The advanced quality control of the raw mix remains a priority for the cement industry, particularly in recent years, where large quantities of alternative fuels and raw materials are used in clinker production, aiming to reduce the CO2 footprint. This study presents an adaptive control system with a variable sampling period for regulating raw mix quality in the raw mill (RM) output in a process with four independent inputs and four outputs: the lime saturation factor (LSF), silica modulus (SM), alumina modulus (AM), and SO3. The three pillars of the system are (1) mill dynamics calculation using exclusively industrial data, (2) the design of the controllers to meet robustness criteria, and (3) performance enhancement through simulators. Our technique periodically adjusts the gains of the controllers based on the mill’s dynamic parameters, which are computed from raw mix laboratory analyses. The presented results correspond to more than 14,000 h of mill operation. The standard deviation of the LSF at the mill outlet ranged from 1.5 to 3, which is equivalent to 1 to 2 standard deviations of LSF reproducibility. The standard deviation of the other moduli was close to the corresponding reproducibility of each. The presented adaptive gain-scheduling controller for LSF can be applicable to a broad range of raw meal grinding systems.