It is empirically known that the packing property and mechanical responses of cohesionless granular materials are influenced by grain shape. For example, the attainable range of void ratio depends on grain shape; angular materials tend to exhibit greater friction angles. Besides, shear wave velocity (Vs ) and small-strain shear modulus (G0 ) of sphere assemblies are affected by surface roughness. However, consensus has yet to be reached on the combined effect of grain shape and surface roughness on G0 and stress-strain relation. This contribution aims to evaluate the shape-roughness combined effect on the strain-dependent mechanical responses of granular materials. Three groups of glass beads having different grain shapes and a silica sand were used, and their grain surfaces were roughened through a systematic procedure using a milling machine. In total, eight materials were subjected to triaxial compression after measurement of Vs. The experimental results reveal that the stress-strain relation of angular particles is remarkably affected by the surface roughness, whereas the roughness effect on the stress-dependent variation in G0 is limited for angular particles.