Some have called bitcoin a real bubble, while, according to others, it is the most radical invention of the twenty-first century. Nevertheless, there is a consensus regarding the disruptive potential of blockchain technology, which is the basis of bitcoin and other similar cryptocurrencies. As the interest in these digital currencies is growing, many vendors around the globe now accept payments in blockchain-based currencies. However, not much is known about how individuals around the world would react to using blockchain-based currencies as spending currencies. Given the global reach of these currencies, in this study, we explore the role of national cultural values in influencing individuals’ willingness to use blockchain-based currencies. To do so, we collected survey data from the U.S. and India. We found that national cultural values (collectivism, power distance, masculinism, uncertainty avoidance, and long-term orientation) significantly affect blockchain-based currency usage.