In reaction-diffusion models of annihilation reactions in low dimensions, single-particle dynamics provides a bottleneck for reactions, leading to an anomalously slow approach to the empty state. Here, we construct a reaction model with a reciprocal bottleneck of reactions on particle dynamics in which single-particle motion conserves the center of mass. We show that such a constrained reaction-diffusion dynamics does not approach an empty state but freezes at late times in a state with fragmented particle clusters. The late-time dynamics and final density are universal, and we provide exact results for the final density in the large-reaction rate limit. Thus, our setup constitutes a minimal model for the fragmentation of a one-dimensional lattice into independent particle clusters. We suggest that the universal reaction dynamics could be observable in experiments with cold atoms or in the Auger recombination of exciton gases. Published by the American Physical Society 2024