Range Of Nanotechnologies Research Articles

Thermal case study of magnetic radiative flow impacts on Newtonian nanofluid over a stretchable plate in absorbent: Box approach

Nanofluid technology represents a significant breakthrough in thermal engineering, with widespread applications spanning heat exchangers, cancer treatment, and heat storage systems. Despite its success in improving heat transfer rates in diverse devices, the challenge of enhancing thermal conductivity using nanoparticles looms large. This study aims to elucidate the 2D flow of nanofluid under suction/injection over a stretching wedge. It considers factors such as Brownian and thermophoretic diffusions, nonlinear heat generation, and thermal radiation. Additionally, it examines the effects of viscous dissipation and Joule heating. Through the conversion of governing nonlinear coupled partial differential equations into a system of coupled ordinary differential equations using similarity transformations, numerical solutions are obtained via the Keller-box method. The analysis delves into the significant impacts of relevant parameters on velocity, temperature, concentration, and microorganism fields, presented graphically. Notably, the findings underscore the role of solid particles in enhancing the thermal efficiency of base fluids. These investigation outcomes are vital for controlling heat transferal rates and fluid velocities throughout a variation of manufacturing processes and industrial sectors, guaranteeing the required quality of the ending product. The perceptions garnered from this research hold capacity for a broad range of industrial purposes and carry consequences through countless engineering disciplines, mostly within the range of nanotechnology.

Carbon Nano tube and it`s medical applications*

The carbon nanotube (CNT) represents one of the most unrivaled contrivances in the domain of new technology represented by contemporary revolution of nanotechnology. CNTs is closed to be the more important branch of nanotechnology which have been matured painstakingly meanwhile the last 20years by many investigators and different types of application papers, researches and studies around the expert because of their senior potency in various area. These tubes are rolled in the hybridization found in the grapheme type of carbon nanotubes. The paramount portions of CNTs are their nimble weightiness, small size with a high aspect ratio, pretty stretchy strength, and kindly forthright traits, which make them profitable as tautologies for various materials such polymers, metallic flatness's and earthenware. CNTs also have potential enforcements in the range of nanotechnology, medical Nano manufacture, transistors, actuators, sensors industrialization, and membranes preparation and capacitors industry. There are assorted techniques, which can be utilized for the compilation of CNTs. These implicate the arc discharge mode, chemical fumigate precipitation (CVD),the laser ablation way and the sol- gel method. CNTs can be monowalled, duplicate-walled and multi-walled. CNTs have individual mechanistic, electrified and optic qualities, commonalty of which has been extensively elaborated. The sitting article-review is converging on the composition, functionalization, differences and enforcements of CNTs. The toxic influence of CNTs is also offered in a concise form. It is clear, by the beginning of the last century, that carbon Nano-tubes (CNTs) were important in the fields of health, such as medicine and pharmacy, which had entered into system of drug delivery. The ability of these compounds attracted the interest of researchers in the fields of biomedicine and its biomedical applications such as advanced imaging, regeneration of organism tissues, drug disposal or gene delivery. There is a lot of interesting evidence about the unique advantages of nanotubes that confirm their effectiveness compared to their negative effects. © 2018 JASET, International Scholars and Researchers Association

Abstract PR09: Polymeric mechanical amplifiers of tumor apoptosis

Abstract Regulation of receptor-mediated phenomenon at the nanoscale in a controlled manner remains a challenge for a broad range of fields, including cell biology, medicine, and bioengineering. Fluid forces play a crucial role in receptor-mediated signaling necessary for physiological function, while materials such as nanoparticles have demonstrated potential for spatiotemporal control of cellular signaling. Here, we have developed polymeric mechanical amplifiers that tether to the cell surface and increase receptor-mediated apoptosis in the presence of physiological fluid flow. The mechanical amplifiers consist of both non-degradable and biodegradable polymer nanoparticles that are tethered to the surface of tumor cells via polyethylene glycol (PEG) linkers. Tethered nanoparticles, in the presence of fluid shear forces observed in vivo, increased the therapeutic effect of a TNF superfamily death ligand (TRAIL) on colon and prostate tumor cells by as much as 50% compared to soluble TRAIL treatment alone, while exerting negligible toxic effects on normal cells. Increasing the number of nanoparticles conjugated to the tumor cell surface enhanced TRAIL-mediated apoptosis under fluid shear exposure, while the therapeutic effect under static conditions was not altered. Our results suggest that the enhanced therapeutic response using polymeric nanoparticles is both receptor-mediated apoptosis-specific and does not affect doxorubicin efficacy. Inhibition studies indicate the response is caspase signaling-dependent, and increased tumor cell death receptor expression in the presence of shear forces is also observed. We show that targeted polymeric nanoparticles delivered to tumor cells in vivo mechanically amplified a subsequent treatment of soluble TRAIL, and reduced both circulating tumor cells in blood and overall tumor cell burden in vivo by over 90%. We conclude that surface-bound polymeric nanoparticles enhance receptor-mediated apoptosis in the presence of physiological shear forces, and represents a potentially new application for a broad range of nanotechnologies to maximize the capacity of receptor-mediated signaling and function in the presence of a ligand. This abstract is also being presented as Poster B35. Citation Format: Michael John Mitchell, Robert Langer. Polymeric mechanical amplifiers of tumor apoptosis. [abstract]. In: Proceedings of the AACR Special Conference on Engineering and Physical Sciences in Oncology; 2016 Jun 25-28; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2017;77(2 Suppl):Abstract nr PR09.