This research aims to determine the behavior of the surface roughness parameters Ra, Rq and Rz in the milling of poly-ether-ether-ketone PEEK, in terms of the machining variables: cutting speed feed rate and the machining strategy. To solve this problem, a response surface study was made with a central design composed of three replicates per point to obtain a surface equation that determines the expected roughness value based on the velocity values of Cutting speed and fate rate. This model was repeated for each machining strategy analyzed: Raster and Spiral. To find the correct values of Rq and Rzin, the manufacturer could find desirable values; it could be for minor friction pieces or better shape forms. This investigation found that the value of Rq and Rz in milling machining with a Raster and Spiral trajectory increases with increasing feed rate and decreasing with cutting speed. Likewise, it was observed that the Raster technique obtains higher roughness values than by Spiral.