Radius In Patients Research Articles

Sclerotic lines around the radial tuberosity of the proximal radius in patients with atypical femoral fractures associated with long-term bisphosphonate use: a preliminary report

Purpose: Sclerotic lines have been detected at specific locations on the forearm and metaphysis of the lower extremities (femur and tibia) in some patients with atypical femoral fractures (AFFs) associated with long-term bisphosphonate (BP) use. Herein, we present our preliminary data relating to the factors associated with the occurrence of sclerotic lines in patients diagnosed with AFFs. Methods: We inspected the clinical charts of patients who were prescribed BPs at our institution between 2010 and 2020. Fifty-six patients were finally investigated, including patients with sclerotic line lesions at the radial tuberosity (21 patients), and those without any pathognomonic lesions on either radius on a simple radiograph (35 patients). Results: No significant between-group differences in basic demographic characteristics, bone mineral density, or the total period of BP administration were observed (p>0.05). Multivariate analyses of the variables that exhibited significant between-group differences in the univariate analyses demonstrated that the time since the last BP administration at the time of AFF diagnosis (odds ratio [OR], 0.441) and the concurrent presence of similar lines on the femur (OR, 36.00) were significantly associated with the presence of sclerotic lines on the proximal radius. The cutoff time after the last BP administration at the time of AFF diagnosis was 16.5 months, which may serve as a predictor for the development of a sclerotic line around the radial tuberosity.Conclusion: Sclerotic lines on the proximal radius were detected more frequently in patients who had been recently treated with a BP or had similar lines on the lower extremities.

Protocol for a prospective randomized trial of surgical versus conservative management for unstable fractures of the distal radius in patients aged 65 years and older.

The primary aim of this study is to quantify and compare outcomes following a dorsally displaced fracture of the distal radius in elderly patients (aged ≥ 65 years) who are managed conservatively versus with surgical fixation (open reduction and internal fixation). Secondary aims are to assess and compare upper limb-specific function, health-related quality of life, wrist pain, complications, grip strength, range of motion, radiological parameters, healthcare resource use, and cost-effectiveness between the groups. A prospectively registered (ISRCTN95922938) randomized parallel group trial will be conducted. Elderly patients meeting the inclusion criteria with a dorsally displaced distal radius facture will be randomized (1:1 ratio) to either conservative management (cast without further manipulation) or surgery. Patients will be assessed at six, 12, 26 weeks, and 52 weeks post intervention. The primary outcome measure and endpoint will be the Patient-Rated Wrist Evaluation (PRWE) at 52 weeks. In addition, the abbreviated version of the Disabilities of Arm, Shoulder and Hand questionnaire (QuickDASH), EuroQol five-dimension questionnaire, pain score (visual analogue scale 1 to 10), complications, grip strength (dynamometer), range of motion (goniometer), and radiological assessments will be undertaken. A cost-utility analysis will be performed to assess the cost-effectiveness of surgery. We aim to recruit 89 subjects per arm (total sample size 178). The results of this study will help guide treatment of dorsally displaced distal radial fractures in the elderly and assess whether surgery offers functional benefit to patients. This is an important finding, as the number of elderly distal radial fractures is estimated to increase in the future due to the ageing population. Evidence-based management strategies are therefore required to ensure the best outcome for the patient and to optimize the use of increasingly scarce healthcare resources.

Abstract for Thesis on Functional Outcome in Fracture in Lower End Radius in Patients Treated with Joshi External Stabilizing System (JESS FIXATOR)

Abstract for Thesis on Functional Outcome in Fracture in Lower End Radius in Patients Treated with Joshi External Stabilizing System (JESS FIXATOR)

Facet Inclinations and Interfacet Angle of the Distal Radius on Posteroanterior Radiographs: Clinical Associations With 3 Carpal Pathologies

The radiographic interfacet angle (IFA), scaphoid facet inclination (SFI), and lunate facet inclination (LFI) of the distal radius were measured in patients with 3 distinct wrist pathologies to determine whether there is an association between these radiographic measurements and these conditions. Posteroanterior wrist radiographs were compiled from patients with 3 types of common wrist pathologies (scaphoid waist fracture [n= 54], scapholunate [SL] dissociation [n= 23], and dorsal ganglion [n= 51]). The patients were all Caucasians aged 20 to 45 years who met strict radiographic criteria. The IFA, SFI, and LFI values of these patients were compared with those obtained from 400 normal wrist radiographs of subjects who met the same selection criteria. In men with a scaphoid waist fracture, the IFA and SFI were significantly greater than in normal men, whereas the LFI was significantly lower. In the SL dissociation group, for all patients and for subgroups stratified according to sex, the IFA and SFI were significantly lower than in the normal matched groups. In the dorsal ganglion group, differences were found in the IFA and SFI for women, but not for men. The facet orientations of the distal radius in patients with scaphoid fracture, SL dissociation, and dorsal ganglion differed from those in the normal population. The IFA alone is most likely to be associated with all 3 pathologies. The SFI and LFI are less likely to be associated with patients with carpal pathologies. Patients with a greater IFA may be susceptible to scaphoid fractures when they fall on an overstretched hand. Patients with a smaller IFA may be susceptible to SL dissociation when they fall on an overstretched hand.

Radiographic Characteristics of the Distal Radius in Patients With Carpal Tunnel Syndrome: A Case-Control Study

Background: Carpal tunnel syndrome (CTS) is a common disorder with several known risk factors. However, the role of radiographic characteristics of the distal radius and risk factors of CTS has been overlooked. Objectives: To identify radiographic characteristics of the distal radius as the risk factors of CTS. Methods: In a case-control study, 60 patients with CTS who underwent surgical treatment (case group) and 60 people who underwent radiographic evaluation for reasons other than CTS (control group) were included. The case and control participants were matched for age and sex. Radiographic records of the patients were reviewed in the picture archiving and communication system, and the distal radius characteristics, including volar tilt, radius slope, radius height, and ulnar variance, were investigated. Results: The Mean±SD volar tilt was 10.49±6.42º in the case group and 16.65±5.31º in the control group (P <0.001). The Mean±SD radius inclination angle was 19.58±4.72º in the case group and 17.88±4.88º in the control group (P=0.049). The Mean±SD height of radius was 10.30±3.21 mm in the case group and 12.24±5.33 mm in the control group (P=0.017). The Mean±SD ulnar variance was 1.36±1.43 mm in the case group and 0.75±0.27 mm in the control groups (P=0.002). Conclusion: Radiological characteristics of the distal radius are significantly different between the CTS and non-CTS patients and could be regarded as the inherent risk factors of CTS development.

Динамика светочувствительности сетчатки на фоне оперативного лечения рецидива макулярного разрыва с применением свободного лоскута ВПМ

The main treatment for macular holes is vitrectomy with peeling of the internal limiting membrane, however, despite the rapid development of macular surgery, the percentage of negative anatomical results after primary surgery remains high. The aim of this work was to evaluate and compare the functional parameters of the central part of the retina using surgical techniques for blocking unclosed macular holes (creating a ILM-free flap in combination with silicone oil tamponade, or creating a ILM-free flap with the application of an ACP mass and tamponade with a gas-air mixture). Material and methods. This study involved 42 patients, the patients were divided into groups in accordance with the technique of reoperative intervention, all patients underwent microperimetry. Results. The retinal photosensitivity along the small radius in patients in the group with tamponade with a gas-air mixture is 1.11 times higher than in patients with silicone oil tamponade, 1.51 times higher in the middle radius, 1.53 times higher in the large radius. Conclusions. In the 2nd group the photosensitivity indicators were higher than in 1st group of patients with using silicone oil tamponade, which can be explained by the negative effect of silicone oil on the macular area. Key words: macular rupture, rigid, free flap, silicone oil, ACP mass, microperimetry.

Trabecular subchondral bone analysis of the distal radius at ultra-high field (7t) MRI: comparison with 3T MRI and radiography

Purpose: Bone fractal signature analysis (FSA) is a tool assessing structural changes that may relate to clinical outcomes and function. Bone structural changes play a role in onset and progression of several musculoskeletal diseases, and FSA has been applied to different anatomic body regions. However, its applicability in a routine clinical environment has not been extensively explored. Our aim was to evaluate and compare bone texture analysis of the distal radius in patients and controls using radiography, 3 Tesla (T) and 7T magnetic resonance imaging (MRI).

Bone Structure Analysis of the Radius Using Ultrahigh Field (7T) MRI: Relevance of Technical Parameters and Comparison with 3T MRI and Radiography.

Bone fractal signature analysis (FSA—also termed bone texture analysis) is a tool that assesses structural changes that may relate to clinical outcomes and functions. Our aim was to compare bone texture analysis of the distal radius in patients and volunteers using radiography and 3T and 7T magnetic resonance imaging (MRI)—a patient group (n = 25) and a volunteer group (n = 25) were included. Participants in the patient group had a history of chronic wrist pain with suspected or confirmed osteoarthritis and/or ligament instability. All participants had 3T and 7T MRI including T1-weighted turbo spin echo (TSE) sequences. The 7T MRI examination included an additional high-resolution (HR) T1 TSE sequence. Radiographs of the wrist were acquired for the patient group. When comparing patients and volunteers (unadjusted for gender and age), we found a statistically significant difference of horizontal and vertical fractal dimensions (FDs) using 7T T1 TSE-HR images in low-resolution mode (horizontal: p = 0.04, vertical: p = 0.01). When comparing radiography to the different MRI sequences, we found a statistically significant difference for low- and high-resolution horizontal FDs between radiography and 3T T1 TSE and 7T T1 TSE-HR. Vertical FDs were significantly different only between radiographs and 3T T1 TSE in the high-resolution mode; FSA measures obtained from 3T and 7T MRI are highly dependent on the sequence and reconstruction resolution used, and thus are not easily comparable between MRI systems and applied sequences.

Investigation of Roll-Over Characteristics in Healthy Old Individuals and Patients With Peripheral Artery Disease

Atherosclerotic blockages in the leg arteries, cause leg pain with ambulation (called claudication), impair gait and substantially reduce the walking ability of patients with peripheral artery disease (PAD). Ankle-foot orthoses are being developed and applied so patients can walk more and with less pain. Roll-over shape (ROS) is a potential design objective for such assistive devices. In the proposed work, we study roll-over characteristics in patients with PAD and healthy older subjects. Gait data of ten healthy older individuals (Age: 72.8 ± 5.5 years) and twenty patients with PAD (Age: 64.1 ± 6.6 years) were collected at self-selected walking speed. In patients with PAD, gait data were collected before the onset of pain and after claudication pain was induced. To generate ROS, the center of pressure data was transformed to the shank-based coordinate system and circular arcs were fit using an optimization program in MATLAB. Independent t-tests with Bonferroni corrections were used to separately compare roll-over radius differences (p<0.05) between healthy older to both walking conditions in patients with PAD. The mean roll-over radius was not significantly different between healthy older vs PAD pain-free (p=0.468) or PAD pain-induced (p=0.289) walking conditions. Our results indicate invariance of ROS radius in patients with PAD, which is consistent with previous literature showing general invariance of ROS in healthy young individuals. Previous biomechanical studies show gait kinematics and kinetics are more affected by PAD than by age. Future studies should focus on the potential adaptive mechanisms in patients with PAD achieving invariant ROS.

Comparison of the effects of tocilizumab monotherapy and adalimumab in combination with methotrexate on bone erosion repair in rheumatoid arthritis

ObjectiveTo compare the effects of interleukin-6 (IL-6) receptor and tumour necrosis factor inhibition on inducing repair of existing bone erosions in patients with very early rheumatoid arthritis (RA).MethodsProspective non-randomised observational...

Lengthening of radius in patients with congenital radial club hand, type II

Background. Congenital radial club hand (CRCH) is characterized by longitudinal underdevelopment of the forearm and hand on the radial surface. Underdevelopment can range from hypoplasia to aplasia of the radius. More than 50 methods to correct the forearm deformities, depending on the degree of radius underdevelopment, have been proposed.&#x0D; Aim. We evaluated the results of CRCH treatment using microsurgical technique and external fixation.&#x0D; Methods. We analyzed 16 patients (age, 4.6 0.9 years) with CRCH type II, according to the classification of Bayne and Klug, treated between 1994 and 2017. The patients were divided into two groups: Group 1 were patients undergoing microsurgical autotransplants of the epimetaphyseal second metatarsal bone with growth plate to the position of the radius defect and group 2 were patients treated by lengthening of the radius with external fixation. We analyzed the types of deformities, size of the radius defects, and range of motion in upper limb joints before the stage of the lengthening. External fixation index and number of complications also were determined. The type and number of recurrent deformities and timing of their detection were analyzed.&#x0D; Results. The observation period ranged from 12 months to 10 years (average, 3.8 years). In group 1, good results were obtained in 62.5% of cases. After transplantation of the metatarsal bone growth plate, the work of the growth plate continued, characterized by increasing radius length in the later observation period. In group 2, good results were obtained in 50% of cases. Clinical and X-ray examinations showed recurrent hand deviation and radius shortening, which required repeated radius lengthening.&#x0D; Conclusion. Microsurgical transplantation of the second metatarsal bone with growth plate is accepted more in reconstruction of the radial bone in patients with CRCH type II due to creation of a growth zone in the distal part of the radius. Radius lengthening via external fixation is applicable while maintaining the distal epimetaphysis and normal transverse dimensions of the radial bone.

Multi-Modal Pain Control in Ambulatory Hand Surgery.

We evaluated postoperative pain control and narcotic usage after thumb carpometacarpal (CMC) arthroplasty or open reduction and internal fixation (ORIF) of the distal radius in patients given opiates with or without other non-opiate medication using a specific dosing regimen. A prospective, randomized study of 79 patients undergoing elective CMC arthroplasty or ORIF of the distal radius evaluated postoperative pain in the first 5 postoperative days. Patients were divided into 4 groups: Group 1, oxycodone and acetaminophen PRN; Group 2, oxycodone and acetaminophen with specific dosing; Group 3, oxycodone, acetaminophen, and OxyContin with specific dosing; and Group 4, oxycodone, acetaminophen, and ketorolac with specific dosing. During the first 5 postoperative days, we recorded pain levels according to a numeric pain scale, opioid usage, and complications. Although differences in our data did not reach statistical significance, overall pain scores, opioid usage, and complication rates were less prevalent in the oxycodone, acetaminophen, and ketorolac group. Postoperative pain following ambulatory hand and wrist surgery under regional anesthesia was more effectively controlled with fewer complications using a combination of oxycodone, acetaminophen, and ketorolac with a specific dosing regimen.

The association between insulin use and volumetric bone mineral density, bone micro-architecture and bone strength of the distal radius in patients with type 2 diabetes – The Maastricht study

Type 2 diabetes mellitus (T2DM) has been associated with an increased risk of fractures, despite normal to increased bone mineral density (BMD). Insulin use is one of the factors linked to this increased fracture risk. However, direct negative effects of insulin on bone quality are not expected since insulin is thought to be anabolic to bone. In this cross-sectional study the association between insulin use and volumetric BMD (vBMD), bone micro-architecture and bone strength of the distal radius, as measured with HR-pQCT, was examined. Data from 50 participants with T2DM of The Maastricht Study (mean age 62±7.5years, 44% women) was used. Participants were classified as insulin user (n=13) or non-insulin user (n=37) based on prescription data. Linear regression analysis was used to estimate the association between current insulin use and HR-pQCT derived parameters. After adjustment for age, sex, body mass index, glycated hemoglobin A1c and T2DM duration, insulin use was associated with lower total vBMD (standardized beta (β):−0.56 (95% CI:−0.89 to −0.24)), trabecular vBMD (β:−0.58 (95% CI:−0.87 to −0.30)), trabecular thickness (β:−0.55 (95% CI:−0.87 to −0.23)), cortical thickness (β:−0.41 (95% CI:−0.74 to −0.08)), log cortical pore volume (β:−0.43 (95% CI:−0.73 to −0.13)), bone stiffness (β:−0.39 (95% CI:−0.62 to −0.17)) and failure load (β:−0.39 (95% CI:−0.60 to −0.17)) when compared to the non-insulin users. Insulin use was not associated with cortical vBMD, trabecular number, trabecular separation, cortical porosity and cortical pore diameter. This study indicates that insulin use is negatively associated with bone density, bone micro-architectural and bone strength parameters. These findings may partly explain the previously observed increased fracture risk in insulin users, although there may be residual confounding by other factors related to disease severity in insulin users.

Association Between Muscle Volume of Lower Limbs and Bone Mineral Density of Radius in Patients of Radiographic Knee Osteoarthritis

Association Between Muscle Volume of Lower Limbs and Bone Mineral Density of Radius in Patients of Radiographic Knee Osteoarthritis

Clinical Outcome of Lateral Wedge Osteotomy of the Radius in Advanced Stages of Kienböck's Disease.

BackgroundRadius osteotomies showed favorable clinical outcome in Kienböck's disease. However, few articles have been published on the long-term outcome of lateral wedge osteotomy of the radius in patients with advanced stage Kienböck's disease.MethodsEleven patients with Lichtman stage IIIB/IV Kienböck's disease (group A; mean follow-up period, 86.1 months; range, 48 to 163 months) and 14 patients with Lichtman stage IIIA Kienböck's disease (group B; mean follow-up period, 85.1 months; range, 49 to 144 months) underwent radial wedge osteotomy between August 2004 and August 2012. Radiological changes of the lunate and radiocarpal joint were compared between two groups after osteotomy. The wrist flexion/extension angle, grip strength, and Disabilities of the Arm, Shoulder and Hand (DASH) scores were evaluated preoperatively and at the final follow-up. The Nakamura Scoring System (NSSK) was used for comprehensive understanding of radiological and clinical outcomes.ResultsNine patients of group A and 11 patients of group B showed radiological improvement in the lunate regarding sclerosis, cystic changes, or fragmentation. No patients showed progression of arthritic changes in radiocarpal and midcarpal joints. The wrist flexion/extension angle, grip strength, and DASH score were significantly improved in both groups after operation, but intergroup difference was not statistically significant at the final follow-up (p = 0.149, p = 0.267, and p = 0.536, respectively). The mean NSSK was 21.6 (range, 15 to 27) in group A and 21.8 (range, 15 to 26) in group B.ConclusionsRadial wedge osteotomy yielded excellent radiological and functional outcomes in advanced stages of Kienböck's disease and these results were comparable to those of Lichtman stage IIIA disease. This technique could be a useful alternative to salvage procedures in the treatment of Lichtman stage IIIB/IV Kienböck's disease without severe radiocarpal arthritis.

Comparative Study of Surgical Treatment of Articular Fractures of the Distal Radius With Volar Locking Screw Plate System in Patients With Workers Compensation

Background: Distal articular radius fractures occur in general in patients at middle age and who are occupationally active. The objective is to evaluate the usefulness of arthroscopy assistance on the reduction and fixation with volar locking screw system in articular fractures of the distal radius in patients with workers compensation. Materials and methods: Retrospective and descriptive study of 53 patients with a mean age of 47.1 years (20-77 years) who underwent surgery in a period of 1 year. The mean age of the 37 patients in the control group was 46.1 years (20-64 years), and the mean age of the 16 patients in the arthroscopic assistance group was 49.5 years (28-77 years). The patients were matched according to several variables: age, sex, type of fracture (according to the Arbeitsgemeinschaft für Osteosynthesefragen [AO] classification), time between the accident and the surgery, number of reoperations and the time of labor reinsertion (discharge) quantify as days off with medical leave. Results: The groups were comparable because there were no significant differences in the variables studied. The mean age of the control group was 46.1 years and the arthroscopy group was 49.5 years ( P = .3396, Student t test). Sex of control group was 22 males (59.5%) and 15 females (40.5%), and the arthroscopic group was 11 males (68.75%) and 5 females (31.25%), P =.522 (chi-square test). The type of fracture was B1-B2-C1-C2 and C-3. The arthroscopic group was type C1-C2-C3 ( P = .738, chi-square test). The time to surgery in control group was 11.9 days and in the arthroscopic group 12.1 days ( P = .9271, Student t test). Significant differences were shown in the time of labor reinsertion and in the numbers of reoperations. Time of labor reinsertion in the control group was 188.3 days (5.5 months) and in the arthroscopic group was 89.8 days (2.9 months), P = .00025, Student t test. The number of reoperations in the control groups was 13 (35.14%) and in the arthroscopic group was 1 (6.25%), P = .000, chi-square test. Conclusion: Patients with articular distal radius fractures with workers compensation treated with a volar locking screw plate system and arthroscopic assistance show less number of reoperation and less time to labor reinsertion compared with patients who underwent the same surgery without arthroscopic assistance.

Effect of malunited fractured distal end of radius on the morphometric parameters of distal radioulnar joint

Abstract Introduction: Malunion is the most frequent complication of fracture distal radius. Fracture malunion has been shown to associate with altered morphometric anatomy of distal radioulnar joint. Objective: This study aims to identify normal radiographic morphometry reference values and variations according to age and sex of distal radioulnar joint. This study was also carried out to determine the radiological correlation between normal and malunited distal radius in patient with unilateral malunited fracture to find out the effect of malunited fractured distal end of radius on the morphometric parameters of distal radioulnar joint. Materials and Methods: After twelve weeks of injury x-ray of injured wrist was compared with the radiograph of the contra lateral normal wrist for the difference in radial length, radial inclination, ulnar variance and palmar tilt. Results: Results of this study showed that there were signiicant difference in distal radius parameters between genders for both groups except for the difference in palmer tilt i.e. since value of P&lt; 0.0001 so there is significant difference between two group 1% level of significant suggesting that with 99% confidence, there is significant difference between mean of normal male and female right wrist parameters of both age group except for palmer tilt. Similarly there were variations in all parameter measurements for those x-ray films showing severe malunion and signiicant differences were noted for all parameters distal radius between normal and malunited wrist in both age groups i.e. since value of P&lt; 0.0001 so there is significant difference between two group 1% level of signiicant suggesting that with 99% conidence, there is signiicant difference for all parameters between mean of normal and malunion group. Conclusion: These results can be used in treatment of the malunited distal radius for correction of deformity at the wrist and achieving the best possible anatomical reduction in the young active patient and at minimizing the intervention in the low demand elderly patient with multiple comorbidities. These data also can be used for clinical research in the designing of wrist implants.

Density, structure, and strength of the distal radius in patients with psoriatic arthritis: the role of inflammation and cardiovascular risk factors.

We investigated the densitometric and microstructural features of the distal radius in psoriatic arthritis (PsA) patients using high-resolution peripheral quantitative computed tomography. PsA patients have unique bone microstructural deficits, manifested as lower cortical bone density and higher cortical porosity, which are associated with a propensity to bone fragility. The aim of this study was to investigate the densitometric, geometric, microstructural, and biomechanical features of the distal radius in psoriatic arthritis (PsA) patients. This study cohort consisted of 53 PsA patients (24 males and 29 females), with an average age of 53.1 years and 53 gender- and age-matched controls. Areal bone mineral density (aBMD) of the hip, lumbar spine, and ultradistal radius was measured by dual-energy X-ray absorptiometry. High-resolution peripheral quantitative computed tomography (HR-pQCT) was performed at the distal radius to obtain measures of volumetric BMD (vBMD), microstructure, and derived biomechanical indices. There were no significant between-group differences in aBMD at the femoral neck, total hip, and ultradistal radius, while aBMD at the lumbar spine was significantly higher in patients. The only indices indicating compromised bone quality in PsA patients were related to cortical bone quality. Cortical vBMD were -3.8% significantly lower, while cortical pore volume, porosity index, and pore diameter were 108, 79.5, and 8.6%, respectively, significantly higher in patients. Cortical stress was marginally lower (-1.3%, p = 0.077) in patients with stress significantly more unevenly distributed (4.9%, p = 0.035). Endocortical perimeter and cortical pore volume were significantly higher in patients with vertebral fracture. Deficits in cortical bone quality were associated with indices of disease activity/severity and were more prominent in patients with type 2 diabetes mellitus or hypertension. There is an intertwined relationship between chronic inflammation, cardiovascular risk factors, and bone loss in PsA. PsA patients seem to have unique bone microstructural deficits which are associated with a propensity to bone fragility.

SAT0413 A Case-Control Study of Density and Microstructure at the Distal Radius in Patients with Psoriatic Arthritis

BackgroundPsoriatic arthritis (PsA) is a chronic progressive destructive arthritis characterized by joint inflammation affecting both cartilage and bone. High-resolution peripheral quantitative computed tomography (HR-pQCT) is a noninvasive imaging technique capable...

Bone Geometry and Volumetric Bone Density at the Radius in Patients with Isolated SHOX Deficiency

The short stature homeobox-containing gene (SHOX) plays an important role in bone development and growth. We aimed to assess bone geometry and volumetric bone mineral density at the radius in patients with isolated SHOX deficiency and to relate these bone parameters to the severity of disproportion between the upper and the lower body segment. 17 patients with isolated SHOX deficiency (median age 12.3 yrs, range 6.7-37.2, 12 children and 5 adults) were examined by peripheral quantitative CT (pQCT) at the non-dominant forearm. Results were expressed as Z-scores using published reference data. Linear regression analyses were performed to describe associations between pQCT parameters and the severity of disproportion expressed as sitting height to standing subischial leg height ratio. Trabecular volumetric bone mineral density (vBMD) at the distal radius was normal, whereas cortical vBMD was decreased (mean Z-scores 0.34±1.5, n.s., and -2.2±2.2, p<0.001, respectively). Total bone cross-sectional area was enlarged at the diaphysis (2.1±1.2, p<0.001), while cortical bone cross-sectional area was normal (-0.51±1.4, n.s.). Consequently, cortical thickness was decreased (-1.2±1.3, p<0.01). The polar strength-strain index as a surrogate of long bone strength was normal (0.40±1.4, n.s.). We found no associations between pQCT parameters and the severity of disproportion. Patients with isolated SHOX deficiency are characterized by decreased cortical vBMD and cortical thickness and enlarged diaphysis. As similar changes have been described in girls with Turner syndrome, these findings suggest that haploinsufficiency of SHOX could cause characteristic skeletal anomalies at the radius.