Radiographic Techniques Research Articles

CBCT as a Novel Tool for Gender Determination using Radio Morphometric Analysis of Maxillary Sinus-A Prospective Study.

The maxillary sinuses are air-filled cavities which vary in size and shape. Sinus radiography has been widely used in the determination of the gender of the individual, especially in forensic investigation for human identification and sexing of individuals. The advanced radiographic techniques like cone beam computed tomography (CBCT), especially the axial and coronal sections, have been considered as a subtle concept in forensic odontology. The current study aimed in evaluating the parameters of the maxillary sinus using CBCT and to identify its implication in gender determination. Current study consists of 50 patients who were divided into two groups, group I consisted of 25 males and group II consisted of 25 females, where maxillary sinus dimensions like maximum length (anteroposteriorly), maximum width (mediolaterally) and maximum height (superioinferiorly) were evaluated using CBCT scans in axial and coronal sections respectively. Shapiro-Wilk test was used to determine the normality and Independent t-test was used to compare the two groups, followed by predictive analysis. Maxillary sinus, right length (p<0.001), right width (p<0.001), right height (p<0.001), left length (p<0.001), left width (p<0.001), left height (p<0.001). Right and left maxillary sinus parameters were different between males and females, with statistical significance indicating the presence of sexual dimorphism. In this study, maxillary sinus parameters like length, width and height in CBCT were significantly different between males and females. Maxillary sinus can be a useful gender predictor in the forensic identification of the individual.

CTNI-62. EVALUATION OF SAFER-SEQS CTDNA ASSAY OPTIMIZED FOR DETECTING LOW CTDNA COUNTS FROM CSF AND PLASMA: ASSESSING SENSITIVITY AND FEASIBILITY FOR CLINICAL IMPLEMENTATION

Abstract BACKGROUND Gliomas with BRAF alterations are often difficult to treat in the recurrent setting due to emergent resistance to FDA-approved targeted therapies. Additionally, it is difficult to assess response to therapy given the limitations of radiographic techniques and the infeasibility of serial tissue sampling. This protocol will serve as a prototype for determining the feasibility of using CSF and plasma circulating tumor DNA (ctDNA) as biomarkers for response to a novel-BRAF inhibitor, plixorafenib. Plixorafenib is a small-molecule selective inhibitor of Class 1 and 2 BRAF mutations that does not induce paradoxical reactivation of MAPK signaling. METHODS This clinical trial is designed as a single institution, signal-finding study to demonstrate the feasibility and sensitivity of detecting ctDNA at baseline and after one month of treatment with plixorafenib (primary endpoint). In addition, we will evaluate the correlation of ctDNA with disease status over time and response rate to plixorafenib. Patients aged 18 years or older with measurable recurrent BRAF-V600 mutant glioma (by RANO 2.0), who have received prior BRAF and/or MEK inhibitor therapy will be screened and consented for the study prior to surgery. Leptomeningeal disease allowed. A total of 12 evaluable patients will be enrolled. Patients will undergo clinically-indicated resection or biopsy for confirmation of disease progression and characterization of putative resistance alterations. All patients will have a ventricular reservoir placed at time of surgery with CSF and plasma sampling. Patients will initiate the study drug (oral plixorafenib 900mg daily with cobicistat 150mg daily) when clinically recovered from surgery. Patients will take the drug continuously for 28-day cycles. MRI, CSF, and plasma assessments will occur approximately every two months to evaluate disease status. Enrollment is planned to begin November, 2024.

Correlations between coagulation abnormalities and inflammatory markers in trauma-induced coagulopathy.

In multiple trauma patients, the occurrence of trauma-induced coagulopathy (TIC) is closely associated with tissue damage and coagulation function abnormalities in the pathophysiological process. This study established a multiple trauma and shock model in Sprague-Dawley (SD) rats and comprehensively utilized histological staining and radiographic imaging techniques to observe injuries in the intestine, liver, skeletal muscles, and bones. Monitoring activated partial thromboplastin time (APTT), platelet (PLT) count, respiratory rate, blood pressure, and other physiological indicators revealed time-dependent alterations in coagulation function and physiological indicators. Enzyme-linked immunosorbent assay (ELISA) measurements of inflammatory factors Tumor Necrosis Factor-alpha (TNF-α), Interleukin-6 (IL-6) and vascular endothelial injury marker (Syndecan-1) were also conducted. Experimental results demonstrated significant changes in tissue structure after multiple traumas, although widespread necrosis or hemorrhagic lesions were not observed. There were time-dependent alterations in coagulation function and physiological indicators. ELISA measurements showed a strong positive correlation between the significant decrease in PLT count and the increase in TNF-α and IL-6 concentrations. The study provides crucial information for the early diagnosis and treatment of TIC. The findings suggest that structured monitoring of coagulation and inflammatory indicators can help in understanding the pathophysiological changes and aid in the management of TIC in multiple trauma patients.

Long‐Term Monitoring of ApoE4 within Aqueous Humor Using Intraocular Lenses Containing Target‐Responsive Inverse Opal Hydrogel

Neurodegenerative diseases, including Alzheimer's disease (AD), pose significant challenges to global healthcare because of their irreversible postsymptomatic progression. Conventional radiographic techniques have limitations in early detection, owing to the time lapse between symptom recognition by individuals and precise inspection using medical instruments. Current research explores ophthalmic approaches to address this gap, investigating the physiological link between ocular health and brain diseases. Intraocular lenses (IOLs), widely used in cataract and refractive surgeries, provide a safe and minimally invasive platform for the continuous monitoring of neurodegenerative disease biomarkers, including those associated with AD. By integrating biomolecule‐responsive sensors with IOLs, it becomes feasible to achieve early diagnosis and long‐term, noninvasive monitoring postimplantation. Herein, a fluorescently labeled inverse opal hydrogel (FIOH) is merged with IOLs for ApoE4 detection, a key risk factor for AD. The permeability and inherent photonic properties of FIOH facilitate the cumulative enhancement of the fluorescence signal. In a simulation of the aqueous humor circulation, the detection limit for ApoE4 is determined to be 0.1 nM. Therefore, FIOH‐integrated IOLs hold promise not only for early detection but also for providing a reliable platform for the continuous, noninvasive monitoring of neurodegenerative diseases after the initial, minimally invasive implantation.

Growth-friendly spinal surgery: Review of the effect on truncal growth

BackgroundPediatric spinal deformity surgery affects ultimate spinal height in the growing child. This effect on ultimate spinal height has also been shown to affect pulmonary development and ultimately pulmonary function. There has been an increasing trend toward growth-friendly spinal surgery in early onset scoliosis to minimize the negative consequences of early spinal fusion surgery. Such growth-friendly techniques include VEPTR, MCGR, and Shilla. Which technique allows for the most growth after initial implantation is still not clear. MethodsAn extensive literature review on the topic of pediatric spinal growth was undertaken. Topics reviewed include: normal growth, growth after intervention by various methods, and the effect on pulmonary function. We have summarized the literature for the techniques identified and compared these with normal population data.. ResultsThe data for various surgical techniques were reviewed. These included VEPTR, standard growing rods, and MCGR. The measurement techniques for determining ultimate spinal growth varied based upon the technique for measurement and the timing of initial and final measurements. The results of attained spinal growth were not directly correlated to pulmonary function values. ConclusionsThere is still no standardized ideal time or technique for assessing the best results in this area. We suggest that some of what is called growth from growth-friendly techniques is lengthening from the initial deformity correction. This nomenclature needs to be clarified. In addition, how and when to determine ultimate spinal growth from each surgical technique and by which radiographic technique needs to be standardized.

Evaluation of the Accuracy of Electronic Apex Locators in Modern Endodontics: An Umbrella Review.

Background and Objectives: To achieve success in endodontic treatment, it is essential to properly perform the steps of shaping, cleansing and obturation. Determining the working length of the canal is, therefore, a process that must be precise and accurate. Electronic apex locators are a useful tool for the clinician to best perform this step of endodontic treatment. Materials and Methods: The purpose of the following umbrella review is to evaluate, through data in the literature, the degree of accuracy of apex locators. Results: Seven systematic reviews were included in the following umbrella review. Five compare the accuracy of apex locators versus radiographic techniques, two compare different types of electronic apex locators, and two analyze the determination of working length in primary teeth. Conclusions: From the results obtained from the following umbrella review, albeit at low levels of evidence, the methods for determining working length using electronic apex locators and other methods, particularly using radiographic evaluation, are equally valid.

Radiological Evaluation of Vascular Structures in Cats Infected with Immature Worms of Dirofilaria immitis.

This study aimed to assess thoracic radiographic abnormalities in cats infected with immature stages of Dirofilaria immitis to evaluate the utility of this diagnostic technique during early infection. A total of 123 cats from a hyperendemic area were classified into three groups: asymptomatic cats seronegative to anti-D.-immitis antibodies (Group A), seropositive asymptomatic cats (Group B), and seropositive cats with clinical signs that were at high risk of heartworm-associated respiratory disease (HARD) (Group C). Radiographic measurements and lung parenchymal abnormalities were analyzed and compared across the groups. Significant differences in several parameters, including CrPA/R4, and CdPA/R9 ratios, were observed between healthy and seropositive cats, suggesting early arterial damage even in the absence of adult worms. Other parameters that showed differences between healthy and infected cats were CVC/Ao and CVC/R4 ratios, but not the VHS. Group C exhibited a marked bronchointerstitial pattern, indicating severe parenchymal alterations associated with clinical signs. The study demonstrated that thoracic radiography can detect early vascular and parenchymal changes in feline D. immitis infections, providing valuable information for diagnosing HARD. However, it also highlights the limitations of radiographic techniques, as some seropositive cats displayed no significant abnormalities. The findings underscore the importance of combining radiography with clinical and serological assessments for a more accurate diagnosis of feline heartworm disease.

Vertical root fracture detection with cone-beam computed tomography in Biodentine™ filled teeth

PurposeThis study aimed to evaluate the accuracy of detecting vertical root fractures in Biodentine™-filled teeth using the Promax 3Dmax cone-beam computed tomography (CBCT) unit compared to periapical radiographs. It tested hypotheses regarding CBCT’s diagnostic superiority in non-root-filled and Biodentine™-root-filled maxillary central incisors and assessed the impact of smaller field of view and lower intensity settings on detection accuracy.Materials and methodsExtracted maxillary incisors were divided into groups based on fracture status and root filling material, then placed in a Thiel-embalmed skull to simulate clinical conditions. The teeth were imaged using periapical radiographs and the CBCT unit under different settings. Fracture thickness was measured with microcomputed tomography for accuracy benchmarking. Multiple observers assessed the images, and statistical analyses were conducted to evaluate diagnostic performance.ResultsIntra-rater reliabilities of consensus scores ranged from good to very good. Specificities were generally higher than sensitivities across all imaging modalities, but sensitivities remained constantly low. None of the Area Under the Curve scores exceeded 0.6, indicating poor overall accuracy for all imaging modalities. Paired comparisons of the area differences under Receiver Operator Characteristic curves revealed no significant differences between the CBCT and periapical radiograph techniques for detecting vertical root fractures in either Biodentine™-filled or non-root-filled teeth.ConclusionsThere was no significant accuracy improvement of the current CBCT device (Promax 3Dmax, Planmeca, Finland) over periapical radiographs in detecting small vertical root fractures in both non-root-filled and Biodentine™-root-filled maxillary central incisors. A smaller field of view with lower intensity did not enhance detection accuracy. These results highlight the challenges in accurately detecting small VRFs, emphasizing the need for further research and technological advancements in this domain.

A liquid metal diffusion measurement technique integrating the x-ray radiography and multi-slice sliding cell.

For measuring melt diffusion with in situ and high accuracy, this paper proposes a multi-slice sliding radiography technique. This technique combines the multi-sliding cell technique and x-ray radiography and inherits the advantages of both. It not only visualizes the diffusion process but is also suitable for the diffusion coefficient measurement of systems with low or even no absorption contrast. In addition, by introducing isotopes, self-diffusion and interdiffusion can, in principle, be measured simultaneously with high precision. The details related to the design of this technique and the experiments are reported in this paper. Reliability and validity of this technique are demonstrated by its measurements in Al80Cu20 melt.

Rapid cargo verification with cosmic ray muon scattering and absorption tomography

Cosmic ray muon tomography is considered a promising method for the non-invasive inspection of shipping containers and trucks. It utilizes highly penetrating cosmic-ray muons and their interactions with various materials to generate three-dimensional images of large and dense materials, like inter-modal shipping containers, typically not transparent with conventional X-ray radiography techniques. The commonly used methods for imaging with muons are based on muon scattering or absorption-transmission data analysis. Due to large thickness of cargo material in shipping container substantial scattering and absorption occur when muons are passing through cargo. One of the key tasks of customs and border security is to verify shipping container declarations to prevent illegal trafficking, and muon tomography could be a viable choice for this task. In this paper, we demonstrate through Monte Carlo simulations using the GEANT4 toolkit that a combined analysis of muon scattering and absorption data can improve the identification of cargo materials compared to using scattering or absorption data alone. The statistical differences in scattering and absorption data for several cargo materials are quantified. For a particular smuggling scenario where tobacco declared as paper towel rolls, it is demonstrated that the combined analysis can accurately distinguish between tobacco and paper towel rolls with 5.5σ accuracy for detector spatial resolution (FWHM) of 0.235 mm, 4.5σ for 1.175 mm resolution (FWHM), and 3.9σ accuracy for 2.35 mm spatial resolution (FWHM), in a short scanning time of 10 seconds. This rapid detection capability has significant implications for anti-smuggling efforts and cargo inspection.

Two stucco sculptures from the “Salone d’Ercole” in the Racconigi Castle (Cuneo, Italy): a case study

Non-invasive and micro-destructive diagnostic investigations were employed for the study of two stucco statues depicting Putti, from the “Salone d’Ercole” in the Racconigi Castle (Cuneo, Italy). The research made it possible to understand the construction technique, constituent materials, and the state of conservation of the statues. This information was useful for placing the artworks in the correct historical-artistic context and for conservation choices and restoration interventions. Different analytical investigations were applied, specifically: a) the internal metal structure was analyzed by cover meter relief combined with digital radiographic technique; b) the stucco composition and its stratigraphy were characterized by Polarized Optical Microscopy (POM), X-ray diffraction (XRD) and Electron Scanning Microscopy coupled with Energy-Dispersive X-ray spectroscopy (SEM-EDX); c) finally, the presence of organic compounds was observed by UV-Induced Visible Fluorescence (UVL) and then characterized by Fourier Transform Infrared Spectroscopy (FT-IR) analyses. The results show that the stucco Putti were made with the techniques and raw materials widely used by Ticino artists and plasterers' workshops active between the 16th and 17th centuries, in the current Canton Ticino region. As regards the state of conservation, decay phenomena such as exfoliation and loss of material were mainly attributable to the presence of epsomite.

A comparison of three methods for establishing an ACL reference length in vivo

As anterior cruciate ligament (ACL) injuries are highly prevalent among active individuals, it is vital to better understand the loading conditions which lead to injury. One method for doing so is through measurement of dynamic, in vivo ACL strain. To measure strain, it is necessary to normalize elongation of the ACL to a ‘reference length’ which corresponds to the point at which the ligament transitions from being unloaded to carrying tension. The purpose of this study was to compare the length of the ACL in three different positions to evaluate their utility for establishing a reference (or zero-strain) length of the ACL.ACL reference length was determined using three different methods for each of ten healthy participants. Using magnetic resonance and biplanar radiographic imaging techniques, we measured the length of the ACL during supine resting, quiet standing, and anterior/posterior (AP) drawer testing. During the AP drawer testing, the slack-taut transition point was defined as the inflection point of the AP translation vs ACL elongation curve.There was good consistency between the three ACL length measurements (ICC=0.80). Differences in mean ACL length between the three methods were within 1 mm.While determining the precise zero-strain length of the ACL in vivo remains a challenge, the reference positions utilized in this study produce consistent measurements of ACL length. These findings are important because reliable measurements of in vivo ACL strain have the potential to serve as indicators of propensity for injury.

Evaluation of the feasibility of equine in-vivo ultrasound technique for the medial branch of the dorsal ramus of the cervical spinal nerves

Ultrasound-guided local anaesthesia is commonly used in veterinary orthopaedics for horses. This study aimed to assess an in vivo ultrasound technique for the medial branch of the dorsal branch of the cervical spinal nerves (MB-DBCSNs) in horses and compare the performance of clinicians with different experience levels. Ten healthy, skeletally mature horses were examined using radiographic and ultrasound (US) techniques in the cervical area (C3–C7). Four operators with varying experience conducted US examinations using a 10 MHz linear and 6 MHz curvilinear transducer over ten training sessions. The number of cervical nerves visualized was recorded. A chi-square test was used to analyse the impact of training, anatomical location, and operator experience on the identification of facet joints. Operator agreement was evaluated with Cohen’s K test. The operators assessed 80 MB-DBCSNs, with radiographs and identified 70 healthy and 10 pathological facet joints. Training significantly improved visualization success, reaching 90% in later sessions. Cranial facet joints (C3–C5) were more frequently visualized (81%) than caudal ones (C5–C7) were (59%). US performance was influenced by the operator’s skill, and agreement among operators ranged from slight to fair. Overall, practice improved cervical nerve visualization in vivo, particularly for cranial nerves, but the technique requires a long learning curve because of low levels of operator agreement.

Three-dimensional assessment of subchondral arc and hip joint coverage angles in the asymptomatic young adult hip.

The primary objective of this study was to develop a custom algorithm to assess three-dimensional (3D) acetabular coverage of the femoral head based on surface models generated from computed tomography (CT) imaging. The secondary objective was to apply this algorithm to asymptomatic young adult hip joints to assess the regional 3D acetabular coverage variability and understand how these novel 3D metrics relate to traditional two-dimensional (2D) radiographic measurements of coverage. The algorithm developed automatically identifies the lateral- and medial-most edges of the acetabular lunate at one-degree intervals around the acetabular rim based on local radius of curvature. The acetabular edges and the center of a best-fit sphere to the femoral head are then used to compute the mean 3D subchondral arc angles and hip joint coverage angles in five acetabular octants. This algorithm was applied to hip models generated from pelvis/hip CT imaging or abdomen/pelvis CT angiograms of 50 patients between 17 and 25 years of age who had no history of congenital or developmental hip pathology, neuromuscular conditions, or bilateral pelvic and/or femoral fractures. Corresponding 2D acetabular coverage measures of lateral center edge angle (LCEA) and acetabular arc angle (AAA) were assessed on the patients' clinical or digitally reconstructed radiographs. The 3D subchondral arc angle in the superior region (58.0 [54.6-64.8] degrees) was significantly higher (p < 0.001) than all other acetabular subregions. The 3D hip joint coverage angle in the superior region (26.2 [20.7-28.5] degrees) was also significantly higher (p < 0.001) than all other acetabular subregions. 3D superior hip joint coverage angle demonstrated the strongest correlation with 2D LCEA (r = 0.649, p < 0.001), while 3D superior-anterior subchondral arc angle demonstrated the strongest correlation with 2D AAA (r = 0.718, p < 0.001). The 3D coverage metrics in the remaining acetabular regions did not strongly correlate with typical 2D radiographic measures. The discrepancy between standard 2D measures of radiographic acetabular coverage and actual 3D coverage identified on advanced imaging indicates potential discord between anatomic coverage and the standard clinical measures of coverage on 2D imaging. As 2D measurement of acetabular coverage is increasingly used to guide surgical decision-making to address acetabular deformities, this work would suggest that 3D measures of acetabular coverage may be important to help discriminate local coverage deficiencies, avoid inconsistencies resulting from differences in radiographic measurement techniques, and provide a better understanding of acetabular coverage in the hip joint, potentially altering surgical planning and guiding surgical technique.

Assessment of Diagnosis of Apical Root Fractures During Tooth Extraction Using Different Radiographic Techniques: An Ex-vivo Study

Objective: This study aimed to examine the diagnostic ability of different imaging techniques for apical root fractures that occur during tooth extraction by specialist dentists in different branches. Methods: Dry human mandibles used for education at Faculty of Dentistry and teeth extracted for routine treatment were used. After the root lengths were measured using a periodontal probe, the samples were adjusted to different lengths. These specimens were placed on a dry human mandible, and images were obtained and recorded using a periapical device, panoramic device, and computed tomography. Radiographs and recordings were performed by an oral and maxillofacial radiologist. The evaluation process was performed by an oral and maxillofacial radiologist, periodontologist, and oral and maxillofacial surgeon. Results: The diagnosis of 1 mm root presence and absence on periapical radiographs showed significant agreement among all observers. In the presence of 2 mm and 3 mm roots, all observers stated that the roots were present. On the panoramic radiographs, moderate agreement was observed in teeth with a 1 mm root. However, poor agreement between observers was observed for teeth with 2 mm and 3 mm roots. Cone-beam computed tomography (CBCT) was effective for the diagnosis of all observers. Conclusion: Consistent with the literature, the present study showed a higher interobserver agreement in CBCT. However, considering the patient's anxiety during the procedure, the duration of local anesthesia, and the surgeon's fatigue, two-dimensional radiographs are generally preferred over CBCT, which has a longer image processing time. Diagnosis using periapical radiographs was more effective than that using panoramic radiographs.

Analysis of the relationship between field size and change in radiation dose to patient and staff based on radiographic technique in fluoroscopy and radiography

In discussions of radiological protection issues in fluoroscopy and radiography the radiation field size is usually mentioned in connection with unnecessary irradiation of the patient’s body parts that do not need to be imaged. However, excessive expansion of the field size leads also to some other effects: the excessive irradiation of assistants and visualized part of patient's body as well as the change in dose rate at the entrance of patient’s body by automatic brightness control. The aim of the present paper is to describe the results of an experimental study of the dependence of such effects on irradiation field size and primary X-ray spectrum. The measurements were carried out in conditions close to those of barium meal test. To simulate the patient body, 5 acrylic plates measuring 30 cm high x 30 cm long x 3 cm thick each were used, totalling 15 cm thick. The X2 RF Sensor (RAYSAFE) was used to measure the dose rate at the entrance and exit surface of the simulator and the specific model for measuring leakage and dispersion, the X2 Survey sensor (RAYSAFE), was used to measure the occupational dose rate. The occupational dose rate detector was located at the position that assistant usually maintains to support the patient's head and/or to administer the contrast. The results show that in radiographic mode dose rate at the exit of the patient’s body increases with the increase of field size. This increase reaches 85%. The increase of occupational dose rate in radiographic mode reaches 850% and is linearly proportional to the field area. In fluoroscopic mode, dose rate at the entrance of the patient’s body decreases proportionally to the increase of field side length because of the automatic brightness control. This effect reaches 25% with grid and 50% without grid.

Comparative evaluation of efficacy in working length determination: Radiography versus Electronic apex locators using in vivo and ex vivo methods with stereomicroscope validation.

Accurate determination of the working length (WL) is crucial for successful endodontic treatment. Various methods, including radiography and electronic apex locators (EALs), are employed for WL measurement, each with its advantages and limitations. This study aimed to compare the accuracy of WL determination using conventional radiography and the Root ZX Mini EAL against an ex vivo gold standard method. Fifty single-rooted teeth scheduled for extraction were included. WLs were determined using radiography (Grossman's method) and the Root ZX Mini EAL. An ex vivo method served as the gold standard with WL carried out on extracted teeth under a stereomicroscope. Statistical analysis included Paired samples t-test, Chi-square test, and Bland-Altman plots. The mean WL values were comparable among methods, with slight variations in precision. The Root ZX Mini EAL demonstrated significantly lower mean absolute error compared to radiography (P < 0.001). Accuracy within ± 0.5 mm and ± 1 mm tolerance ranges favored the EAL over radiography (P = 0.04 and P = 0.004, respectively). The Root ZX Mini EAL exhibited superior accuracy and lower error rates in WL determination compared to radiography. Integrating EALs alongside radiographic techniques is recommended to optimize WL precision in clinical practice.

Development of physiologically relevant synthetic thrombus for use in visual analysis of in vitro mechanical thrombectomy device testing

BackgroundIschemic stroke is a leading cause of death and significant long-term disability worldwide. Mechanical thrombectomy is emerging as a standard treatment for eligible patients. As clinical implementation of stent retrieval...

Analysis of palatal rugae pattern and maxillary sinus index for gender determination.

Correlation between rugoscopy and lateral cephalometric radiographic technique for gender determination is of interest. A cross sectional study was conducted on 100 subjects within an age group of 20 to 50 years. Distribution of rugae patterns and morphometric analysis of maxillary sinus was done for gender correlation. Wavy curved and straight rugae patterns were observed to be more in female gender as compared to males. The mean MSI was higher in females (1.32) when compared with males (1.26). Both the morphometric analysis of maxillary sinus and rugoscopy has been proved to be a valuable tool in the assessment of sexual dimorphism. But, morphometric analysis of maxillary sinus is relatively a new and reliable method for gender determination using maxillary sinus index.

Epidemiology and diagnosis of metabolic dysfunction-associated fatty liver disease

The most common chronic liver illness worldwide is metabolic dysfunction linked to fatty liver disease (MAFLD), which is poorly understood by doctors and patients. Many people with this disease develop steatohepatitis, cirrhosis and its consequences, as well as extrahepatic manifestations; these conditions are particularly common if they are linked to diabetes mellitus or obesity. A breakthrough with numerous benefits is the switch from NAFLD to MAFLD in terms of terminology and methodology. The diagnosis of MAFLD is based on affirmative criteria; unlike NAFLD, it is no longer based on exclusion. The diagnosis of MAFLD and the evaluation of steatosis and fibrosis is achieved using liver biopsy and non-invasive laboratory or radiographic techniques. We briefly address the most recent developments in MAFLD epidemiology and diagnosis.