Localized tissue infection induced by Salmonella has been rarely described in humans. Staphylococcus aureus and coagulase negative Staphylococcus species are the most commonly isolated pathogens in long bone osteomyelitis. Osteomyelitis induced by Salmonella species was less common in the literature. We reported a rare case of osteomyelitis of tarsus caused by Salmonella group C who was treated successfully with surgical debridement and antibiotics. In conclusion, a structured thinking is important for a localized wound, not only for diagnosis but also for treatment. A localized wound may be a presentation of systemic infection. Adequate drainage, thorough debridement, dead space management, wound protection, and a 6-week period of specific antimicrobial coverage are still useful principle in facing specific soft tissue infection or osteomyelitis.
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