The reliance of the commercial transportation industry on fossil fuels has long contributed to pollutant and greenhouse gas emissions. Since full electrification of medium- and heavy-duty vehicles faces limitations due to the large battery capacity required for extended driving ranges, this study explores a Range-Extended Electric Vehicle (REEV) for medium-duty Class 6 pick-up and delivery trucks. This hybrid architecture combines an electric powertrain with an internal combustion engine range-extender. Maximizing the efficiency of REEVs requires an Energy Management Strategy (EMS) to optimally split the power between the two power sources. In this work, a hierarchical EMS is developed through model-based design and validated via Hardware-In-The-Loop (HIL) simulations. The proposed EMS demonstrated a 7% reduction in fuel consumption compared to a baseline control strategy, while maintaining emissions and engine start frequency comparable to a benchmark globally optimal EMS obtained with dynamic programming. Furthermore, HIL results confirmed the strategy’s real-time implementation feasibility, highlighting the practical viability of the controller. This research underscores the potential of REEVs in significantly reducing emissions and fuel consumption, as well as providing a sustainable alternative for medium-duty truck applications.