Radionuclide Emission Tomography Research Articles

Quantitative spect measurement of the tissue blood flow in myocardium by the absolute uptake of radiopharmaceutical <sup>99m </sup>TC -Technetril

Background. Quantitative calculation of tissue blood flow by means of radionuclide emission tomography is of great importance in studies of myocardial blood supply. Quantifying blood flow with PET requires a medical cyclotron. 99mTc-Technetrile is a unique radiopharmaceutical (rfp) with a high and approximately the same extraction fraction by the myocardium and other tissues — chemical microspheres.Objective. Development of a technique for calculating tissue blood flow for a quantitative assessment of the blood supply to the heart muscle, according to the determination of tissue absorption of 99mTc-Technetrile during CardioSPECT.Design and methods. The distribution of rfp — chemical microspheres 99mTc-Technetrile in the body is proportional to blood flow. Determining the amount of accumulation of rfp in different regions can be performed using SPECT. Weused data of 14 patients with myocardial infarction, who underwent SPECT with 99mTc-Technetrile, with the calculation of tissue blood flow.Results. Evaluation of rMBF at rest in the area of unaffected myocardium revealed rMBF = 65±7 ml/min/100 g, in segments with the presence of viable myocardium according to the ultrasound test with dipyridamole rMBF = 53±7 ml/min/100 g, in postinfarction regions of the transmural damage to the left ventricular wall without viable myocardium rMBF = 27±8 ml/min/100 g.Conclusion. The calculation of tissue blood flow via CardioSPECT is useful for pathophysiological assessment of the blood supply to the heart muscle.

Movable calibration collimator and system and method using same

A movable calibration collimator for a radionuclide emission tomography camera, and a calibration system using same, having a wall of material which is opaque to radionuclide emissions and is movable in a first direction relative to the camera. One or more patterns of openings are defined by the wall to pass radionuclide emissions. The openings of each pattern are aligned in a direction transverse to the first direction to provide an array of camera images upon movement of the wall relative to the camera. The number of images generated for the array are greater than the number of openings. A method of using such a calibration collimator to perform linearity correction involves installing the calibration collimator and a line source of radionuclide emissions, acquiring a camera image of the pattern of openings, and incrementing the calibration collimator for a desired number of increments. Each camera image, collected at each position of the collimator, has a position image for each opening. The camera images are combined to produce an array having a greater number of position images than the numbers of openings. Position estimation made by the camera is corrected based on the correlation between the location of the position images and the position of the openings.

Analyze: A Comprehensive, operator-interactive software package for multidimensional medical image display and analysis

A comprehensive software package, called ANALYZE, has been developed (1) which permits detailed investigation and evaluation of multidimensional biomedical images. ANALYZE can be used with 3-D imaging modalities based on x-ray computed tomography, radionuclide emission tomography, ultrasound tomography, and magnetic resonance imaging. The software is written entirely in “C” and runs on standard UNIX workstations. The ANALYZE package features integrated, complimentary tools for fully interactive display, manipulation and measurement of multidimensional image data. The software architecture permits systematic enhancements and upgrades which has fostered development of a readily expandable package. It provides an effective shell for custom software prototyping and turnkey applications. This paper provides a general description of this software as well as specific details on the methodology employed to develop it, both conceptual and technical. Applications of the software are illustrated.

4782233 Multifield collimator system and method and radionuclide emission tomography camera using same : Sebastian Genna, Andrew P Smith assigned to Digital Scintigraphics Inc

4782233 Multifield collimator system and method and radionuclide emission tomography camera using same : Sebastian Genna, Andrew P Smith assigned to Digital Scintigraphics Inc

Interactive display and analysis of 3-D medical images

The ANALYZE software system, which permits detailed investigation and evaluation of 3-D biomedical images, is discussed. ANALYZE can be used with 3-D imaging modalities based on X-ray computed tomography, radionuclide emission tomography, ultrasound tomography, and magnetic resonance imaging. The package is unique in its synergistic integration of fully interactive modules for direct display, manipulation, and measurement of multidimensional image data. One of the most versatile and powerful capabilities in ANALYZE is image volume rendering for 3-D display. An important advantage of this technique is that it can be used to display 3-D images directly from the original data set and to provide on-the-fly combinations of selected image transformations, such as surface segmentation, cutting planes, transparency, and/or volume set operations (union, intersection, difference, etc.). The module has been optimized to be fast (interactive) without compromising image quality. The software is written entirely in C and runs on standard UNIX workstations.

Multidimensional biomedical image display and analysis in the biotechnology computer resource at the Mayo Clinic

A powerful new microcomputer-based system has been developed which permits detailed investigations and evaluation of 3-D and 4-D biomedical images. The system comprises a network of powerful workstations to which all the information in a large 3-D image data base is accessible for rapid display, manipulation, and measurement. The system supports 3-D imaging modalities based on X ray, radionuclide emission tomography, ultrasound tomography, and magnetic resonance imaging. The system provides important capabilities for simultaneously representing and analyzing both structural and functional data and their relationships in various organs of the body. This paper provides a detailed description of this system, as well as some of the rationale, background, theoretical concepts, and practical considerations related to system implementation and applications.

Nuclear magnetic resonance tomography of the brain.

Nuclear magnetic resonance (NMR) has long promised to provide a risk-free alternative method for both structural and functional tomography of the human body, since the original small scale demonstration of its principles by Lauterbur. The considerable technical problems involved in scaling up a successful 8 cm diameter line-scan NMR imaging apparatus have been overcome, and 128 x 128 element NMR tomograms of electronically definable planes less than 1 cm thick through the living brain can be produced routinely in total time of less than 2.5 min. The method used is briefly described, and it is compared with radionuclide emission tomography, which it most resembles. The contrast mechanism in the images and the hazard are also briefly discussed.