Rapid Pressure Changes Research Articles

Accelerating Numerical Simulations of CO2 Geological Storage in Deep Saline Aquifers via Machine-Learning-Driven Grid Block Classification

The accurate prediction of pressure and saturation distribution during the simulation of CO2 injection into saline aquifers is essential for the successful implementation of carbon sequestration projects. Traditional numerical simulations, while reliable, are computationally expensive. Machine learning (ML) has emerged as a promising tool to accelerate these simulations; however, challenges remain in effectively capturing complex reservoir dynamics, particularly in regions experiencing rapid changes in pressure and saturation. This article addresses the challenges by introducing a fully automated, data-driven ML classifier that distinguishes between regions of fast and slow variation within the reservoir. Firstly, we demonstrate the variability in pressure across different reservoir grid blocks using a simple brine injection and production scenario, highlighting the limitations of conventional acceleration approaches. Subsequently, the proposed methodology leverages ML proxies to rapidly and accurately predict the behavior of slow-varying regions in CO2 injection simulations, while traditional iterative methods are reserved for fast-varying areas. The results show that this hybrid approach significantly reduces the computational load without compromising on accuracy. This provides a more efficient and scalable solution for modeling CO2 storage in saline aquifers.

Study on the redistribution mechanism and secondary purge strategy of proton exchange membrane fuel cells

Effective control of membrane water content is essential for increasing the space for ice formation during the cold start stage and enhancing the success rate of start-up. Shutdown purge can effectively lower the membrane water content following fuel cell operation. However, during the cooling and standing process after purge, the rapid change in saturated vapor pressure can result in the redistribution of membrane dissolved water, leading to an increase in its content and a reduction in the success rate of cold start. Therefore, this study establishes a multidimensional, multiphase simulation model to comprehensively and thoroughly analyze the redistribution mechanism after purging and investigates the relationship between membrane water content and cold start. This is achieved by identifying the maximum membrane water content boundary during the cold start process and ultimately improving the success rate of cold start through a secondary purge strategy. The research results indicate that the membrane water content of the fuel cell increases from 2.31 to 8.31 after redistribution. During the cold start stage, the cold start success of the fuel cell under different environmental temperatures exhibits relatively specific boundary conditions, with the cold start process being closely related to the load current density and initial membrane water content. After implementing the secondary purging strategy, the membrane water content of the fuel cell decreases again, displaying favorable cold start characteristics in the cold start stage and successfully starting at −10 °C. This study can provide a reliable basis for the development of purging strategies during shutdown and offer a theoretical foundation for the boundary identification process of cold start.

The rheology of rhyolite magma from the IDDP-1 borehole and Hrafntinnuhryggur (Krafla, Iceland) with implications for geothermal drilling

Changes in rhyolite melt viscosity during magma decompression and degassing exert a first order control on ascent through the crust and volcanic eruption style. These changes have as yet unknown hazard implications for geothermal drilling in pursuit of particularly hot fluids close to magma storage regions. Here, we exploit the situation at Krafla volcano in which rhyolite has both erupted at Earth's surface and been sampled at shallow storage depths via drilling of the 2009 IDDP-1 and 2008 KJ-39 boreholes. We use differential scanning calorimetry to constrain that the IDDP-1 magma quenched to glass at ∼ 700 K, at a rate of between 7 and 80 K.min−1. We measure the equilibrium viscosity of the IDDP-1 rhyolite at temperatures close to the glass transition interval and show that the rhyolite viscosity is consistent with generalized viscosity models assuming a dissolved H2O concentration of 2.12 wt%. We couple these results with micro-penetration and concentric cylinder rheometry over a range of potential magma storage temperatures to constrain the response of surficial Krafla rhyolites to stress. The surficial rhyolites at Krafla match the same viscosity model, assuming a lower dissolved H2O concentration of 0.12 wt%. Our results show that at a storage temperature of 1123–1193 K, the viscosity of the stored magma is ∼ 3×105 Pa.s. At the same temperature, the viscosity following degassing during ascent to the surface rises to ∼ 2×109 Pa.s. Finally, we use high-stress compression tests on the Hrafntinnuhryggur surface obsidian to determine the onset of unrelaxed behavior and viscoelastic melt rupture or fragmentation pertinent to understanding the melt response to rapid pressure changes that may be associated with further (near-) magma exploration at Krafla. Taken together, we characterize the relaxation and viscosity of these magmas from source-to-surface.

Research advances on the mechanisms of reservoir formation and hydrocarbon accumulation and the oil and gas development methods of deep and ultra-deep marine carbonates

Based on the new data of drilling, seismic, logging, test and experiments, the key scientific problems in reservoir formation, hydrocarbon accumulation and efficient oil and gas development methods of deep and ultra-deep marine carbonate strata in the central and western superimposed basin in China have been continuously studied. (1) The fault-controlled carbonate reservoir and the ancient dolomite reservoir are two important types of reservoirs in the deep and ultra-deep marine carbonates. According to the formation origin, the large-scale fault-controlled reservoir can be further divided into three types: fracture-cavity reservoir formed by tectonic rupture, fault and fluid-controlled reservoir, and shoal and mound reservoir modified by fault and fluid. The Sinian microbial dolomites are developed in the aragonite-dolomite sea. The predominant mound-shoal facies, early dolomitization and dissolution, acidic fluid environment, anhydrite capping and overpressure are the key factors for the formation and preservation of high-quality dolomite reservoirs. (2) The organic-rich shale of the marine carbonate strata in the superimposed basins of central and western China are mainly developed in the sedimentary environments of deep-water shelf of passive continental margin and carbonate ramp. The tectonic-thermal system is the important factor controlling the hydrocarbon phase in deep and ultra-deep reservoirs, and the reformed dynamic field controls oil and gas accumulation and distribution in deep and ultra-deep marine carbonates. (3) During the development of high-sulfur gas fields such as Puguang, sulfur precipitation blocks the wellbore. The application of sulfur solvent combined with coiled tubing has a significant effect on removing sulfur blockage. The integrated technology of dual-medium modeling and numerical simulation based on sedimentary simulation can accurately characterize the spatial distribution and changes of the water invasion front. Afterward, water control strategies for the entire life cycle of gas wells are proposed, including flow rate management, water drainage and plugging. (4) In the development of ultra-deep fault-controlled fractured-cavity reservoirs, well production declines rapidly due to the permeability reduction, which is a consequence of reservoir stress-sensitivity. The rapid phase change in condensate gas reservoir and pressure decline significantly affect the recovery of condensate oil. Innovative development methods such as gravity drive through water and natural gas injection, and natural gas drive through top injection and bottom production for ultra-deep fault-controlled condensate gas reservoirs are proposed. By adopting the hierarchical geological modeling and the fluid-solid-thermal coupled numerical simulation, the accuracy of producing performance prediction in oil and gas reservoirs has been effectively improved.

Enhancing equipment qualification testing facility for nuclear power plants: Achieving rapid temperature and pressure increase during design basis events

The present study focuses on the development of an equipment qualification (EQ) testing facility for Class 1E equipment in nuclear power plants (NPPs), emphasizing the need to ensure safety functions under design basis events (DBEs). The Republic of Korea (ROK) has implemented international safety standards to support large NPP projects, necessitating the development of domestic EQ testing facilities to reduce the dependence on foreign facilities. To address this need, herein, a specialized facility capable of simulating harsh DBE conditions that may occur in NPPs in ROK was constructed. Through exhaustive research, target temperature and pressure profiles were developed for pressurized water reactors, and a superheated steam injection technique was devised for rapid temperature and pressure changes. The present study contributes to the advancement of domestic EQ testing capabilities, achieving up to 230 °C and 700 kPa within 30 s.

Study on the Transient Flow Characteristics of Multistage Centrifugal Pumps during the Startup Process before System Operation

Multistage pumps are essential in emergency water supply, irrigation, and other systems undergoing unavoidable hydraulic transitions like pump startup and valve operations. These transitions cause rapid changes in impeller speed, flow rate, and pressure, destabilizing the internal flow field and impacting system reliability. To study transient flow characteristics, a numerical analysis of a three-stage pump was conducted, focusing on vortex identification, entropy production, and time–frequency pressure pulsation. Using the SST turbulence model, the simulation analyzed different start times and flow rate variations. Findings revealed that shorter startup times intensified transient effects, with the head increasing rapidly initially and then stabilizing. Vortex structures showed periodic development and dissipation. Entropy production rose with impeller speed, peaking higher with shorter startups. Blade passing frequency dominated pressure pulsations, with increased low-frequency pulsations as speed rose. During valve opening, flow stabilization accelerated with increasing flow rates, reducing amplitude and eliminating low-frequency components. This research aids the reliable operation of high-pressure pumping systems in energy storage.

Significant Earth’s responses of the 2022 Tonga eruption across Taiwan from multiple sensor observations

On 15 January 2022, a massive underwater volcano erupted in the Tonga region, releasing a significant amount of volcanic ash and gases into the atmosphere. The United States Geological Survey (USGS) estimated the seismic source to have a surface wave magnitude (Ms) of 5.8. This eruption was observed from space, and the resulting atmospheric shockwave swept across the Pacific Ocean. Reports from various locations worldwide indicated rapid fluctuations in air pressure following this event. Taiwan, situated in the western Pacific, approximately 8,500 km from the eruption source, observed significant changes. During this volcanic eruption, both rapid air pressure changes and several significant changes in the Earth’s physical parameters were observed in Taiwan. The Tonga eruption is a unique event, and comprehensive observations provide an opportunity to explore and explain the mechanisms behind this extreme event. Data from ground surface air pressure gauges, coastal tide gauges, underwater pressure gauges, infrasound sensors, digital microphones, and seismometers were collected. These data were analyzed to identify their origin and explain their interactions. The results of this study first present the detailed propagation characteristics of air pressure waves in the Taiwan region and verify the occurrence of a specific tsunami phenomenon caused by the atmospheric disturbance from the Tonga eruption. It follows a distinct mechanism, explaining its arrival time and wave height distribution around Taiwan, which is different from conventional tsunamis of tectonic origins, which are formed by rapid changes in water caused by earthquakes or underwater landslides.

Submillisecond in situ X-ray diffraction measurement system with changing temperature and pressure using diamond anvil cells at BL10XU/SPring-8.

Recently, there has been a high demand for elucidating kinetics and visualizing reaction processes under extreme dynamic conditions, such as chemical reactions under meteorite impact conditions, structural changes under nonequilibrium conditions, and in situ observations of dynamic changes. To accelerate material science studies and Earth science fields under dynamic conditions, a submillisecond in situ X-ray diffraction measurement system has been developed using a diamond anvil cell to observe reaction processes under rapidly changing pressure and temperature conditions replicating extreme dynamic conditions. The development and measurements were performed at the high-pressure beamline BL10XU/SPring-8 by synchronizing a high-speed hybrid pixel array detector, laser heating and temperature measurement system, and gas-pressure control system that enables remote and rapid pressure changes using the diamond anvil cell. The synchronized system enabled momentary heating and rapid cooling experiments up to 5000 K via laser heating as well as the visualization of structural changes in high-pressure samples under extreme dynamic conditions during high-speed pressure changes.

Rapid weather changes are associated with daily hospital visitors for atrial fibrillation accompanied by abnormal ECG repolarization: a case-crossover study

BackgroundAtrial fibrillation (AF) is highly prevalent in the population, yet the factors contributing to AF events in susceptible individuals remain partially understood. The potential relationship between meteorological factors and AF, particularly with abnormal electrocardiograph (ECG) repolarization, has not been adequately studied. This case-crossover study aims to investigate the association between meteorological factors and daily hospital visits for AF with abnormal ECG repolarization in Shanghai, China.MethodsThe study cohort comprised 10,325 patients with ECG-confirmed AF who sought treatment at Shanghai Sixth People's Hospital between 2015 and 2018. Meteorological and air pollutant concentration data were matched with the patient records. Using a case-crossover design, we analyzed the association between meteorological factors and the daily count of hospital visitors for AF with abnormal ECG repolarization at our AF center. Lag analysis models were applied to examine the temporal relationship between meteorological factors and AF events.ResultsThe analysis revealed statistically significant associations between AF occurrence and specific meteorological factors. AF events were significantly associated with average atmospheric pressure (lag 0 day, OR 0.9901, 95% CI 0.9825–0.9977, P < 0.05), average temperature (lag 1 day, OR 0.9890, 95% CI 0.9789–0.9992, P < 0.05), daily pressure range (lag 7 days, OR 1.0195, 95% CI 1.0079–1.0312, P < 0.01), and daily temperature range (lag 5 days, OR 1.0208, 95% CI 1.0087–1.0331, P < 0.01). Moreover, a significant correlation was observed between daily pressure range and daily temperature range with AF patients, particularly those with abnormal ECG repolarization, as evident in the case-crossover analysis.ConclusionThis study highlights a significant correlation between meteorological factors and daily hospital visits for AF accompanied by abnormal ECG repolarization in Shanghai, China. In addition, AF patients with abnormal ECG repolarization were found to be more vulnerable to rapid daily changes in pressure and temperature compared to AF patients without such repolarization abnormalities.

Contemporary mechanics of conductive hearing loss

The middle ear plays a critical role for the conversion of acoustic energy to mechanical vibrations that subsequently enter the cochlea. It is middle ear impedance matching through ossicular coupling that has enabled land-dwelling vertebrates to hear soft airborne sounds. Conductive hearing loss may result from damage to the delicate middle ear structures following infection, trauma or rapid pressure changes. An understanding of the mechanics of the middle ear significantly improves the oto-surgeon's ability to effectively diagnose conductive hearing loss, localize the responsible lesion and then effectively correct the conduction abnormality. This article reviews some of the basic knowledge of middle ear mechanics for sound transmission, highlights recent advances in developing new techniques to assist in diagnosis of middle ear disease, and finally sheds light on future research aimed at improving the diagnosis and management of middle ear pathology.

Microscopic mechanisms of pressure-induced amorphous-amorphous transitions and crystallisation in silicon

Some low-coordination materials, including water, silica, and silicon, exhibit polyamorphism, having multiple amorphous forms. However, the microscopic mechanism and kinetic pathway of amorphous-amorphous transition (AAT) remain largely unknown. Here, we use a state-of-the-art machine-learning potential and local structural analysis to investigate the microscopic kinetics of AAT in silicon after a rapid pressure change. We find that the transition from low-density-amorphous (LDA) to high-density-amorphous (HDA) occurs through nucleation and growth, resulting in non-spherical interfaces that underscore the mechanical nature of AAT. In contrast, the reverse transition occurs through spinodal decomposition. Further pressurisation transforms LDA into very-high-density amorphous (VHDA), with HDA serving as an intermediate state. Notably, the final amorphous states are inherently unstable, transitioning into crystals. Our findings demonstrate that AAT and crystallisation are driven by joint thermodynamic and mechanical instabilities, assisted by preordering, occurring without diffusion. This unique mechanical and diffusion-less nature distinguishes AAT from liquid-liquid transitions.

External standard calibration method for high-repetition-rate shock tube kinetic studies with synchrotron-based time-of-flight mass spectrometry.

The signal levels observed from mass spectrometers coupled by molecular beam sampling to shock tubes are impacted by dynamic pressures in the spectrometer due to rapid pressure changes in the shock tube. Accounting for the impact of the pressure changes is essential if absolute concentrations of species are to be measured. Obtaining such a correction for spectrometers operated with vacuum ultra violet photoionization has been challenging. We present here a new external calibration method which uses VUV-photoionization of CO2 to develop time-dependent corrections to species concentration/time profiles from which kinetic data can be extracted. The experiments were performed with the ICARE-HRRST (high repetition rate shock tube) at the DESIRS beamline of synchrotron SOLEIL. The calibration experiments were performed at temperatures and pressures behind reflected shock waves of 1376 ± 12 K and 6.6 ± 0.1 bar, respectively. Pyrolytic experiments with two aromatic species, toluene (T5 = 1362 ± 22 K, P5 = 6.6 ± 0.2 bar) and ethylbenzene (T5 = 1327 ± 18 K, P5 = 6.7 ± 0.2 bar), are analyzed to test the method. Time dependent concentrations for molecular and radical species were corrected with the new method. The resulting signals were compared with chemical kinetic simulations using a recent mechanism for pyrolytic formation of polycyclic aromatic hydrocarbons. Excellent agreement was obtained between the experimental data and simulations, without adjustment of the model, demonstrating the validity of the external calibration method.

Enhanced microwave assisted pyrolysis of waste rice straw through lipid extraction with supercritical carbon dioxide.

A combination of supercritical carbon dioxide (scCO2) extraction and microwave-assisted pyrolysis (MAP) have been investigated for the valorisation of waste rice straw. ScCO2 extraction of rice straw led to a 0.7% dry weight yield of lipophilic molecules, at elevated temperatures of 65 °C and pressures of 400 bar. Lipid compositions (fatty acids, fatty alcohol, fatty aldehydes, steroid ketones, phytosterols, n-alkanes and wax esters) of the waxes obtained by scCO2 were comparable to those obtained Soxhlet extraction using the potentially toxic solvent n-hexane. ScCO2 extraction positively influenced the pyrolysis heating rate, with a rate of 420 K min-1 for particles of 500-2000 μm, compared to 240 K min-1 for the same particle size of untreated straw. Particle size significantly affected cellulose decomposition and the distribution of pyrolysis products (gaseous, liquid and char), highlighting the importance of selecting an adequate physical pre-treatment. TG and DTG of the original rice straw and resulting biochar produced indicated that cellulose was completely decomposed during the MAP. While a rapid pressure change occurred at ∼120 °C (size > 2000 μm) and ∼130 °C (size 500-2000 μm) during MAP and was associated with the production of incondensable gas during cellulose decomposition, this takes place at significantly lower temperatures than those observed with conventional pyrolysis, 320 °C. Wax removal by scCO2 influences the dielectric properties of the straw, enhancing microwave absorption with rapid heating rates and elevated final pyrolysis temperatures, illustrating the benefits of combining these sustainable technologies within a holistic rice straw biorefinery.

Open-source controller for dynamic cardiovascular models

Cardiovascular pressure sensors require dedicated, reliable, and customisable performance testing equipment. Devices available on the market, such as pulsatile pumps and pulse multipliers, offer limited adaptability to the needs of pressure sensor testing or are highly complex tools designed for other purposes. Therefore, there is a strong need to provide an adaptable and versatile device for characterisation during prototype development, prior to animal model testing. Early development requires detailed characterisation of a sensor performance in a realistic environmental scenario. To address this need, we adapted an off-the-shelf pressure chamber with a custom Arduino-based controller to achieve a rapid change in pressure that simulates the pulsatile profile of human blood pressure. The system is a highly customisable tool, and we have experimentally shown that it works successfully in a wide range of pressures from 30 mmHg to 400 mmHg with a resolution of 2 mmHg. By adjusting the chamber volume using a water balloon, we achieved a cycle rate of up to 120 beats per minute. The device can be operated directly from the Arduino IDE or with a customised graphical user interface developed by our research group. The proposed system is intended to assist other researchers in the development of industrial and biomedical pressure sensors.

Blast Overpressures as a Military and Occupational Health Concern.

This tutorial reviews effects of environmental stressors like blast overpressures and other well-known acoustic contaminants (continuous, intermittent, and impulsive noise) on hearing, tinnitus, vestibular, and balance-related functions. Based on the overall outcome of these effects, detailed consideration is given to the health and well-being of individuals. Because hearing loss and tinnitus are consequential in affecting quality of life, novel neuromodulation paradigms are reviewed for their positive abatement and treatment-related effects. Examples of clinical data, research strategies, and methodological approaches focus on repetitive transcranial magnetic stimulation (rTMS) and electrical stimulation of the vagus nerve paired with tones (VNSt) for their unique contributions to this area. Acoustic toxicants transmitted through the atmosphere are noteworthy for their propensity to induce hearing loss and tinnitus. Mounting evidence also indicates that high-level rapid onset changes in atmospheric sound pressure can significantly impact vestibular and balance function. Indeed, the risk of falling secondary to loss of, or damage to, sensory receptor cells in otolith organs (utricle and saccule) is a primary reason for this concern. As part of the complexities involved in VNSt treatment strategies, vocal dysfunction may also manifest. In addition, evaluation of temporospatial gait parameters is worthy of consideration based on their ability to detect and monitor incipient neurological disease, cognitive decline, and mortality. Highlighting these respective areas underscores the need to enhance information exchange among scientists, clinicians, and caregivers on the benefits and complications of these outcomes.

Effect of mechanical stresses on viral capsid disruption during droplet formation and drying

Identification of the mechanisms by which viruses lose activity during droplet formation and drying is of great importance to understanding the spread of infectious diseases by virus-containing respiratory droplets and to developing thermally stable spray dried live or inactivated viral vaccines. In this study, we exposed suspensions of baculovirus, an enveloped virus, to isolated mechanical stresses similar to those experienced during respiratory droplet formation and spray drying: fluid shear forces, osmotic pressure forces, and surface tension forces at interfaces. DNA released from mechanically stressed virions was measured by SYBR Gold staining to quantify viral capsid disruption. Theoretical estimates of the force exerted by fluid shear, osmotic pressures and interfacial tension forces during respiratory droplet formation and spray drying suggest that osmotic and interfacial stresses have greater potential to mechanically destabilize viral capsids than forces associated with shear stresses. Experimental results confirmed that rapid changes in osmotic pressure, such as those associated with drying of virus-containing droplets, caused significant viral capsid disruption, whereas the effect of fluid shear forces was negligible. Surface tension forces were sufficient to provoke DNA release from virions adsorbed at air-water interfaces, but the extent of this disruption was limited by the time required for virions to diffuse to interfaces. These results demonstrate the effect of isolated mechanical stresses on virus particles during droplet formation and drying.

On the Thermoelastic Influence of Fluid-Gas Phase Transition Pressure on the Closed Structural Storage Container

The current paper presents a finite element method (FEM) axisymmetric solution based on commercial software for an isotropic closed-ended container filled with fluid, located in the triple point phase (liquefied gas) while being converted into gas through a phase transition to critical point phase by a simultaneously rapid change of pressure and temperature to their critical values. The whole chemical process will be simulated through thermo-elastic analysis that is controlled by temperature-displacement dynamic coupling and subjected to step function boundary conditions alongside liquefied triple point initial conditions. In the process, the maximum principal stresses will be determined and illustrated as dependent on the container thickness. In the process, investigation will be carried out for prominent parameters, like, container hollow geometry type (spherical, ellipsoidal, and cylindrical) and raw material of the container. Commercial software solution calibration against existing literature solutions has been performed. Also, the solution accuracy was examined by element size mesh analysis to be coherent. In conclusion, the best materials to use were Molybdenum TZM and Tungsten while the preferred shape is the ellipsoidal shape. However, a typical vessel that is still durable with sufficient thermal strength for gas storage purposes is a cylinder body container with spherical ended cups made from Aluminum 6061 T6.

Research on performance improvement of acoustic resonance-based wind sensors by using dual closed-loop control

To achieve high-precision and high-stability detection of wind speed and direction in complex environments, this research proposes a dual closed-loop control scanning technique for the wind sensor system based on the acoustic resonance principle. This technique has been found to significantly enhance the system’s performance indicators. The acoustic resonance method used on wind sensors allows for the simultaneous modulation of frequency and intensity of signals generated by the transducer, resulting in linear scanning of the ultrasonic transducer. Frequency modulation resolves the issue of a resonance frequency shift caused by environmental factors like pressure and temperature, while intensity modulation addresses transducer performance degradation over time and can significantly improve the signal-to-noise ratio. However, when confronted with issues such as wind shear, the rapid change in the ambient pressure of the wind sensor may lead to the failure of the frequency modulation, followed by the change in the rate of wind shear, resulting in significant errors in wind speed detection. Therefore, the dual closed-loop control method is used to combine the frequency scanning modes—the slow and long scanning and the short and fast scanning. The slow and long scanning is used to solve the resonance frequency shift caused by various slow external changes and achieve frequency following, while the short and fast scanning resolves the resonance frequency shift resulting from rapid changes in wind shear and achieves rapid frequency following. Experimental results demonstrate that the scanning method employing dual closed-loop control can accurately measure wind speed and direction. The wind speed measurement range is 0–50 m/s, with a measurement accuracy of ±0.3 m/s (≤15 m/s)/±4% (&amp;gt;15 m/s), while the wind direction measurement range is 0°–360°, with a measurement accuracy of ±3°. After improvements, the system has high accuracy and stability and strong anti-interference ability and is less affected by environmental changes in complex environments.

Effect of initial temperature and pressure on thermal behavior of ethanol/oxygen fuel mixture with shock wave by molecular dynamics simulation

Ethanol is often considered a green fuel because it is produced from renewable resources such as corn, sugarcane, and other biomass. When an unsteady shock wave passes through a fluid, it causes the fluid to undergo rapid and extreme changes in temperature and pressure. The effect of ethanol fuel on shock waves is complex and depends on a variety of factors. Understanding the effects of ethanol fuel on shock waves is essential for optimizing combustion processes and minimizing the risk of engine damage or failure. The effect of initial temperature (IT) and initial pressure (IP) on the thermal behavior (TB) (heat flux (HF) and thermal conductivity (TC)) of ethanol and oxygen is investigated using molecular dynamics (MD) simulation. The results showed that the potential energy (PE) converged to 4.84 kcal/mol. The total energy (TE) converged to 5.73 kcal/mol. By increasing the IT from 600 K to 660 K, the HF increased from 68.23 W/m2 to 84.09 W/m2. With the IT increase from 600 K to 660 K, the TC increased from 0.44 W/m.K to 0.53 W/m.K. By increasing the IP from 0 bar to 5 bar, the HF decreased from 68.23 W/m2 to 59.44 W/m2. By increasing the IP from 0 bar to 5 bar, the TC decreased from 0.44 W/m.K to 0.36 W/m.K.

Renal denervation guided by novel blood pressure response patterns of renal nerve stimulation in human: A case series study

Renal nerve stimulation (RNS) could localize the renal nerve innervation through rapid blood pressure (BP) changes for renal denervation (RDN). Recently, novel BP response patterns have been demonstrated in animals. The current study was to verify the presence of these patterns in humans and examine the feasibility of using them to guide selective RDN. Fourteen patients with mild resistant hypertension were included in this prospective analysis. RNS was performed before and after radiofrequency-based RDN. Invasive monitoring was used continuously to obtain beat-to-beat BP. Ambulatory BP (ABP) monitoring was measured at baseline, 5&amp;ndash;7 days, and 6&amp;ndash;12 months, respectively. Five types of BP responses were summarized during RNS before RDN, namely: (1) BP persistently elevated; (2) BP dropped and then elevated above the baseline; (3) BP dropped and then recovered, but not over the baseline; (4) BP fluctuated in the vicinity of the baseline; and (5) BP persistently dropped. Selective RDN was performed at the site with elevated BP. The 24-h ABP decreased from 141 &amp;plusmn; 12/94 &amp;plusmn; 9 mmHg at baseline to 130 &amp;plusmn; 11/85 &amp;plusmn; 8 mmHg at 5 &amp;ndash; 7 days (P = 0.001 for systolic BP [SBP], P = 0.003 for diastolic BP [DBP]) and 127 &amp;plusmn; 11/85 &amp;plusmn; 8 mmHg at 6 &amp;ndash; 12 months (P = 0.009 for SBP, P = 0.019 for DBP). The average heart rate fell from 77 &amp;plusmn; 8 bpm to 71 &amp;plusmn; 5 bpm (P = 0.01) and 72 &amp;plusmn; 7 bpm (P = 0.043), respectively. Our study showed five types of BP responses elicited by RNS in humans. RDN guided by these BP responses was feasible and resulted in obvious BP reduction, and they may potentially provide precise guidance for RDN.