This study presents an investigation of a heat pipe with a mesh wick, utilizing machine learning (ML) techniques. The model including radial basis function interpolation (RBF), Kriging model (KRG), and the k-nearest neighborhood model (K-NN) were studied and compared. A set of training and validating populations were classified using a k-means clustering technique. The design variable included the geometric shape of heat pipe such as its diameter, the properties and percentage used of working fluid, and the temperature at the evaporator. The prediction case study included the heat transfer rate (q), and total difference temperature between evaporator and condenser section (ΔT). The prediction results found that the ΔT gave the most accurate indicator while the q is passable to applied. The Kriging model proved to be the most accurate, achieving an RMSE of 0.9896 and R2 of 0.9149 for heat transfer rate prediction, and an RMSE of 0.1902 and R2 of 0.9398 for total temperature difference prediction with 90 % training data. The second-best accuracy was achieved by the RBF model, with the linear, thin plate, and cubic spline kernels performing reasonably well.