Rational Insight Research Articles

African Swine Fever Virus Immunosuppression and Virulence-Related Gene.

African swine fever virus (ASFV), a highly contagious pathogen characterized by a complex structure and a variety of immunosuppression proteins, causes hemorrhagic, acute, and aggressive infectious disease that severely injures the pork products and industry. However, there is no effective vaccine or treatment. The main reasons are not only the complex mechanisms that lead to immunosuppression but also the unknown functions of various proteins. This review summarizes the interaction between ASFV and the host immune system, along with the involvement of virulence-related genes and proteins, as well as the corresponding molecular mechanism of immunosuppression of ASFV, encompassing pathways such as cGAS-STING, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), Janus Kinase (JAK) and JAK Signal Transducers and Activators of Transcription (STAT), apoptosis, and other modulation. The aim is to summarize the dynamic process during ASFV infection and entry into the host cell, provide a rational insight into development of a vaccine, and provide a better clear knowledge of how ASFV impacts the host.

Logical exceptionalism: Development and predicaments

AbstractThis paper examines the conceptions of logic from Leibniz, Hume, Kant, Frege, Wittgenstein and Ayer, and regards the six philosophers as the representatives of logical exceptionalism. From their standpoints, this paper refines the tenets of logical exceptionalism as follows: logic is exceptional to all other sciences because of four reasons: (i) logic is formal, neutral to any domain and any entities, and general; (ii) logical truths are made true by the meanings of logical constants they contain or by logicians' rational insight to consequence relations; (iii) logical truths are analytical, a prior and necessary, so not‐revisable; and (iv) logical laws are normative for how to correctly think. However, logical exceptionalism has encountered difficult open problems: What are logical constants? How to justify basic laws of logic? How are logical laws accessible to us? How to explain the reasonability of rival logics and select from them? How to explain the universal applicability of logical laws? How to explain the normativity of logical laws for correct thinking? This paper concludes that logical anti‐exceptionalism is more hopeful to successfully answer these questions than logical exceptionalism.

Designing Thiadiazoloquinoxaline-Based Conjugated Polymers for Efficient Organic Photovoltaics: A DFT/TDDFT Study.

Clean and renewable energy development is becoming frontier research for future energy resources, as renewable energy offers sustainable and environmentally friendly alternatives to non-renewable sources such as fossil fuels. Among various renewable energy sources, tremendous progress has been made in converting solar energy to electric energy by developing efficient organic photovoltaics. Organic photovoltaic materials comprising conjugated polymers (CP) with narrow optical energy gaps are promising candidates for developing sustainable sources due to their potentially lower manufacturing costs. Organic semiconductor materials with a high electron affinity are required for many optoelectronic applications. We have designed a series of organic semiconductors comprised of cyclopentadithiophene as a donor and thiadiazoloquinoxaline (TQ) as an acceptor, varying the π-conjugation and TQ-derivatives. We have employed density functional theory (DFT) and time-dependent DFT (TDDFT) to evaluate the designed CP's optoelectronic properties, such as optical energy gap, dipole moment, and absorption spectra. Our DFT/TDDFT result shows that the energy gap of CPs is lowered and redshifted in the absorption spectra if there is no insertion of conjugation units such as thiophene and selenophene between donor and acceptor. In addition, selenophene shows relatively better redshift behavior compared to thiophene. Our work also provides rational insight into designing donor/acceptor-based CPs for organic solar cells.

Free Will, Foreknowledge, and Creation: Further Explorations of Kant’s Molinism

AbstractWhile Kant’s position concerning human freedom and divine foreknowledge is perhaps the least Molinist element of his multifaceted take on free will, Kant’s Molinism (minimally defined) is undeniable when it comes to the threat ensuing from the idea of creation. In line with incompatibilism and with careful qualifications in place, he ultimately suggests regarding free agents as uncreated. Given the limitations of our rational insight, this assumption is indispensable for granting that finite free agents can acquire their intelligible characters by themselves. Nonetheless, Kant concedes that creation may, as a matter of fact, be compatible with what for Molina is the pre-volitionality of the counterfactuals of freedom.

Rational Insight and Partisan Justification: Responding to Bogardus and Burton, Thurow, and Kvanvig

Rational Insight and Partisan Justification: Responding to Bogardus and Burton, Thurow, and Kvanvig

Digital servitization bridging relational asymmetry

PurposeThis paper aims to investigate how firms such as Xerox, which have transitioned to a digital servitization business model, bridge relational asymmetry. It continues the theme of sustainability from the traditional three pillars—environmental, economic and social sustainability—to relational in terms of the quality of the relationship between the service provider and the customers.Design/methodology/approachUsing an exploratory method, qualitative data from the case of Xerox, a pioneering company that embraces servitization business models, has been gathered. The combination of exploratory archival and literature searches allows for a more in-depth understanding of servitization and how it bridges (or does not bridge) the relational asymmetry.FindingsThe results reveal that a relational dimension is inherent in the servitization business model, whereas in order to achieve sustainability, it must leverage transparency, which may be either an enabler or an impairing factor. A borderline for a transparent relationship that distinguishes these two parameters is established.Research limitations/implicationsThe study's single-case firm was limited to Xerox as an industry forerunner and could only represent mature and multinational enterprises.Practical implicationsWith the purpose of providing high-quality service, this exploratory paper gives managers rational insight into whether and when it is sustainable to fill the relational asymmetry between them as service providers and their customers.Social implicationsFrom the relational asymmetry perspective, the authors shed light on the aspect of transparency, which is a pivotal cause of any asymmetric relationship. Through the case of Xerox, the study further sheds light on the dual effect of transparency, which could either be an “enabling” or an “impairing” factor. Putting it together, the use of interaction as a basis for co-creation is at the crux of the emerging reality.Originality/valueThis paper examines servitization from a new perspective, proposing that the relational asymmetry bridged by servitization will determine the future of organizations that differentiate themselves through quality relationships.

Study on the essential features for MOFs to reversible adsorption of H2S at room temperature

Metal-organic frameworks (MOFs) have been extensively studied for hydrogen sulfide (H2S) capture. However, reversible adsorption of H2S by MOFs materials, which allow the adsorbents to be repeatedly used, remains challenging. To get a rational insight into the reversible H2S adsorption on MOFs, eight MOFs with different features were selected as representatives, and their behaviors of adsorption and desorption for H2S in three cycles were investigated in a fixed-bed reactor. X-ray diffraction and nitrogen adsorption-desorption characterization were used to confirm the reversibility based on the alterations in MOFs’ physical and chemical properties before and after H2S adsorption. The results indicated that only UiO-66, MOF-801, and Mg-MOF-74 exhibited reversibility among these selected MOFs. Nevertheless, their highest H2S capacity is only 3.81 mg/g, far away from the practical application. Calculation results of adsorption sites, the density of states, adsorption distance, and the heat of adsorption show that a weak interaction between MOFs and H2S, which is afforded by metal centers or/and organic ligands, is needed for reversible adsorption. However, it is difficult to get a satisfactory H2S removal capacity in such a situation. Introducing new adsorption sites into structurally stable MOFs is considered an efficient strategy for increasing their reversible adsorption capacity.

Explaining Rationalist Weak Conciliationism: A Challenge

Abstract In his book, Disagreement, Deference, and Religious Commitment, John Pittard presents and critiques what he calls the “master argument for disagreement-motivated religious skepticism.” This argument purports to show, using only higher-order reasoning and facts about religious disagreement, that nobody’s religious outlook is justified (at least, nobody aware of the argument). The master argument presupposes that any attempt to vindicate one’s religious outlook must employ dispute-independent reasons. Pittard objects to this assumption and argues, instead, for rationalist weak conciliationism: the view that partisan justification can be had when (and only when) one has rational insight into the claim in question. In this paper, I raise a challenge for rationalist weak conciliationism; in short, it is difficult to explain why only rational insight provides partisan justification while maintaining that a wide range of beliefs, including religious beliefs, can be justified in a partisan way.

Construction of 2D/2D Bi4O5Br2/Bi2WO6 Z-scheme heterojunction for highly efficient photodegradation of ciprofloxacin under visible light

Enhancing the heterointerface contact determined by the dimensionality of each component is essential for the rapid migration of photogenerated charge carriers. Herein, the 2D/2D Bi4O5Br2/Bi2WO6 Z-scheme heterojunction was successfully synthesized through a simple chemical co-precipitation followed by a hydrothermal process. Remarkably, the optimized Bi4O5Br2/Bi2WO6 heterojunction achieved superior photocatalytic efficiency of 91.0% and ascendant stability for the degradation of ciprofloxacin (CIP) under visible light illumination. More importantly, degradation pathway and photocatalytic mechanism analysis revealed that the reinforced photodegradation efficiency can be ascribed to the intimate heterointerface between 2D Bi4O5Br2 and 2D Bi2WO6, which facilitated the fast migration and separation of photoinduced carriers, thus enhancing the photocatalytic activity. Furthermore, the effect of pH, CIP concentration, inorganic cations and anions, and different contaminants were systematically investigated to explore the potential of practical applications. This work gives rational insight into the developing 2D/2D Z-scheme heterojunction for environmental remediation.

Some Reluctant Skepticism about Rational Insight

Abstract There is much to admire in John Pittard’s recent book on the epistemology of disagreement. But here we develop one concern about the role that rational insight plays in his project. Pittard develops and defends a view on which a party to peer disagreement can show substantial partiality to his own view, so long as he enjoys even moderate rational insight into the truth of his view or the cogency of his reasoning for his view. Pittard argues that this may happen in ordinary cases of religious disagreement—cases in which it’s a live skeptical possibility that one is misdescribing his insight, or not having insight at all—and therefore one need not be strongly conciliatory even in the face of peer disagreement. Yet Pittard agrees that one should be strongly conciliatory in cases of disagreement involving, e.g., visual perception and dim rational insight, since the sort of fallible, corrigible evidence involved in such cases may be counterbalanced by symmetrical evidence on the part of one’s disagreeing peer. We worry that there’s an inconsistency here. If it’s unreasonable to show partiality to one’s visual experience (or dim rational insight) in cases like “Horse Race” and “Restaurant Check,” it’s likewise unreasonable to show partiality in religious disagreements to one’s moderate rational insight, fallible and corrigible as it is.

Radiobiologie de la radiothérapie interne vectorisée

With several specialities approved by EMA in the last years, targeted radionuclide therapy (TRT) is undergoing a strong development and treat more and more patients. Compared to previously approved radiopharmaceuticals (e.g. Zevalin™), treatments are now fractionated (several injections) and spread over several months. The absorbed dose and absorbed dose rate, the genetic and/or epigenetic characteristics of the tumours, but also the intercellular communications such as those involving the immune system, are becoming the key parameters to be considered in order to improve the effectiveness of the treatment while protecting healthy tissue. Radiobiology, using both preclinical models and a growing number of available clinical data, should provide rational insight into both the efficacy and toxicity of this continuous low dose rate radiotherapy form for better patient management.

Hegel’s Camel. From the History of Reconciliation to the Theory of Atonement

Abstract The paper discusses the relationship between “atonement” and “reconciliation” in systematic theology, claiming that Hegel’s concept of reconciliation (Versöhnung) continues to influence contemporary English-speaking theology. It is argued that the so-called theories of atonement often tacitly assume “Hegel’s camel”, an idea consisting of three propositions as follows: (i) atonement is a consistent umbrella concept that pertains to the systematic explanation of the entire work of Christ, (ii) atonement contains both an overarching rational insight and a moral code of conduct that provide an apology for the truth of Christian faith, (iii) Anselm of Canterbury has seminal importance when this rational atonement is explained. The paper complements the author’s historical-critical discussion of “reconciliation” undertaken in St. Andrews Encyclopedia of Theology.

Hepatogenesis and hepatocarcinogenesis: Alignment of the main signaling pathways.

Development is a symphony of cells differentiation in which different signaling pathways are orchestrated at specific times and periods to form mature and functional cells from undifferentiated cells. The similarity of the gene expression profile in malignant and undifferentiated cells is an interesting topic that has been proposed for many years and gave rise to the differentiation-therapy concept, which appears a rational insight and should be reconsidered. Hepatocellular carcinoma (HCC), as the sixth common cancer and the third leading cause of cancer death worldwide, is one of the health-threatening complications in communities where hepatotropic viruses are endemic. Sedentary lifestyle and high intake of calories are other risk factors. HCC is a complex condition in which various dimensions must be addressed, including heterogeneity of cells in the tumor mass, high invasiveness, and underlying diseases that limit the treatment options. Under these restrictions, recognizing, and targeting common signaling pathways during liver development and HCC could expedite to a rational therapeutic approach, reprograming malignant cells to well-differentiated ones in a functional state. Accordingly, in this review, we highlighted the commonalities of signaling pathways in hepatogenesis and hepatocarcinogenesis, and comprised an update on the current status of targeting these pathways in laboratory studies and clinical trials.

Can Rational Emotive Behaviour Therapy (REBT) and Mindfulness be Integrated Effectively within High Performance Settings?

Our critical commentary explores the overlaps and divergences between Rational Emotive Behaviour Therapy (REBT) and contemporary mindfulness practice and considers whether the approaches could be integrated and applied effectively within two high performance settings in particular: sport and business. It highlights how REBT and mindfulness share similar philosophical positions on the causes of emotional disturbance, on the importance of acceptance, and on cultivating self-awareness to respond healthily and adaptively to adverse events. It also acknowledges diverenges relating to REBT and mindfulness’ respective positions on judgement of thoughts, an emphasis on the present moment, and meditative practice. We observe that by cultivating metacognitive awareness—a capacity to impartially observe thinking—mindfulness may help individuals in high performance settings to see more clearly how their beliefs influence their emotional, cognitive, and behavioural outcomes. Mindfulness could thus potentially aid an individual’s transition from intellectual insight to emotional rational insight within an REBT framework. Moreover, appropriately integrated mindfulness practice alongside REBT-based work may help individuals within high performance settings, and beyond, to cultivate a mindset that is grounded in the present, less distracted and more task focused, potentially enhancing performance outcomes.

Self-Assembled Interwoven Nanohierarchitectures of NaNbO3 and NaNb1–xTaxO3 (0.05 ≤ x ≤ 0.20): Synthesis, Structural Characterization, Photocatalytic Applications, and Dielectric Properties

Dependence on fossil fuels for energy purposes leads to the global energy crises due to the nonrenewable nature and high CO2 production for environmental pollution. Therefore, new ways of nanocatalysis for environmental remediation and sustainable energy resources are being explored. Herein, we report a facile surfactant free, low temperature, and environmentally benign hydrothermal route for development of pure and (5, 10, 15, and 20 mol %) Ta-doped horizontally and vertically interwoven NaNbO3 nanohierarchitecture photocatalysts. To the best of our knowledge, such a type of hierarchical structure of NaNbO3 has never been reported before, and changes in the microstructure of these nanoarchitectures on Ta-doping has also been examined for the first time. As-synthesized nanostructures were characterized by different techniques including X-ray diffraction analysis, electron microscopic studies, X-ray photoelectron spectroscopic studies, etc. Ta-doping considerably affects the microstructure of the nanohierarchitectures of NaNbO3, which was analyzed by FESEM analysis. The UV–visible diffused reflectance spectroscopy study shows considerable change in the band gap of as-synthesized nanostructures and was found to be ranging from 2.8 to 3.5 eV in pure and different mole % Ta-doped NaNbO3. With an increase in dopant concentration, the surface area increases and was equal to 5.8, 6.8, 7.0, 9.2, and 9.7 m2/g for pure and 5, 10, 15, and 20 mol % Ta-doped NaNbO3, respectively. Photocatalytic activity toward the degradation of methylene blue dye and H2 evolution reaction shows the highest activity (89% dye removal and 21.4 mmol g–1 catalyst H2 evolution) for the 10 mol % NaNbO3 nanostructure which was attributed to a change in the conduction band maximum of the material. At 100 °C and 500 kHz, the dielectric constants of pure and 5, 10, 15, and 20 mol % Ta-doped NaNbO3 were found to be 111, 510, 491, 488, and 187, respectively. The current study provides the rational insight into the design of nanohierarchitectures and how microstructure affects different properties of the material upon doping.

Natural belief in persistent selves

ABSTRACT In “Of Personal Identity”, Hume attempts to understand why we ordinarily believe in persistent selves. He proposes that this ontological commitment depends on illusions and fictions: the imagination tricks us into supposing that an unchanging core self remains static through the flux and change of experience. Recent work in cognitive science provides a good deal of support for Hume’s hypothesis that common beliefs about the self are founded on psychological biases rather than rational insight or evidence. We naturally believe in personal persistence, according to this emerging research, because we are prone to categorize the world in terms of hidden essences and structure our lives in terms of whole life stories.

Utilizing 2D materials to enhance H2 generation efficiency via photocatalytic reforming industrial and solid waste

Sustainable valorization of industrial and solid wastes by utilizing them as feedstock to generate H2 via the photocatalytic reforming (PR) process holds great promise. It can also be an effective method to treat solid waste that otherwise would require tedious and expensive processes. This approach has the potential to offer energy solutions and form value-added chemicals. In this direction, developing photocatalysts and tuning their properties play an essential role in advancing the H2 generation efficiency. This Review article explores the application of 2D photocatalysts to generate H2 via PR of industrial waste (H2S) and solid waste, such as plastic and biomass. Despite having favorable optoelectronic properties, 2D photocatalysts are not widely employed for the PR process. The latest progress in employing 2D photocatalysts to realize efficient H2 evolution from biomass, plastic, and industrial waste such as H2S is detailed in this Review. A correlation between the properties of 2D photocatalysts with H2 evolution rate is discussed. We also emphasize understanding the mechanism involved in the PR process and the importance of 2D photocatalysts design. Such rational insight aids in further enhancing the H2 generation efficiency by effectively using solid/industrial waste as a feedstock.

Influence of anion substitution on 3D-architectured Ni-Co-A (A=H, O, P) as efficient cathode materials towards rechargeable Zn-based battery

Among various Zn-based batteries, transition metal compounds have been widely studied as cathode materials in alkaline electrolyte. However, the correlation between anion species and the electrochemical performance of corresponding compounds is still not well understood. Here, we construct a 3D-architecrured F doping Ni/Co hydroxides/oxides/phosphides (FNCA, A = H, O, P) as the model materials and deeply explore the effect of anion substitution on cathode material for Zn batteries. Electrochemical measurements are combined with theoretical calculations to reveal the mechanisms of FNCA delivering considerable dissimilarity in electrochemical properties. In-depth analysis suggests that the surface-dominated redox behaviors are greatly affected by the anion substitution, though the reversible capacity is just produced by the valence change of metal cations. The FNCP exhibits the highest capacity among three samples but an inferior cycling stability. As contrast, the FNCO shows a balanced characteristic of good capacity and superior cycling performance. Based on the understanding, we construct FNCA//Zn batteries. As expected, the FNCP//Zn batteries delivers the highest specific capacity of 318 mAh g−1 and a superior energy density of 532.7 Wh kg−1 at a power density of 1.673 kW kg−1, but an inferior cycling stability reserved from the individual FNCP electrode. This work provides a rational insight for deep understanding the behaviors that anions affect electrochemical energy storage but not participate in redox reactions, and offer more effective feasibility to design high capacity and durable cathode materials for aqueous Zn-based batteries.

A Rational Insight into the Effect of Dimethyl Sulfoxide on TNF-α Activity.

Direct inhibition of tumor necrosis factor-alpha (TNF-α) action is considered a promising way to prevent or treat TNF-α-associated diseases. The trimeric form of TNF-α binds to its receptor (TNFR) and activates the downstream signaling pathway. The interaction of TNF-α with molecular-grade dimethyl sulfoxide (DMSO) in an equal volumetric ratio renders TNF-α inert, in this state, TNF-α fails to activate TNFR. Here, we aimed to examine the inhibition of TNF-α function by various concentrations of DMSO. Its higher concentration led to stronger attenuation of TNF-α-induced cytokine secretion by fibroblasts, and of their death. We found that this inhibition was mediated by a perturbation in the formation of the functional TNF-α trimer. Molecular dynamics simulations revealed a transient interaction between DMSO molecules and the central hydrophobic cavity of the TNF-α homodimer, indicating that a brief interaction of DMSO with the TNF-α homodimer may disrupt the formation of the functional homotrimer. We also found that the sensitizing effect of actinomycin D on TNF-α-induced cell death depends upon the timing of these treatments and on the cell type. This study will help to select an appropriate concentration of DMSO as a working solvent for the screening of water-insoluble TNF-α inhibitors.

Green Synthesis of Cerium Oxide Nanoparticles (CeO2 NPs) and Their Antimicrobial Applications: A Review.

During the last decade green synthesized cerium oxide nanoparticles (CeO2 NPs) attracted remarkable interest in various fields of science and technology. This review, explores the vast array of biological resources such as plants, microbes, and other biological products being used in synthesis of CeO2 NPs. It also discusses their biosynthetic mechanism, current understandings, and trends in the green synthesis of CeO2 NPs. Novel therapies based on green synthesized CeO2 NPs are illustrated, in particular their antimicrobial potential along with attempts of their mechanistic elucidation. Overall, the main objective of this review is to provide a rational insight of the major accomplishments of CeO2 NPs as novel therapeutics agents for a wide range of microbial pathogens and combating other diseases.