Reactive Control Research Articles

Access to Functionalized Amines and Medium N-Heterocycles via Amine-Enabled Remote C-H Alkynylation.

By using weakly coordinating amines, we developed remote C-H alkynylation with precise control of reactivity and regioselectivity, enabling modification of complex drugs, natural products, and materials. The readily transformable alkyne-containing amine products would facilitate expedient delivery of molecular libraries of functionalized amines and medium N-heterocycles, which are previously elusive to access. Moreover, the introduced alkyne functionality could serve as a versatile handle to expand the diversity and synthetic application of this remote C-H functionalization.

Arkypallidal neurons in the external globus pallidus can mediate inhibitory control by altering competition in the striatum

Reactive inhibitory control is crucial for survival. Traditionally, this control in mammals was attributed solely to the hyperdirect pathway, with cortical control signals flowing unidirectionally from the subthalamic nucleus (STN) to basal ganglia output regions. Yet recent findings have put this model into question, suggesting that the STN is assisted in stopping actions through ascending control signals to the striatum mediated by the external globus pallidus (GPe). Here, we investigate this suggestion by harnessing a biologically constrained spiking model of the cortico-basal ganglia-thalamic (CBGT) circuit that includes pallidostriatal pathways originating from arkypallidal neurons. Through a series of experiments probing the interaction between three critical inhibitory nodes (the STN, arkypallidal cells, and indirect pathway spiny projection neurons), we find that the GPe acts as a critical mediator of both ascending and descending inhibitory signals in the CBGT circuit. In particular, pallidostriatal pathways regulate this process by weakening the direct pathway dominance of the evidence accumulation process driving decisions, which increases the relative suppressive influence of the indirect pathway on basal ganglia output. These findings delineate how pallidostriatal pathways can facilitate action cancellation by managing the bidirectional flow of information within CBGT circuits.

Quantitative Assessment of the Effect of Instability Levels on Reactive Human Postural Control Using Different Sensory Organization Strategies

Reactive postural control (RPC), essential for maintaining balance during daily activities, relies on a complex sensory system integrating visual, vestibular, and proprioceptive inputs. Deficits in RPC can lead to falls, especially in unpredictable environments where sensory inputs are challenged. Traditional rehabilitation often fails to prepare patients adequately for real-world conditions. This study aims to explore the effects of varying instability levels (ILs) and sensory integration strategies (SIS) on RPC by evaluating balance disturbances without applying additional external force. Twenty-five healthy participants (12 men, 13 women, 24.5 ± 6.1 years) performed balance tasks on Abili® platforms with adjustable ILs (0, 1, 2, 3) while altering sensory strategies (Basic, Visual, Proprioception, Vestibular) using the Modified Clinical Test of Sensory Integration and Balance (mCTSIB). RPC efficiency was measured using the 95th percentile confidence interval for chest movement’s ellipsoid volume and average velocity, analyzed with Wilcoxon signed-rank tests and Cliff’s delta effect size. Results showed significant increases in chest movement velocity and volume, particularly with the Vestibular strategy at higher ILs, with a 7176% increase in chest volume from Basic strategy at 0IL to Vestibular strategy at 3IL. Additionally, removing visual input (Visual and Vestibular strategies) had a greater impact on chest movement than increasing instability levels. These findings underscore the significant role of combined platform instability and reduced sensory input on postural control. This study presents a novel method for challenging balance and suggests that sensory integration with variable instability could be valuable in training and rehabilitation, even for healthy individuals.

Characterisation of Varying Iron Ores and Their Thermal Decomposition Kinetics Under HIsarna Ironmaking Conditions

In the pre-reduction cyclone of the HIsarna process, both thermal decomposition and gas reduction of the injected iron ores occur simultaneously at gas temperatures of 1723–1773 K. In this study, the kinetics of the thermal decomposition of three iron ores (namely OreA, OreB and OreC) for HIsarna ironmaking were analysed as an isolated process with a symmetrical thermogravimetric analyser (TGA) under an inert atmosphere. Using various methods, the chemical and mineralogical composition, particle size distribution, morphology and phase distribution of the ores were analysed. The ores differ in their mineralogy and morphology, where OreA only contains hematite as iron-bearing phase and OreB and OreC include goethite and hematite. To obtain the kinetic parameters in non-isothermal conditions, the Coats–Redfern Integral Method was applied for heating rates of 1, 2 and 5 K/min and a maximum temperature of 1773 K. The TGA results indicate that goethite and hematite decomposition occur as a two-stage process in an inert atmosphere of Ar. The proposed reaction mechanism for the first stage of goethite decomposition is chemical reaction with an activation energy ranging from 46.55 to 60.38 kJ/mol for OreB and from 69.90 to 134.47 kJ/mol for OreC. The proposed reaction mechanism for the second stage of goethite decomposition is diffusion, showing an activation energy ranging between 24.43 and 44.76 kJ/mol for OreB and between 3.32 and 23.29 kJ/mol for OreC. In terms of hematite decomposition, only the first stage was analysed. The proposed reaction mechanism is chemical reaction control. OreA shows an activation energy of 545.47 to 670.50 kJ/mol, OreB one of 587.68 to 831.54 kJ/mol and OreC one of 424.31 to 592.32 kJ/mol.

Gas Phase Reactions of Pristine and Single-Atom-Doped Copper and Silver Clusters: Probing Size-Dependent Stability and Novel Superatoms.

Gas phase reactions have been a subject of research interest, enabling reliable strategies to explore the stability and reactivity of metal clusters as well as to probe novel superatoms that form the building blocks to assemble new materials with tailored properties. Coinage metal clusters have attracted great research attention due to their simple electronic shell structures and rich photochemical and catalytic properties at relatively low cost. This perspective focuses on the recent progress made in studying the gas phase reactions of undamaged and single-atom-doped Cun±,0 and Agn±,0 clusters with O2, CO, and NO molecules. It covers various aspects, such as reaction mechanisms, relationships between structure and activity, control of reactivity by changing cluster size and composition, and the identification of novel superatoms (Cu18-, Ag13-, Ag17-, and Ag15O+). Lastly, we provide a detailed account of the obstacles and prospective avenues for future research in order to establish a connection between these findings and nanocluster systems that have practical applications.

Emulsification and pH Control for Sustainable Thermochemical Fluids Reactivity

Managing chemical reactivity is crucial for sustainable chemistry and industry, fostering efficiency, reducing chemical waste, saving energy, and protecting the environment. Emulsification is used for different purposes, among them controlling the reactivity of highly reactive chemicals. Thermochemical fluids (TCFs), such as NH4Cl and NaNO2 salts, have been utilized in various applications, including the oil and gas industry. However, the excessive reactivity of TCFs limits their applications and consequently negatively impacts the potential success rates. In this study, an emulsification technique was employed to control the high reactivity of TCFs explored at 50% and 70% in diesel, using three distinct emulsifier systems at concentrations of 1%, 3%, and 5% to form water-in-oil emulsions. The reactivity of 4M neat TCFs and emulsified solutions was examined in an autoclave reactor as a function of triggering temperatures of 65–95 °C, volume fraction, and emulsifier type and concentration. Additionally, this study explores an alternative method for controlling TCF reactivity through pH adjustment. It investigates the impact of TCFs at pH values ranging from 6 to 10 and the initial pressure on the resulting pressure, temperature, and time needed to initiate the TCF’s reaction. The results revealed that both emulsification and pH adjustment have the potential to promote sustainability by controlling the reactivity of TCF reactions. The findings from this study can be utilized to optimize various downhole applications of TCFs, enhancing the efficiency of TCF reactions and success rates. This paper presents in detail the results obtained, and discusses the potential contributions of the examined TCFs’ reactivity control techniques to sustainability.

Influence of wind farm fault current control strategies on distance protection during unsymmetrical faults

Abstract This paper evaluates the performance of distance protection near a wind farm with type IV wind turbines with various basic fault current control strategies implemented in the power converters. The considered fault control strategies include control of purely positive sequence currents or combined positive and negative sequence currents for reactive power support of various magnitudes. A multi-variable study is performed in PSCAD to show performance of a basic algorithm of distance protection at a 420 kV line in a vicinity of the wind farm. The results show that the majority of relay failures occur for phase-phase-ground faults, that reactive current control has less influence in strong grid than in weak grid, and that standard wind turbine fault control procedure of providing balanced current might result in fault currents much smaller than maximum allowed (usually 1.2 pu).

Efficient separation and recovery of cobalt from grinding waste of cemented carbide using a sulfuric acid-sodium persulfate mixed solution

The mechanical processing of cemented carbide often generates a considerable amount of grinding waste from cemented carbide (GWCC), which serves as an important secondary resource for recovering Co and W. However, efficient separation of tungsten carbide (WC) and Co from GWCC remains challenging. This study tested an efficient process for separating Co from GWCC using a mixed solution of H2SO4-Na2S2O8. Under optimum conditions of 20 g/L H2SO4, 30 g/L Na2S2O8, 60 °C, and 1 h, the leaching efficiency of Co reached 97.0 %, compared to only 58.6 % when using H2SO4 alone. The kinetics of Co leaching in H2SO4 and H2SO4-Na2S2O8 solutions were determined to be a combination of chemical reaction control and diffusion control, suggesting that Co leaching rate in H2SO4 solution is significantly enhanced by introducing Na2S2O8. Finally, complete recovery of Co was achieved, and pure Co powder with a flower-cluster morphology was prepared from the leaching solution through oxalic acid precipitation followed by vacuum pyrolysis. The regenerative WC and Co powder can be recycled for cemented carbide production.

A sensitivity analysis of the impact of shut-in water cut of reactive control on net present value of waterflooding under reservoir uncertainty

A sensitivity analysis of the impact of shut-in water cut of reactive control on net present value of waterflooding under reservoir uncertainty

A new integrated modelling and control of ternary pumped storage hydro power generation for small signal stability studies

Pumped storage hydro power generation (PSHPG), a reliable renewable energy source with an energy storage feature, can impart efficient damping torque to power system oscillations to improve small signal stability with appropriate modelling and additional compensation through the governor. But ternary PSHPG (T-PSHPG) has the unique feature of hydraulic short circuit (HSC) mode, where both pumping and generating modes operate simultaneously. This study presents a novel fourth-order modified Heffron Phillips (MHP) model of T-PSHPG in coordination with a multi-band Power system stabilizer (MB-PSS) employing 2-way penstock, where primary penstock circulates water from the upper reservoir to the lower reservoir through the turbine and secondary penstock divides primary penstock, thereby creating short-circuit path through the pump. Also, this model includes additional reactive power droop control to maintain the voltage profile. A new state space matrix has been developed for coordinating T-PSHPG in HSC mode with MB-PSS. The control parameters of the proposed coordinated model are set by a new multi-objective differential evolution-improved particle swam optimization (DE-IPSO) algorithm. With variable load, random solar and wind source penetrations, it has been found that the proposed model can provide adequate damping actions. The sensitivity of the proposed model has been observed by varying critical model parameters by ±50 %. For all conditions, the settling time of speed variation is within 2.672 s to 5.951 s and the minimum damping ratio lies within 0.105 to 0.455. The minimum damping ratio is 0.32 and the settling time is found to be 3.1 s for system response subject to sudden solar power variation, which has been observed by shifting system eigenvalues toward the left half of the complex plane. Time and frequency domain parameters with sensitivity analysis predict system oscillations being damped effectively with consistency for the proposed modelling and control strategy. The results are verified in real-time with OPAL-RT real-time digital simulator. It has been justified by the present study that appropriate modelling of T-PSHPG along with coordinated control action provided by MB-PSS can handle critical power system oscillations efficiently and effective damping torque can be imparted in HSC mode.

Interleukin‐6 transcripts up‐regulation in lymph nodes from unicentric and multicentric Castleman disease

AbstractIntroductionCastleman disease (CD) represents a spectrum of heterogeneous lymphoproliferative disorders sharing peculiar histopathological features, clinically subdivided into unicentric CD (UCD) and multicentric CD (MCD) and presenting with variable inflammatory symptoms. Interleukin (IL)‐6 and other cytokines play a major role in mediating CD inflammatory manifestations. Although the local microenvironment seems to be among the major sources of hypercytokinemia, the precise cellular origin of IL‐6 production in CD is still debated.MethodsA series of five nodal CD of different subtypes (one UCD, two idiopathic MCDs [iMCDs], one HIV‐negative human herpesvirus 8 (HHV8)‐associated MCD, and one HIV‐positive HHV8‐associated MCD) and a non‐CD reactive control were tested using RNAscope analysis and a dual in situ hybridization (ISH)/immunohistochemistry technique, in order to quantify IL‐6 expression and its spatial distribution. Quantitative analyses of in situ mRNA were performed on digitalized slides using the HISTOQUANT software (3DHISTECH) and differences between cases were evaluated by the Kruskal‐Wallis test.ResultsRNA‐ISH documented increased IL‐6 expression in all CD lymph nodes, independently from clinical and pathological subtypes, however, the highest levels were found in HHV8+ cases and statistically significant differences in IL‐6 expression were found only between HHV8+ MCD and control case. Dual RNA‐ISH for IL6 coupled with immunohistochemistry analysis showed that IL‐6 was overexpressed in CD31‐positive endothelial cells in 5/5 CD tested cases but not in the control case.ConclusionOur findings suggest that nodal IL‐6 expression seems to be significantly upregulated in HHV8+ MCD, but a trend toward increased nodal IL‐6 expression was noticed also in UCD and iMCD‐not otherwise specified. CD31+ endothelial cells probably represent one of the major sources of IL‐6 production in the nodal microenvironment.

Stroke impairs the proactive control of dynamic balance during predictable treadmill accelerations.

We maintain balance during gait using both proactive and reactive control strategies. Damage to the brain from a stroke impairs reactive balance, but little is known about how a stroke impacts proactive control during walking. Identifying stroke-related impairments to proactive control could inform the design of interventions to improve balance and reduce fall risk. Therefore, we determined if people with and without stroke differ in their ability to use proactive strategies during predictable treadmill accelerations. Groups of 14 adults with and without stroke walked with single-belt accelerations at random (every one to five strides) and regular (every three strides) intervals. We quantified the effects of the perturbations as changes to center of mass (COM) speed and used mechanical leg work to quantify the proactive strategies to slow the COM. Participants without stroke reduced peak COM speed better than those with stroke when perturbations were at regular intervals (-0.023 versus -0.001 m/s; p=0.007). They also reduced positive leg work more during the perturbation step than the group post-stroke (-7.7% versus -1.9%; p=0.004). Together, these results demonstrate that the sensorimotor impairments resulting from a stroke impair the ability to generate effective proactive adjustments to reduce the destabilizing effects of predictable perturbations.

Dorsolateral prefrontal cortex to ipsilateral primary motor cortex intercortical interactions during inhibitory control enhance response inhibition in open-skill athletes

Numerous studies have reported that long-term sports training can affect inhibitory control and induce brain functional alterations. However, the influence of environmental dynamics in sports training on inter-cortical connectivity has not been well studied. In the current study, we used twin-coil transcranial magnetic stimulation to investigate the functional connectivity between dorsolateral prefrontal cortex (DLPFC) and ipsilateral primary motor cortex (M1) during proactive and reactive inhibition in participants with sports skills in dynamic environment (open-skill experts), stable environment (closed-skill experts), and no sports skills (controls). Using a modified stop signal task, proactive inhibition was measured by the response delay effect (RDE), and reactive inhibition was measured by the stop-signal reaction time (SSRT). Intra-hemispheric DLPFC-M1 interactions and single pulse motor-evoked potentials (MEPs) were measured during the task. A stronger inhibitory effect of the DLPFC over M1 was observed during early reactive control stages compared to baseline levels. In addition, this inhibitory effect was pronounced when comparing open-skill experts to non-athlete controls, a relationship that was significantly correlated with superior reactive control performance. Furthermore, DLPFC to M1 influencing direction shifted from late proactive control to reactive control. Behavioral results also demonstrated enhanced proactive control abilities in open-skill experts relative to controls. Such enhancement may be due to the combination of environmental complexity and physical fitness in long-term skill training.

ELSMOR - towards European Licensing of Small Modular Reactors:Methodology recommendations for light-water small modular reactors safety assessment.

Decarbonization of energy production is key in today's societies and nuclear energy holds an essential place in this prospect. Besides heavy-duty electricity production, other industrial and communal needs could be served by integrating novel nuclear energy production systems, among which are low-power nuclear devices, like small modular reactors (SMRs). The ELSMOR (towards European Licensing of Small Modular Reactors) European project addresses this topic as an answer to the Horizon 2020 Euratom NFRP-2018-3 call. The consortium includes 15 partners from eight European countries, involving research institutes, major European nuclear companies and technical support organizations. The 3.5-year project, launched in September 2019, investigates selected safety features of light-water (LW) SMRs with focus on licensing aspects. Providing a comprehensive compliance framework that regulators can adopt and operate, the licensing process of such SMRs could be optimized, helping their deployment. In this prospect, as a result of ELSMOR's work, this article gives an overview of the specific issues that LW-SMRs may bring about in the different domains of nuclear safety, in terms of: •Methodological standpoints: safety goals, safety requirements, safety principles (defence-in-depth implementation);•Main safety functions of reactivity control, decay heat removal and confinement management;•Severe accident management;•Other safety issues particular to SMRs: use of shared systems; performing of multi-unit probabilistic safety assessment (PSA); spent fuel management, transport and disposal management. In this article, adequate methodologies are developed to deal with these issues and to help assess the safety of LW-SMRs. This work gives a precious synthesis of the safety assessment issues of LW-SMRs and of the associated methodologies developed in the context of the ELSMOR European project.

Detection of Axial Locations of Control Rods Using Movable In-core Detectors

Background Reactivity control in Pressurized Water Reactors (PWRs) relies on Rod Cluster Control Assemblies (RCCAs), or control rods (CRs), and boric acid diluted in primary circuit water. The control rods’ axial location inside the reactor core is typically provided by means of two redundant systems: the Rod Positioning Indicator (RPI) and the Rod Control System (RCS). Methods The current work focuses on the development of an additional method for the detection of control rod axial location inside the reactor core of a Pressurized Water Reactor (PWR) using the Advanced Flux Mapping System (AFMS) and its Movable In-core Detectors (MIDS). The paper presents the methodology employed and the results of the first validation campaigns. Results Two validation campaigns were carried out, targeting respectively equilibrium and non-equilibrium xenon axial distribution. The routine proved successful in identifying control rods’ axial insertion in different operating conditions including Flux Maps (FMs) acquired at 2%, 50% and 75% power. Conclusions The routine developed at Beznau Nuclear Power Plant will serve as an additional core monitoring tool to be employed in case of suspicious or faulty indication coming from the main control rod location methods. The developed method proved able to locate control rods’ axial insertion with few steps error, equivalent to maximum 1.6% of total fuel height (i.e. 5 cm as maximum error). There is room for potential improvements with regards to the uncertainty model currently implemented.

Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axis

Under neuroinflammatory conditions, astrocytes acquire a reactive phenotype that drives acute inflammatory injury as well as chronic neurodegeneration. We hypothesized that astrocytic Delta-like 4 (DLL4) may interact with its receptor NOTCH1 on neighboring astrocytes to regulate astrocyte reactivity via downstream juxtacrine signaling pathways. Here we investigated the role of astrocytic DLL4 on neurovascular unit homeostasis under neuroinflammatory conditions. We probed for downstream effectors of the DLL4-NOTCH1 axis and targeted these for therapy in two models of CNS inflammatory disease. We first demonstrated that astrocytic DLL4 is upregulated during neuroinflammation, both in mice and humans, driving astrocyte reactivity and subsequent blood-brain barrier permeability and inflammatory infiltration. We then showed that the DLL4-mediated NOTCH1 signaling in astrocytes directly drives IL-6 levels, induces STAT3 phosphorylation promoting upregulation of astrocyte reactivity markers, pro-permeability factor secretion and consequent blood-brain barrier destabilization. Finally we revealed that blocking DLL4 with antibodies improves experimental autoimmune encephalomyelitis symptoms in mice, identifying a potential novel therapeutic strategy for CNS autoimmune demyelinating disease. As a general conclusion, this study demonstrates that DLL4-NOTCH1 signaling is not only a key pathway in vascular development and angiogenesis, but also in the control of astrocyte reactivity during neuroinflammation.

Aryne Chemistry: Generation Methods and Reactions Incorporating Multiple Arynes.

Arynes hold significance for the efficient fusion of (hetero) arenes with diverse substrates, advancing the construction of complex molecular frameworks. Employing multiple equivalents of arynes is particularly effective in the rapid formation of polycyclic cores found in optoelectronic materials and bioactive compounds. However, the inherent reactivity of arynes often leads to side reactions, yielding unanticipated products and underlining the importance of a detailed investigation into the use of multiple arynes to fine-tune their reactivity. This review centers on methodologies and syntheses in organic reactions involving multiple arynes, categorizing based on mechanisms like cycloadditions, σ-bond insertions, nucleophilic additions, and ene reactions, and discusses aryne polymerization. The categorization based on these mechanisms includes two primary approaches: the first entails multiple aryne engagement within a single step while the second approach involves using a single equivalent of aryne sequentially across multiple steps, with both requiring strict reactivity control to ensure precise aryne participation in each respective step. Additionally, the review provides an in-depth analysis of the selection of aryne precursors, organized chronologically and by activation strategy, offering a comprehensive background that supports the main theme of multiple aryne utilization. The expectation remains that this comprehensive review will be invaluable in designing advanced syntheses engaging multiple arynes.

Neural Correlates of Reactive Inhibition in Gambling Disorder: An FMRI Study with Transcranial Magnetic Stimulation (TMS)

Gambling Disorder (GD) is a condition characterized by a persistent and recurrent pattern of problematic gambling behavior. Despite significant advances in understanding the neurobiological correlates of Gambling Disorder phenomenological manifestation, there are still several unanswered questions regarding the pathophysiological mechanisms underlying GD. There is substantial evidence from fMRI studies on the role of pre-SMA stimulation in psychiatric conditions with impairments in response inhibition such as behavioral addictions on enhancing the activity of the brain circuitry involving the right inferior (IFG) and middle frontal gyrus (MFG) (two cortical areas are differentially associated with two distinct aspects of control inhibition). In this study we utilized task-related functional Magnetic Resonance Imaging (fMRI) to explore the impact of continuous Theta-Burst Stimulation (cTBS) on the pre-Supplementary Motor Area (pre-SMA) in patients with Gambling Disorder (GD). Four GD patients underwent cTBS on bilateral pre-SMA, administered with the MagVenture MagPro R30 stimulator with add-on theta-burst option (MagVenture INC.) using a Cool D-B80 figure-of-eight coil. cTBS consists of bursts of 3 pulses separated by 20 ms (i.e., 50 Hz) delivered repeatedly at theta frequency on the pre-SMA bilaterally. Changes in Functional Connectivity (FC) were assessed before and after Real or Sham treatment using CONN functional connectivity toolbox and Statistical Parametric Mapping (SPM). The study aimed to determine whether cTBS influences the functional connectivity between pre-SMA and right prefrontal areas, specifically the right Inferior Frontal Gyrus (rIFG) and right Middle Frontal Gyrus (rMFG), and whether these changes correlate with treatment outcomes. Results indicated that real cTBS treatment increased functional connectivity between pre-SMA and both rIFG and rMFG, suggesting enhanced control inhibition. This was associated with a reduction in Gambling Disorder symptom severity, assessed with the Pathological Gambling version of the Yale-Brown Obsessive-Compulsive Scale (PG-YBOCS) and the Gambling Urges Questionnaire (GUQ), indicating a treatment response. Conversely, sham cTBS did not elicit the same positive FC changes in the reactive control inhibition network, aligning with behavioral measures. The study highlighted the potential of cTBS on pre-SMA in modulating inhibitory control circuit. Overall, this preliminary investigation provides a foundation for future investigations into the neurobiological mechanisms underlying GD and the potential efficacy of TMS interventions.

The effects of subsensory electrical noise stimulation on the reactive control of balance during support surface perturbations

BackgroundThe ability to respond effectively to balance perturbations is crucial for fall prevention. Subsensory electrical stimulation (SES) applied to the skin leads to improved proactive balance control but there is limited evidence on the SES effect on reactive balance control. Research QuestionsTo test the efficiency of SES in improving reactive balance control against unpredictable support surface perturbations and to compare the effects of SES applied to the trunk and the lower legs. MethodsTwenty-three young adults stood on a treadmill while recovering from 15 forward and 15 backward surface translations of increasing magnitude to determine the backward and forward stepping thresholds (BSTh and FSTh). Then, they recovered from three repetitions of forward and backward perturbations of fixed magnitude to determine the characteristic of the compensatory step (i.e., step time, step length, step delay and Margin of Stability - MOS). Each test was conducted with no stimulation (NS), leg stimulation (LS), or trunk stimulation (TS) equal to 90% of the sensory threshold. Repeated-measures ANOVA and Tukey post-hoc tests were used to analyze the main and interaction effects of stimulation and repetition. ResultsTS and LS increased the BSTh by 31.5% (p=0.002) and 16.4% (p=0.028), respectively, with greater effects of TS; (ii) during backward perturbations, TS reduced compensatory step time by 9.0%, step length by 17.1%, and MOS at compensatory heel strike by 17.7% (p<0.016); and (iii) during forward perturbations, LS and TS reduced the step time by 4.5% and 3.5% (p<0.017), and increased the minimum MOS by 7.8% and 4.5%, respectively (p<0.048). SignificanceThis is the first study that showed how the application of SES affects reactive balance control during support surface perturbations. TS was more effective than LS during backward perturbations. TS may be an effective strategy to enhance balance control during reactive postural tasks, thus potentially reducing fall risk.

Modeling Polystyrene Nanoplastics Degradation in Water via Photo-Fenton Treatment: A Shrinking-Particle Approach

In this study, kinetic models for the photo-Fenton oxidation of polystyrene nanoplastics (NPs) in water were developed, considering particles with decreasing diameters. Various reaction parameters affecting the oxidation rate, such as particle size (140−909nm), agitation speed (250−1000rpm), and operating temperature (25 and 60 °C) were investigated. Oxidation progress was evaluated through turbidity measurements, TEM, and FTIR analysis, while leached intermediates were identified via Pyr-GC-MS and IC. Due to changes in NPs surface reactivity, the overall reaction rate was divided into two stages, following a free-radical mechanism. Using equations derived from the classic Shrinking Core Model, the oxidation of NPs was determined to proceed under chemical reaction control, with negligible mass transfer limitations. Additionally, the Prout-Tompkins model was found to accurately represent the degradation process. The proposed mechanisms and models provide valuable insights for describing and predicting the advanced oxidation of NPs under different operating conditions and treatment methods.