Drawing on a sensemaking perspective, this study aims to theoretically and empirically investigate the effects of PCPA on radical innovation and how regulatory uncertainty and technological uncertainty affect firms’ choice of PCPA as well as its effectiveness on radical innovation. Hierarchical regression analyses are conducted to test the research model based on survey data collected from 227 manufacturing firms in China. The results indicated that PCPA has a significant positive effect on radical innovation. Both regulatory uncertainty and technological uncertainty relate positively to PCPA. In addition, regulatory uncertainty strengthens the positive relationship between PCPA and radical innovation, while technological uncertainty weakens the relationship. Our findings offer fresh insights into the use of PCPA to manage the uncertain external environment when pursuing radical innovation activities in China.