AbstractAccording to the principle of indifference, when a set of possibilities is evidentially symmetric for you – when your evidence no more supports any one of the possibilities over any other – you're required to distribute your credences uniformly among them. Despite its intuitive appeal, the principle of indifference is often thought to be unsustainable due to the problem of multiple partitions: Depending on how a set of possibilities is divided, it seems that sometimes, applying indifference reasoning can require you to assign incompatible credences to equivalent possibilities. This paper defends the principle of indifference from the problem of multiple partitions by offering two guides for how to respond. The first is for permissivists about rationality, and is modeled on permissivists' arguments for the claim that a body of evidence sometimes does not uniquely determine a fully rational credence function. The second is for impermissivists about rationality, and is modeled on impermissivists' arguments for the claim that a body of evidence does always uniquely determine a fully rational credence function. What appears to be a decisive objection against the principle of indifference is in fact an instance of a general challenge taking different forms familiar to both permissivists and impermissivists.