This study investigates the axial compression behavior of Concrete-Filled Steel Tubular (CFST) short columns from a mesoscopic perspective. Concrete is regarded as a three-phase composite material consisting of aggregates, mortar, and interfacial transition zones (ITZs). The Concrete Damaged Plasticity (CDP) model was employed to simulate the nonlinear mechanical response and fracture characteristics of concrete. Verified against experimental results, the numerical model excels in realistically simulating the uniaxial compression behavior of CFST short columns. Subsequently, factors influencing the macroscopic behavior of CFST short columns were investigated. Results indicate that the random aggregate model adopted for concrete enables a more realistic prediction of the behavior of CFST short columns. Additionally, circular section steel tubes demonstrate a stronger confinement effect compared to square ones. With increasing lateral confinement, the properties of CFST short columns, such as bearing capacity and ductility, are significantly enhanced.