As a result of the study, age norms for basic reading parameters were determined. Maximum reading speed in group I was 192.5 ± 1.2, in group II — 180.6 ± 1.1 and in group III — 168.9 ± 0.8 words/min. Critical print size in group I was 0.14 ± 0.01, in group II — 0.24 ± 0.01, and in group III — 0.36 ± 0.01 logMAR. The reading acuity in group I was 0.009 ± 0.006, in group II — 0.075 ± 0.04, in group III — 0.143 ± 0.005 logMAR. The differences between the studied parameters in groups I/II, I/III and II/III were statistically significant (p 0.05). CONCLUSIONS: The indicators of reading parameters obtained during the study can be used as approximate age norms.

Impact of nitrogen, sulphur and silicon application on the growth and yield of lowland rice (Oryza sativa L.) in the Cauvery delta zone of Tamil Nadu

Enhancing agricultural sustainability demands optimizing fertilizer usage for increased yield. Application of key nutrients like nitrogen, essential for plant vigour, sulphur aiding metabolic processes, and silicon fortifying plant resilience, stand vital. Strategically refining the application of these elements is crucial for augmenting crop output while ensuring ecological balance. So, the field experiment was conducted at the Experimental Farm, Faculty of Agriculture, Annamalai University during Rabi season of the year 2022-2023 to study the effect of nitrogen, sulphur and silicon application on growth and yield of lowland rice. The experiments were laid out in randomized block design (RBD) with three replications. The treatment consisted of 100 % and 125 % nitrogen, 30 and 45 kg sulphur/ha and silicon with different combinations. Half dose of nitrogen and full dose of phosphorus and potassium were applied basally just before transplanting except control treatment. 25 kg N/ha supplied through urea according to Leaf Color Chart (LCC4) reading to the respective treatment plots. Among the different treatments tried, 125% RDN (50% N basal + LCC4 @ 25kg N/ha through Urea) + 45 kg S/ha (Sulphur through Gypsum) + 200 kg Si/ha (Silicon through Diatomaceous Earth) recorded the higher plant height (110.48 cm), LAI (6.74), CGR (9.20 g/m2/day), DMP (13441 kg/ha), number of tillers/m2 (567.18), number of panicles/m2 (406.93), number of filled grains/panicle (133.13), grain yield (6419 kg/ha) and straw yield (7935 kg/ha). The results indicated that, combined use of 125 % nitrogen, 45 kg S/ha, 200 kg Si/ha improved the yield attributes and yield of rice.

Effects of brightness variations on a smartphone-based version of Radner reading charts.

The purpose of this study was to evaluate the equivalence of smartphone-based measurements of near visual acuity under different screen brightness conditions with a standard near visual acuity test. On a sample of 85 participants, we have evaluated near visual acuity with a smartphone-based version of the Radner reading chart at three distinct screen brightness levels. Results have been compared with those obtained with classical Radner paper charts. We have found that, when a sufficient screen brightness is employed, the smartphone-based version of the Radner reading chart produces results that are in line with the paper Radner charts while low brightness levels lead to a significant underestimation of reading acuities. This result was consistent across different refractive conditions. In conclusion, we have shown that handheld devices, such as smartphones, can be potentially exploited for remote measurements of near visual acuity provided a correct control of brightness screen is employed.

Mandibular Bone Height Measurements for Tooth Implantation by Using Film and Digital Panoramic Radiograph

An important objective of the preoperative radiographs evaluation of the implant is to determine the height and width of the bone available for implant insertion. The aim of the study is to confirm the ability of film and digital panoramic radiographs by measuring the distance from the crest of alveolar bone to the roof of the mandibular canal, also compare each type of radiographs using with the tracing chart reading which is a standard measure for both implant length and diameter that supply with the implant system.In this study thirty nine patients needing implants in the lower premolars and molars region in both sides were included. Digital panoramic radiograph were examined by using computerized analysis by software of dimax system , by measuring the distance from the crest of alveolar bone to the roof of the mandibular canal , while in film panoramic radiograph, a ruler was used to measure the distance from the crest of the alveolar bone to the roof of the mandibular canal with the utilization of a viewing box. it was found that film panoramic radiograph had higher value than digital panoramic radiograph in all sites of the teeth specially in the molar region.

Reading charts in logarithmic scale

Seeing clearly from a distance close to our nose, to the end of our outstretched arms, is relevant during a large part of a human being’s day. Being able to read is a frequent activity for most people. Assessing near vision is part of the daily work of an ophthalmologist. Knowing what is the maximum performance of a patient’s near visual capacity allows us not only to detect ocular pathologies, but also aspects related to neurodegenerative processes. Nowadays, the correct measurement of near vision requires the use of charts developed on a logarithmic scale, which are standardized at international level. In this paper some historical aspects will be reviewed and the current characteristics of logarithmic scale reading charts will be described, with the aim of stimulating their use in the daily clinical practice, also explaining the existing differences between the use of the Jaeger test and the new Byromat reading char.

Visual acuity and reading print size requirements in children with vision impairment

ABSTRACT Clinical Relevance The support of students with a vision impairment throughout education could be enhanced by assessing the functional reading ability of the individual. This visual assessment could inform educators of individualised student needs and potentially improve the academic achievement for these students. Background Support for children with a vision impairment within a classroom is typically based on clinical findings of distance visual acuity and visual fields. Therefore, determining optimal print size for reading is essential to ensure best academic outcomes. Secondary aims were to investigate the possible impact of underlying pathology on reading ability. Methods Forty-seven participants were recruited from a state-wide support service for children with a vision impairment in South Australia. Three visual acuity groups were formed based on World Health Organisation definitions of mild, moderate, and severe vision impairment. Correlation between clinical measures of distance visual acuity using the Freiburg Visual Acuity Test, were compared with reading acuity and critical print size (smallest font before reading speed reduced) using Minnesota low vision reading chart (MNREAD). Results No significant correlations were found for mild (0.20–0.49 logMAR) and severe (1.00–1.52 logMAR) vision impairment groups between distance visual acuity and reading acuity read (p = .64, CI [−.585, .395]/p = .82, CI [−.48, .58]) or critical print size (p = .78, CI [−.57, .45]/p = .43, CI [−.34, .68]. A significant correlation was found for the moderate vision impairment group: 0.50–0.99 logMAR for minimum reading acuity (p < .001, CI [.44, .91]) and critical print size (p = .03, CI [.05, .80]). Conclusions Standard clinical measures of distance visual acuity are an unpredictable estimate of reading ability in children with mild and severe vision impairment. Additional measures of functional near reading ability could provide a more meaningful indicator of reading ability and help provide optimum support to students through education.

Post-mortem digital forensic analysis of the Garmin Connect application for Android

The Garmin Vivosmart 4 smartband can monitor various health metrics, including heart rate, oxygen saturation, body composition, and stress levels. It is a quite popular fitness tracking device, as its Android companion application – Garmin Connect – has been downloaded more than 10 million times and can provide critical forensic artifacts such as timestamped GPS-based locations. In this work, we analyze the Garmin Connect application to identify i) relevant digital forensic artifacts, and ii) assess methods to retrieve cloud-based data relevant to a digital forensic examination. For this purpose, we first establish a test scenario where the paired device/application collects data in regular real-world situations using a rooted smartphone running Android 11. The smartphone is then examined to gain insights into the data stored by the application and identify meaningful digital artifacts.To ease and automate the task of digital forensic practitioners, we have developed the Garmin Connect for Android Analyzer (GC4AA) set of Python 3 modules tailored for the digital forensic framework Android Logs Events And Protobuf Parser (ALEAPP). These open-source modules parse dumps of a Vivosmart 4 data directory and create reports displaying several digital artifacts, such as health metrics, GPS data and routes, and phone notifications. They automate the information-gathering process and produce a report specially tailored for Garmin Connect data, highlighting the most relevant artifacts. Our results show that the analysis of paired Garmin Collect/Vivosmart 4 with GC4AA can yield more digital forensic artifacts than existing open-source tools, including the following new artifacts: i) Daily Summary data; ii) GPS data; iii) Response Cache data; iv) Network Logs; v) Facebook API tokens; vi) Device Synchronization cache; vii) SpO2 reading charts. Our contributions include a graphical presentation of the collected data, greatly improving its readability and analysis.

Risk factors for recurrent healthcare-facility associated Clostridioides difficile infection in a Swedish setting

ObjectiveThe objectives were to determine the risk factors for recurrent healthcare facility-associated Clostridioides difficile infection (HCF-CDI) in a high CDI incidence, low antibiotic use setting and to determine if length of cefotaxime exposure is a risk factor for recurrent HCF-CDI. MethodsThe risk factors for recurrent HCF-CDI were evaluated with a retrospective nested case control study based on chart reading. The risk factors were evaluated univariately and multivariately. Length of risk antibiotic exposure was evaluated further in a subanalysis. ResultsRisk factors for recurrent HCF-CDI were renal insufficiency (25.4% of cases compared to 15.4% of controls p = 0.006) and metronidazole treatment of initial CDI episode (88.4% compared to 71.7% p = 0.01). Exposure to cefotaxime and risk for recurrent CDI showed a dose-dependent relationship (linear by linear p = 0.028). ConclusionsRenal insufficiency and metronidazole treatment were independent risk factors for recurrent HCF-CDI in our setting. The relationship between cefotaxime exposure and risk for recurrent HCF-CDI, dose-dependent, could be evaluated further in a setting with high cefotaxime use.

New Terminology and Methodology for the Assessment of the Vitreous, Its Floaters and Opacities, and Their Effect on Vision: Standardized and Kinetic Anatomical and Functional Testing of Vitreous Floaters and Opacities (SK VFO Test)

To introduce VFO and SK VFO Test: new, more representative terminology for symptoms of vitreous floaters/opacities (VFO) and new standardized kinetic (SK) anatomical-functional assessment. Eight eyes underwent before-after limited vitrectomy (LV): best-corrected visual acuity, low-luminance visual acuity, Minnesota Low Vision Reading Chart near visual acuity in logMAR, contrast sensitivity function (CV1000E), and straylight measurements (SM) (HDA/LDA/C-Quant). SK infrared confocal scanning laser ophthalmoscopy (SK IRcSLO) and swept-source widefield optical coherence tomography (SS-WF-OCT) identified VFO and posterior vitreous detachment (PVD). SK IRcSLO was performed with gaze directed towards the extreme superior, inferior, and lateral directions. Anatomical-functional results after LV improved in 7 eyes (87.5%): objective scatter index (27.34%), disturbance index (47.97%) and C-Quant Log units (2.26%). Pre-LV SK IRcSLO and SS-WFOCT imaging identified dynamic well-defined VFO and PVD status (100%). A residual asymptomatic anterior cortical vitreous-induced shadowing ripple effect was detected post-LV. This is the first objective-standardized test accounting for VFO kinesis and intermittent effect. There is potential for personalizing treatment and establishing best candidates for laser or surgery. [Ophthalmic Surg Lasers Imaging Retina 2023;54:306-315.].

A systematic review of reading tests.

Adequate near and intermediate visual capacity is important in performing everyday tasks, especially after the introduction of smartphones and computers in our professional and recreational activities. Primary objective of this study was to review all available reading tests both conventional and digital and explore their integrated characteristics. A systematic review of the recent literature regarding reading charts was performed based on the PubMed, Google Scholar, and Springer databases between February and March 2021. Data from 11 descriptive and 24 comparative studies were included in the present systematic review. Clinical settings are still dominated by conventional printed reading charts; however, the most prevalent of them (i.e., Jaeger type charts) are not validated. Reliable reading capacity assessment is done only by those that comply with the International Council of Ophthalmology (ICO) recommendations. Digital reading tests are gaining popularity both in clinical and research settings and are differentiated in standard computer-based applications that require installation either in a computer or a tablet (e.g., Advanced VISION Test and web-based ones e.g., Democritus Digital Acuity Reading Test requires no installation). It is evident that validated digital tests will prevail in future clinical or research settings and it is upon ophthalmologists to select the one most compatible with their examination routine.

The STArgardt Remofuscin Treatment Trial (STARTT): design and baseline characteristics of enrolled Stargardt patients.

Background: This report describes the study design and baseline characteristics of patients with Stargardt disease (STGD1) enrolled in the STArgardt Remofuscin Treatment Trial (STARTT). Methods: In total, 87 patients with genetically confirmed STGD1 were randomized in a double-masked, placebo-controlled proof of concept trial to evaluate the safety and efficacy of 20 milligram oral remofuscin for 24 months. The primary outcome measure is change in mean quantitative autofluorescence value of an 8-segment ring centred on the fovea (qAF 8). Secondary efficacy variables are best corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), mesopic microperimetry (mMP), spectral domain optical coherence tomography (SD-OCT), reading speed on Radner reading charts, and patient-reported visual function as assessed by the National Eye Institute Visual Functioning Questionnaire 25 (NEI VFQ-25) and Functional Reading Independence (FRI) Index. Results: Mean age of participants was 35±11 years with 49 (56%) female. Median qAF 8 value was 438 Units (range 210-729). Median BCVA and LLVA in decimal units were 0.50 (range 0.13-0.80) and 0.20 (range 0.06-0.63), respectively. The median of the mean retinal sensitivity with mMP was 20.4 dB (range 0.0-28.8). SD-OCT showed median central subfield retinal thickness of 142 µm (range 72-265) and median macular volume of 1.65 mm 3 (range 1.13-2.19). Compared to persons without vision impairment, both reading performance and patient-reported visual function were significantly lower (p<0.001, one sample t-test). Mean reading speed was 108±39 words/minute with logRAD-score of 0.45±0.28. Mean VFQ-25 composite score was 72±13. Mean FRI Index score 2.8±0.6. Conclusions: This trial design may serve as reference for future clinical trials as it explores the utility of qAF 8 as primary outcome measure. The baseline data represent the largest, multi-national, STGD1 cohort to date that underwent standardized qAF imaging, reading speed assessment and vision-related quality of life measures which all contribute to the characterization of STGD1. EudraCT registration: 2018-001496-20 (09/05/2019).

Towards a standardisation of reading charts: Font effects on reading performance-Times New Roman with serifs versus the sans serif font Helvetica.

The purpose was to compare systematically the legibility of a font without serifs (Helvetica) and one with serifs (Times New Roman). Three paragraphs that were equal in the number of words, syllables, characters, difficulty and reading length were printed at equal size, with equal spacing between the lines and equal layout (paperback style), in either the sans serif typeface Helvetica Neue T1 55 Roman (Adobe) or the serif typeface Times New Roman PS Roman (Adobe). They were also printed in newspaper format in the serif font. The paragraphs were presented in random order (Latin square design) to 36 participants between 18 and 38 years of age (wearing their best-corrected visual acuity). Reading duration was measured with a stopwatch. Reading time, reading speed and the number of reading errors were compared. For the paperback layout, no significant difference in reading time (p=0.50) or reading speed (p=0.56) was found between the two fonts. The correlation between the two fonts was high for both reading time and speed (r=0.93). The mean number of reading errors was the same (0.31 ±0.58 errors/text) for both fonts. There was a significant difference in reading time and speed between the paperback and the newspaper layout. The legibility of Helvetica and Times New Roman is similar when investigated under equivalent conditions. Thus, these two font types can be used as interchangeable standard typefaces.

Possible limits of calibrating reading charts with the Landolt ring: a microscopic study

PurposeTo evaluate microscopically whether the print quality and accuracy of sizing of Landolt ring near vision charts are adequate for the calibration of reading charts.MethodsNear vision charts with Landolt rings from Oculus GmbH (C-Test; Wetzlar, Germany), Precision Vision (Woodstock, IL) and the RADNER Charts were examined, as well as custom-made Landolt rings optimized for print quality. Microscopic investigations and measurements were performed by using a Huvitz HSZ 600 stereomicroscope (Nikon NIS Elements software) to evaluate the height of the Landolt rings, the thickness of the lines, and the width of the openings. The deviations from the mathematically correct values, which were calculated as given in the EN/ISO 8596 and by the International Council of Ophthalmology (ICO), were analyzed (calculated for a test distance of 40 cm).ResultsAll the near vision charts showed notable deficiencies in print quality and aberrations from the nominal values in the height, thickness of the lines, and width of the openings. The openings were too narrow, whereas the height and thickness of the lines were larger than the nominal values. Even the openings of Landolt rings optimized for print quality were not always within an acceptable 5% tolerance and need further improvement.ConclusionThis study reports inaccuracies in the heights, thicknesses of the lines, and widths of the openings of Landolt rings in all the near vision charts investigated. The extent of these inaccuracies excludes such near vision charts as reference tests for the calibration of reading charts. The x-height in relation to the visual angle still seems to be the most reliable method for standardizing the print sizes for reading charts.

The STArgardt Remofuscin Treatment Trial (STARTT): design and baseline characteristics of enrolled Stargardt patients

Background: This report describes the study design and baseline characteristics of patients with Stargardt disease (STGD1) enrolled in the STArgardt Remofuscin Treatment Trial (STARTT). Methods: In total, 87 patients with genetically confirmed STGD1 were randomized in a double-masked, placebo-controlled proof of concept trial to evaluate the safety and efficacy of 20 milligram oral remofuscin for 24 months. The primary outcome measure is change in mean quantitative autofluorescence value of an 8-segment ring centred on the fovea (qAF8). Secondary efficacy variables are best corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), mesopic microperimetry (mMP), spectral domain optical coherence tomography (SD-OCT), reading speed on Radner reading charts, and patient-reported visual function as assessed by the National Eye Institute Visual Functioning Questionnaire 25 (NEI VFQ-25) and Functional Reading Independence (FRI) Index. Results: Mean age of participants was 35±11 years with 49 (56%) female. Median qAF8 value was 438 Units (range 210-729). Median BCVA and LLVA in decimal units were 0.50 (range 0.13-0.80) and 0.20 (range 0.06-0.63), respectively. The median of the mean retinal sensitivity with mMP was 20.4 dB (range 0.0-28.8). SD-OCT showed median central subfield retinal thickness of 142 µm (range 72-265) and median macular volume of 1.65 mm3 (range 1.13-2.19). Compared to persons without vision impairment, both reading performance and patient-reported visual function were significantly lower (p&lt;0.001, one sample t-test). Mean reading speed was 108±39 words/minute with logRAD-score of 0.45±0.28. Mean VFQ-25 composite score was 72±13. Mean FRI Index score 2.8±0.6. Conclusions: This trial design may serve as reference for future clinical trials as it explores the utility of qAF8 as primary outcome measure. The baseline data represent the largest, multi-national, STGD1 cohort to date that underwent standardized qAF imaging, reading speed assessment and vision-related quality of life measures which all contribute to the characterization of STGD1. EudraCT registration: 2018-001496-20 (09/05/2019)