Uncooled semiconductor lasers are sensitive to ambient temperature variation which makes the PID thermal control for the uncooled semiconductor is complicated. In this work, a kind of enumeration PID tuning method based on S-domain experimental correlation thermal control model for the uncooled semiconductor lasers is introduced. Numeric validation and enumeration PID tuning of S-domain experimental correlation model for uncooled semiconductor are conducted. Results shows that the control accuracy prediction result of the S-domain experimental correlation model has a deviation of 3.6% in contrast with CAE simulation result. The PID tunning speed of rapid enumeration S-domain experimental correlation method is 17,000 times that of CAE method.