More data and information is being captured from systems, machines, and devices and made available to industrial information technology (IT) systems. The information is processed on-the-fly, enabling IT-based management systems to generate updated information for real-time control of the manufacturing processes. This data capturing and collection for IT systems is often referred to as the Internet of Things (IoT). When adopted to the industrial requirements, such as robustness, reliability, timeliness, and security, it is often termed as the industrial IoT (IIoT) [A1]. IIoT has attracted the attention of both the industry and academia since it is expected to enhance day-to-day activities, create new business models, products, and services, and as a broad source of research topics and ideas. Meanwhile, it is envisioned that the fifth-generation (5G) networks will be a cornerstone in future wireless industrial connectivity, and currently, there are multitude of ongoing research efforts in their design and optimization. Future industries willembrace use cases with numerous wireless-connected sensors and devices, and judging by the demand, massive machine-type communication and ultra-reliable low-latency communication (URLLC) in the literature and standardization activities, have been identified as two of the three main communication scenarios for 5G. These scenarios demand intelligent, scalable, and robust radio access techniques, network architectures, and deployment options to meet industrial demands [A2]. Therefore, more in-depth research is needed for IIoT and sensor networks in 5G-and-beyond wireless communication systems to address various challenges, including the following. 1)Transmit power control policy should be judiciously designed to improve both the spectrum efficiency and energy efficiency effectively; higher transmit powers can improve reliability but increase the interference and battery consumption. 2)Low-latency communication and computing is one of the significant challenges in 5G-and-beyond IIoT; uploading the device data to the cloud computing centers has high latency and resources waste issues in sensor networks. 3)Addressing privacy and security problems [A3] in the 5G-IIoT is fundamental to the further development and spread of 5G-IIoT. 4)Reliability and latency requirements of URLLC services, requiring less than 1-ms user plane latency and higher than 99.999% reliability, are demanding to meet, especially in time-varying industrial wireless channels. 5)Radio resource allocation, sharing, and isolation with performance guarantees under dynamic traffic conditions are critical issues for emerging IIoT applications requiring real-time support of massive connected devices. 6)5G-and-beyond IIoT networks must satisfy industrial-grade coverage, capacity, time-sensitive networking, and over-the-air time synchronization requirements [A4].