Random Design Research Articles

Evaluation of Growing Media and Chemical Treatment on the Seedling Growth of High Chill Peach

The present study entitled “Evaluation of Growing Media and Dormancy Breaking Chemical on the Seedling Growth of High Chill Peach” was conducted at Dept. of Horticulture, College of Agriculture and Horticulture Research Centre, G.B.P.U.A&T, Pantnagar, Uttarakhand during the year 2022-23. The experiments were carried out in Factorial Complete Randomized Design (FCRD) with 3 replications per treatment. Under seedling growth studies, the total numbers of treatment were 16 with 2 factors comprising of four growing media (soil: sand: FYM, soil: sand: vermicompost, soil: sand: cocopeat and soil: FYM: vermicompost: cocopeat) and four chemical treatments (control, GA3 @ 500 ppm, kinetin @ 50 ppm and thiourea @ 5000 ppm). In the experiment the maximum seedling length, shoot fresh weight, shoot dry weight, root length, root fresh weight and root dry weight was recorded in soil: FYM: vermicompost: cocopeat, GA3 @ 500 ppm and interaction M4C3 (soil: FYM: vermicompost: cocopeat + GA3 @ 500ppm) while the minimum values were recorded in soil: sand: cocopeat, control and M3C1. Result from this study discovered that GA3 @ 500 ppm along with the growing media soil: FYM: vermicompost: cocopeat recorded the maximum seedling length, diameter, number of leaves, leaf area, shoot fresh weight and shoot dry weight which can be recommended for raising the rootstocks for the production of quality planting material of peach for seedling rootstock.

Dietary Zanthoxylum bungeanum leaf powder improves growth performance and antioxidant capacity via Nrf2/HO-1 signaling pathway in broilers

Abstract This study focused on the effects of dietary Zanthoxylum bungeanum leaves (ZBL) powder on the growth performance and antioxidant capacity via the Nrf2/HO-1 signaling pathway in broilers. The experiment adopted a single-factor completely random design, and 440 healthy one-day-old AA broiler chicks were randomly divided into four groups: the control group (CON) was fed a corn-soybean meal-based diet, the CZ1 group was fed a basic diet with 1% ZBL powder, the CZ2 group fed a basic diet with 2% ZBL powder, and the CZ3 group fed a basic diet with 3% ZBL powder. The experiment was divided into the starter period (1-21 d) and the grower period (22-42 d). There were five replicates per group in the starter period, with 22 chickens per replicate. The same grouping as in the starter period was used in the grower period, with 20 chickens per replicate. The results showed that the addition of ZBL powder to the diet had no adverse effects on the growth performance and morphological structure of the intestine of broiler chickens in the CZ1 and CZ2 groups (P > 0.05). Compared with the control group, the diet with 1% and 2% ZBL powder significantly increased the antioxidant indicators such as CAT, T-AOC, and T-SOD in the serum and liver tissue of broiler chickens, it upregulated the related genes expression of nuclear factor erythroid derived-2/heme oxygenase-1 (Nrf2/HO-1) signaling pathway such as Nrf2, NQO1, HO-1, SOD1, and CAT in the jejunal mucosa and enhanced the expression of ZO-1 and OCLN genes in the jejunal mucosa (P < 0.05). In conclusion, dietary supplementation with 1% and 2% of ZBL powder into the daily diet can enhance the body's antioxidant capacity by elevating antioxidant levels in both serum and liver, upregulates the expression of genes associated with the Nrf2/HO-1 signaling pathway in the jejunal mucosa, and helps maintain the integrity of the intestinal mucosal barrier. The optimal addition level of ZBL powder in the diet was determined by quadratic regression analysis to be 1.36%-1.60% during days 1-21 and 1.14%-1.50% during days 22-42.

Kelimpahan Serangga akibat Beberapa Teknik Pengendalian pada Tanaman Kacang Panjang (Vigna sinensis L.)

The decline in the production of long beans in Indonesia is one of the causes of a pest attack. The majority of farmers in Indonesia, still use synthetic pesticides as a pest control effort. The aim of this research is to obtain a pest control technique that gives the lowest result against insect abundance in long bean crops. (Vigna sinensis L). The study used a single factor random group design (RAK) method with 6 repetitions and 4 treatments including: No Treatment/Control (K), Biointensive Control (PB), Combined Control (PK) and Synthetic Control. (PS). The sampling of insects is done using 3 traps: yellow traps, pitfall traps and insect net traps. Sampling is done 10 times, starting from 1 – 10 mst. The data analyzed using a scale fingerprint, on a different real result will be performed a further trial of the Minimum Real Difference with a degree of 5%. PS control shows the results of the analysis with the lowest average abundance on insect net trap (SNT) of (130.17) and pitfall trap (PFT) of (147.50) different real from other treatments, but no real difference on yellow board trap (YST) of size (104,50).

Physical Activity Outcomes of a Culturally Tailored, Father-Focused, and Family-Centered Health Promotion Program for Mexican-Heritage Families: ¡Haz Espacio Para Papi! (Make Room for Daddy)

Despite the health benefits of physical activity (PA), many individuals do not meet PA recommendations. Family-centered PA approaches, particularly active engagement by Mexican-heritage fathers, may support family PA. This study reports PA outcomes of a culturally tailored, father-focused, and family-centered, program for Mexican-heritage families. Promotora researchers recruited participating families (n = 59, n = 42 complete cases), consisting of children (mean age: 10.1 [SD = 0.9]), fathers, and mothers from five randomly selected geographic clusters in low-resourced colonias in south Texas, in a stepped-wedge randomized design. PA was measured using wrist-worn ActiGraph GT9X accelerometers. Statistical analyses for moderate-to-vigorous PA (MVPA), light PA (LPA), and sedentary time for the child, father, and mother were conducted using linear mixed models. The findings were as follows: children had no significant changes in MVPA (p = 0.18), LPA (p = 0.52), or sedentary behavior (p = 0.74); fathers had no significant changes in MVPA (p = 0.94), LPA (p = 0.17), or sedentary behavior (p = 0.15); and mothers had a significant decrease in LPA (p < 0.01), and no significant changes in MVPA (p = 0.66) or sedentary behavior (p = 0.77). Despite null results, this study provides an example of a culturally tailored, family-focused program implemented among Mexican-heritage families with limited PA resources and opportunities. Future PA interventions may require higher PA-focused doses over longer time periods to produce a significant change in LPA, MVPA, or sedentary time.

Pengaruh Aplikasi Edible Coating Gel Lidah Buaya dan Kitosan terhadap Mutu Buah Stroberi pada Penyimpanan Suhu Ruang dan Suhu Rendah

Strawberries are nonclimateric fruits harvested in the final stages of ripening, so they are highly damaged due to cellular fragility, high respiration rate, and susceptibility to fungal growth. This study aims to test the effectiveness of edible coating of aloe vera gel and chitosan to maintain the quality and shelf life of strawberries. The study was carried out by experimental method with split plot by group random design. Storage temperature treatment as the main plot consists of two treatment levels, namely 25±2o C and 4±1o C, while the concentration of edible coating combination as a plot consists of five treatment levels, namely control without edible coating, aloe vera gel 40%, chitosan 2%, aloe vera gel 40% + chitosan 2%, and aloe vera gel 20% + chitosan 1%. Quality attributes including weight loss, fruit hardness, total dissolved solids, decay index, and shelf life are observed until total deterioration occurs. The results showed that at a storage temperature of 25±2° C, chitosan 2% treatment was more able to maintain the quality attributes of strawberries compared to other treatments. Meanwhile, at a storage temperature of 4±1°C, edible coating treatment of 40% aloe vera gel and 40% aloe vera gel + 2% chitosan which more effectively maintains the quality attributes of strawberries. However, for shelf life parameters, only the temperature factor of the storage room affects the length of shelf life of strawberries. The longest shelf life is achieved at low temperature storage (4±1°C) with edible coating treatment of 40% aloe vera gel + 2% chitosan (13.33 days). However, according to the LSD test at a real level of 5%, this value was not significantly different from other edible coating treatments stored at low temperatures, including the lowest shelf life that occurred in controls without edible coatings (10.67 days).

Split‐plot experiments with replicated runs in pharmaceutical synthesis

AbstractRestricted randomised designs are essential in the pharmaceutical synthesis due to the operational restrictions and their cost‐effectiveness compared to entirely randomised designs. Specifically, the split‐plot designs are very effective in reducing the cost of an experiment in the presence of hard‐to‐change factors and/or of multi‐stage processes. In classical designs, replicated runs for pure‐error estimation are commonly employed, but they are rarely used in the more complex setting of restricted randomisation. The reason is that, in practice, experiments in industry rarely can follow all the assumptions/conditions that are included in the methodological papers. In this work, we demonstrate how a split‐plot design based on a Bayesian ‐optimality criterion built to ensure more precise pure‐error estimation of the variance components can be easily adapted to fit the additional needs, the speedy implementation and the restrictions that a real case scenario in industry often imposes. We focus on the practical aspect of how to modify the complex design in a way that keeps/improves the desired qualities and on how to assess impact of changes that are more arbitrary.

Trends in dietary choline and betaine intake among Chinese adults: the China Health and Nutrition Survey 1991-2011.

Choline and its derivative betaine are important methyl donors, components of cell membrane phospholipids, or precursors of the neurotransmitter acetylcholine and the gut microbial metabolite trimethylamine-N-oxide. We aimed to investigate trends in dietary intake and food sources of total choline, individual choline forms, and betaine in Chinese adults using data from the China Health and Nutrition Survey (CHNS) 1991-2011. The sample was drawn from urban and rural communities in 12 provinces or autonomous regions with a multistage, random cluster design. Dietary intake was estimated using three consecutive 24-hour dietary recalls in combination with a household food inventory. Linear mixed-effect models were constructed to calculate adjusted mean intake values and 95% confidence intervals (CIs) using R version 4.2.2. A total of 11,188 men and 12,279 women aged 18 years or older were included. Between 1991 and 2011, total choline intake increased from 219.3 (95% CI: 215.1-223.4) mg/d to 269.0 (95% CI: 265.6-272.5) mg/d in men and from 195.6 (95% CI: 191.8-199.4) mg/d to 240.4 (95% CI: 237.4-243.5) mg/d in women (both P-trends <0.001). Phosphatidylcholine was the major form of dietary choline and its contribution to total choline increased from 46.9% in 1991 to 58.8% in 2011. Cereals were the primary food source of total choline before 2000 while eggs had ranked at the top since 2004. Dietary betaine intake was relatively steady over time with a range of 134.0-151.5 mg/d in men (P-trend <0.001) and 111.7-125.3 mg/d in women (P-trend >0.05). In conclusion, Chinese adults experienced a significant increase in dietary intake of choline, particularly phosphatidylcholine during 1991-2011 and animal-derived foods have replaced plant-based foods as the main food sources of choline. Betaine intake remained relatively stable over time. Future efforts should address the health effects of these changes.

Physical Characteristics, Moisture Content and Organoleptic Properties of Afkir Laying Hen Meat with Different Marination Durations in Pineapple Crown Extract

Afkir laying hen meat has a tough texture, making it less desirable to consumers. Pineapple crown extract is known to improve the texture of spent laying hen meat due to its bromelain enzyme content. This study aims to determine the effect of marination duration using pineapple crown extract on the pH, cooking loss, water content, water holding capacity, texture, and organoleptic value of spent laying hen meat. The study was conducted using a Completely Randomized Design with 4 treatments (different marination times of 0, 2, 4, and 6 hours) and 5 replications. The parameters observed in this study included pH, cooking loss, water content, water holding capacity, texture, and organoleptic values. Test data were analyzed statistically using Analysis of Variance with a 5% significance level, and if significant effects were found, the analysis was followed by Duncan’s Multiple Range Test. Organoleptic test data were analyzed with the Kruskal-Wallis method, and if there were significant effects, further analysis was conducted using the Mann-Whitney test. The results showed a significant effect (P&lt;0.05) of marination time using pineapple crown extract on the pH, water content, and organoleptic parameters, including taste, texture, color, and overall preference, with no significant effect (P&gt;0.05) on cooking loss, water holding capacity, or the aroma attribute in the organoleptic test. Marination time also decreased the toughness of afkir laying hen meat texture, as analyzed descriptively. Marination for 2-6 hours decreased pH and water content, tenderized the texture, and improved meat preference. Keywords: Afkir laying hen; bromelain; tenderness; pineapple crown; marination

The impact of conditional cash transfer (CCT) on health and education in a coastal community: A randomized control trial (RCT) and regression discontinuity design (RDD)

This study evaluates the impact of the Pantawid Pamilyang Pilipino Program (4Ps), a national conditional cash transfer (CCT) on the health and education of beneficiaries in the coastal community of Maangas, Presentacion, Camarines Sur. It compares households receiving 4Ps benefits to a control group of non-recipients with similar sociodemographic characteristics to establish counterfactuals. Using a Randomized Control Trial (RCT) approach, data were collected from 157 participants in each treatment and control group through structured questionnaires. Descriptive statistics were utilized to analyze the economic profiles of respondents, revealing diverse representations. Logistic regression models unveiled significant correlations between attendance, dropout rates, and various predictor variables, notably the 4Ps program and eligibility, location, household size, and perceptions. Regarding health outcomes, the analysis demonstrates the positive impact of 4Ps membership on reducing child mortality, improving child growth, and promoting healthcare-seeking behaviors. Factors such as clinic visits, health insurance, and health beliefs also significantly influence health outcomes. RDD underscores the effectiveness of the 4Ps program in poverty alleviation, with eligibility playing a key role in enhancing income outcomes among beneficiaries. Prioritizing access to healthcare services, reinforcing the importance of regular clinic visits, and optimizing child health outcomes are crucial steps towards sustainability of the program. Tailored interventions based on enrollment status and academic performance can help prevent student attrition. Providing aid to coastal communities and embedding livelihood support programs in 4Ps can break the cycle of poverty by integrating these initiatives into the current structure of the program.

Bambara groundnut starch-soluble dietary fibre nanocomposite stabilised emulsions: Optimisation of emulsion stability and studies on time-dependent rheological properties

Due to their inherent thermodynamic instability, emulsions require stabilisers to maintain their integrity and prevent destabilisation. The effect of emulsion components (Bambara groundnut starch-soluble dietary fibre nanocomposite (STASOL), orange oil and water) on the rheological and stability properties of STASOL-stabilised emulsions was optimised. A randomised D-optimal exchange mixture design was used to determine the ratio of STASOL, orange oil and water required for a stable emulsion. The stability of these emulsions was evaluated using the initial mean backscattering index (BSAVO), Turbiscan stability index (TSI) and hysteresis loop area (HLA). The BSAVO (%), TSI and HLA of the emulsions ranged from 50.73% (14:30:56 STASOL:oil:water) to 70.47% (20:30:50 STASOL:oil:water), 0.0005 (20:30:50 STASOL:oil:water) to 0.1000 (8:42:50 STASOL:oil:water) and 0.37 Pas-1 (10:32:58 STASOL:oil:water) to 5.69 Pas-1 (20:30:50 STASOL:oil:water), respectively. Emulsions exhibited a direct relationship between STASOL concentration and stability metrics, with the highest stability achieved at 20% STASOL concentration, 30% orange oil and 50% water. An increase in STASOL concentration coupled with a decrease in oil concentration results in a stable emulsion. Numerical optimisation and experimental validation confirmed the effectiveness of the selected formulation, demonstrating STASOL's potential as a natural stabiliser in beverage emulsions and its ability to enhance stability compared to synthetic alternatives.

Effectiveness of cryotherapy in preventing oral mucositis in pediatric cancer patients in Jordan: a randomized controlled trial.

The study aimed to evaluate the effectiveness of cryotherapy in preventing oral mucositis in pediatric patients receiving chemotherapy. An evidence-based practice project utilized a randomized control trial design with two groups (experimental and control groups). Fifty-nine pediatric patients with cancer in Jordan, aged 8-18 years, were randomly assigned to the experimental group (n=29) or the control group (n=30). The intervention was conducted from June 2022 to December 2022. The severity of oral mucositis among pediatric cancer patients was assessed using the World Health Organization oral mucositis grade. There were no significant differences in sex or disease type among the groups. On days 7, 14, and 21, we observed notable between-group differences in treatment responses and the intensity of oral mucositis, highlighting the efficacy of cryotherapy in diminishing the severity of oral mucositis. This study supports the use of cryotherapy as a preventive measure for oral mucositis among pediatric oncology patients in Jordan. The findings suggest that cryotherapy effectively reduces the severity of oral mucositis. Further research is necessary to investigate the broader impacts of cryotherapy.

Development and effect of hybrid simulation program for nursing students: focusing on a case of pediatric cardiac catheterization in Korea: quasi-experimental study.

Hybrid simulation has emerged to increase the practicality of simulation training by combining simulators and standardized patient (SP) that implement realistic clinical environments at a high level. This study aimed to develop a hybrid simulation program focused on case of pediatric cardiac catheterization and to evaluate its effectiveness. The hybrid simulation program was developed according to the Analyze, Design, Develop, Implement, and Evaluate (ADDIE) model. And deep learning-based analysis program was used to analyze non-verbal communication with SP and applied it for debriefing sessions. To verify the effect of the program, a quasi-experimental study using a random assignment design was conducted. In total, 48 nursing students (n=24 in the experimental group; n=24 in the control group) participated in the study. Knowledge (F=3.53, p=.038), confidence in clinical performance (F=9.73, p<.001), and communication self-efficacy (F=5.20, p=.007) showed a significant difference in both groups and interaction between time points, and the communication ability of the experimental group increased significantly (t=3.32, p=.003). Hybrid simulation program developed in this study has been proven effective, it can be implemented in child nursing education. Future research should focus on developing and incorporating various hybrid simulation programs using SP into the nursing curriculum and evaluating their effectiveness.

Enumeration of Genetic Variability Parameters and Association among Early Seedling Growth Parameters under Polyethylene Glycol (PEG) induced Osmotic Stress in rabi Sorghum (Sorghum bicolor (l.) Moench)

Aims: The research aims to explore the variability within diverse rabi sorghum germplasms and identify the relationships among different early seedling growth traits. This will provide valuable insights for future breeding programs, aiding in the development of resilient sorghum varieties that can contribute to improved food security and agricultural sustainability. Study Design: The study was conducted by employing factorial complete randomized design (FCRD) with two replications. Where, two factors was considered, genotype as first factor and PEG concentration as second. Place and Duration of Study: The experiment was conducted during rabi season of 2023 at University of Agricultural Sciences Dharwad, Karnataka. Methodology: A total of 156 germplasm lines of rabi sorghum were assessed in vitro for early seedling growth characteristics, including germination percentage, shoot length, root length, seedling dry weight, and seedling vigor indices I and II, under both control and osmotic stress conditions induced by polyethylene glycol (PEG). Osmotic stress was induced by dissolving PEG 6000 in distilled water to achieve the desired concentration. The germplasm lines were then subjected to germination and early growth under these conditions using the paper towel method. The genetic variability parameters for each trait were quantified to examine the degree of variability in the material used, and correlation analysis was performed to understand the relationships among the traits studied. Results: The variance analysis showed highly significant differences among genotypes, treatments, and the genotype-by-environment (G×E) interactions. Genetic variability parameters revealed considerable variability across all traits studied, which tended to increase with higher stress levels. Moderate to high GCV and PCV was observed for all the traits studied. Correlation analysis demonstrated a strong, significant positive relationship among all seedling parameters, except between root length and shoot length, as well as between shoot length and germination percentage under control conditions. Conclusion: The study emphasizes the effect of osmotic stress on the early vigor and growth of sorghum seedlings. The findings reveal significant variability in seedling traits, suggesting that selection can be employed for genetic enhancement of these traits. Correlation analysis identified specific traits or combinations of traits that should be considered when selecting genotypes tolerant to osmotic stress conditions. These findings offer great potential to guide and improve selection and breeding programs focused on enhancing drought tolerant sorghum varieties.

Phytochemicals and Functional Properties of Pitaya Juice Powders

Background: Crassulacean acid metabolism plants, such as Stenocereus spp., are climate warming-resilient crops used as food and for by-products elaboration in arid and semi-arid agroecosystems. A few studies on secondary metabolites have been conducted in pitayo fruit (PF), but there are no reports of these compounds in juice powders (JP) with (JPS) or without seeds (JPWS). This study was devoted to characterizing the juice powders (JPS and JPWS) of five pitayas with different flesh colors with regard to some phytochemical and functional attributes. Methods: The study was conducted with a completely random design with factorial arrangement in treatments (PF × JP). Results: Differences among pitayas were related to peel and flesh color attributes. Except for soluble dietary fiber, the remainder of the non-digestible carbohydrates were greater in JPS than in JPWS of all pitayas. Phenols and flavonoids were found to be the highest in the JPWS of all pitayas, whereas total saponins were the highest in JPS of the ‘Pink’ pitaya. The JPWS of the ‘Yellow’ and ‘Reddish-Purple’ pitayas had the highest content of betaxanthins and indicaxanthins, respectively. Antioxidant capacity was the highest in JPS of ‘Reddish-Purple’ and ‘Pink’ pitayas. Conclusions: Except for some phenolic compounds, the study suggests that pitayas’ JPS would benefit human health when freshly consumed or as elaborated by-products.

Kemiri Sunan Buds Induction (Reutealis trisperma (Blanco) Airy Shaw) For In Vitro in Ms Media with Different Concentrations of the Substance Growing Manager

Need oil fuel in Indonesia has increased. Oil production reached only 410,000 barrels per day while the needs of up to 1 million barrels per day. One plant is capable of producing biofuels is Pecan sunan. Vegetative reproduction has been hampered by the limited number of obtained so that necessary research in vitro. This research aims to know the concentration of the substance growing balance sitokinin (BA, TDZ and kinetin) and Auxin (NAA) in Pecan sunan buds induces on the MS medium. Experimental design used was Complete Random Design simple. The treatment is the composition of the basic MS medium with medium that is combined with the astringent balance grow NAA (0.5 mg/l), BA (1-3 mg/l), TDZ (0.2 mg/l) and kinetin (2 mg/l). The result of the observation form buds, but callus changes color and size kalus. Before and after color callus subculture of potentially forming buds is the A9 (MS + 0.5 mg/l NAA + 3 mg/l BA + 2 mg/l kinetin). While kalus response tends to be good on the A5 is 0 MS media (MS + 0.5 mg/l NAA + 2 mg/l BA + 0.2 mg/l TDZ) and G media is A2 (MS + 0.5 mg/l NAA + 2 mg/l BA).

Growth Increase of Gelam (Melaleuca Leucadendron) Burnt Peatland Through the Provision of Soil Conditioner (Study in Londerang Peat Protection Forest)

The protected forest of Londerang Jambi is an area of hydrological unity with a surface area of 12.484 ha that is located in the district of Tanjung Timur and Muaro Jambi, which is surrounded by palm plantations and forest of industrial crops and 10 villages in the Districts of Tanjung Jabung Timur and Jambi. Based on the results of the Landsat 8 OLI image analysis and the SPOT 7 image interpretation by WWF Indonesia in 2015 that the Londerang Forest Protection Area (HLG) has an area of 12.848 Ha, currently the steep vegetation cover that canopies closely on the HLG Londerang remains only less than 10% of the area of HLG londerang due to forest fires in 2015. An attempt to overcome the situation has been made, one of them in the HLG Londerang being made an of the Hydrological Union of Mendahara-Sungai Batanghari which has been intervened by the Badan Restorasi Gambut (BRG). This effort was also carried out by the KIFC (Korea Indonesia Forest Center) by revegetating the blocks of land that had been burned in HLG Londerang. The planting has been carried out from the beginning of 2022 to December 2022. The species of plants planted among them are Pulai Rawa (Alstonia scholaris), Balangeran (Shorea balangeran), Gelam (Melaleuca leucadendron). In order to support the success of the revegetation, intensive maintenance is required, including the provision of soil fertilizers such as dolomite and NPK fertilizer. The research was conducted for seven months from May to December 2023 at HLG Londerang. Measuring fields are made with group random designs (RAK). The clustering is based on the difference in the height of the groundwater surface

The Effect of Adhesive Ratio on the Quality of Charcoal Briquettes

This study used cassava stem charcoal and charcoal from forest fires mixed with tapioca adhesive at different ratios, the aim was to analyze the effect of different adhesive ratios on the quality of charcoal briquettes.Charcoal briquettes are formed using a 40 bar press machine with a pressing time of 10 minutes. The mixture of charcoal briquette raw materials uses a tapioca adhesive ratio of 2%, 4%, 6%, 8% and 10%.Testing is carried out to determine the quality, then analyzed and compared with the SNI 01-6235-2000 standard.The effect of adhesive ratio on adhesive quality was analyzed using a Completely Randomized Design (CRD). The test results show the following values:density 0.54 g/cm3, moisture content 4.97%, compressive strength 28.43 kg/cm2, volatile matter content 36.02%, ash content 6.36%, fixed carbon content 56.45% and calorific value 6,195 cal/gobtained from a 10% adhesive ratio. The adhesive ratio has a very significant effect on the water content, compressive strength and calorific value; has a significant effect on the density value; and has no significant effect on the volatile matter value, ash content and bound carbon content.The results of charcoal briquette testing mostly meet the standards according to SNI (No. 01-6235-2000)

Digitized Seedbed Soil Quality Assessment from Worn and Edge Hardened Cultivator Sweeps

Tillage tools for seedbed soil management are often subjected to low stress abrasion wear, which could negatively affect seedbed quality and crop productivity. Limited studies exist that quantify the effects of worn tillage tools on seedbed quality and crop yield. This research investigated the influence of tillage tool wear on seedbed preparation by evaluating the effect of cultivator sweep wear on soil tilth utilizing a light detection and ranging (LiDAR) sensor. The framework consists of a seedbed tillage field experiment using a Completely Randomized Design (CRD) experiment in six replicates of two-tillage treatments (new and worn cultivator sweeps). After seedbed tillage, loosely tilled soil aggregates were removed to expose the seedbed soil profile, and then seedbed roughness statistical measures were estimated from LiDAR-scanned seedbed soil surface. Three statistical analyses (Analysis of Variance (ANOVA), Kolmogorov–Smirnov (KS), and Earth Mover’s Distance (EMD)) were compared to quantitatively evaluate the soil roughness estimated from the LiDAR seedbed surface data. Seedbed prepared by new and worn cultivator sweeps showed significant differences (p &lt; 0.05) in soil roughness variables of standard deviation, coefficient of variation, and kurtosis. Data analysis from the ANOVA and KS methods revealed that LiDAR-extracted soil roughness patterns were statistically influenced by tillage treatment. EMD analysis detected noticeable disparities between the tillage treatments and new versus worn cultivator sweeps. This study concludes that tillage tool wear substantively affects seedbed quality, as evidenced by LiDAR soil profile estimated attributes of soil roughness and three statistical methods (ANOVA, KS, and EMD). Our study supports the adoption of LiDAR technology for seedbed management, highlighting its applicability to evaluate seedbed quality that accounts for the wear life cycle of cultivator sweeps.

Implementation of sodium-glucose co-transporter 2 inhibitors in patients with heart failure through a new digital strategy (EMAIL-HF): a randomised clinical trial study design

Abstract Introduction Delayed implementation of new medical discoveries remains a global healthcare challenge and is mainly due to the complexity of cross-institutional patient care. Sodium-glucose co-transporter-2 (SGLT-2) inhibitors is the latest medical discovery in heart failure (HF) and have recently been added to clinical guidelines as they have proven to reduce the risk of adverse cardiovascular outcomes in patients with HF across the ejection fraction spectrum. Whether a new digital strategy can optimise and accelerate the implementation of SGLT2 inhibitors in patients living with HF is of great importance for public health. Purpose To evaluate whether a new and streamlined digital strategy can optimise and accelerate the implementation of SGLT2 inhibitors in patients with HF. Design and methods: The trial is a multicentre, parallel group, register-based randomised clinical study, evaluating the effect and potential of a new digital strategy to implement new guideline therapies to patients living with a chronic disease, specifically SGLT2 inhibitors to patients with HF (figure 1). The setup employs data from nationwide health registers and official digital letters to inform patients about the new therapy option and invite them to have their eligibility evaluated by a HF specialist and start therapy. A total of ~10,000 patients with HF across the ejection fraction spectrum (with and without diabetes), who have not yet been started on SGLT2 inhibitors, are identified through Danish nationwide health registers, and randomised 1:1 to receive the digital letter (figure 2). The primary outcome is the proportion of patients redeeming a prescription of a SGLT2 inhibitor within six months. Secondary outcome is a composite HF endpoint consisting of all-cause death or HF hospitalisation. Other outcome measures are renal failure, stroke and myocardial infarction, safety outcomes, adherence to therapy and proportion of vulnerable patient groups initiating therapy including immigrants, elderly, frail patients, patients with lower socioeconomic level and lower educational level. A total of 4689 patients have been randomised (February 2024) and data will be presented in 2025. Conclusions The trial will determine the efficacy and safety of a new and streamlined digital strategy to implement SGLT2 inhibitors to patients with chronic HF. The setup has the potential to be used in a broad spectrum of patients living with chronic diseases and is expected to be highly cost-effective.Figure 1.Study hypothesisFigure 2.Study design

Gambling disorder and its associated factors in university students

Abstract Background Gambling disorder (GD) is defined as persistent and uncontrollable gambling behaviour that has negative effects on an individual’s life. This can lead to financial problems, poor academic performance, and health problems. GD has been associated with psychological disorders like depression, anxiety, and attention-deficit hyperactivity disorder (ADHD). We aimed to examine the gambling disorder and its associated factors in university students. Methods We conducted a cross-sectional study among students at a university in Eskisehir (Türkiye) in 2024. A stratified random sample design was used. Five faculties were randomly selected. A total of 1,201 students were included according to the stratum weight of the faculties. A questionnaire including sociodemographic characteristics, South Oaks Gambling Screen (SOGS), and Adult ADHD Self-Report Scale (ASRS) was applied. Data were analysed through descriptive statistical analyses and multivariate logistic regression models. Results The mean age was 21.5±2.8 years, and 46.8% were male. While 48.7% of the students stated that they had gambled at least once, 2.2% had a gambling disorder. The three most common types of gambling played by students were stock market (28.2%), bet on sports (22.0%), and scratch cards (18.2%). In multivariate analysis, being male (Odds ratio-OR:6.5, 95%CI:1.4-29.8), having lost years during education (OR:2.7, 1.1-6.8), having relatives with gambling problems (OR:8.0, 1.8-36.2), investing greater amounts of money in gambling (OR:3.7, 1.0-13.0), and having a high probability of ADHD (OR:4.3, 1.4-12.8) were found to be predictors for GD. Conclusions Although about half of the students had engaged in gambling activities, only a small proportion showed signs of GD. We can conclude that being male, having lost years in education, having relatives with gambling problems, investing larger amounts of money in gambling, and having a higher probability of ADHD are predictors of GD among students. Key messages • Implementing educational campaigns at universities to raise awareness of the potential risks and consequences associated with GD could be beneficial. • It may be helpful if mental health services at the university were equipped to consider mental health conditions such as ADHD, that contribute to GD.