Radiological Suspicion Of Malignancy Research Articles

Preoperatively suspected gallbladder cancer improves survival compared with incidental gallbladder cancer in pT3 patients.

The aim was to compare survival for incidental gallbladder cancer (IGBC), respectively, preoperatively suspected gallbladder cancer (GBC), subjected to surgery for different pathological tumour (pT) stages and in different treatment groups in a national cohort. Data were collected and crosslinked from two national quality registers, SweLiv (2009-2019) and GallRiks (2009-2016). Survival was estimated using Kaplan-Meier analysis. The log-rank test and Cox regression analyses were used to compare groups. In total, 466 IGBC patients, including 225 who only underwent simple cholecystectomy (SC), and 477 GBC patients were included. Most patients were female, with small differences in mean age between groups. In all IGBC patients compared with GBC patients, an improved 5-year overall survival in pT3 GBC undergoing surgery (GBC 13% vs all IGBC 8%, p < 0.001), was seen. GBC was shown to be an independent predictor for improved survival in pT3 patients (hazard ratio (HR): 0.6; 95% confidence interval (CI): 0.4-0.8, p < 0.001). In addition, in GBC with curative reresection compared with IGBC SC and IGBC with curative resection, an improved 5-year overall survival in pT3 GBC was shown (GBC 20% vs all IGBC 10%, p < 0.001). GBC was an independent predictor for improved survival in pT3 patients with curative resection (HR: 0.4; 95% CI: 0.3-0.7, p < 0.001). GBC was shown to be an independent predictor for improved survival in pT3 patients, and patients with GBC may benefit from one-stage resection. It is, therefore, reasonable to recommend that radiological suspicion of malignancy should be evaluated at a liver tumour centre to optimize patient outcomes.

Can the sampling method affect the detection of incidental gallbladder carcinoma? Comparative analysis of two sampling methods

Gallbladder cancer (GBC) is the most common biliary tract carcinoma and is commonly diagnosed incidentally in cholecystectomies performed for gallstones. GBC are mostly unrecognizable macroscopically, and sampling is therefore import. This single center study aimed to find out the effect of sampling method on the identification rate of incidental GBC by comparing random sampling and longitudinal full-thickness slice sampling, which was developed in high-incidence areas. A hospital electronic database was searched for cholecystectomy specimens submitted to the pathology department between 01/2000 and 03/2016. Cases with a preoperative clinical and/or radiological suspicion of neoplasia and cases with a macroscopically identified mass were excluded from the study. Two groups were formed according to the sampling method: “random sampling” group (Group 1, n = 10,954) and “full-thickness slice sampling” group (Group 2, n = 5254). In the first group, random samples from the fundus, body and neck were submitted in gallbladders without grossly visible pathology. In the second group, a full-thickness slice sampling protocol was performed, wherein a longitudinal full-thickness slice, including fundus, corpus-neck and the cystic duct margin was submitted for each gallbladder. Statistical comparisons of GBC incidence and clinicopathologic features was performed. In group 1, GBC prevalence was 0.6 % and low grade dysplasia (LGD) was detected in 199 cases (1.8 %). In group 2, GBC prevalence was 1.5 %, LGD was detected in 166 cases (3.2 %). The GBC rate in Group 2 was significantly (p < 0.05) higher than Group 1. The two groups did not show any statistically significant differences in age, sex and presence of gallstones (p > 0.05). In conclusion, this is the largest study comparing two grossing methods in gallbladders without preoperative clinical and/or radiological suspicion of malignancy and macroscopically identified mass. This study demonstrates the importance of systematic and algorithmic sampling in the detection of GBC.

Giant Malignant Phyllodes Tumour of Breast- A Clinical Dilemma and Surgical Challenge

Phyllodes tumour is an uncommon tumour of the breast. It is fibroepithelial in origin and mostly benign. Giant phyllodes tumours are described as tumours with size more than 10 cm and are extremely rare. Differentiating malignant and benign tumours pathologically is difficult and needs clinical judgement and high index of suspicion. A 50-year-old female presented with complaint of swelling in the left breast. On further evaluation, it was diagnosed as phyllodes tumour on biopsy. She underwent left mastectomy and excision of pectoralis major muscle due to clinical and radiological suspicion of malignancy. Postoperative histopathology report revealed malignant phyllodes tumour. Cases of giant phyllodes tumour should undergo adequate imaging and image guided biopsy with high index for suspicion for malignancy. They should be operated as per the principles of oncosurgery as there is a high probability of such huge tumours harboring malignancy.

Granular cell tumour of the breast - diagnostic radiology case study

A 53 year old female patient presented with a suspicious palpable breast mass with a clinical and radiological suspicion of malignancy. Histological evaluation, however, revealed a rare benign neoplasm. Granular cell tumor is a rare neoplasm that may occur in any anatomical part of the body, most commonly the tongue. GCT of the breast is commonly a benign neoplasm. However, clinically and radiologically it can mimic breast malignancy. It commonly presents as a painless palpable lump while the sonogram and mammogram are variable. FNA or core needle biopsy is diagnostic and wide local excision is the choice of management.

Heterotopic Gastric Mucosa in a Duplication Cyst of the Common Hepatic Duct Mimicking Cholangiocarcinoma

Heterotopic gastric mucosa in biliary tract is a congenital anomaly that can prove significant clinical dilemmas. Here we report the case of a 28-year-old female patient presenting with jaundice, pruritus, and altered liver tests, with predominant cholestasis. Liver biopsy revealed histological changes suggesting large bile duct obstruction with advanced fibrosis. At imaging, common hepatic duct stricture due to an intraluminal enhancing mass was observed. Endoscopic retrograde cholangiopancreatography and upper echoendoscopy revealed a firm mass of the common hepatic duct with a complete obstruction, suspicious for cholangiocarcinoma. Fine-needle aspiration biopsy performed under echoendoscopic guidance revealed fundic type gastric mucosa. Despite histological result, radiological suspicion of malignancy together with advanced fibrosis prompted a segmental resection of biliary tract. At macroscopic examination, the common hepatic duct presented a focal pseudocystic appearance with a firm zone of subtotal stenosis. Histology revealed a duplication cyst lined by heterotopic fundic gastric mucosa. Heterotopic gastric mucosa of the biliary tract should be suspected in young patients without know risk factors for hepatobiliary malignancies. Imaging and careful histological examination are mandatory for optimal management. Liver fibrosis, secondary to chronic biliary obstruction may be a significant late complication.

Clinical and Cytological Spectrum of Granulomatous Mastitis and Utility of FNAC in Picking up Tubercular Mastitis: An Eight-Year Study.

Granulomatous Mastitis (GM) is a rare, benign, inflammatory disease of the breast. It is a well known mimicker of malignancy, clinically and radiologically. Patients are often subjected to number of tests for the right diagnosis. Non-specific Granulomatous Mastitis (NGM) and Tubercular Mastitis (TBM) are chief among the various causes of GM. They are important to be diagnosed early as their treatment varies significantly. Fine Needle Aspiration Cytology (FNAC) is simple, patient friendly and primary investigation modality in cases of lump in breast. To find out the utility of FNAC in differentiating NGM and TBM. All cases of granulomatous mastitis diagnosed on cytology over eight years were retrospectively retrieved. The clinical and radiological history was obtained from the patient file. The slides were stained with haematoxylin and eosin stain as well as Leishman stains. Special stains like Periodic Acid Schiff (PAS) and Ziehl Neelsen (ZN) stain were used for fungus and Mycobacteriumtuberculosis respectively. Histopathological correlation of the available cases was done. Clinical presentation and cytological morphology of individual cases was studied in detail. Twenty one cases of GM obtained, of which 16 were NGM and five were TBM. Both diseases were common among young reproductive women who presented with unilateral breast lump of varying duration. Almost 25% of NGM and 60% of TBM has clinical suspicion of malignancy. About 30% had radiological suspicion of malignancy. Nearly 62.5% of NGM patients had painful swelling and none of tubercular mastitis patients had pain. About 31% of NGM patients underwent prior abscess drainage and 40% of TBM patients gave history of tuberculosis. Almost 6.25% of NGM and 60% of TBM had axillary lymphadenopathy. Cytologically epithelioid cells were identified in 100% of patients whereas, granulomas were seen in 62.5% and 80% of NGM and TBM smears respectively. Langhans giant cells were frequent among TBM and foreign body giant cell among NGM. Caseous necrosis was seen in 60% of TBM and absent in NGM smears. Though, NGM and TBM is said to have overlapping features, our study highlights few clinical and cytological differences which aid in differentiating the two entities at primary level. FNAC along with special stain must be advocated as the primary tool of diagnosis in cases of GM.

Results of surgical resection in the treatment of small-cell lung cancer

Background: This study aims to investigate the role of a surgical approach in the treatment of small-cell lung cancer (SCLC), and evaluate the possible effects of combining the surgical approach with other treatment modalities for survival. Methods: Twenty patients (16 males, 4 females; mean age 58.3 years; range 41 to 76 years) who had a clinical and radiological suspicion of malignancy, who underwent an exploratory thoracotomy since diagnostic methods proved ineffective, and whose pathological results were reported as SCLC between January 1998 and January 2008 were reviewed retrospectively. Ten upper lobectomies, two lower lobectomies, six pneumonectomies and two inferior bilobectomies were performed along with radical lymph node dissection. All cases were evaluated according to age, gender, diagnostic methods, the operations performed, postoperative follow-up and survival results. Results: The results of the postoperative histopathological assessments were reported as small-cell lung cancer and mixed type tumors were observed in 11 cases. Five of the cases were stage 1, six were stage 2, and nine were stage 3. During the postoperative period all cases received chemotherapy, and radiotherapy was applied to the cases with nodal metastases. The five-year survival rate was calculated as 76% for stage 1 and 2 cases, 13% for stage 3 cases and 86% and 15% for N0 and N1-2 cases, respectively. Conclusion: Surgical treatment for SCLC can be considered in early stage (T1-2 N0) cases. In the presence of N2, a surgical approach should be avoided. Postoperative chemotherapy should be applied after surgical resection, and mediastinal radiotherapy should be added in cases with nodal metastasis.

Total thyroidectomy for the surgical treatment of multinodular goiter

The indications for surgical treatment of multinodular goiter (MNG) are pressure symptoms, suspicion of malignancy, and cosmetic concerns. We report our clinical experience of performing total thyroidectomy (TT) for MNG, focusing on outcome and complications, to evaluate its effectiveness. The medical records of 154 patients who underwent TT for MNG between 2005 and 2007 were reviewed retrospectively. We examined the ratio of thyroid nodules to the thyroid gland, pathological fine-needle aspiration biopsy findings, and the ultrasonographic characteristics of the nodules, and recorded the early and late postoperative complications. The most frequent indications for surgery were large nodules with or without radiological suspicion of malignancy (65%), hyperthyroidism (20%), and cosmetic problems or compression symptoms (15%). Seventeen (11%) patients had symptomatic, transient hypocalcemia, and 1 (0.6%) had permanent hypocalcemia. Other complications included hematoma in 1 (0.6%) patient, temporary unilateral recurrent laryngeal nerve palsy in 10 (6.4%), permanent unilateral recurrent laryngeal nerve palsy in 3 (1.9%), and seroma in 2 (1.3%). There was no significant relationship between complications and histopathology, nodule size, thyroid size, hyperthyroidism, age, or gender. Total thyroidectomy is the right surgical decision for MNG since it achieves complete remission of symptoms and eliminates malignancy, with low morbidity and mortality rates.

Xanthogranulomatous inflammation of ascending colon with mucosal involvement: Report of a first case

Xanthogranulomatous inflammation (XGI) is a rare phenomenon and can involve any organ system. The involvement of colon is rarely described in the literature. We herein report a case of XGI in a 60 year-old male who presented with friable ulceroinfiltrative mass in colon. Right hemicolectomy was performed with clinical and radiological suspicion of malignancy. This is the first reported case of XGI in ascending colon with mucosal involvement.

Percutaneous Fine Needle Aspiration Biopsy for the Intrathoracic Lesions: What is the Meaning of Non-Diagnostic Results?

Purpose: To know what is the meaning of non-diagnostic results of fine needle aspiration biopsy (FNAB) and whether repeated aspiration is needed or not in those situations. Materials and Methods: We reviewed 1845 patients who underwent FNAB from 1997 to 2001. Non-diagnostic results of the first FNAB were divided into four groups: insufficient number of cells, cells, necrotic debris and atypical cells. We analyzed final diagnosis of 531 patients who had non-diagnostic results from the first FNAB. Among them, 207 lesions were re-biopsied because of clinical and radiologic suspicion of malignancy. The diagnostic yield of repeated FNAB was analyzed and compared with the results of the first FNAB. Results: Among 255 cases with inflammatory cells onlyresults, 120 cases were confirmed benignancy on follow-up. Twenty nine of 50 atypical cells (58%) were malignant on follow-up. One hundred one of 207 repeated FNAB resulted in the non-diagnostic reports, and 106 of 207 repeated FNAB were diagnosed as specific diagnosis. Among thirty lesions showing atypical cells on the repeated FNAB, 22 (73%) were identified as malignant neoplasms. Conclusion: When the specimen of FNAB shows atypical cells, the possibility of malignancy is very high. When the results of FNAB is non-diagnostic in the cases with clinical and radiological suspicion of malignancy, repeated FNAB procedures should be seriously considered and will be helpful for accurate specific diagnosis.

Number Seventy-Five: Part 1

A 63 yr old woman was admitted to hospital with a 12 mth history of restrictive lung disease. She had a mitral valve prolapse murmur, and atrial fibrillation. She had recently developed increasing shortness of breath, and a productive cough. Chest x-ray revealed an extensive infiltrate of the right lung, and CT scan showed perihilar nodularity of the right lung and no evidence of mediastinal lymphadenopathy. There was atelectasis of the right lower lobe. No other abnormalities were seen, and there was a strong clinical and radiological suspicion of malignancy. She died unexpectedly within 24 hrs of admission, and her death was reported to the Coroner.

Percutaneous fine needle aspiration cytology of the pancreas: advantages and pitfalls.

Fine needle aspiration of the pancreas was performed in 62 patients with radiological suspicion of malignancy. All fine needle aspirates were taken under computed tomography or ultrasound guidance. Fine needle aspirates were positive in 31 of 41 patients with histologically or clinically confirmed pancreatic carcinoma. There were no false positive results. The sensitivity of this method for detecting malignant disease was 86%. Cytology was not able to provide conclusive results of benign conditions. Difficulties were encountered in diagnosing well differentiated carcinoma and neuroendocrine tumours and distinguishing them from reactive epithelium and islet cell hyperplasia, respectively. This resulted in a 12.1% false negative rate. There were no complications in our series. Percutaneous fine needle aspiration proved a reliable method of diagnosing pancreatic carcinoma.