Crossover Rate Research Articles

Comparison of outcomes between anticoagulation and antiplatelet therapies for intracranial arterial dissections.

This study aimed to evaluate real-world data on the differences in outcomes between antiplatelet (AP) and anticoagulation (AC) therapies for intracranial arterial dissection (IAD). This study included patients with symptomatic unruptured IAD between 2010 and 2021 that were treated with anti-thrombotics. Patients were dichotomized to AC and AP based on a treatment policy analysis. Primary endpoints were a composite of ischemic early neurological deterioration, recurrent ischemic or hemorrhagic stroke, or 3-month mortality. Arterial changes were evaluated both in the early (during admission) and late (after discharge) periods. A treatment effectiveness analysis was also performed with AC, AP and a third group of antithrombotic cross-overs. Propensity score matching (PSM) was used to adjust significant baseline differences. In unruptured IAD patients (N = 311), the AC group (N = 211) presented with a higher rate of ischemic stroke or TIA (74.4% vs. 51.0%, p < 0.001) and steno-occlusive morphology (vs. dilatation, 63.0% vs. 39.0%, p < 0.001) compared to AP group (N = 100). After PSM, there was no difference in rates of primary endpoint (9.4% vs. 6.5%, p = 0.470). The results of the treatment effectiveness analysis resembled that of the treatment policy analysis. However, there was a high rate of cross-overs from AC to AP (57/211 [27.0%]). In this group, there was a higher rate of early arterial changes (26.8% vs. 13.1%, p = 0.019) compared to the AC group. In patients with unruptured IAD, this study did not show differences in primary endpoints according to antithrombotic regimen, while there was a high rate of cross-overs from AC to AP.

A fuzzy logic-genetic algorithm for full truckload transportation problem

This work addresses a full truckload commodity selection and multiple depot vehicle routing problem with time windows (FTSMDVRPTW). The goal of the problem is to design a set of selective truck routes that maximize overall profit subject to time window constraints. Each truck route is an arrangement of full truckload transportation commodities that begins at a departure point and ends at an arrival point. It is unnecessary to serve all commodities; only those that provide a higher profit are chosen. We introduce a meta-heuristic based on a combination of fuzzy logic controller (FLC) and genetic algorithm (GA) to solve the FTSMDVRPTW, where the crossover and mutation rates are adjusted during the GA’s evolutionary process using an FLC. We demonstrate the effectiveness and efficiency of the proposed FLC+GA through experimental results on randomly generated instances for the considered problem.

Pembrolizumab Versus chemotherapy in microsatellite instability–high or mismatch repair–deficient metastatic colorectal cancer: 5-year follow-up from the randomized phase 3 KEYNOTE-177 study

BackgroundResults from the phase 3 KEYNOTE-177 study established pembrolizumab as a new first-line standard of care for microsatellite instability–high or mismatch repair–deficient (MSI-H/dMMR) metastatic colorectal cancer (mCRC). Previous results from KEYNOTE-177 showed a statistically significant and clinically meaningful improvement in progression-free survival (PFS) with pembrolizumab versus chemotherapy ± bevacizumab/cetuximab in MSI-H/dMMR mCRC. Results after >5 years of follow-up are reported. Patients and methodsAdults with untreated MSI-H/dMMR mCRC were randomly assigned 1:1 to receive pembrolizumab 200 mg intravenously every 3 weeks or chemotherapy. Patients assigned to chemotherapy could cross over to pembrolizumab after centrally confirmed progressive disease. Dual primary end points were PFS per RECIST v1.1 and overall survival (OS). Secondary end points included duration of response (DOR) and safety. ResultsAt data cutoff (July 17, 2023), median follow-up was 73.3 months (range, 64.9-89.2). Overall, 307 patients were assigned to receive pembrolizumab (n=153) or chemotherapy (n=154). Fifty-seven (37.0%) patients assigned to chemotherapy crossed over to pembrolizumab per protocol; 39 (25.3%) received a PD-(L)1 inhibitor off protocol (effective crossover rate, 62%). Median OS was 77.5 months with pembrolizumab versus 36.7 months with chemotherapy (hazard ratio [HR], 0.73; 95% CI, 0.53-0.99); 5-year OS rates were 54.8% versus 44.2%. Median PFS was 16.5 months with pembrolizumab and 8.2 months with chemotherapy (HR, 0.60; 95% CI, 0.45-0.79). Median DOR was 75.4 months (range, 2.3+ to 80.1+) with pembrolizumab versus 10.6 months (range, 2.8 to 71.5+) with chemotherapy. Compared with chemotherapy, fewer patients in the pembrolizumab arm experienced adverse events (80% versus 99%; grade 3-5, 22% versus 67%). ConclusionsWith >5 years of follow-up, responses to pembrolizumab remained durable. Median OS was over twice as long in patients treated with pembrolizumab versus chemotherapy in first line despite an effective crossover rate of 62%. Pembrolizumab remains a standard of care for MSI-H/dMMR mCRC.

The Cost Evaluation of Day-Case Compared With Inpatient Stapes Surgery for Otosclerosis: Subanalysis of a Randomized Controlled Trial.

To evaluate the difference in overall, hospital, and out-of-hospital cost difference of day-case stapes surgery, compared with inpatient stapes surgery, while maintaining equal hearing outcomes and quality of life (QoL). A single-center, nonblinded, randomized controlled trial in a tertiary referral center. A total of 112 adult patients planned for primary or revision stapes surgery for clinically suspected otosclerosis were randomly assigned to either the day-case or inpatient treatment group. An evaluation was performed of the difference in total health care-related costs (hospital and out-of-hospital costs) from a hospital and patient perspective over the course of 1 year. Audiometric measurements included pure-tone audiometric measurements and speech audiometry measured at 2 months and 1 year postoperatively. QoL was assessed at 3 months and 1 year postoperatively, using the EQ-5D and HUI3 questionnaires. A total of 109 cases (100 patients) were analyzed due to three dropouts. The total health care-related costs were €16,586 in the inpatient group (n = 54) and €16,904 in the day-case group (n = 55). The mean postoperative hospital stay was 0.9 days (mean costs of €854) in the inpatient group and 0.5 days (mean costs of €561) in the day-case group (both mean differences statistically significant), with a crossover rate from day-case to the inpatient group of 36% (n = 20) and a crossover rate from inpatient to the day-case group of 11% (n = 6). There were no differences in postoperative complications and objective hearing outcomes. Besides an increased number (0.2) of postoperative telephone consultations in the day-case group, there were no statistically significant differences in postoperative hospital and out-of-hospital costs or visits. The QoL showed no statistically significant differences. A day-case approach in primary or revision stapes surgery does not result in a statistically significant reduction of health care-related hospital and out-of-hospital costs compared with an inpatient approach. It also does not affect the surgical outcome (objective audiometric measurements and complication rate), QoL, and postoperative course (number of postoperative hospital and out-of-hospital visits).Level of evidence: 1.

Clinical evaluation of a novel single-use therapeutic gastroscope: a pilot feasibility study.

The trend toward disposable products in gastrointestinal endoscopy, including single-use endoscopes, remains undeterred, even though crucial questions of sustainability and performance have not been sufficiently studied. The first single-use therapeutic gastroscope was recently approved in Europe, but clinical data to support its use are currently lacking. We aimed to evaluate the performance of this novel device in routine procedures requiring a large working channel. Between January and May 2024, consecutive patients with an indication for therapeutic gastroscopy were included prospectively. The primary outcome was intraprocedural technical success rate. Eight gastrointestinal bleedings, two pancreatic necrosectomies, four foreign body removals, four stent placements, and two cryo-balloon ablations were performed. The technical success rate was 84% (16/19 patients). Crossover to a standard endoscope was required in three procedures. Clinical success was achieved in all cases with technical success. Overall user experience was 3.2 on a Likert scale of 1-5. No adverse events were reported. The single-use therapeutic gastroscope demonstrated feasibility in various therapeutic procedures; however, a 16% crossover rate and fair user assessment score suggest that further technical improvements to the device are necessary.

Parameter Identification in Triple-Diode Photovoltaic Modules Using Hybrid Optimization Algorithms

Identifying the parameters of a triple-diode electrical circuit structure in PV modules is a critical issue, and it has been regarded as an important research area. Accordingly, in this study, a differential evolution algorithm (DEA) is hybridized with an electromagnetism-like algorithm (EMA) in the mutation stage to enhance the reliability and efficiency of the DEA. A new formula is presented to adapt the control parameters (mutation factor and crossover rate) of the DEA. Seven different experimental data sets are used to improve the performance of the proposed differential evolution with an integrated mutation per iteration algorithm (DEIMA). The results of the proposed PV modeling method are evaluated with other state-of-the-art approaches. According to different statistical criteria, the DEIMA demonstrates superiority in terms of root mean square error and main bias error by at least 5.4% and 10%, respectively, as compared to other methods. Furthermore, the DEIMA has an average execution time of 27.69 s, which is less than that of the other methods.

Differential evolution with multi-strategies for UAV trajectory planning and point cloud registration

The present study introduces a novel adaptive algorithm, MELSHADE-cnEpSin, which aims to enhance the performance of LSHADE-cnEpSin, which is not only stands out as one of the most competitive versions of differential evolution but also holds the distinction of being one of the CEC winner algorithms. Compared to the original methodology, four main distinctions are presented. To begin with, we adopt an adaptive selection mechanism (ASM) of crossover rate Cr value based on the external archive to rechoose a suitable value. In the next place, a nonlinear population reduction strategy using Sigmoid function is employed to improve population distribution. Additionally, a restart strategy is implemented to mitigate the risk of algorithmic convergence towards suboptimal solutions. Furthermore, the performance of MELSHADE-cnEpSin was evaluated using standard CEC2017 and CEC2022 test suites in conjunction with nine CEC-winning algorithms (L-SHADE, EBOwithCMAR, AGSK, LSHADE-SPACMA, LSHADE-cnEpSin, ELSHADE-SPACMA, EA4eig, MadDE and APGSK-IMODE) as well as two novel algorithms (ACD-DE and MIDE). Furthermore, MELSHADE-cnEpSin was effectively employed to address the challenge of UAV trajectory planning in intricate mountainous terrain and underwent simulation with point cloud registration cases utilizing a rapid global registration dataset, thereby showcasing the potential of MELSHADE-cnEpSin in tackling real-world optimization problems.

A hapten design strategy to enhance the selectivity of monoclonal antibodies against malachite green

Malachite green (MG), a triphenylmethane dye, is used in the aquaculture industry as a disinfectant and insect repellent due to its potent bactericidal and pesticidal properties. However, its use poses potential environmental and health risks. This study analyzed and designed two haptens using computer simulation. Serum data confirmed the feasibility of introducing an arm at the dimethylamine group. Subsequently, a highly selective monoclonal antibody strain was successfully prepared based on the hapten. After optimizing the working conditions of indirect competitive enzyme-linked immunosorbent assay (IC-ELISA), the IC50 value was 0.83 ng/mL, with a detection limit (IC10) of 0.08 ng/mL and a linear range of 0.19–3.52 ng/mL. The developed monoclonal antibody exhibited a crossover rate of less than 0.1% with other similar structures and can be used to establish an immunoassay.

Traditional Versus Distal Radial Access for Coronary Diagnostic and Revascularization Procedures: Final Results of the TENDERA Multicenter, Randomized Controlled Study.

Traditional transradial access (TRA) is widely used for coronary and non-coronary interventions with significant improvements in procedural outcomes; however, it is associated with RAO that precludes repeat use of the same artery for possible future TRI and other purposes. Distal radial access (DRA) has been proposed as an effective alternative to decrease RAO rates. Published literature describing the RAO rate after DRA versus TRA from various RCT and clinical registries has shown conflicting results. This study compared the forearm radial artery occlusion (RAO) rate assessed by Doppler ultrasound between distal and conventional radial access at 1-year follow-up after the initial procedure. TENDERA was a multicenter, randomized controlled study comparing DRA versus TRA for coronary diagnostic and interventional procedures using 5 or 6F hydrophilic-coated sheaths. The primary endpoint was forearm RAO at 12 months after radial access. The secondary endpoints included puncture time, sheath insertion and total procedure time, radiation dose, and vascular access site-related complications. Eight hundred and fifty patients were randomized to either TRA (n = 418) and DRA (n = 432) groups. In the intention-to-treat analysis, the rate of forearm RAO at 12 months was observed in 39 patients (4.6%) and was significantly reduced in the DRA group compared with the TRA group (2.5% vs. 6.7%, RR 2.59 [95% CI 1.29-5.59], p = 0.010). Analysis in per protocol population has shown consistent results with forearm RAO rate 2.8% in the DRA group versus 6.5% in the TRA group (p = 0.008). The crossover rate was higher (4.6% vs. 1%, p = 0.013) and median hemostasis time was shorter (156.5 min vs. 180 min, p < 0.001) with DRA. Overall bleeding (BARC 1-2) and postprocedure hematoma > 5 cm occurred less frequently in the DRA group compared with the TRA group (3.2% vs. 20.5%, p < 0.001% and 9.0% vs. 27.0%, p < 0.001, respectively). No significant differences were observed in total procedure time and radiation dose between groups. DRA for coronary diagnostic and interventional procedures is associated with reduced forearm RAO rate and shorter hemostasis time, but a longer sheath insertion time and higher crossover rate compared with TRA. ClinicalTrials.gov: NCT04211584.

Enhancing guidewire efficacy for transradial access: the EAGER randomised controlled trial

Abstract Background and Purpose The standard J tip peripheral guidewire used to perform coronary angiography was originally designed for transfemoral access and large vascular interventions over 70 years ago. The 3mm J tip on the standard wire is larger than the typical radial artery diameter and has limited ability to navigate smaller tortuous peripheral arteries increasing the risk of vessel spasm, and potentially reducing procedural success. We compared the efficacy and safety of a hydrophilic 1.5mm J tip guidewire (intervention - ‘baby J wire’) upfront versus the standard fixed core 0.035" J wire (‘control wire’). Methods Investigator initiated, blinded multicentre randomised trial conducted in Australia. Patients undergoing clinically indicated transradial coronary angiography were randomized 1:1 to either control or baby J peripheral guidewire use upfront. The primary endpoint was technical success defined as gaining access to the aortic root with the randomised guidewire. Secondary endpoints included total procedural time, time to aorta and coronary intubation, crossover rates to alternate wire or access site, fluoroscopy times, radial artery spasm, haematoma (EASY criteria), bleeding complications (BARC criteria) and vascular complications (VARC 2 criteria). Major adverse cardiac events (MACE) and clinical endpoints were adjudicated by a blinded independent clinical events committee. Results 330 patients were enrolled over a 9-month period from October 2022 to June 2023. The median age was 69 years (36% female), BMI 29kg/m2. The primary efficacy endpoint of technical success was achieved more frequently in the intervention group (96% v 85%; ARR 10.9% (95% CI 4.6 -17.2); P &amp;lt;0.001). Women were significantly more likely to benefit from the intervention related to higher failure rates with the control wire (69% vs 93% in men; P = &amp;lt; 0.001). Overall procedure times were similar between the groups (median 1135 vs 1354 seconds; P=0.094) but fluoroscopy time was lower in the baby J wire group (median 344 vs 491 seconds; P = 0.024). Radial completion of procedures was high and did not differ between groups (100% v 98%; P=0.2). Clinically significant bleeding (BARC2+) was more common in the control wire group (3% v 0%; P=0.017). There were no differences in MACE or vascular complications. Conclusion The hydrophilic 1.5mm J tip Baby J peripheral guidewire leads to greater upfront technical success and reduced fluoroscopy time for transradial coronary angiography compared to the standard 3mm J tip guidewire. The baby J hydrophilic guidewire is safe and may have key incremental benefits for the transradial approach particularly in patients with smaller diameter radial arteries including women.Primary Outcome

Comparison of radial artery occlusion between traditional radial access and distal radial access for coronary angiography and intervention: A prospective cohort study

BackgroundThe radial approach is now recommended as the default strategy in diagnostic coronary angiography and percutaneous coronary intervention. Radial artery occlusion (RAO) is the most common complication that limits subsequent angiographic procedures through this access. Recently, distal radial access (DRA) has been recommended as an alternative access site. Despite lower RAO rates in DRA in some recent clinical trials, concerns remain regarding possible complications and limitations due to the small size of the distal radial artery. ObjectiveThe present study aimed to compare traditional radial access (TRA) and DRA concerning RAO in percutaneous coronary procedures. MethodsIn the present prospective cohort study, percutaneous coronary procedures were performed via DRA or TRA in 2 study groups. All consecutive participants underwent DRA from September 2021 to March 2022 and TRA from April 2022 to June 2022. Ultrasonography was performed preprocedurally in the DRA group, and patients with small distal artery diameters (<2 mm) were excluded. The same 6-Fr sheaths and standard air-filled compression devices were used in both groups. The primary endpoint was RAO in ultrasound sonography on the first postprocedural day, and the secondary endpoints were the success rate, access time, angiography time, radial artery spasms, and vascular access complications. ResultsA total of 298 patients were assigned to the DRA group and 278 to the TRA group. The RAO rate was significantly higher in the TRA group than in the DRA group (10.1 % vs 0.9 %; P = 0.0001; OR, 0.08, 95 % CI, 0.01–0.27). The success rate was significantly higher in the TRA group (96 % vs 90.2 %; P = 0.009). Access crossovers were done on 12 patients (4.0 %) in the TRA group and 24 patients (9.8 %) in the DRA group (P < 0.001). The mean access time was significantly lower in the TRA group than in the DRA group (1.9 min vs 2.9 min; P < 0.001). The mean angiography time did not significantly differ between the groups (10.2 min in the TRA group vs 9.9 min in the DRA group). The rate of radial artery spasms was not significantly different between the 2 groups (13.8 % in the TRA group vs 14.5 % in the DRA group). The rates of access site hematoma (12.4 % vs 2.3 %; P < 0.001) and bleeding (10.7 % vs 4.1; P = 0.005) were significantly higher in the TRA group. ConclusionsDRA was safe and feasible with lower rates of RAO and access site complications than TRA. Thus, it could be used as an alternative approach in percutaneous coronary procedures. However, the trade-off for these advantages of DRA is an increase in cross-over rate, and a decrease in puncture success rate.

Modeling The Hydrogen Crossover Through Membrane With And Without Catalyst Layers

The hydrogen crossover flux is expressed as a function of the difference in the partial pressure of hydrogen and total pressure difference between the supply and permeate sides of a membrane. The hydrogen crossover rate was measured under several operating conditions by micro gas chromatography. The permeation flux was not influenced by the total pressure difference up to 50 kPa. A bare Nafion membrane and the membrane with catalyst layers were modeled as a stack of bulk and skin layers. Hydrogen permeability of both samples showed identical bulk layer expressed by a power-law equation of the moisture content and an Arrhenius equation of temperature with an activation energy of 22.8 kJ mol–1. The measurement of skin layer resistance wasn’t successful since the skin layer resistance was too low to be measured. A skin layer of Nafion with a catalyst layer wasn’t observed due to formation of fused layer.

Modeling The Hydrogen Crossover Through Membrane With And Without Catalyst Layers

The hydrogen crossover flux is expressed as a function of the difference in the partial pressure of hydrogen and total pressure difference between the supply and permeate sides of a membrane. The hydrogen crossover rate was measured under several operating conditions by micro gas chromatography. The permeation flux was not influenced by the total pressure difference up to 50 kPa. A bare Nafion membrane and the membrane with catalyst layers were modeled as a stack of bulk and skin layers. Hydrogen permeability of both samples showed identical bulk layer expressed by a power-law equation of the moisture content and an Arrhenius equation of temperature with an activation energy of 22.8 kJ mol–1. The measurement of skin layer resistance wasn’t successful since the skin layer resistance was too low to be measured. A skin layer of Nafion with a catalyst layer wasn’t observed due to formation of fused layer.

Local ionic transport enables selective PGM-free bipolar membrane electrode assembly

Bipolar membranes in electrochemical CO2 conversion cells enable different reaction environments in the CO2-reduction and O2-evolution compartments. Under ideal conditions, water-splitting in the bipolar membrane allows for platinum-group-metal-free anode materials and high CO2 utilizations. In practice, however, even minor unwanted ion crossover limits stability to short time periods. Here we report the vital role of managing ionic species to improve CO2 conversion efficiency while preventing acidification of the anodic compartment. Through transport modelling, we identify that an anion-exchange ionomer in the catalyst layer improves local bicarbonate availability and increasing the proton transference number in the bipolar membranes increases CO2 regeneration and limits K+ concentration in the cathode region. Through experiments, we show that a uniform local distribution of bicarbonate ions increases the accessibility of reverted CO2 to the catalyst surface, improving Faradaic efficiency and limiting current densities by twofold. Using these insights, we demonstrate a fully platinum-group-metal-free bipolar membrane electrode assembly CO2 conversion system exhibiting <1% CO2/cation crossover rates and 80-90% CO2-to-CO utilization efficiency over 150 h operation at 100 mA cm−2 without anolyte replenishment.

Conservation of mutation and recombination parameters between mammals and zebra finch.

Most of our understanding of the fundamental processes of mutation and recombination stems from a handful of disparate model organisms and pedigree studies of mammals, with little known about other vertebrates. To gain a broader comparative perspective, we focused on the zebra finch (Taeniopygia castanotis), which, like other birds, differs from mammals in its karyotype (which includes many micro-chromosomes), in the mechanism by which recombination is directed to the genome, and in aspects of ontogenesis. We collected genome sequences from three generation pedigrees that provide information about 80 meioses, inferring 202 single-point de novo mutations, 1,174 crossovers, and 275 non-crossovers. On that basis, we estimated a sex-averaged mutation rate of 5.0 × 10-9 per base pair per generation, on par with mammals that have a similar generation time. Also as in mammals, we found a paternal germline mutation bias at later stages of gametogenesis (of 1.7 to 1) but no discernible difference between sexes in early development. We also examined recombination patterns, and found that the sex-averaged crossover rate on macro-chromosomes (1.05 cM/Mb) is again similar to values observed in mammals, as is the spatial distribution of crossovers, with a pronounced enrichment near telomeres. In contrast, non-crossover rates are more uniformly distributed. On micro-chromosomes, sex-averaged crossover rates are substantially higher (4.21 cM/Mb), as expected from crossover homeostasis, and both crossover and non-crossover events are more uniformly distributed. At a finer scale, recombination events overlap CpG islands more often than expected by chance, as expected in the absence of PRDM9. Despite differences in the mechanism by which recombination events are specified and the presence of many micro-chromosomes, estimates of the degree of GC-biased gene conversion (59%), the mean non-crossover conversion tract length (~23 bp), and the non-crossover to crossover ratio (6.7:1) are all comparable to those reported in primates and mice. The conservation of mutation and recombination properties from zebra finch to mammals suggest that these processes have evolved under stabilizing selection.

Long-term health-related quality of life and rhythm outcomes of catheter ablation versus antiarrhythmic drugs in patients with atrial fibrillation

BackgroundData on long-term effects of catheter ablation vs antiarrhythmic drugs (AADs) on health-related quality of life (HRQoL) and atrial fibrillation (AF) burden are limited. ObjectiveThe study aimed to assess long-term HRQoL and rhythm data in patients with symptomatic AF. MethodsThe 75 patients who underwent ablation and 74 receiving AADs in the Catheter Ablation compared with Pharmacological Therapy for Atrial Fibrillation (CAPTAF) trial were followed for 48 months. The General Health subscale of the 36-Item Short-Form Health Survey, time to first AF episode ≥1 hour, and AF burden, recorded by implantable cardiac monitors, were compared. ResultsOne hundred forty-seven patients completed follow-up, with 7 crossovers in the ablation group and 34 crossovers in the AAD group. General Health improved by ablation from a median of 62 points at baseline to 79.2 points at follow-up (P < .001) and by AADfrom a median of 67 to 77 points (P < .001), without treatment differences (P = .77). Time to first AF episode ≥1 hour was longer (median 257 days in the ablation group vs 180 days in the AAD group; P = .025). The cumulative AF burden during follow-up was lower in the ablation group (median 0.3%; interquartile range [IQR] 0%–1.4%) than in the AAD group (1.6%; IQR 0.1%–11.0%); P = .01. The cumulative reduction in AF burden compared with baseline was greater in the ablation group (median −89.5%; IQR −98.4% to −51.3%) than in the AAD group (−52.7%; IQR −92.6% to 263.6%); P < .001. ConclusionHRQoL improvement in long-term did not differ between ablation and AAD groups despite a larger reduction in AF burden after ablation. The results should be interpreted in the light of a high crossover rate in the AAD group.

Low-cost and durable polyvinyl alcohol modified polyethylene separator for vanadium redox flow battery

Porous separators are considered a viable alternative to the high cost Nafion membrane for vanadium redox flow battery (VRFB) commercialization. However, the porous separators suffer from high vanadium ion crossover due to the presence of large micron size pores, which leads to decay in capacity of the VRFB system. To tackle the same, a composite separator is synthesized wherein a cross-linked polyvinyl alcohol (PVA) layer is coated on to the porous polyethylene silica separator (PE separator) to mitigate the vanadium ion crossover rate and employed in the VRFB application. Scanning electron microscopy (SEM) analysis confirmed the successful coating of the PVA film on to the PE separator. Synthesized PE-PVA separator showed a significant decrease in the vanadium ion crossover by 31.44 times compared to the pristine PE separator. Consequently, the self-discharge time increases by 8 and 1.66 times compared to the pristine PE separator and the Nafion117 membrane, respectively. VRFB cell equipped with the synthesized separator showed better capacity retention with a capacity fade rate of 0.2 % Ah·cycle−1 than the Nafion117 membrane (0.5 % Ah·cycle−1). In-situ and ex-situ oxidative stability of the separator is explored in detail and a degradation mechanism of the cross-linked PVA membrane is proposed accordingly. The synthesized single side coated PE-PVA´ separator exhibits higher coulombic efficiency of 99 % and comparable energy efficiency of 71 % at a current density of 120 mA·cm−2 and demonstrated excellent lifetime durability tested up to 1600 charge-discharge cycles at 80 mA·cm−2.

Elite-guided Resampling and Multi-mutation based Differential Evolution with exponential crossover for numerical optimization

In the existing Differential Evolution (DE) research, there are two main crossover schemes: exponential crossover and binomial crossover. Most researchers believe that binomial crossover is skilled in handling numerical optimization problems while exponential crossover has the advantage in handling optimization problems with certain correlation between adjacent variables. However, we discover that DE variants with exponential crossover can achieve performance comparable to advanced ones utilizing binomial crossover in optimization applications, provided that an appropriate crossover rate CR and associated parameter control are established. In this paper, an Elite-guided Resampling and Multi-mutation based DE with exponential crossover (ERM-DE) is raised to fill the blank in this field, and its main highlights are as follows: First, a novel structure with two stages is raised in our ERM-DE algorithm. The first stage is elite-guided global opposition learning based resampling, and the other is novel exponential crossover DE evolution stage. Second, a Novel Parameter Control (NPC) technique involving scale factor F and crossover rate CR is raised. Different from applying the fitness-based parameter control, the adaptation schemes of the parameters F and CR in our ERM-DE algorithm are fitness-independent. In addition, this NPC technique will also be selectively applied to the trial vector generation strategy DE/target-to-pbest/1/exp with or without optional archive. Third, a novel population Diversity Enhancement Mechanism (DEM) is proposed, which can enhance population diversity by recalculating individuals in a stagnant state. Finally, a time stamp mechanism is posed to deal with outdated inferior and historical solutions in the external archive. A Large test suite with 88 benchmark functions from CEC2013, CEC2014, and CEC2017 test suites is used for algorithm validation and the experimental results indicate that our ERM-DE demonstrates competitiveness with several state-of-the-art DE variants.

Research on Multi-Objective Low-Carbon Flexible Job Shop Scheduling Based on Improved NSGA-II

To optimize the production scheduling of a flexible job shop, this paper, based on the NSGA-II algorithm, proposes an adaptive simulated annealing non-dominated sorting genetic algorithm II with enhanced elitism (ASA-NSGA-EE) that establishes a multi-objective flexible job shop scheduling model with the objective functions of minimizing the maximum completion time, processing cost, and carbon emissions generated from processing. The ASA-NSGA-EE algorithm adopts an adaptive crossover and mutation genetic strategy, which dynamically adjusts the crossover and mutation rates based on the evolutionary stage of the population, aiming to reduce the loss of optimal solutions. Additionally, it incorporates the simulated annealing algorithm to optimize the selection strategy by leveraging its cooling characteristics. Furthermore, it improves the elite strategy through incorporating elite selection criteria. Finally, by simulation experiments, the effectiveness of the improved NSGA-II algorithm is validated by comparing it with other algorithms.

A novel hybrid adaptive differential evolution for global optimization

Differential Evolution (DE) stands as a potent global optimization algorithm, renowned for its application in addressing a myriad of practical engineering issues. The efficacy of DE is profoundly influenced by its control parameters and mutation strategies. In light of this, we introduce a refined DE algorithm characterized by adaptive parameters and dual mutation strategies (APDSDE). APDSDE inaugurates an adaptive switching mechanism that alternates between two innovative mutation strategies: DE/current-to-pBest-w/1 and DE/current-to-Amean-w/1. Furthermore, a novel parameter adaptation technique rooted in cosine similarity is established, with the derivation of explicit calculation formulas for both the scaling factor weight and crossover rate weight. In pursuit of optimizing convergence speed whilst preserving population diversity, a sophisticated nonlinear population size reduction method is proposed. The robustness of each algorithm is rigorously evaluated against the CEC2017 benchmark functions, with empirical evidence underscoring the superior performance of APDSDE in comparison to a host of advanced DE variants.