Disintegration Rate Research Articles

Development and Characterization of Fast-Dissolving Tablets to Enhance Bioavailability of BCS Class II Drugs by Solid Dispersion Method

Background: Rapid tablet or capsule dissolution requires the tablet to disintegrate and dissolve at a higher rate, enhancing drug dissolution and bioavailability. Suitable disintegrants have shown an appreciable rate of disintegration or dissolution. Using factorial design for formulation to improve bioavailability is a key focus in pharmaceutical research to enhance dissolution Methods: Azelnidipine (Azp) tablets were formulated with Hydroxypropyl β-cyclodextrin (HβCD), β-cyclodextrin (βCD), and Kolliphor HS15 (HS15) to enhance solubility. A 23 factorial design optimized the formulation, focusing on disintegration time (DT) and time for 90% dissolution (T90). Eight formulations (F1-F8) were prepared using the kneading method. Tablets were evaluated for physical properties, drug content, friability, dissolution, and drugexcipient interactions (FTIR and DSC). The optimal formulation (F9) was determined via desirability analysis. Results: Tablets showed acceptable Carr's index (CI), Hausner ratio (HR), and Angle of Repose (AR). Increasing βCD concentration decreased DT, enhancing water absorption and faster dissolution. βCD tablets had the lowest DT among the formulations, with F4 showing the best disintegration. Higher HS15 concentration also reduced DT, with F8 achieving the highest drug release (T90%) within 60 minutes. R² values ranged from 0.922 to 0.994, indicating high predictability. The optimal formulation had a desirability of 1.0, consisting of 3.523 mg HS15, 28.4 mg βCD, and 1.49 mg βCD, with a DT of 102 ± 1.13 seconds and 98% dissolution. FTIR and DSC confirmed no drug–excipient interactions. Conclusion: Optimized super disintegrant concentrations and wet granulation techniques resulted in tablets with strong mechanical properties, rapid disintegration, and consistent drug content. Future research and in vivo studies should explore additional excipient combinations.

Two factors facilitate the cost-effective and harmless cementation of rare earth slags through MICP technology: Carbonic anhydrase bacteria and endogenous calcium ions

Microbially induced carbonate precipitation (MICP), a solidification/stabilization technique that doesn't interfere with recycling and can reduce the migration of pollutants, has been employed to cement rare earth slags (RES). Currently, the MICP process of the urease/carbonic anhydrase pathway has attracted considerable attention. However, the MICP process of the urease pathway may produce high concentrations of ammonia, which can cause secondary contamination; the addition of a calcium source (calcium chloride) may increase the cost of the treatment process. In this study, two factors, carbonic anhydrase bacteria and endogenous calcium ions (Ca²⁺), facilitated the MICP technology to cost-effectively and harmlessly cement RES and stabilize contaminants. The findings indicated that strain Z1 could utilize endogenous Ca²⁺ to cement the RES, thereby enhancing its unconfined compressive strength, reducing the disintegration rate, radiation dose, and wind erosion intensity, and facilitating the stabilization of heavy metals and radionuclides. In comparison to the CK group, the leaching concentrations of Cu2+, Pb2+, Zn2+, Cd2+, Th(Ⅳ), and U(Ⅵ) in the C1 group were reduced by 42.37 %, 20.20 %, 18.77 %, 22.53 %, 12.32 %, and 23.66 %, respectively. The treatment effect can be further enhanced by adding exogenous Ca2+. This study's findings can help reduce the potential environmental risks in the long-term sequestration of RES, while also providing technical support for the sustainable development of the rare earth industry.

Predictive Modelling and Functional Group of Clay Soil Treated with Steel Slag and Calcium Carbide Residue

Swell-shrink subgrade soils like clay are rich in sulphate and exhibit a high rate of volume change by swelling and shrinking during wet and dry cycles, respectively, leading to heaves, cracks, and differential settlement of pavement layers. The aim of this study was to establish predictive simulation models and functional group of clay soil treated with steel slag and calcium carbide residue. Physical and geotechnical tests (such as California bearing ratio (CBR), compaction characteristics, and consistency parameters) were carried out on the unstabilised and stabilised clay soil. Using SPSS statistical software (version 23), multiple linear regression analysis was applied to the experimental data that relate CBR to compaction parameters and additive contents (steel slag and calcium carbide residues). The generated models gave a reliable coefficient of determination, R2 , of 0.990, and 0.998, which can be used to successfully predict both unsoaked and soaked CBR of the stabilised clay soil, respectively. Fourier transform infrared spectroscopy (FTIR) analysis was examined on the clay soil, the additives, and the stabilised clay soils. The FTIR analysis showed weak peaks at 1115 and 1103 cm-1 for all the stabilised clay soils, and this revealed that both additives drastically reduced the sulphate content in the clay soil, which consequently reduced the expansion, cracking, and disintegration rates. As a result, the clay soil's chemical bonding was enhanced through physico- chemical mechanisms.

Mechanical behavior and strengthening mechanism of loess stabilized with xanthan gum and guar gum biopolymers

Abstract The structural properties of loess are susceptible to change when subjected to external loads and complex environments, leading to various geological disasters. To investigate the mechanical behavior and strengthening mechanism of loess stabilized with biopolymers such as xanthan gum and guar gum, especially for soils with low bearing capacity and stability in engineering applications, we conducted research on the improvement of soil with xanthan gum and guar gum, tests including unconfined compressive strength, disintegration, direct shear, and microstructure tests were conducted. Among the four different dosages of biopolymers (0%, 0.5%, 1%, 2%) and four different curing ages (1 day, 3 days, 7 days, 14 days), the 2% content of biopolymer and 14 days had the greatest impact on the mechanical properties of loess, Both the compressive and shear strength, as well as the water stability of solidified loess, improve with higher content of xanthan gum and guar gum or prolonged curing time; however, the disintegration rate decreases. Microscopic analysis indicates that the biopolymers effectively fill the gaps between soil particles and attach to the particle surfaces, forming fibrous and reticular structures that improve the interparticle bonding and ultimately increase the strength and water stability of the loess. Xanthan gum and guar gum biopolymers can improve the mechanical properties and water stability of loess, enhance the erosion resistance and improve the water-holding capacity. These outcomes suggest that guar gum and xanthan gum biopolymers have the potential to serve as environmentally sustainable alternatives to conventional soil stabilizers.

The effect of biodegradable polymer blending on the disintegration rate of PHBV, PBS and PLA in soil

This study generates new insights into the disintegration phenomena that take place upon blending different classes of biodegradable polymers. Polymer blending is found to be an effective method to tailor the disintegration rate of these polymers in soil. It is shown that the biodegradation of poly(hydroxybutyrate-valerate) (PHBV) can be accelerated by blending with polybutylene succinate adipate (PBSA) and polycaprolactone (PCL). The observed high rate of disintegration of polybutylene succinate (PBS) in soil (severe deterioration in 4 weeks, and fragmentation in 4 months) does not fully align with its current reputation in the market as a polymer that is non-biodegradable in soil. Disintegration trials executed in soil media with different inoculants demonstrate that the biodegradation rate of PBS in soil is highly dependent on the specific soil conditions. Moreover, it is shown that the biodegradation of PBS can be substantially accelerated by blending it with PBSA (fragmentation in 8 weeks). Finally, it is shown that the disintegration of polylactic acid (PLA) in soil can be enhanced by blending it with PCL. Experiments that monitor the CO2 evolution of these blends, both in soil and in home composting environments, demonstrate that not just the disintegration, but also the overall biodegradation of PLA is enhanced by blending with PCL (39% conversion to CO2 in 12 months incubation in soil; 89% conversion to CO2 in 6 months incubation in home composting conditions). This opens up possibilities for targeted blending strategies to reduce potential accumulation of PLA-based plastics in soil environments.

Enhancing functional properties of compostable materials with biobased plasticizers for potential food packaging applications

The demand of non-toxic and biobased plasticizers is substantially growing, particularly in biodegradable thermoplastics-based packaging applications. Herein, a derivative of citric acid (CITREM-LR10), usually used as food additive, was evaluated for the first time as plasticizer in PLA and Ecovio® biopolymers. Films containing 10 %(w/w) of CITREM-LR10 were prepared and compared with films plasticized with another biobased compound, SOFT-NSAFE, derived from acetic acid. The incorporation of both plasticizers provokes a slight reduction of the glass transition, however, only CITREM-LR10 was able to augment the elongation at break value of PLA films. A further evaluation of the films by Raman confocal microscopy showed the segregation of the CITREM-LR10 in microdomains, which could explain the enhanced elongation at break value, behaving as stress concentrators. In addition, CITREM-LR10 provides antimicrobial activity against S. aureus and both plasticizers give antioxidant properties, and almost negligible diffusion in food simulated solution. Composting studies showed that the plasticizers do not have effect on the disintegration rate of the films. In spite of these outstanding properties, the water vapour and oxygen barrier properties of the films worsen with its incorporation, therefore, the inclusion of fillers in the material together with the plasticizers would be necessary to improve such properties for food packaging applications.

A Short Review on Techniques useful to Enhance Solubility and Drug Dissolution Rate for Intensification of Bioavailability

Dissolvability assumes an essential part in accomplishing the imperative grouping of prescription in the circulation system to exhibit pharmacological impacts, as it includes the course of a strong substance dissolving in a fluid stage to make a uniform combination. The essential test experienced in forming drugs is the restricted watery solvency of novel medication particles. At the point when inadequately dissolvable medications are managed orally, higher portions are expected to achieve the ideal helpful plasma fixation. Administrative bodies and wellbeing associations use the Bio drug Order Framework to classify intensifies in light of their dissolvability and penetrability. This order framework is utilized to lay out bio equality for substances that are exceptionally dissolvable and profoundly penetrable, involving disintegration for the purpose of evidence. Drugs displaying poor watery solvency experience slow disintegration rates, bringing about commonly low bio accessibility upon oral organization. This survey article expects to investigate methodologies for accomplishing successful ingestion and improving bio accessibility. This article examines different procedures and techniques for working on the dissolvability of inadequately solvent medications. Solvency is essential for a medication's successful fixation at the objective activity site. The decision of strategy relies upon the medication's temperament, properties, and pharmacokinetic conduct. Different strategies can be utilized separately or in mix to further develop drug dissolvability. The decision of strategy relies upon the medication's quality, viability, and relationship with different synthetic compounds, dependability, and final result yield, while likewise thinking about financial variables.

Combining radio frequency heating and alkaline treatment for enhancement of sludge disintegration and volatile fatty acids production from anaerobic fermentation

Sludge pretreatment plays a crucial role in solubilizing particulate matters to release organic matter for subsequent anaerobic fermentation (AF). This study innovatively combines radio frequency (RF) heating and alkaline treatment, and finds that the combined pretreatment achieved a sludge disintegration rate of 35.11 %, which is 15.19 % and 8.48 % higher than single RF or alkaline pretreatment. The dissociated ions from the alkali are conducive to RF action on sludge. Furthermore, the combined pretreatment significantly benefits the subsequent AF experiments, resulting in a 9-fold increase in volatile fatty acids production. Considering cost-effectiveness, the optimal operating condition is a 10-minute RF treatment at pH 10 with a total cost of 4.35 × 10-3 dollars per kg soluble chemical oxygen demand (SCOD) increased. These findings provide a foundational basis for the development of a novel technology for sludge pretreatment.

Reducing sludge formation by enhancing biological decay of biomass: a mathematical model

Abstract We investigate a model for an activated sludge process that contains a chemical reactor unit attached to a bioreactor. Inside the chemical reactor unit, a process takes place which increases the decay coefficient of heterotrophic biomass. This mimics a number of experimental techniques which are used to decrease the mass of sludge. Such techniques are of growing interest as the activated sludge process produces large volumes of sludge; the costs associated with its disposal are significant. Our primary interest is to investigate how the operation of the chemical reactor unit changes the steady-state concentrations of both the total suspended solids within the biological reactor and the chemical oxygen demand in the effluent stream. The operation of a chemical reactor unit always increases the value of chemical oxygen demand in the effluent stream. The behaviour of the total suspended solids is more complicated; in some cases, the operation of the CRU increases the total suspended solids. For a fixed value of the chemical oxygen demand in the influent stream, we show that both the percentage reduction in the total suspended solids and the chemical oxygen demand in the effluent stream are increasing functions of the soluble substrate in the feed. The same trends occur when the influent composition is fixed, and the disintegration rate inside the chemical reactor unit is increased. This leads to dichotomic behaviour, decreasing the total suspended solids increases the chemical oxygen demand in the effluent stream. There are two consequences of this behaviour. Firstly, there are some waste streams that can not be cleaned using the process configuration considered in this paper. Secondly, the imposition of a target value for the chemical oxygen demand in the effluent stream imposes a maximum achievable reduction in the total suspended solids in the biological reactor. Higher reductions can not be achieved without causing the chemical oxygen demand in the effluent stream to exceed the target value.

Enhancing biocementation performance in low permeability clayey soil through sand column strategy

Soil erosion is a common phenomenon which causes lots of geological and engineering disasters. Clayey soil erosion control is a hot research topic and a challenging issue for its low permeability and lack of effective infiltration of treatment solutions. In this study, a coupling microbially induced calcium carbonate precipitation (MICP)-sand column method was proposed as a promising and sustainable technique to mitigate surface clayey soil erosion with adjustable treatment depth. Seven groups of soil samples were prepared, including pure soil, MICP-treated soil, and MICP-sand column method-treated soil. A series of disintegration tests and penetration tests were conducted to investigate the method feasibility and adjusting mechanism of erosion mitigation with varying sand column heights and diameters. Compared to pure soil sample, sample treated by MICP-sand column (6 cm-height and 3 cm-diameter) method could reach a maximum reduction of 50 % in ultimate disintegration rate and a 30 % increase in the highest penetration resistance. The sample has a 7.9 cm effective treatment depth, which is 5.3 times of the MICP-treated sample. The mechanism of erosion mitigation can be attributed to that the sand column serves as a favorable path for the bacteria suspension and cementation solution in low-permeability-clayey soil and improves the effective depth of MICP treatment. Adjusting the height and diameter of sand column can change the calcium carbonate distribution, especially at the locations near the surface and around the sand column. In this study, the optimal height and diameter are 6 cm and 3 cm, respectively, and finally form a U-shape three-layer structure. The structure significantly increases the proportion of the hard crust layer and weak-cemented layer with high hydro-mechanical properties. In conclusion, the coupling MICP-sand column method with reasonable height and diameter of sand column shows the ability to control surface erosion of soil and has better long-term mitigation performance.

Application of Guar Gum Treatment of Basalt Residual-Soil Shallow Slope in Early Ecological Restoration

This paper found that environmentally friendly guar gum biopolymers are helpful for stopping the erosion of basalt residual-soil shallow slopes, while also improving the problems of poor stability, difficult growth of early vegetation, and weak initial resistance to the rainfall scouring of these slopes under extreme climatic conditions. Then, to illustrate the effects of the guar gum treatment, laboratory tests have been conducted, including a soil strength test, water retention and water absorption tests, a disintegration test, and a simulated rainfall erosion test, and the pattern of its effect on vegetation growth has been explored. The results indicate that as the content of guar gum increases, both the cohesion and angle of internal friction exhibit a trend of first increasing and then decreasing; the angle of internal friction varies within a range of 21° to 26°. The evaporation rate, water absorption rate, and disintegration rate of this guar gum-treated soil were significantly reduced, while the cracking of the surface layer was significantly improved. The disintegration rate of the soil is only about 2%, as the guar gum content is greater than 1%. Moreover, there is no sign indicating that vegetation germination was affected by the guar gum, meaning that it maintains a favorable environment for vegetation to grow. Guar gum-cured slopes were significantly protected under heavy rainfall washout conditions, with a 94.85% reduction in total soil loss from the slope surface compared to untreated slopes. Since the pores of soil are filled with guar gum hydrogel, the erosion resistance of soil is greatly enhanced. The results of this study will provide a scientific basis for engineering the protection of shallow slopes of basalt residual soils.

Multilayer Film Comprising Polybutylene Adipate Terephthalate and Cellulose Nanocrystals with High Barrier and Compostable Properties.

In the present study, a multilayer, high-barrier, thin blown film based on a polybutylene adipate terephthalate (PBAT) blend with polyhydroxyalkanoate (PHA), and composed of four layers including a cellulose nanocrystal (CNC) barrier layer and an electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) hot-tack layer, was characterized in terms of the surface roughness, surface tension, migration, mechanical and peel performance, barrier properties, and disintegration rate. The results showed that the film exhibited a smooth surface. The overall migration tests showed that the material is suitable to be used as a food contact layer. The addition of the CNC interlayer had a significant effect on the mechanical properties of the system, drastically reducing the elongation at break and, thus, the flexibility of the material. The film containing CNCs and electrospun PHBV hot-tack interlayers exhibited firm but not strong adhesion. However, the multilayer was a good barrier to water vapor (2.4 ± 0.1 × 10-12 kg·m-2·s-1·Pa-1), and especially to oxygen (0.5 ± 0.3 × 10-15 m3·m-2·s-1·Pa-1), the permeance of which was reduced by up to 90% when the CNC layer was added. The multilayer system disintegrated completely in 60 days. All in all, the multilayer system developed resulted in a fully compostable structure with significant potential for use in high-barrier food packaging applications.

Study on Stability Analysis Method of Loess Slope Based on Catastrophe Theory – A Case Study of Loess Slope in Yili, Xinjiang

Based on the mutation theory, the paper studies the stability of loess slope, and discusses the loess slope in Yili region in Xinjiang. From the perspective of mechanics, the paper focuses on the influence of mutation phenomenon on the stability of loess slope, and deeply analyzes the mechanical mechanism in the mutation process. As an effective tool to study the phenomenon of discontinuous change, mutation theory has important applications in the stability analysis of loess slopes. By applying the mutation theory, the mutation characteristics of the loess slope in the Xinjiang Yili area were analyzed. In terms of mechanical mechanism, the stress distribution, deformation characteristics and the instability mode are discussed in detail. Through theoretical analysis and numerical simulation, it is found that when the slope stress reaches a certain critical value, mutation will occur, leading in a sharp decline of slope stability. Specific data show that in a typical loess slope in Yili area, when the stress reaches about 0.6 MPa, the slope changes, and the displacement instantly increases to more than twice the original, indicating that the slope has been in a state of instability. In the case study of loess slope in Yili, Xinjiang, the slope stability is comprehensively evaluated by combining field investigation to monitoring data and indoor test. By identifying and analyzing the mutation characteristics of the slope, it is found that there are widespread subsidence and disintegration problems in this area, which play a key role in the mutation process. The specific data show that the subsidence coefficient of the loess slope in Yili area is generally above 0.05, and the disintegration rate is more than 0.5% per hour. These factors jointly aggravate the mutation risk of the slope. Based on the above data analysis, the paper puts forward targeted disaster prevention and mitigation measures, including strengthening slope drainage, using appropriate reinforcement technology, etc. These measures aim to reduce the risk of mutation and improve the stability of the loess slope.

Generalizing the Mittag-Leffler Function for Fractional Differentiation and Numerical Computation

This work aims to investigate fractional differential equations using the Magnus Gösta Mittag-Leffler (GML) function and compare the finding with convention calculus approaches. It examines the solutions with one, two, and three parameters using the GML function for different values of α, β, and γ. We also test the convergence of the GML function of two parameters and check the validity and the computational time complexity. Moreover, we extend the GML function into three dimensions within the domain of complex variables utilizing numerical computing software. Graphs of the single-parameter GML E α (x), illustrates diverse disintegration rates across various α values, emphasizing dominant asymptotic trends over time periods.

Preparation and Characterization of Dutasteride Nanoparticles as Oral Fast-Dissolving Film

Background: Dutasteride, is a drug whose mechanism of action is inhibition of the enzyme 5-alpha reductase. It has been approved for use in the treatment of benign prostatic hyperplasia. Dutasteride has low solubility and high permeability, which classifies it as Biopharmaceutics classification system class II, according to the Biopharmaceutics Classification System. It has a water solubility of only 0.038 ng/mL and a slow dissolving rate, resulting in its exclusive availability in the market as a formulation contained within soft gelatin capsules. Objective: The aim of this study involves two parts. First, is the enhancement of dutasteride dissolution rate, by the creation of dutasteride nanosuspension, and second is the enhancement of patient compliance by the transformation of this nanosuspension to oral fast-dissolving film, which is characterized by its fast disintegration, stability, and ease of administration. Methods: The solvent anti/solvent precipitation method was used to formulate dutasteride nanosuspension. In addition, dutasteride nanoparticles oral fast dissolving films were prepared by using the solvent casting method. To compare the in vitro release patterns of pure dutasteride film and selected dutasteride nanoparticles film, the statistical analysis for the dissolution investigation was conducted using the model-independent technique (employing similarity factor f2) utilizing a DD solver. The selected dutasteride nanoparticle film was supposed to be the test material, while the pure dutasteride film was supposed to serve as the reference. Results: dutasteride nanosuspension demonstrated a high enhancement of the dissolution rate. In addition, the prepared dutasteride nanoparticles oral fast-dissolving film exhibited a further increase in the rate of dissolution and fast disintegration, and the administration is easy, all of these properties making it a promising dosage form. Conclusion: Nanosuspension is an excellent approach for enhancing the solubility, dissolution rate, and effectiveness of drugs with limited aqueous solubility such as dutasteride. In addition, the oral fast-dissolving film can be considered a promising dosage form that will increase patient compliance due to its high dissolution rate, fast disintegration, and easy administration.

Enhancing sustainability and biodegradability of poly(butylene succinate) (PBS) composite filaments reinforced with cocoa bean shell residues

AbstractIn this research, we have successfully produced biodegradable composite filaments using Poly(butylene succinate) (PBS) and cocoa bean shell residues (CBS). These composite filaments, fabricated by incorporating up to 20 wt% of the natural filler into the PBS matrix through extrusion processing, have undergone rigorous rheological, mechanical, thermal, morphological, and soil disintegration characterizations. The results have unveiled the potential of printing biodegradable biocomposite filaments, with the materials demonstrating thermal stability in the printing process temperature range. However, a reduction in thermal stability was observed with the incorporation of the natural filler. Differential scanning calorimetry (DSC) analyses indicated a small crystallinity variation for the composites concerning the pure PBS matrix. Furthermore, incorporating the natural filler improved the disintegration rate in the composites' soil, suggesting that CBS can increase and modulate the biodegradation rate of the PBS matrix, thereby expanding its applications in sustainable packaging, 3D printed parts for consumer goods, and agriculture.Highlights Sustainable innovation by using PBS‐CBS filaments for eco‐conscious production. CBS boosts biodegradation and soil disintegration. Shaping a greener future with eco‐friendly 3D printing of PBS‐CBS biocomposites.

Pharmacological and technological studies in the development of tablet composition with acorus calamus leaf extract

The aim: To determine the optimal qualitative and quantitative composition of auxiliary substances for tablets containing dry extract of Acorus calamus leaves and the solid dispersion of quercetin, their relatively therapeutic dose and antiexudative activity. Materials and methods: This study determined a relatively therapeutic dose of dry extract of Acorus calamus leaves, investigated the impact of various auxiliary substances on the properties of tablets formulated with active ingredients - dry extract of Acorus calamus leaves and solid dispersion of quercetin, and assessed antiexudative activity these tablets. The comprehensive analysis entailed the utilization of standardized pharmacopoeial methods to evaluate the quality of the tablet samples. These methods encompassed a range of assessments designed to ensure that the tablets met the requisite pharmacological standards, focusing on key characteristics such as dissolution rate and stability. Determination of the relatively therapeutic dose and antiexudative activity made using standard pharmacological methods in laboratory rats. Results: In-depth exploration during the study led to identifying Ac-Di-Sol and Lubripharm SSF as the most suitable auxiliary substances for the tablet composition. Detailed analysis revealed that Ac-Di-Sol, when utilized at a 10 % concentration, markedly improved the tablets' disintegration rate without adversely affecting their structural integrity. Concurrently, Lubripharm SSF was observed to significantly enhance the tablets' mechanical stability by reducing their friability. Conclusions: As a result of the study, the relatively therapeutic dose of dry extract of Acorus calamus leaves, and the solid dispersion of quercetin, optimal auxiliary substances for the tablet formulation - Ac-Di-Sol and Lubripharm SSF - were established. The conducted research enabled the development of a tablet composition that aligns with the requisite pharmacotechnological specifications and conditions of the modern pharmaceutical industry and demonstrates high antiexudative activity relative to monocomponent substances and famous drugs

Permeability and Disintegration Characteristics of Loess Solidified by Guar Gum and Basalt Fiber.

Loess has the characteristics of loose, large pore ratio, and strong water sensitivity. Once it encounters water, its structure is damaged easily and its strength is degraded, causing a degree of subgrade settlement. The water sensitivity of loess can be evaluated by permeability and disintegration tests. This study analyzes the effects of guar gum content, basalt fiber content, and basalt fiber length on the permeability and disintegration characteristics of solidified loess. The microstructure of loess was studied through scanning electron microscopy (SEM) testing, revealing the synergistic solidification mechanism of guar gum and basalt fibers. A permeability model was established through regression analysis with guar gum content, confining pressure, basalt fiber content, and length. The research results indicate that the addition of guar gum reduces the permeability of solidified loess, the addition of fiber improves the overall strength, and the addition of guar gum and basalt fiber improves the disintegration resistance. When the guar gum content is 1.00%, the permeability coefficient and disintegration rate of solidified soil are reduced by 50.50% and 94.10%, respectively. When the guar gum content is 1.00%, the basalt fiber length is 12 mm, and the fiber content is 1.00%, the permeability of the solidified soil decreases by 31.9%, and the disintegration rate is 4.80%. The permeability model has a good fitting effect and is suitable for predicting the permeability of loess reinforced with guar gum and basalt fiber composite. This research is of vital theoretical worth and great scientific significance for guidelines on practicing loess solidification engineering.

Exploring the efficacy of biosynthesized cupric oxide nanoparticles from Jasminum sambac flower extract in wastewater treatment: Experimental investigations and potential applications

Researchers have shown significant interest in the creation of sustainable green techniques for synthesising metal oxide nanomaterials in the past few years. Plant-mediated production is considered an affordable and feasible alternative to traditional physical and chemical approaches. This study presents a straightforward approach for the environmentally friendly production of copper oxide nanoparticles (CuO NPs) by a solution combustion technique utilising Jasminum sambac Flower Extract. The CuO NPs produced during biosynthesis were analysed using UV-Vis, XRD, FT-IR, SEM, TEM, HPLC, BET and EDX techniques. The SEM pictures reveal that the fragments possess a sponge-like structure characterised by a substantial surface area. An investigation into the photocatalytic activity of CuO NPs shows that they are effective as a catalyst for the breakdown of methylene blue (MB) when exposed to UV and solar radiation. Furthermore, the study demonstrated a pH dependence in the breakdown of MB. According to the study, the best starting concentration of dye for breaking down things completely is 2.5 parts per million (ppm), which results in a remarkable 79 % disintegration rate. The findings indicate that CuO NPs have the ability to effectively treat water by decomposing contaminants such as methylene blue, providing a sustainable method for treating wastewater.

Calorimetric investigation on heat release during the disintegration process of pharmaceutical tablets

The compendial USP〈701〉 disintegration test method offers a crucial pass/fail assessment for immediate release tablet disintegration. However, its single end-point approach provides limited insight into underlying mechanisms. This study introduces a novel calorimetric approach, aimed at providing comprehensive process profiles beyond binary outcomes. We developed a novel disintegration reaction calorimeter to monitor the heat release throughout the disintegration process and successfully obtained enthalpy change profiles of placebo tablets with various porosities. The formulation comprised microcrystalline cellulose (MCC), anhydrous lactose, croscarmellose sodium (CCS), and magnesium stearate (MgSt). An abrupt temperature rise was observed after introducing the disintegration medium to tablets, and the relationship between the heat rise time and the tablet’s porosity was investigated. The calorimeter’s sensitivity was sufficient to discern distinct heat changes among individual tablets, and the analysis revealed a direct correlation between the two. Higher porosity corresponded to shorter heat rise time, indicating faster disintegration rates. Additionally, the analysis identified a concurrent endothermic process alongside the anticipated exothermic phenomenon, potentially associated with the dissolution of anhydrous lactose. Since lactose is the only soluble excipient within the blend composition, the endothermic process can be attributed to the absorption of heat as lactose molecules dissolve in water. The findings from this study underscore the potential of utilising calorimetric methods to quantify the wettability of complex compounds and, ultimately, optimise tablet formulations.