Ranking Of Categories Research Articles

Abstract 4534: Taxol therapy-induced catalytic EZH2 limits therapeutic responses in PTEN null prostate cancer

Abstract Prostate cancer (PCa) is the most common cancer and a major cause of cancer related deaths in men in North America. The phosphatase and tensin homolog gene (PTEN) is frequently inactivated in PCa. Approximately 40% of primary and 70% of metastatic PCa's have genomic alterations in the PI3K-signaling, mostly through the loss of PTEN. Majority of metastatic PCa associated with PTEN loss are treated with docetaxel; an FDA approved therapy for recurrent PCa. However, in PTEN null PCa docetaxel treatment enhances senescence and does not significantly impact tumor volume. These findings were further confirmed in PCa patients with decreased levels of PTEN. In order to understand the global impact of docetaxel in PTEN null PCa we performed an unbiased RNA-seq of prostate tissues harvested from docetaxel treated prostate specific PTEN null mice. Data analysis showed strong enrichment of chromatin modifying enzymes reactome, mainly PRC2 as one of the top ranked categories. Among them EZH2, an oncogenic methyltransferase was found to be significantly upregulated. Quantitative PCR analysis confirmed statistically significant upregulation of EZH2 in docetaxel treated mice compared to vehicle control. EZH2 upregulation was independent of androgen levels as both androgen dependent and independent cells showed striking upregulation of EZH2 when treated with docetaxel. Next, we confirmed the nature of the upregulated EZH2 (catalytic or non-catalytic) by docetaxel. EZH2 methyltransferase activity assay data showed significant induction of methyltransferase activity by docetaxel in both androgen dependent and independent conditions and in PTEN null mouse tissues. Further, we measured other methyltransferase marks i.e. H3K27me1&2, H3K4me3, H3K9me3 in the presence of docetaxel and found only specific upregulation of H3K27me3, confirming upregulation of only catalytic EZH2 by docetaxel. These data suggested a need for co-targeting EZH2 during docetaxel treatment in PTEN null PCa conditions. In order to provide a proof-of-principle we performed a tumor xenograft study in nude mice implanted with PTEN null PC3 cells. Combination of DZNeP (an EZH2 inhibitor) and docetaxel significantly inhibited tumor growth compared to each agent alone. Results obtained from the xenograft studies prompted us to perform a preclinical study in prostate specific PTEN null mice. Data obtained from this study clearly showed a significant reduction in number of high grade lesions in PTEN null tumors in combination group when compared to either docetaxel or DZNeP treated mice. We also observed clearance of senescent cells and accumulation of CD8+ T cells and classical dendritic (CD8+ Clec9a+ positive) cells. Our data suggests the necessity of designing a combination therapy of targeting EZH2 during docetaxel treatment specifically, which will likely increase the efficacy of docetaxel in PTEN null PCa. Citation Format: Mohammad Imran Khan, Abid Hamid, Vaqar Mustafa Adhami, Chloe Lang, Hasan Mukhtar. Taxol therapy-induced catalytic EZH2 limits therapeutic responses in PTEN null prostate cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4534.

Optimal Demand Response Scheduling With Real-Time Thermal Ratings of Overhead Lines for Improved Network Reliability

This paper proposes a probabilistic framework for optimal demand response scheduling in the day-ahead planning of transmission networks. Optimal load reduction plans are determined from network security requirements, physical characteristics of various customer types, and by recognizing two types of reductions, voluntary and involuntary. Ranking of both load reduction categories is based on their values and expected outage durations, while sizing takes into account the inherent probabilistic components. The optimal schedule of load recovery is then found by optimizing the customers’ position in the joint energy and reserve market, while considering several operational and demand response constraints. The developed methodology is incorporated in the sequential Monte Carlo simulation procedure and tested on several IEEE networks. Here, the overhead lines are modeled with the aid of either static-seasonal or real-time thermal ratings. Wind generating units are also connected to the network in order to model wind uncertainty. The results show that the proposed demand response scheduling improves both reliability and economic indices, particularly when emergency energy prices drive the load recovery.

Relational Job Characteristics and Work Engagement: Mediation by Prosocial Motivation

This study tested the relation between perceived social impact, social worth, and work engagement in the military, and mediating effects of prosocial motivation. We tested hypotheses using structural equation modeling analysis in a field study with 322 officers and sergeants and 1,045 soldiers of the Portuguese Army. Results confirmed that perceived social impact and social worth were associated with work engagement. Furthermore, regardless of the rank category, perceived social impact was associated with higher prosocial motivation, which in turn was associated with higher work engagement. In the soldiers subsample, results further indicated that soldiers’ perceived social worth was associated with higher prosocial motivation, which in turn was related to higher work engagement. The direct effects of perceived social impact and social worth on work engagement, and the mediating role of prosocial motivation supported the hypothesis that perceptions of social impact and social worth may strengthen the motives to “do good” (prosocial motivation), leading to an upward spiral that cultivates work engagement among members of the military.

Factors influencing cigarette smoking among soldiers and costs of soldier smoking in the work place at Kakiri Barracks, Uganda

BackgroundAlthough Uganda has a relatively low prevalence of smoking, no data exists on cigarette use among military personnel. Studies in other countries suggests military service is a risk factor for...

Computations in Symmetric Fusion Categories in Characteristicp

We study properties of symmetric fusion categories in characteristic $p$. In particular, we introduce the notion of a super Frobenius-Perron dimension of an object $X$ of such a category, and derive an explicit formula for the Verlinde fiber functor $F(X)$ of $X$ (defined by the second author) in terms of the usual and super Frobenius-Perron dimension of $X$. We also compute the decomposition of symmetric powers of objects of the Verlinde category, generalizing a classical formula of Cayley and Sylvester for invariants of binary forms. Finally, we show that the Verlinde fiber functor is unique, and classify braided fusion categories of rank two and triangular semisimple Hopf algebras in any characteristic.

ON CLASSIFICATION OF AUTOMATED SYSTEMS

[For the English abstract and full text of the article please see the attached PDF-File (English version follows Russian version)].ABSTRACT The article deals with the problems of creating a unified classification of automated systems. The urgency of the problem is justified. From the standpoint of dialectical explanation the properties of objects are analyzed and identified. Signs of belonging to classes, categories, position of systems in categorical ranks, hierarchy of types are described. The author’s version of a universal classification is offered. Keywords: railway, infrastructure, management, decision-making, automated systems, classification, dialectical method

How to Build a Standardized Country-Specific Environmental Food Database for Nutritional Epidemiology Studies.

There is a lack of standardized country-specific environmental data to combine with nutritional and dietary data for assessing the environmental impact of individual diets in epidemiology surveys, which are consequently reliant on environmental food datasets based on values retrieved from a heterogeneous literature. The aim of this study was to compare and assess the relative strengths and limits of a database of food greenhouse gas emissions (GHGE) values estimated with a hybrid method combining input/output and LCA approaches, with a dataset of GHGE values retrieved from the literature. France is the geographical perimeter considered in this study, but the methodology could be applied to other countries. The GHGE of 402 foodstuffs, representative of French diet, were estimated using the hybrid method. In parallel, the GHGE of individual foods were collected from existing literature. Median per-food-category GHGE values from the hybrid method and the reviewed literature were found to correlate strongly (Spearman correlation was 0.83), showing similar rankings of food categories. Median values were significantly different for only 5 (out of 29) food categories, including the ruminant meats category for which the hybrid method gave lower estimates than those from existing literature. Analysis also revealed that literature values came from heterogeneous studies that were not always sourced and that were conducted under different LCA modeling hypotheses. In contrast, the hybrid method helps build reliably-sourced, representative national standards for product-based datasets. We anticipate this hybrid method to be a starting point for better environmental impact assessments of diets.

Abstract TP429: Early Oral Anticoagulation After Acute Ischemic Stroke in Patients With Atrial Fibrillation

Introduction: Uncertainty exists as to the optimum interval for initiation of oral anticoagulation (OAC) after an acute ischemic stroke (AIS) in patients with atrial fibrillation (AF). Randomized clinical trials of novel oral anticoagulants excluded patients with AIS within 7-14 days. We sought to identify patients at low risk for early initiation of OAC after AIS. Hypothesis: The benefit of starting OAC within 2 days to prevent recurrent AIS outweighs the risk of hemorrhagic transformation (HT) in select patients. Methods: Following IRB approval, we completed a retrospective review of patients from the Cleveland Clinic from 2012-2014 with AIS, AF, and at least 1 follow up visit. In addition to demographic and medical history, acute infarct volume on imaging, presence of HT on imaging prior to OAC, timing and type of oral anticoagulation, and ischemic and hemorrhagic complications were noted. Early OAC was defined as starting within 48 hours after stroke onset, and late OAC was thereafter. The two groups were compared using Fisher’s exact test for categorical and Wilcoxon Rank Sum for numeric variables. Results: One hundred patients (median age 76, interquartile range 66-84) met our study criteria. Thirty-one patients were started on OAC within 2 days vs 53 patients after 2 days (median 1 days vs median 11 days). Compared to patients started on OAC after 2 days, those who initiated OAC within 2 days had significantly lower infarct volume (median 3.35 ml vs median 9.8 ml; p<0.0001), initial NIHSS (median 3 vs median 7; p <0.0001), and fewer people with blood on brain imaging (3% vs 26%; p= 0.0074). Age, prior stroke, and choice of OAC were not significantly associated with timing of OAC. No patients had recurrent AIS or symptomatic HT at median follow-up observation of 37 days. One patient had a non-CNS major hemorrhage after starting OAC. Sixteen patients were not started on OAC for a variety of reasons. Conclusions: Our results suggest the safety of early initiation of OAC with 2 days in an appropriately selected population of patients with AIS, who have small infarct volumes, mild stroke severity, and lack of HT.

The meaning of categorical ranks in evolutionary biology

Despite having been utilized for over 250 years, Linnaean ranks are periodically dismissed by some systematists and evolutionary biologists. Here, we discuss recent criticisms and point out that they are often the result of a misunderstanding of both the meaning and the intent of such ranks. Although arbitrary in some cases, ranks contain meaningful taxonomic information, facilitate communication, and serve as proxies for a fully resolved and correctly dated tree of life. Ranks favor communication and evolutionary comparisons, but they do not make assumptions about equal age or diversity for any two taxa with the same Linnaean category.

Decomposing hierarchical alignment: Co-arguments as conditions on alignment and the limits of referential hierarchies as explanations in verb agreement

AbstractApart from common cases of differential argument marking, referential hierarchies affect argument marking in two ways: (a) through hierarchical marking, where markers compete for a slot and the competition is resolved by a hierarchy, and (b) through co-argument sensitivity, where the marking of one argument depends on the properties of its co-argument. Here we show that while co-argument sensitivity cannot be analyzed in terms of hierarchical marking, hierarchical marking can be analyzed in terms of co-argument sensitivity. Once hierarchical effects on marking are analyzed in terms of co-argument sensitivity, it becomes possible to examine alignment patterns relative to referential categories in exactly the same way as one can examine alignment patterns relative to referential categories in cases of differential argument marking and indeed any other condition on alignment (such as tense or clause type). As a result, instances of hierarchical marking of any kind turn out not to present a special case in the typology of alignment, and there is no need for positing an additional non-basic alignment type such as “hierarchical alignment”. While hierarchies are not needed for descriptive and comparative purposes, we also cast doubt on their relevance in diachrony: examining two families for which hierarchical agreement has been postulated, Algonquian and Kiranti, we find only weak and very limited statistical evidence for agreement paradigms to have been shaped by a principled ranking of person categories.

Investigation of Truck Weights and Dimensions Using WIM Data

This paper presents a study carried out with extensive weigh-in-motion (WIM) data collected on the French main road network, involving 3 millions of trucks. The data were collected by three WIM stations located on highly trafficked highways and motorways, continuously over a whole year. The data were analyzed using statistical software developed by the US National Science Foundation.The trucks of the traffic flow were classified into almost 20 categories, depending on the silhouette, number and spacing of axles, body configuration (trailer/semi-trailer), type of axles (steering, driving or standard axle) and wheel or tire (single, twin, wide). The data were analyzed by category.The location of the centre of gravity of the payload was calculated and the variability of its abscissa along the vehicle was analyzed in each category. The loading patterns and behavior were analyzed and the results reported here for 5-axle articulated trucks and 2-axle rigid truck with 2-axle trailer.Then, the axle load distributions were analyzed by axle rank and truck category, and modeled with multimodal Gaussian probability distribution functions. The modes have been determined using a maximum of likelihood method. These modes are useful to design endurance tests of truck tires.These investigations provide a better knowledge about truck loading, overloads and truck aggressiveness on infrastructure, and may lead to optimization policies. In this case, the results are used directly in the domain of tyre optimization.

Visual scenes are categorized by function.

How do we know that a kitchen is a kitchen by looking? Traditional models posit that scene categorization is achieved through recognizing necessary and sufficient features and objects, yet there is little consensus about what these may be. However, scene categories should reflect how we use visual information. Therefore, we test the hypothesis that scene categories reflect functions, or the possibilities for actions within a scene. Our approach is to compare human categorization patterns with predictions made by both functions and alternative models. We collected a large-scale scene category distance matrix (5 million trials) by asking observers to simply decide whether 2 images were from the same or different categories. Using the actions from the American Time Use Survey, we mapped actions onto each scene (1.4 million trials). We found a strong relationship between ranked category distance and functional distance (r = .50, or 66% of the maximum possible correlation). The function model outperformed alternative models of object-based distance (r = .33), visual features from a convolutional neural network (r = .39), lexical distance (r = .27), and models of visual features. Using hierarchical linear regression, we found that functions captured 85.5% of overall explained variance, with nearly half of the explained variance captured only by functions, implying that the predictive power of alternative models was because of their shared variance with the function-based model. These results challenge the dominant school of thought that visual features and objects are sufficient for scene categorization, suggesting instead that a scene's category may be determined by the scene's function.

"Workforce Differentiation, Organizational Justice, and Perceived Organizational Support"

This study investigates how workforce differentiation affects organizational justice and perceived organizational support (POS). Based on theories of organizational justice and social exchange, it is hypothesized that workforce differentiation affects POS via perceptions of overall organizational justice, such that a higher workforce category ranking of an employee leads to increased perceptions of organizational justice. Organizational justice, in turn, is hypothesized to a positive relationship with POS. The results show empirical support for the hypothesized mediation process. In addition, several hypotheses about the moderating influence of individual differences on these relationships are put forward and tested.

On the classification of weakly integral modular categories

We classify all modular categories of dimension 4m, where m is an odd square-free integer, and all ranks 6 and 7 weakly integral modular categories. This completes the classification of weakly integral modular categories through rank 7. Our results imply that all integral modular categories of rank at most 7 are pointed (that is, every simple object has dimension 1). All strictly weakly integral (weakly integral but non-integral) modular categories of ranks 6 and 7 have dimension 4m, with m an odd square free integer, so their classification is an application of our main result. The classification of rank 7 integral modular categories is facilitated by an analysis of actions on modular categories by two groups: the Galois group of the field generated by the entries of the S-matrix and the group of isomorphism classes of invertible simple objects. The interplay of these two actions is of independent interest, and we derive some valuable arithmetic consequences from their actions.

Markers of T-cell senescence and physical frailty: insights from Singapore Longitudinal Ageing Studies.

Background:Elderly individuals have an eroded immune system but whether immune senescence is implicated with the development of frailty is unknown. The underlying immune mechanisms and the link between markers of senescence and physical frailty is not well established.Methods:We explored the association of specific T-cell subset markers of immune differentiation and senescence on CD4+ and CD8+ cells (CD28−, CD27− and CD57+) and the immune risk profile (inverted CD4/CD8 ratio <1) with physical frailty among 421 participants who were frail (N=32), prefrail (N=187) and robust (N=202) in the Singapore Longitudinal Ageing Study cohort.Results:In ordinal logistic regression models relating tertile category rank scores of immune biomarker with frailty status (robust, prefrail and frail), CD8+CD28−CD27+ (odds ratio (OR)=1.35, P=0.013), CD4+CD28−CD27+ (OR=1.29, P=0.025), CD8+CD28− (OR=1.31, P=0.022), and CD4/CD8 ratio (OR=1.27, P=0.026) were positively associated with frailty, controlling for age, sex and multimorbidity. CD4/CD8 ratio less than one was not associated with frailty (OR=0.84, P=0.64). In stepwise multinomial logistic regression controlling for age, sex and comorbidity, only CD8+CD28−CD27+ was the independent predictor of prefrailty: highest tertile of the immune marker significantly predicted prefrailty (versus low tertile, OR=1.72, P=0.037) and frailty (OR=2.56, P=0.06).Conclusion:The study supports the hypothetical role of immune senescence in physical frailty, particularly in regard to the observed loss of CD28 expression from both CD8+ cells and CD4+ cells, but not for CD27 or CD4/CD8 ratio as a marker of senescence. The potential of CD8+CD28−CD27+ as a biological marker of frailty should be further investigated in prospective studies.

The FechDeck: a hand-tool for exploring psychophysics

Learning the methods of psychophysics is an essential part of training for perceptual experimentation, and hands-on experience is vital, but gaining this experience is difficult because good tools for learning are not available. The FechDeck is an ordinary deck of playing cards that has been modified to support learning the methods of psychophysics. Card backs are printed with noise patterns that span a range of densities. Faces are augmented with line segments arranged in “L” patterns. Jokers are printed with ruled faces and with backs that serve as standards. Instructions provided with the FechDeck allow users to perform threshold experiments using Fechner's methods of adjustment, limits, and constant stimuli; scaling experiments using Thurstone's ranking, paired comparison, and successive categories methods; and Stevens's magnitude estimation method. Spreadsheets provided with the deck support easy data entry and meaningful data analysis. An online repository supporting the FechDeck has been established to facilitate dissemination and to encourage open source development of the deck.

Chordate phylogeny and the meaning of categorial ranks in modern evolutionary biology.

In a recent review, Satoh et al. [[1][1]] discuss the evolutionary relationships among chordates and several of the scenarios that have been proposed to elucidate their origin. While we believe that the article is interesting in principle, as is the topic itself, we see, however, a major conceptual

Measuring the Talk Test as a Continuous Rather than Categorical Variable

PURPOSE: The Talk Test (TT) is a useful surrogate of ventilatory (VT) and respiratory compensation (RCT) thresholds in exercise prescription. It is inherently a categorical variable, however the factors driving speech difficulty are likely more continuous than categorical. This study examines the perception of speech difficulty, using a visual analog scale, versus the traditional categorical variables. METHODS: Physically active volunteers (n=20) performed three incremental (25W + 25W/2 min) cycle tests in a counterbalanced order: a) with gas exchange to measure VT & RCT, b) with normal TT categories (Positive, Equivocal, Negative) at the end of each stage, and c) by marking a visual analog scale (VAS) at the end of each stage. RESULTS: The VAS rating of speech difficulty @ Max=9.3 + 1.1, @ RCT=6.6 + 2.3, and at VT=4.3 + 2.3 were similar to the VAS rating at the LP TT=3.1 + 0.6, EQ=4.3+1.1 and NEG=5.6+1.4, were very similar to the RPE ratings. The overall curve of VAS ratings changed smoothly across TT categories (figure). CONCLUSIONS: Although the TT is clearly a categorical ranking method, it appears to represent boundaries in a smoothly increasing sense of speech difficulty that is closely associated with VT & RCT.

Evaluation of the physical activity of German soldiers depending on rank, term of enlistment, and task area.

Physical fitness of soldiers plays an important role during combat operations and training for deployment. The aim of this study was to collect data on the physical activity of soldiers of all rank categories and to identify task areas in which inactivity and the resulting health problems such as obesity, cardiovascular disease, and musculoskeletal problems pose a special risk. For this purpose, the physical activity of 169 German soldiers of different ranks and task areas was measured. These soldiers wore accelerometer-based physical activity monitors for a period of 7 days. Their activities were also documented in standardized forms. The results showed that officers (541 steps/h) had the lowest level of physical activity during their duties (compared to noncommissioned officers): 600 steps/h, and junior enlisted personnel: 724 steps/h). With respect to term of enlistment, conscripts and temporary-career volunteers showed a higher level of physical activity than regulars (751 and 640 vs. 539 steps/h). With respect to different task areas, drivers showed the highest activity level, whereas staff personnel showed the lowest. High-ranking personnel and soldiers in staff positions were shown to have the lowest physical activity level. In these groups, possible health problems caused by physical inactivity could be alleviated.

The German version of the Camberwell Assessment of Need for the Elderly (CANE): evaluation of content validity and adaptation to the German-speaking context.

The Camberwell Assessment of Need for the Elderly (CANE) was developed for the assessment of physical-, psychological-, and environment-related needs in the elderly. The aim of this study was to revise and adapt the German version of the CANE with regard to the content validity of the instrument. Following a multistage approach, face-to-face interviews using the CANE, an expert survey and a multidisciplinary consensus conference were conducted in order to evaluate the frequency and relevance of met and unmet needs in the German elderly population, and to modify the content of the CANE for the German-speaking countries. In Germany, unmet physical needs including physical health, medication, eyesight/hearing/communication, mobility/falls, self-care, and continence were found to have top priority closely followed by social needs (company, intimate relationships, daytime activities, information, and abuse/neglect). Psychological needs were the lowest ranked care category. Experts' proposals for the improvement of the German version of the CANE were collected. All findings were discussed and integrated in the multidisciplinary consensus conference with the result of a revised and adapted CANE that is applicable in the German-speaking context. The provision of an adapted and improved German version of the CANE may substantially contribute to a comprehensive and valid assessment of needs in the elderly population. The results of this study represent an important basis for comprehensive needs assessment in the elderly in the theoretical and practical field of healthcare and health services research.