Radioactive Isotopes Of Iodine Research Articles

Characteristics of exposure to radioactive iodine during a nuclear incident.

During a nuclear accident, numerous products of nuclear fission are released, including isotopes of radioactive iodine. Among them is iodine-131, with a half-life of 8.02 days, which emits β radiation. For decades, it has been effectively and safely used in medicine. However, in the event of a nuclear accident, uncontrolled exposure can have harmful biological effects. The main sources of internal contamination with iodine-131 are contaminated air, food and water. The most exposed organ is the thyroid gland, where radioactive iodine accumulates via the Na+/I- symporter (NIS). NIS does not distinguish between radioactive iodine isotopes and the stable isotope iodine-127, which is essential for the synthesis of thyroid hormones. Exposure to radioactive iodine during a nuclear accident is primarily associated with papillary thyroid cancer, whose incidence begins to increase a few years after exposure. Children and adolescents are at the highest risk, and the risk is particularly significant for individuals living in iodine-deficient areas. Ensuring an adequate iodine supply is therefore crucial for lowering the risk of the harmful effects of exposure to radioactive iodine at the population level. Protecting the thyroid with potassium iodide tablets significantly reduces radiation exposure, as stable iodine prevents the entry of radioactive iodine into the thyroid. Such protection is effective only within a narrow time window - a few hours before and after the exposure and is recommended only for those under 40 years of age, as the risks of excessive iodine intake outweigh the potential benefits in older individuals.

N-Heteroatom Engineered Nonporous Amorphous Self-Assembled Coordination Cages for Capture and Storage of Iodine.

Radioactive iodine isotopes from nuclear-related activities, present substantial risks to human health and the environment. Developing effective materials for the capture and storage of these hazardous molecules is paramount. Traditionally, nonporous solids were historically considered ineffective for adsorbing target species. In this study, we investigate the potential of four nonporous, amorphous, self-assembled coordination cages (C1, C2, C3, and C4) featuring varying numbers of nitrogen atoms within the core (pyridyl/triazine unit) and specific cavity sizes for iodine adsorption. These coordination cages demonstrate remarkable adsorption abilities for iodine in both vapor and solution phases, facilitated by enhanced electron-pair interactions. The cages exhibit high uptake capacities of up to 3.16 g g-1 at 75 °C, the highest among metal-organic cages and up to 434.29 mg g-1 in solution, highlighting the efficiency of these materials across different phases. Even at ambient temperature, they show significant iodine capture efficiency, with a maximum value of 1.5 g g-1. Furthermore, these robust materials can be recycled, enduring at least five reusable cycles without apparent fatigue. Overall, our findings present a "N-heteroatom engineering" approach for the development of recyclable amorphous containers for the capture and storage of iodine, contributing to the mitigation of nuclear-related risks.

Impact of (nano ZnO/multi-wall CNTs) prepared by arc discharge method on the removal efficiency of stable iodine 127I and radioactive iodine 131I from water

Radioactive iodine isotopes especially 131I are used for diagnosis and treatment of different types of cancer diseases. Due to the leak of radioactive iodine into the patient’s urine in turn, the wastewater would be contaminated, so it is worth preparing a novel adsorption green material to remove the radioactive iodine from wastewater efficiently. The removal of 127I and 131I contaminants from aqueous solution is a problem of interest. Therefore, this work presents a new study for removing the stable iodine 127I− and radioactive iodine 131I from aqueous solutions by using the novel nano adsorbent (Nano ZnO/MWCNTs) which is synthesized by the arc discharge method. It is an economic method for treating contaminated water from undesired dissolved iodine isotopes. The optimal conditions for maximum removal are (5 mg/100 ml) as optimum dose with shacking (200 rpm) for contact time of (60 min), at (25 °C) in an acidic medium of (pH = 5). After the adsorption process, the solution is filtrated and the residual iodide (127I−) is measured at a maximum UV wavelength absorbance of 225 nm. The maximum adsorption capacity is (15.25 mg/g); therefore the prepared nano adsorbent (Nano ZnO/MWCNTs) is suitable for treating polluted water from low iodide concentrations. The adsorption mechanism of 127I− on to the surface of (Nano ZnO/MWCNTs) is multilayer physical adsorption according to Freundlich isotherm model and obeys the Pseudo-first order kinetic model. According to Temkin isotherm model the adsorption is exothermic. The removal efficiency of Nano ZnO/MWCNTs for stable iodine (127I−) from aqueous solutions has reached 97.23%, 89.75%, and 64.78% in case of initial concentrations; 0.1843 ppm, 0.5014 ppm and 1.0331 ppm, respectively. For the prepared radio iodine (131I−) solution of radioactivity (20 µCi), the dose of nano adsorbent was (10 mg/100 ml) and the contact time was (60 min) at (pH = 5) with shacking (200 rpm) at (25 °C). The filtration process was done by using a syringe filter of a pore size (450 nm) after 2 days to equilibrate. The removal efficiency reached (34.16%) after the first cycle of treatment and the percentage of residual radio iodine was (65.86%). The removal efficiency reached (94.76%) after five cycles of treatment and the percentage of residual radio iodine was (5.24%). This last percentage was less than (42.15%) which produces due to the natural decay during 10 days.

Iodide ion-imprinted chitosan beads for highly selective adsorption for nuclear wastewater treatment applications

Iodide ions from radioactive iodine isotopes are common contaminants present in nuclear wastewater from nuclear power plants which are considered hazardous contaminants to be released in water sources even at low concentrations due to their association with metabolic disorders, therefore its removal from the nuclear wastewater effluents is necessary. Chitosan beads are natural and cost-efficient adsorbents that have been used for ion removal from wastewater. However, issues of poor selectivity persist in achieving high-efficiency iodide ion removal. In this study, ion-imprinted chitosan beads (IIC) have been synthesized using the phase-inversion method, IIC beads were modified by cross-linking with epichlorohydrin (IIC-EPI) and modified by cross-linking with epichlorohydrin and silicon dioxide nanoparticles (IIC–SiO2-EPI). Through 4 h of batch adsorption experiments, IIC beads achieved a maximum adsorption capacity (Qe) of 0.65 mmol g−1 and showed more preference for the iodide ions compared to the non-imprinted chitosan beads which achieved a maximum adsorption capacity of 0.27 mmol g−1 at pH 7. While the modified beads IIC-EPI and IIC-SiO2-EPI beads have boosted the adsorption capacities to 0.72 mmol g−1 and 0.91 mmol g−1. Scanning electron microscopic cross-sectional images have shown more pores and cavities than the surface images which agrees with the multilayer heterogeneous diffusion suggested by the Freundlich adsorption isotherm, that the experimental data has fitted. Adsorption kinetic data have fitted the Pseudo-second-order model as well as the Weber and Morris intraparticle model, which suggest an intraparticle pore diffusion adsorption mechanism, with the involvement of the physical electrostatic interactions with the cationic chitosan surface.

Synthesis of magnetic-responsive imidazole-based poly (ionic liquid)s as a recycle adsorbent for simultaneously removing iodine molecules and iodide ions

Nuclear waste management and nuclear energy generation require the proper disposal of 129I and 131I, which are radioactive isotopes of iodine. For recognition of different types’ iodine, a magnetic poly (ionic liquid)s (Fe3O4@SiO2-MPS-PILs) was formed by the selected imidazole ionic liquid monomer and core–shell Fe3O4@SiO2-MPS via free radical polymerization. The resulting adsorbent containing plenty of imidazole N-heterocycle units, benzene rings, and ionic bonds in the backbones was suitable for simultaneously adsorbing iodine molecules and iodide ions. The adsorption mechanisms for iodine in cyclohexane and iodide ions from aqueous solution were based on charge transfer and ion exchange mechanisms, respectively. The adsorption equilibrium for iodine in cyclohexane was attained at 12 h, and the kinetics of iodine adsorption closely followed the pseudo-second-order model. Iodine adsorption on Fe3O4@SiO2-MPS-PILs was best described by Langmuir model with a maximum iodine adsorption capacity of approximately 714.29 mg g−1. Iodide ions adsorption was best explained with Freundlich model and a maximum adsorption capacity of 335.80 mg g−1 was achieved in an iodide solution with a 500 mg L–1 concentration. Notably, Fe3O4@SiO2-MPS-PILs retained over 90 % of its original adsorption performance after the 5th cycle. This work proves that the adsorbent Fe3O4@SiO2-MPS-PILs was efficient and recyclable, and has good application prospects in the practical treatment of iodine and iodide.

Microbial involvement in iodine cycle: mechanisms and potential applications.

Stable iodine isotopes are essential for humans as they are necessary for producing thyroid gland hormones. However, there are hazardous radioactive iodine isotopes that are emitted into the environment through radioactive waste generated by nuclear power plants, nuclear weapon tests, and medical practice. Due to the biophilic character of iodine radionuclides and their enormous biomagnification potential, their elimination from contaminated environments is essential to prevent the spread of radioactive pollution in ecosystems. Since microorganisms play a vital role in controlling iodine cycling and fate in the environment, they also can be efficiently utilized in solving the issue of contamination spread. Thus, this paper summarizes all known on microbial processes that are involved in iodine transformation to highlight their prospects in remediation of the sites contaminated with radioactive iodine isotopes.

Highly effective liquid and solid phase extraction methods to concentrate radioiodine isotopes for radioiodination chemistry.

Radioactive iodine isotopes play a pivotal role in radiopharmaceuticals. Large-scale production of multi-patient dose of radioiodinated nuclear medicines requires high concentration of radioiodine. We demonstrate that tetrabutylammonium chloride and methyltrioctylamonium chloride are effective phase transfer reagents to concentrate iodide-124, iodide-125 and iodide-131 from the corresponding commercial water solutions. The resulting concentrated radioiodide, in the presence of either phase transfer reagent, does not hamper the chemical reactivity of aqueous radioiodide in the copper (II)-mediated one-pot three-component click chemistry to produce radioiodinated iodotriazoles.

Selective removal of radioactive iodine from water using reusable Fe@Pt adsorbents

Environmental damage from serious nuclear accidents should be urgently restored, which needs the removal of radioactive species. Radioactive iodine isotopes are particularly problematic for human health because they are released in large amounts and retain radioactivity for a substantial time. Herein, we prepare platinum-coated iron nanoparticles (Fe@Pt) as a highly selective and reusable adsorbent for iodine species, i.e., iodide (I−), iodine (I2), and methyl iodide (CH3I). Fe@Pt selectively separates iodine species from seawater and groundwater with a removal efficiency ≥ 99.8%. The maximum adsorption capacity for the iodine atom of all three iodine species was determined to be 25 mg/g. The magnetic properties of Fe@Pt allow for the facile recovery and reuse of Fe@Pt, which remains stable with high efficiency (97.5%) over 100 uses without structural and functional degradation in liquid media. Practical application to the removal of radioactive 129I and feasibility for scale-up using a 20 L system demonstrate that Fe@Pt can function as a reusable adsorbent for the selective removal of iodine species. This systematic procedure is a standard protocol for designing highly active adsorbents for the clean separation and removal of various chemical species dissolved in wastewater.

Important effects of relative humidity on the formation processes of iodine oxide particles from CH3I photo-oxidation

In this work, laboratory chamber experiments of gas-phase methyl iodide photolysis in the presence of ozone at three relative humidity conditions were performed to study the formation and physico-chemical properties of iodine oxide particles. The obtained results revealed significant morphological changes of iodine oxide particles that were observed to depend on relative humidity. The formed iodine oxide particles under dry conditions were supposed to be agglomerates of fine hygroscopic crystals. On the other hand, a humid atmosphere was observed to favor the formation of isomeric, tetragonal and orthorhombic hygroscopic crystals potentially composed of HIO3 likely formed from progressive hydration of iodine oxide clusters. This process leads to a release of molecular iodine, I2, which may indicate a potential role of I2O4 in the particles’ evolution processes. The obtained results on the iodine oxides’ behavior are important to the nuclear power plant safety industry since many of the organic iodides that may be released during a major nuclear power-plant accident contain radioactive isotopes of iodine that are known to have lethal or toxic impacts on human health.

Simultaneous SPECT imaging with 123I and 125I - a practical approach to assessing a drug and its carrier at the same time with dual imaging

Radiolabeling of a drug with radioactive iodine is a good method to determine its pharmacokinetics and biodistribution in vivo that only minimally alters its physicochemical properties. With dual labeling, using the two radioactive iodine isotopes 123I and 125I, two different drugs can be evaluated at the same time, or one can follow both a drug and its drug delivery system using a single photon emission computed tomography (SPECT) imager. One difficulty is that the two radioisotopes have overlapping gamma spectra. Our aim was therefore to develop a technique that overcomes this problem and allows for quantitative analysis of the two radioisotopes present at varied isotope ratios. For this purpose, we developed a simple method that included scatter and attenuation corrections and fully compensated for 123I/125I crosstalk, and then tested it in phantom measurements. The method was applied to the study of an orally administered lipid formulation for the delivery of fenofibrate in rats. To directly compare a traditional study, where fenofibrate was determined in plasma samples to SPECT imaging with 123I-labeled fenofibrate and 125I-labeled triolein over 24 h, the drug concentrations were converted to standardized uptake values (SUVs), an unusual unit for pharmaceutical scientists, but the standard unit for radiologists. A generally good agreement between the traditional and the radioactive imaging method was found in the pharmacokinetics and biodistribution results. Small differences are discussed in detail. Overall, SPECT imaging is an excellent method to pilot a new formulation with just a few animals, replaces blood sampling, and can very quickly highlight potential administration problems, the excretion pathways and the kinetics. Furthermore, dual labeling with the two radioisotopes 123I and 125I clearly shows if a drug and its drug delivery system stay together when traveling through the body, if slow drug release takes place, and where degradation/excretion of the components occurs.

Evaluation of radioiodine (129I) dissolution from sediment of a brackish lake beside a spent nuclear fuel reprocessing plant in Japan

Dissolution fluxes of stable (127I) and radioactive (129I) isotopes of iodine from a brackish lake sediment beside a spent nuclear fuel reprocessing plant in Japan were evaluated through two kinds of experiments: incubation using a sediment core sample for 24 h, and observation of 127I and 129I concentrations in sedimentary pore water. For 127I, the dissolution flux evaluated in the incubation experiment was comparable with that obtained from the vertical gradient of 127I concentration in pore water in the observation experiment. This suggests that degradation of organic matter in the surface sediment is an important source of dissolved 127I found in the water. For 129I, the dissolution flux estimated in the incubation experiment showed negative values, indicating the transfer of 129I to the sediment from the overlying water (i.e., absorption). Moreover, the flux evaluated from the observation experiment was positive. This result suggests that degradation of organic matter in the surface sediment is scarcely important to the supply of 129I from the sediment to the water in the studied lake. The dissolution flux of 129I estimated in the observation experiment was smaller than the absorption flux of 129I in the incubation experiment. This potentially indicates that the dissolution of sedimentary 129I does not significantly change 129I concentrations in the water and sediment of the lake. This hypothesis was consistent with previous research conducted for the studied lake.

EXPERIMENTAL MODELS OF THE HYPOTHYROIDISM

Hypothyroidism is a systemic chronic disease that occurs as a result of a deficiency of thyroid hormones (thyroid hormones): triiodothyronine and tetraiodothyronine (thyroxine). Targets of thyroid hormones are almost all organs and tissues of the human body, which explains the variety of clinical manifestations that occur when these hormones are deficient. Recently, basic research through the use of experimental models has become more relevant and allowed us to obtain a number of new morphological and functional changes that occur in hypothyroidism. This review discusses the main experimental models of hypothyroidism: surgical, radioactive, dietary, anti-thyroid administration and genetics’ model. The main principle of the surgical model of hypothyroidism is to remove the thyroid gland. The radioactive model is based on the introduction of a radioactive isotope of iodine to laboratory animals. The dietary model is based on the use of a special diet with a limited amount of iodine. The drug model is based on the introduction of antithyroid drugs - methylimidazole and propylthiouracil. The principle of the genetic model consists in special genetic manipulations with the genome of laboratory animals. The advantages and disadvantages of each model are discussed. The use of sophisticated equipment has brought specialists closer to a more complete and holistic understanding of the morphological and functional manifestations of hypothyroidism. Researching of experimental models is an important tool in relation to the studying of the mechanisms underlying hypothyroidism and, as a result, in improving prevention and treatment-diagnostic strategies.

Mass spectrometry – based imaging techniques for iodine-127 and iodine-129 detection and localization in the brown alga Laminaria digitata

129I is one of the main radioisotopes of iodine derived from the nuclear fuel cycle that can be found sustainably in the environment due to its long half-life. In coastal marine environment, brown macroalgae, such laminariales (or kelps), are known to naturally feature highest rates of iodine accumulation, and to be an important source of biogenic volatile iodinated compounds released to the atmosphere. These seaweeds are therefore likely to be significantly marked by but also potential vectors of radioactive iodine. In order to better understand the chemical and isotopic speciation of iodine in brown algal tissues, we combined mass spectrometry-based imaging approaches in natural samples of Laminaria digitata young sporophytes, collected at two different locations along the south coast of the English Channel (Roscoff and Goury). Laser desorption ionization (LDI) and desorption electrospray-ionization techniques (DESI), coupled with mass spectrometry, confirmed the predominance of inorganic I− species on the surface of fresh algae, and a peripheral iodine localization when applied on micro-sections. Moreover, radioactive isotope 129I was not detected on plantlet surface or in stipe sections of algal samples collected near Roscoff but was detected in L. digitata samples collected at Goury, near La Hague, where controlled liquid radioactive discharges from the ORANO La Hague reprocessing plant occur. At the subcellular scale, cryo-fixed micro-sections of algal blade samples from both sites were further analyzed by secondary ion mass spectrometry (nano-SIMS), leading to similar results. Even if the signal detected for 129I was much weaker than for 127I in samples from Goury, the chemical imaging revealed some differences in extracellular distribution between radioactive and stable iodine isotopes. Altogether LDI and nano-SIMS are complementary and powerful techniques for the detection and localization of iodine isotopes in algal samples, and for a better understanding of radioactive and stable iodine uptake mechanisms in the marine environment.

Update on diagnosis and treatment of hyperthyroidism: ultrasonography and functional imaging.

Ultrasonography and radionuclide imaging using [99mTc]Pertechnetate or radioactive iodine isotopes are essential tools used during the diagnostic workup of hyperthyroidism with or without structural alterations of the thyroid. Color duplex sonography and ultrasound elastography may add important information to find the cause of the hormone excess. During the last few years, hybrid imaging using SPECT/-(CT) or PET-based methods, such as [124]Iodine-PET/CT or [124]Iodine-PET/ultrasound have been increasingly used, playing a role in the context of localizing ectopic thyroid tissue or in multinodular goiter. Recently, promising data has been published on the use of [99mTc]MIBI imaging in amiodarone induced hyperthyroidism.

Esophageal stenting for unresectable cancer (review of literature)

To date, the main way to stop dysphagia for patients with unresectable esophageal cancer is stenting. Being widely accepted and effective, this technique, however, allows for oral nutrition only for an average of 3–4 months and is accompanied by the development of a wide range of complications. Recent Russian and foreign publications in the field show that evaluation of the effectiveness of the stenting technique, including analysis of possibility of complications development, is important for practical application. To improve long-term outcomes, the potential trends in the method evolution have already been identified. The stents coated with radioactive isotopes of iodine are among of the actively used novelties. Application of 3D printing for the manufacture of custom-tailored stents, as well as the inclusion of chemotherapeutic agents in the coating of self-expanding metal stents seem promising approach. The search for a «perfect stent» continues under paradigm of personalization.

Fundamental principles and techniques of experimental modeling of hypothyroidism: a literature review

The purpose of our paper is to discuss principles and techniques of experimental modeling of hypothyroidism in laboratory animals, as well as reviewing advantages and disadvantages of experimental models. Materials and methods. Comparative analysis of contemporary international biological and medical publications in PubMed/MEDLINE and Embase databases; analysis of contemporary national scientific sources using Google Scholar database. Results. To date, there are six basic principles of experimental modeling of hypothyroidism, i.e.: dietary, drug, surgical, immunological, radioisotope, genetic. Each of the techniques can be used for simulation of the main conditions for hypothyroidism development. Dietary modeling stands for the iodine intake restriction because iodine is an indispensable component in thyroid hormones synthesis. Drug modeling means the use of antithyroid drugs that block thyroid hormones synthesis. Surgical modeling principle involves thyroidectomy. The principle of immunological modeling of hypothyroidism consists in administration of immunosuppressants to animal body. The principle of radioisotope modeling of hypothyroidism lies in acting with a radioactive isotope of iodine on animal body. Genetic modeling principle leads to stimulation of gene mutations in laboratory animals to encode the thyroid hormones formation or their receptors, and results in appearance of the transcription factors responsible for development of the thyroid gland. Conclusion. Hypothyroidism is a very common pathological condition affecting many organs and tissues. Thus, employment of the hypothyroidism experimental models to study fundamental pathophysiological and pathomorphological processes represents a scientific and research topic of immediate interest. Each of the hypothyroidism modeling principles is specific, and provides for simulation of particular conditions needed for hypothyroidism development in laboratory animals. Taking into consideration numerous beneficial effects of thyroid hormones upon almost all organs and tissues of human body, it is noteworthy that experimental models of hypothyroidism shall be highly sought after by researchers practicing in all medical specialties.

The new method for obtaining titanosilicate AM-4 and its decationated form: Crystal chemistry, properties and advanced areas of application

Abstract Layered microporous titanosilicate AM-4 (Aveiro-Manchester-4) is a synthetic analog of microporous lintisite-type minerals. We applied the hydrothermal method to synthesize AM-4 compound from different titanium sources, i.e. titanium (III) chloride solution, titanyl-sulfate (titanite ore treatment product) and sodium metasilicate by stepwise cooling of an initial titanium-silicate mixture. In acid solution the crystal structure of AM-4 transformed into a novel layered titanosilicate SL3 (synthetic decationated lintisite) with a unique topology that consists of Ti2Si4O10(OH)4 nano-blocks. It was found that SL3 compound had a tendency for uptake of Ag from the standard test copper-nickel electrolyte. A possibility of repeated use of SL3 as a renewable sorbent was shown on the example of sorption Ca2+ cations. Both AM-4 and SL3 compounds can be considered as new functional materials of renewable and thermally stable nature with potential application for sorption and immobilization of the radioactive iodine isotopes.

Учет физико-химических форм йода-131 для определения радиационного воздействия выбросов при нормальной эксплуатации промышленной реакторной установки на ФГУП «ПО «Маяк»

The determination of the physicochemical forms of radioiodine in the gas-air environment of an industrial nuclear reactor is necessary to solve related problems – technological control and radiation safety. In the technological context, the results obtained make it possible to adequately assess the efficiency of purification of emissions of radioactive iodine isotopes, the choice of instruments and methods for controlling emissions. In the context of radiation safety, research results make it possible to correctly assess the radiation effects on the environment and humans, substantiation of emission standards for the atmosphere and confirmation of the safety of operation of an industrial reactor installation. The research method is based on the difference in the deposition of radioiodine on a set of one AFA-RMP aerosol filter and six filters of the AFA-SI type, which makes it possible to separately determine the 131I aerosol, easily and hardly sorbed form. It has been shown that the non-purified gas-aerosol mixture mainly contains radioactive iodine in the form of gaseous hardly adsorbed compounds. For 131I, the most probable percentage in volumetric activity of hardly adsorbed, easily adsorbed compounds and iodine aerosols was obtained. Based on the data obtained, an assessment of dose loads was carried out taking into account the annual emissions of the reactor installation and weather conditions. A conservative approach to assessing the radiation exposure of 131I emissions is 47 times higher than the assessment taking into account its physicochemical forms.

Synthesis of Conjugated Mesoporous Hyper-cross-linked Polymers for Efficient Capture of Dibenzothiophene and Iodine.

Porous organic polymers have recently received great attention because of their promising applications in the removal of thiophene compounds in liquid fuels and for the nuclear waste (such as radioactive iodine isotopes) treatments. Herein, a series of conjugated mesoporous hyper-cross-linked polymers (CMHPs) were prepared through our newly developed silicon-promoted cationic polymerization in a straightforward manner. The CMHPs exhibited extended π-conjugation, intrinsic porosity, high surface area, and excellent physicochemical stability. They showed an outstanding dibenzothiophene uptake capacity of ∼1335 mg g-1, which far exceeded many reported porous organic polymers. Meanwhile, these CMHPs showed high adsorption capacity for iodine vapor. Altogether, the CMHPs prepared by the facile and metal-free cationic reactions have great potential in adsorption of harmful substances and environmental protection.

Evaluation of decontamination factor of radioactive methyl iodide on activated carbons at high humid conditions

Radioactive iodine (131I) released from nuclear power plants has been a critical environmental concern for workers. The effective trapping of radioactive iodine isotopes from the off-gas stream generated from nuclear facilities is an important issue in radioactive waste treatment systems evaluation. Numerous studies on retaining methyl iodide (CH3I131) by impregnated activated carbons under the high content of moisture have been extensively studied so far. But there have been no good results on how to remove methyl iodide at high humid conditions up to now. A new challenge is to introduce other promising impregnating chemical agents that are able to uptake enough radioactive methyl iodide under high humid conditions. In order to develop a good removal efficiency to control radioiodine gas generated from a high humid process, activated carbons (ACs) impregnated with triethylene diamine (TEDA) and qinuclidine (QUID) were prepared. In addition, the removal efficiencies of the activated carbons (ACs) under humid conditions up to 95% RH were evaluated by applying the standard method specified in ASTM-D3808. Quinuclidine impregnated activated carbon showed a much higher decontamination factor above 1,000, which is enough to meet the regulation index for the iodine filters in nuclear power plants (NPPs).