When a train traverses a curved bridge, it inherently tends to shift laterally outward. To counteract this propensity, the strategy of track superelevation is employed. After earthquake, curved bridges may exhibit diverse degrees of residual deformation. The precise failure mechanisms that compromise train safety and passenger comfort during transit over curved bridges, particularly under the combined influence of residual deformation, centrifugal force, and track superelevation, remain not entirely comprehended. A comprehensive system integrating trains with curved track-bridges is developed to examine the impact of girder end misalignments on residual track irregularities. The analysis concentrated on the dynamic time-history responses of trains traversing bridges featuring girder misalignments, exploring a range of amplitudes, train velocities, and curve radii. The findings revealed significant variances in the dynamic train responses, especially in lateral acceleration and the Nadal index, when contrasting centripetal and centrifugal girder side misalignments. Furthermore, it is discerned that lateral misalignment at the girder ends markedly affects train lateral acceleration and the Nadal index, with a relatively minor influence on other dynamic response metrics. Finally, the thresholds for misalignment deformation were summarized, for curve radii of 800, 1000, and 1200 meters, the comfort deformation thresholds at 100 km/h are determined to be 23, 23, and 20 mm respectively, while the safety deformation thresholds are found to be 26, 30, and 38 mm respectively. At a speed of 120 km/h, the comfort deformation thresholds for the same curve radii are 18, 18, and 15 mm, with the safety deformation thresholds at 12, 15, and 21 mm.