We look into the problem of stochastic resetting with refractory periods. The model dynamics comprises diffusive and motionless phases. The diffusive phase ends at random time instants, at which the system is reset to a given position—where the system remains at rest for a random time interval, termed the refractory period. A pathway formulation is introduced to derive exact analytical results for the relevant observables in a broad framework, with the resetting time and the refractory period following arbitrary distributions. For the paradigmatic case of Poissonian distributions of the resetting and refractory times, in general with different characteristic rates, closed-form expressions are obtained that successfully describe the relaxation to the steady state. Finally, we focus on the single-target search problem, in which the survival probability and the mean first passage time to the target can be exactly computed. Therein, we also discuss optimal strategies, which show a non-trivial dependence on the refractory period.