Flow Rate Ratio Research Articles

PLA/PLGA nanocarriers fabricated by microfluidics-assisted nanoprecipitation and loaded with Rhodamine or gold can be efficiently used to track their cellular uptake and distribution

This study represents a pioneering investigation into using microfluidic technology for manufacturing PLA and PLGA nanocarriers (NCs) loaded with tracer molecules or metals through a co-precipitation protocol that involves saturating the water phase. The effects of total flow rate (TFR), flow rate ratio (FRR), surfactant amount, and polymer concentration on particle sizes and distributions were examined. The average size of PLA-NCs varied from 349 ± 175 nm to 170 ± 64 nm, with surface charges ranging from −13 to −6 mV. In contrast, PLGA-NCs had an average size between 192 ± 46 nm and 100 ± 34 nm, with surface charges from –23 mV to −53 mV. Increasing the TFR from 6 to 10 mL/min with a fixed FRR of 1:1 and reducing polymer concentrations in the organic phase from 20 to 5 mg/mL generally resulted in smaller NC sizes and distributions (monodispersed), with PLGA-NCs consistently exhibiting smaller dimensions. Under these specific conditions, Rhodamine B (Rhod) and gold (Au) were successfully loaded, achieving encapsulation efficiencies exceeding 50 %. Electron microscopy analysis confirmed that the nanocarriers exhibited a consistent spherical shape with smooth surface morphology. X-ray energy-dispersive spectroscopy (EDX) revealed a uniform distribution of gold within the polymer matrix. PLA-NCs were effectively internalized by various cell types, including human Peripheral Blood Mononuclear Cells (PBMCs), HT-29 colon cancer cells, and C6 glioma cells. Uptake occurred in a dose-dependent manner for PLA-NCs sized at 260 ± 51 nm, with only 30 % internalization at 2 mg/mL concentration after 24 to 48 h. Notably, smaller PLA-NCs with a mean size of 170 ± 64 nm achieved nearly 100 % uptake across all tested cell types after 48 h, indicating that particle size significantly influenced cellular uptake

Numerical Prediction of Solid Particle Erosion in Jet Pumps Based on a Calibrated Model

Jet pumps are widely used in petrochemical processes, nuclear cooling, and wastewater treatment due to their simple structure, high reliability, and stable performance under extreme conditions. However, when transporting solid-laden two-phase flows, they face severe erosion problems, leading to reduced efficiency, malfunctions, or even failure. Therefore, optimizing jet pump performance and extending its service life is crucial. In this study, an experimental platform was established to conduct experiments on wall erosion in jet pumps. The CFD-DEM method was used to simulate the solid–liquid two-phase flow in the jet pump, comparing six erosion models for predicting erosion rates. The Grey Wolf Optimization algorithm was applied to calibrate model coefficients. The results indicate that the Neilson erosion model shows the best consistency with the experimental results. The inlet flow rate significantly influenced the erosion rates, while the flow rate ratio had a smaller effect. The particle concentration exhibited a nonlinear relationship with erosion, with diminishing impact beyond a certain threshold. As the factors varied, the erosion distribution tended to be uniform, but high erosion areas remained locally concentrated, indicating intensified localized erosion.

Correlation between nova volume flow rate and TOF signal intensity ratio: value in unilateral internal carotid artery occlusion.

Non-invasive optimal vessel analysis quantitative magnetic resonance angiography (NOVA-QMRA) has emerged as a valuable tool to characterize cerebral hemodynamics in intracranial atherosclerotic disease (ICAD). Our aim was to explore the eventual correlation between volume flow rate (VFR) measured via NOVA-QMRA and signal intensity ratio (SIR) of time-of-flight (TOF) MRA in M1- and P2-segments bilaterally in patients with unilateral internal carotid artery (ICA) occlusion. Patients with acute, subacute or chronic unilaterall ICA occlusion receiving NOVA-QMRA between June 2019 and June 2021 were retrospectively included. In bilateral M1- and P2-segments VFR was assessed by means of NOVA-QMRA and a region of interest (ROI) was selected to measure TOF SIR. A correlation between TOF SIR and VFR was tested by means of Pearson correlation coefficient. Mean difference of TOF SIR and VFR between ipsilateral (to occluded ICA) and contralateral M1- and P2-segments was analyzed using a two-sided Welch's t test. Fifty-five patients with unilateral ICA occlusion were included (acute: 28; subacute: 8; chronic: 19). Both ipsilateral (r = 0.536, p < 0.001) and contralateral (r = 0.757, p < 0.001) TOF SIR correlated significantly with NOVA VFR. This observation proved especially true for patients with chronic ICA occlusion. Both VFR (165.18 vs 110.60, p < 0.001) and TOF SIR (4.96 vs 2.70, p < 0.001) were higher in contralateral than ipsilateral M1-segments; whereas, the contrary was observed for P2-segments (VFR 72.35 vs 102.12, p < 0.001, TOF SIR 2.87 vs 3.39, p = 0.016). The study results showed that TOF SIR significantly correlated with phase-contrast derived flow volume in patients with symptomatic ICA occlusion. This correlation remains the same regardless of the stage of the ischemic stroke (acute vs subacute vs chronic). Furthermore, significantly high VFR and TOF SIR in ipsilateral P2-segments may provide evidence of leptomeningeal collateralization in acute patients. Standardly performed TOF SIR Sequences might be of help for a qualitative evaluation of the flow in M1- and P2-segments in patients with unilateral ICA occlusions. NOVA QMRA allows precise quantitative measurements of the flow in cerebral vessels.

Enhancement of perpendicular magnetic anisotropy in W/Co/Pt films by nitrogen doping in the W layer

The modulation of perpendicular magnetic anisotropy (PMA) in films has been the subject of considerable research interest, as it is proposed to be a key component for the design and realization of efficient magnetic switching in spintronic devices. In this study, we report the appearance of PMA in the as-deposited WNx/Co/Pt films without annealing. The strength of the PMA is quantified by means of effective magnetic anisotropy constant Keff, which is correlated with the N2 gas/Ar gas flow rate ratio PN2. The highest Keff value, 1.347 × 106 erg/cm3, is obtained for the sample deposited with PN2 of 40%. This phenomenon can be explained in two ways. On the one hand, the results of the experiment demonstrate that appropriate nitrogen doping can facilitate the formation of an ideal nitrided state at the WNx/Co interface, while simultaneously reducing the roughness of the WNx/Co interface, which, in turn, enhances the PMA of the WNx/Co/Pt films. On the other hand, the first-principles calculations indicate that the enhancement of PMA can be attributed to the modification of orbital hybridization at the Co/Pt interface by WNx. This innovative approach has the potential to advance the development of high-performance magnetic random-access memory devices.

A microfluidic approach for controllable synthesis of TiO2 submicrospheres

TiO2 submicrospheres are used in dye-sensitized solar cells and Li-ion batteries to enhance energy conversion efficiency and volumetric performance. In this study, a microfluidic chip was designed for the realization of the continuous controllable synthesis of TiO2 submicrospheres. The chip utilizes two T-channels to discrete dispersed phases into droplets, and a Y-channel to fuse the two dispersed phase droplets. The droplets generation process, the influencing factors of droplet length and the fusion process of droplets were investigated. The effects of the flow rate ratio of titanium oxysulfate and ammonia solutions, microchannel geometrical profiles including the Y-channel entrance angle on the size of the synthesized TiO2 were studied. The length of the generated droplets was found to decrease with increasing continuous-phase flow rate, and increase with increasing dispersed-phase flow rate and microchannel cross-section area. When the flow rate ratio of titanium oxysulfate solution and ammonia solution was 1:1, the average diameter of TiO2 spheres synthesized was the smallest, around 300 nm. Increasing the microchannel cross-section and Y-channel entrance angle were beneficial in obtaining larger TiO2 submicrospheres. This proposed microfluidic strategy has the potential for applications required continuous synthesis of TiO2 submicrospheres with controllable sizes.

A preliminary experimental study on atomization rainfall properties by two-jet collision in high dam discharge

The energy dissipation method commonly employed for flood discharge in high dams involves the collision of jets in the air. This approach frequently results in the issue of flood discharge atomization. This study experimentally investigates the rainfall characteristics resulting from the interaction between a surface-orifice jet and a deep-orifice jet during high dam discharges. The research explores various flow rate ratios and collision angles of the two jets, focusing on the spatial distribution of rainfall intensity, as well as the size and velocity of droplets post-collision. The findings revealed that the rainfall distribution on the horizontal plane resembles a mushroom cloud, with the maximum rainfall intensity at the center. Increasing the collision angle between the jets significantly increases the dispersion range of atomized rainfall, while the maximum intensity decreases. Additionally, as the jet flow rate ratio increases, the dispersal range of rainfall initially expands before stabilizing, with relatively minor variations in intensity. Following a two-jet collision, the trajectory of the jet was derived, and the associated parameters were determined using experimental data. The probability distributions for droplet size and velocity closely approximated Gaussian distributions. The study also observed that the number of droplets per unit time, along with the ensemble-averaged diameter and velocity, initially increases and then decreases longitudinally. Meanwhile, the number of droplets per unit time gradually decreases in the lateral direction, while the ensemble-averaged diameter and velocity remain relatively constant. Furthermore, with an increase in the jet flow rate ratio, both the ensemble-averaged diameter and velocity of droplets follow a pattern of initial increase and subsequent decrease, while the collision angle has no significant impact.

Assessing boundary conditions in CFD for transvalvular pressure gradient calculation in cardiac hemodynamics

Abstract Background Computational fluid dynamics (CFD), which has the advantages of providing detailed pressure distribution, has been widely used for cardiac function assessment and heart disease diagnosis. However, the results are usually influenced by the boundary conditions. Particularly, the transvalvular pressure gradient, which serves as a crucial indicator for mitral stenosis and the efficacy of mitral valve surgery, can easily be miscalculated. Here, we assess the effects of widely used boundary conditions on the transvalvular pressure gradient computed based on the Bernoulli equation and the line probe, respectively. Purpose This study aims to determine the effects of boundary conditions on the transvalvular pressure gradient in CFD. Methods We constructed cardiac models including left atrium, left ventricle, aorta from CT and mitral valve from transesophageal echocardiography data (Figure 1). The intraventricular flow fields were computed using CFD tool with four different boundary conditions (BC) at the same cardiac output. BC1 involved specifying the total flow rate of the aorta, with zero pressure at the entrance of the pulmonary veins. BC2 maintained equal flow rates at the entrances of the pulmonary veins. BC3 followed Murray's law, where the flow rate ratio in the pulmonary veins is proportional to the 1.5 power of the area ratio. BC4 followed Poiseuille's law, where the flow rate ratio is proportional to the square of the area ratio. The results encompassed the mean transvalvular pressure gradient and peak transvalvular pressure gradient obtained through the Bernoulli equation and the line probe methods, respectively. Results Figures 2(A-D) present the contours of transvalvular pressure under peak flow velocity conditions and the isosurfaces of vorticity within the ventricle. The results show that the pressure within the atrium is notably lower in the BC2, leading to a 63% underestimation in the mean transvalvular pressure gradient and a 22.9% deviation in the peak transvalvular pressure gradient (Figure 2 F). The transvalvular pressure gradient for BC1, BC3, and BC4 do not exceed 10%. The results reveal that the pressure distribution and vorticity within the ventricle are consistent, primarily due to the influence of the mitral valve. Conclusion When evaluating transvalvular pressure gradient using CFD, it is crucial to specify appropriate boundary conditions. Using inappropriate boundary conditions may lead to underestimation of the transvalvular pressure gradient, thereby affecting further diagnostic decisions. In research studies, it is recommended to allocate flow in different branch vessels according to Murray's law, where the flow in different branch vessels is proportional to the 1.5 power of the vessel cross-sectional area.Modelling flow chartTransvalvular pressure gradient

An innovative quick-decision strategy for evaluating the applicability of extractive distillation process with a preconcentration column in separating high-concentration organic waste liquid

In the face of the high energy consumption challenge in separating high-concentration organic waste liquid through extractive distillation (ED), the concept of preconcentration provides a new strategic direction. Therefore, it has become crucial to determine the suitability of the ED process with a preconcentration column for processing such complex mixture. Taking this into consideration, the study proposes an innovative quick-decision method that utilizes thermodynamic analysis of ternary phase diagram to determine the ratio of theoretical product flowrate at the bottom of the preconcentration column to the feed flowrate, which serves as the basis for deciding whether to choose the ED process with a preconcentration column for handling such separation tasks. Three azeotropic systems with different thermodynamic characteristics are chosen as case studies: cyclohexane/ethyl acetate/ethanol (Case 1), ethyl acetate/ethanol/water (Case 2), and n-hexane/ethyl acetate/acetonitrile (Case 3). The task of separating the above three systems is accomplished through the application of both three-column extractive distillation configuration (TCED), and four-column extractive distillation configuration (FCED). The objective functions for multi-objective optimization of all separation configurations include the minimum total annual cost (TAC), the minimum entropy generation and the minimum CO2 emissions. The research findings indicate that when the ratio of theoretical product flowrate at the bottom of the preconcentration column to the feed flowrate is not less than 0.56, or when there is a significant concentration difference among the components in the feed stream, the FCED configuration exhibits clear advantages over the TCED configuration in terms of economic, environmental, and thermodynamic aspects.

Investigation of Titanium Nitride as an Effective Interphase for Carbon-Fiber-Reinforced Silicon Carbide Ceramic Matrix Composites.

Ceramic matrix composites (CMCs) have played a significant role in increasing the efficiency of gas turbine engines. CMCs combine the high temperature resistance of ceramics with the high mechanical strength of ceramic fibers into a single unit. Interphase layers are a crucial component in CMCs, as they prevent ceramic fibers from oxidation and introduce strengthening mechanisms into the composite. Hexagonal boron nitride and pyrolytic carbon are the most commonly used interphase layers in the aerospace industry. Other than that, very few materials have been evaluated as interphase layers. In this study, we explore the possibilities of using titanium nitride as an interphase layer in single-tow CMCs (mini composite) representative of a unidirectional composite at a smaller scale. T-300 carbon fibers were coated with TiN by atmospheric pressure chemical vapor infiltration using TiCl4, N2, and H2. The deposition temperature, precursor flow rate ratio, total precursor flow rate, and deposition time were optimized to obtain high-quality coatings. The best coating was produced at 800 °C, 4:1 H2 [TiCl4]/N2 ratio, 125 standard cubic centimeters per minute (N2 + H2 [TiCl4]) total flow precursor flow rate, and 2 h of deposition time. At these conditions, the coatings displayed good fiber coverage, good fiber adhesion, minimum fiber linkage, and minimum surface roughness. There was minimum fiber degradation after TiN coating, with a retention of 95% of the initial Young's modulus and 26% of the ultimate tensile strength of the carbon fiber. Adding the TiN interphase coating to the Cf/SiC CMC increased the ultimate tensile strength of the composite by 1122% and Young's modulus by 150%.

Oil circulation ratio prediction in a vapor compression system using a discharge side oil separator and mass flow correction

Oil circulation ratio (OCR) is defined as the ratio of the mass flow rate of oil to the total mass flow rate of refrigerant-oil mixture in a vapor compression system. The standard method for measuring OCR uses liquid line sampling as described in ASHRAE Standard 41.4. Sampling is tedious, alters the steady state operation of the system, depends on different parameters, and only applies to miscible refrigerant-oil pairs. A potential method for measuring real-time OCR is by using an oil separator to separate the refrigerant flow from the oil flow and using the individual flow rates to calculate OCR. Neither a liquid line, nor refrigerant-oil miscibility are necessary for this separation-based method. No oil separator is perfect as some oil always escapes with the separated refrigerant, and some refrigerant, dissolved in oil, always escapes with the separated oil. This can significantly reduce the accuracy of the procedure. The present study investigates OCR measurements using an oil separator-based approach for a full vapor compression cycle working with R134a and PAG ISO 46 oil. A full cycle allows sampling to also be performed in parallel for validation. Mass flow corrections were performed to account for refrigerant dissolved in separated oil, and for oil entrained by separated refrigerant. OCR values from the oil separator-based approach, upon mass flow correction, were within 6 % of the sampling results. The usefulness of the oil separation efficiencies at the oil and vapor outlet ports for the oil separator-based approach is discussed.

INFLUENCE OF THE RATIO OF GASE CONSUMPTION N&lt;sub&gt;2&lt;/sub&gt;/Ar AND MAGNETRON POWER ON THE DENSITY AND STOICHIOMETRIC COMPOSITION OF TIN&lt;sub&gt;X&lt;/sub&gt; FILMS SYNTHESIZED BY MAGNETRON SPUTTERING METHOD

The films of titanium nitride were deposited by direct current magnetron sputtering on the surface of singlecrystalline silicon samples in an Ar-N2 atmosphere for use as a diffusion barrier. The thickness and density of films were measured by X-ray reflectometry. The design of the MAGNA TM-200-01 installation has been changed to increase the supply of nitrogen into the chamber. The influences of sputtering conditions, including the flow rate of nitrogen and argon gases and their N2 /Ar ratios in the range of 1–60 in the chamber, magnetron power of 690–1400 W on the formation of TiNx films, their density and stoichiometric composition, were studied. It is shown that the value of x is affected not only by the N2 /Ar gas flow rate ratio, but also by the magnetron power. At the sputtering parameters 1200 W, N2 /Ar = 30, 0.8 Pa, 320 s and 100°C, a maximum density of 5.247 g/cm3 of a film was achieved, which corresponds to the composition TiN0.786 = Ti56N44. The presence of nanocrystalline film of titanium nitride and the absence of a nanocrystalline titanium phase were confirmed by photographic X-ray diffraction. It was found that for the synthesis of titanium nitride as close as possible to the stoichiometric composition TiN0.770 - TiN0.786, it is necessary to use magnetron power in the range of 900–1200 W, nitrogen rate of 30 cm3 /min with low argon flows of 1–5 cm3 /min.

Unraveling the alternative process configurations for more environmentally friendly Maleic Anhydride production

This study aims to propose and evaluate alternative configurations for producing maleic anhydride (MA) through the n-butane oxidation pathway to enhance overall environmental friendliness. Seven alternative configurations, which vary in the number of non-adiabatic reactors and heat exchange methods, as well as the stripping agents used for recovering MA in the purification section, are rigorously designed and comprehensively compared. Among the proposed configurations, we have found that the one utilizing single reactor with co-current cooling and water as the stripping agent (Scheme 2) shows the most promise. It has an optimal yield of 70.0 %, an energy efficiency of 97.52 %, and exergy efficiency of 44.92 %. A cradle-to-gate life cycle impact assessment determines a Global Warming Potential (GWP) of 0.091 kg-CO2eq/kg-MA from this scheme. In contrast, a techno-economic evaluation determines a minimum required selling price (MRSP) of 0.965 USD/kg-MA from this scheme. All these indicators are superior compared to those documented in the existing literature, suggesting a higher level of environmental friendliness. Subsequently, a suitable control strategy is proposed for the optimized Scheme 2 and evaluated by rejecting various kinds of feed disturbances (i.e., ± 10 % change in feed flowrate, ± 5 % change in molten salt flowrate, 1 % and 2 % of i-butane as feed impurity, and catalyst deactivation up to 40 %). Enhanced controllability is achieved by regulating the flowrate ratio between the flashed liquid and the n-butane (FL/NBU), which promptly indicates the reaction conversion during production. Based on the findings, we have concluded that overall environmental friendliness can be significantly enhanced with moderate modifications in the process configuration, which are easily feasible in the industry.

Aerodynamic design of two-stage centrifugal compressor for vehicle hydrogen fuel cell

Abstract The on-board hydrogen fuel cell is a power generation device that converts the chemical energy of hydrogen and oxygen directly into electrical energy. The centrifugal compressor mainly provides oxygen for the cathode of the fuel cell system. With the rapid development of the hydrogen fuel cell industry, the key components of the air compressor field are also developing rapidly. In the technical route, most companies launched two-stage compression centrifugal air compressors in response to the increasing power of the product development trend. The newly developed hydrogen fuel cell system power has reached above 120kW to meet the needs of heavy trucks and other applications. Both the flow rate and pressure ratio of the air compressor are required to increase accordingly. Based on the reduction of parasitic power, the optimal efficiency at the working point of the two-stage centrifugal air compressor is taken as the design goal, from one-dimensional aerodynamic calculation to two-dimensional flow channel design. Finally, the feasibility and accuracy of the aerodynamic design are verified based on key parameters such as pressure ratio, flow rate, and efficiency of the final stage through CFD flow field simulation and test data comparison. The results show that the flow rate is consistent with the calculated flow field, and the maximum error of pressure ratio and efficiency is less than 2%, which meets the target requirements. The research results can provide a research and development basis for designing high-performance centrifugal air compressors for fuel cell vehicles.

Comprehensive performance analysis and optimization of an ORC-HDH system for power and freshwater production driven by marine exhaust gas

Freshwater serves as a vital energy source for ships, underscoring the paramount importance of research into desalination systems in facilitating diverse and reliable energy supply for maritime vessels. Aiming at numerous waste heat of marine engines and the shortage of freshwater resources on board, this paper designs an innovative waste heat recovery (WHR) system. It includes an organic Rankine cycle, a compression refrigeration cycle, and a humidification-dehumidification (HDH) desalination system to recover waste heat from exhaust gases in cascades, which can effectively produce power, cooling, and freshwater, respectively. A parametric study of the co-generation system in terms of the freshwater production, gained output ratio (GOR), cost per unit of freshwater production, net power output, and per unit of output power cost, are conducted to identify the key operating parameters. A set of operating parameters is determined for the HDH system with a temperature of the humidifier outlet of 358.15 K and a mass flow rate ratio (MR) of seawater to humid air of 4.5. The effect of the relative humidity and temperature of the humid air, as well as the salinity and temperature of the seawater, on the performance of the HDH subsystem are analyzed. And the optimal operating conditions of the co-generation system are obtained through multi-objective cuckoo search optimization. The results demonstrate that the co-generation system can produce an output-power of 1479.8 kW, 500 kW, and 0.49 kg/s for cooling and freshwater production by using the working-fluid R365mfc/Cyclopentane with a mixing ratio of 33:67 under optimal conditions. The GOR and cost per unit of HDH subsystem are 1.62 and 1.70 $/m3, with a capital payback period of 4.18 years. The equivalent output-power of the co-generation system is 9.5 % higher than that of an ORC system.

Numerical investigation of the performance and flow field of an annular jet pump with throat aeration

The method of throat aeration was used to improve the performance of the annular jet pump (AJP). In order to study the influence of throat aeration on the performance and flow field of the AJP, the CFD method was used. The results show that at a low flow rate ratio ( q) the appropriate aeration rate can narrow or even eliminate the recirculation region. Meanwhile, the efficiency of AJP is improved at a medium-to-high q. Notably, the maximum increase in efficiency is 7.32% at q = 0.7 and the optimal aeration rate should be between 1% and 2%. Since the dynamic viscosity of air is much lower than water, a small amount of air attached to the wall can reduce friction loss. The air flows along the wall after the air aerated into the throat, reducing the shear stress between the high-speed jet and the wall. At a low q, most of the area in the throat is the high efficiency drag reduction region which the drag reduction rate exceeds 80%. Moreover, the high efficiency drag reduction region extends toward the diffuser when the q is high. In addition, throat aeration can optimize the pressure distribution near the wall and axis.

Quantification of Bictegravir and its impurities: A novel RP-UPLC Approach for Development and Validation.

A new ultra-pressure liquid chromatography (UPLC) method was developed for accurately and reliably quantifying impurities in Bictegravir. The method utilized Waters Acquity HSSC18 column (50mm x 2.1mm, 1.8 µ) at room temperature. The mobile phase consists of Acetonitrile and Buffer (0.1 percent formic acid) in 80:20 and pumped at a flow rate of 0.2 mL/min. This optimized method achieves exceptional separation of Bictegravir and its impurities with excellent resolution at 281 nm. The method’s accuracy is demonstrated by a % recovery range for Bictegravir and its impurities between 99.1% and 100.3%. The correlation coefficient (R²) for BIC and its impurities is consistently above 0.999, indicating high linearity. The method’s robustness was confirmed by its stability against variations in flow rate and mobile phase ratio. Additionally, forced degradation studies confirmed the stability of Bictegravir, highlighting the method’s reliability. Overall, developed UPLC method is precise, accurate, robust, and linear, making it suitable for routine analysis of BIC-related substances in quality control laboratories at manufacturing sites during commercial production.

Preparation of Baicalin Liposomes Using Microfluidic Technology and Evaluation of Their Antitumor Activity by a Zebrafish Model.

Baicalin (BCL), a well-known flavonoid molecule, has numerous therapeutic applications. However, its low water solubility and bioavailability limit its applicability. Microfluidics is a new method for liposome preparation that provides efficient and rapid control of the process, improving the stability and controllability. This study used microfluidic techniques to create baicalin liposomes (BCL-LPs), first screening for optimal total flow rates (TFR) and flow rate ratios (FRR), and then optimizing the phospholipid concentration, phospholipid-to-cholesterol ratio, and Tween-80 concentration using univariate and response surface methodology approaches. The study found that the ideal phospholipid content was 9.5%, the phospholipid-to-cholesterol ratio was 9:1 (w:w), and the Tween-80 concentration was 15%. BCL-LPs achieved 95.323% ± 0.481% encapsulation efficiency under the optimum circumstances. Characterization indicated that the BCL-LPs were spherical and uniform in size, with a mean diameter of 62.32 nm ± 0.42, a polydispersity index of 0.092 ± 0.009, and a zeta potential of -25.000 mV ± 0.216. In vitro experiments found that BCL-LPs had a better slow-release effect and stability than the BCL monomer. In zebrafish bioassays, BCL-LPs performed better than BCL monomer in terms of biological activity and bioavailability. The established method provided a feasible medicine delivery platform for BCL and could apply for the transport and encapsulation of more natural compounds, expanding the applications of drug delivery systems in healthcare and cancer therapies.

Optimizing supply and production management through energy storage strategies: A solar cold production approach using artificial neural networks

The reliability of clean renewable energy hinges on robust energy systems, with storage serving a critical function. This paper investigates the influence of various storage types and configurations on thermal performance, with a focus on optimal sizing for economic and environmental cost reduction. To achieve this objective, we simulate a solar cooling facility with varied configurations of hot/cold storage installations. This study employs an ANN methodology with a multi-layer perceptron approach to forecast unit performance for each configuration based on data generated during the simulation process. In the pursuit of the most efficient and high-performance network, a comprehensive investigation is conducted on the number of neurons, activation functions, and training algorithms. Subsequently, the optimization process, conducted through a genetic algorithm, determines the Pareto fronts representing the best solution sets. The comparison shows that a system design with double hot and cold storage tanks shows superior techno-economic-environmental performance. Among possible optimum solution sets, a point with this specification is selected; flow rate ratio, minimum flow ratio, cooling capacity ratio, cold storage ratio, and hot storage ratio of 1.2, 0.4, 0.91, 3.4, and 3.8, respectively. This configuration anticipates a levelized cost of cooling at 341 USD/MWhr, representing a 13 % reduction compared to the benchmark.

Performance Analysis and Optimization of Supercritical CO2 Recompression Brayton Cycle Coupled With Organic Flash Cycle With a Two-Phase Expander

Abstract In this work, a combined supercritical CO2 recompression Brayton cycle (SCRBC)/organic flash cycle with a two-phase expander (OFCT) system is proposed to improve the thermal efficiency of the SCRBC, which utilizes a two-phase expander to replace the high-pressure throttling valve of a basic organic flash cycle (OFC). In addition, the OFCT is coupled at the waste heat end of the SCRBC as the bottom cycle for the use of waste heat at low temperatures. A comprehensive comparison is carried out for different organic working fluids, including the R123, R245fa, R142B, R236ea, and R600, regarding the thermal performance, environmental effect, and safety levels. Furthermore, influences of various factors on the thermal performance of the combined SCRBC/OFCT cycle are also examined, including the top cycle pressure ratio, top cycle turbine inlet temperature, mass flowrate ratio, evaporation temperature, and the condenser's pinch point temperature difference. A multi-objective optimization approach is employed on the combined SCRBC/OFCT system, which considers both the thermal efficiency and the specific investment cost as the objective function, and the optimization procedure is implemented through the nondominated sorting genetic algorithm II (NSGA-II) algorithm. The Pareto solution set and the compromise solution are finally obtained. The results indicate that the optimized combined SCRBC/OFCT system can improve the thermal efficiency by 11.75% and 9.70% when compared with the SCRBC and SCRBC/OFC, respectively.

Effect of cap layer and post growth on-site hydride passivation on the surface and interface quality of InAsP/InP hetero and QW structures

The performance of devices made from III-V compound semiconductors relies heavily on their surface and interface properties. The InAsP/InP material system is recently gaining interest due to its suitability for the next generation of long-haul classical and quantum communication applications. Researchers are studying how surface and interface properties affect the efficiency of the device and concludes that the epitaxial growth conditions responsible for creating surface and interface states require further improvement. To address this, we have studied the effect of the top (cap) layer and post-growth on-site hydride passivation on the properties of InAsP/InP hetero-structures grown using metal-organic vapor phase epitaxy technique. The flow rate and flux ratios of the hydrides significantly affect the surface reaction rates and gas-phase diffusion coefficients, which in turn impact the As↔P exchange mechanisms. Our findings suggest that post-growth on-site arsine passivation encourages the As↔P substitutions at the vicinity of the desorption sites of phosphorus, leading to the arsenic-rich surface of InAsP with the diffused hetero-interfaces. The activation energy for such As↔P exchange reaction mechanism is evaluated as ∼ (1.4 ± 0.3) eV. On the other hand, it has been observed that the thin cap layer of InP protects the surface of the InAsP epilayer and thereby preserving the sharp interface. Further, surface photovoltage and photoluminescence spectroscopy is employed to examine the role of the diffused and sharp interface of InAsP/InP hetero-structures in charge carrier transport, their redistribution and recombination process. Our analysis of the energy transitions occurring in the surface photovoltage and photoluminescence spectrum reveal that the energy band alignment and the subsequent charge carrier redistribution processes is influenced by the surface and interface states. These changes in the surface photovoltage phase spectra of InAsP/InP system also support the role of surface and interface states in the generation and separation of the charge carriers. The study provides insights into the effects of As↔P exchange on surface and interfacial quality, highlighting the implications for optoelectronic device development using InAsP/InP material system.