IntroductionGastro-esophageal Reflux Disease (GERD) is a significant global health issue affecting millions and placing a substantial burden on healthcare systems. This study investigates the prevalence and influencing factors of GERD among the urban population in Saudi Arabia, amidst rapid urbanization and lifestyle changes. The goal is to provide insights for targeted interventions and improved public health strategies. MethodologyA cross-sectional study was conducted using a comprehensive methodology. A validated, bilingual questionnaire was used to collect data on demographics, awareness, psychosocial aspects, symptoms, and medical history. The study included 493 participants, and data were collected through an online survey. Statistical analysis was performed using SPSS and Excel, maintaining a statistical power of 80 %. ResultsThe survey included 493 participants, revealing the following key findings: Gender distribution: 41.37 % male, 58.62 % female (p = 0.053). Age categories: 18–25 (25.35 %), 26–40 (18.05 %), 41–55 (26.97 %), 56 and above (29.61 %) (p = 0.055). Nationality: 51.92 % Saudi, 48.07 % non-Saudi (p = 0.058). Other notable demographics: marital status, education levels, smoking habits, nutritional habits, BMI categories, and prevalence of bariatric surgery. GERD symptoms and psychological factors showed significant associations. Treatment preferences and lifestyle modifications varied widely. The data provide essential insights for tailored interventions and healthcare strategies. ConclusionThis study highlights the complex demographic patterns and lifestyle factors associated with GERD in Saudi Arabia's urban population. The findings emphasize the importance of tailored interventions and inform healthcare, research, and policy decisions for effective GERD management in urban settings.