Types Of Radiation Research Articles

SMP30 Alleviates Oxidative Stress and Regulates Ca2+-ATPase Activity in UVR-B-Induced Cataracts in Rats

Purpose Oxidative stress, ultraviolet radiation, and calcium imbalance are key components in the onset and advancement of cataract, which continue to be the leading cause of blindness globally. An important newly discovered aging maker, Senescence marker protein 30 (SMP30) regulates calcium and participates in mitigating oxidative stress damage. Here, we examined the beneficial role of SMP30 in protecting against ultraviolet radiation type B (UVR-B)-induced cataract in rats. Methods Wistar rats (2 months) were arbitrarily assigned into 4 groups of 10 rats. These groups included the Control group, UVR-B group, adeno-associated virus 2 vectors negative control (AAV2-NC) group, and adeno-associated virus 2-mediated overexpression of SMP30 (AAV2-SMP30) group. The control group received Phosphate-buffered saline (PBS) via injection, while the AAV2-NC group and AAV-SMP30 group were separately injected with AAV2-NC and AAV2-SMP30 vectors. In addition to the control group, the remaining three experimental groups were subjected to ultraviolet light exposure 4 weeks post-injection. The lens opacity was examined by stereoscopic microscope, and the lenses were separated to measure oxidative damage parameters particularly superoxide dismutase (SOD), glutathione peroxidase (GPX), and Ca2+-ATPase activity. The localization and expression of SMP30 and Ca2+-ATPase in the lenses were determined using immunohistochemistry and RT-qPCR. Results After UVR-B irradiation, the AAV2-SMP30 group exhibited a substantial decrease in lens opacity compared to the UVR-B group. The results revealed a notable downregulation of SMP30 expression and the activities of SOD, GPX, and Ca2+-ATPase of rat lens following exposure to UVR-B radiation. However, SMP30 overexpression partially reversed these effects. In vivo experiments demonstrated SMP30 overexpression attenuated the UVR-B-induced decline in SOD, GPX, and Ca2+-ATPase activities. Conclusion This study demonstrates that SMP30 has the potential to reduce lens opacity caused by UVR-B by increasing antioxidant stress and regulating Ca2+-ATPase activity. SMP30 might be a cutting-edge target for the treatment of cataracts.

Broccoli Byproduct Extracts Attenuate the Expression of UVB-Induced Proinflammatory Cytokines in HaCaT Keratinocytes

Broccoli byproducts are an important source of bioactive compounds, which provide important benefits for human skin due mainly to their antioxidant and anti-inflammatory properties. The primary target of UVB radiation is the basal layer of cells in the epidermis, with keratinocytes being the most abundant cell population in this layer. Given the wide range of side effects caused by exposure to UVB radiation, reducing the amount of UV light that penetrates the skin and strengthening the protective mechanisms of the skin are interesting strategies for the prevention of skin disorders. This work aims to evaluate the protective mechanisms triggered by broccoli by-products extract (BBE) on HaCaT keratinocytes exposed to UVB radiation as well as the study of the regenerative effect of these extracts on the barrier of skin keratinocytes damaged by superficial wounds as a strategy to revalorize this agricultural waste. The results obtained revealed that the BBEs exhibited a high cytoprotective effect on the HaCaT exposed to UVB light, allowing it to effectively reduce the intracellular content of ROS, as well as effectively attenuating the increase in proinflammatory cytokines (IL-1β, IL-6, IL-78, TNF-α) and COX-2 induced by this type of radiation. Furthermore, the BBE could be an excellent regenerative agent for skin wound repair, accelerating the migration capacity of keratinocytes thus contributing to the valorization of this byproduct as a valuable ingredient in cosmetic formulations.

Improving Treatment Quality of Gynecologic Cancers with Online Adaptive Brachytherapy Using Deep Learning-Based CT Imaging

This study proposes a framework for online adaptive three-dimensional (3D) brachytherapy, a type of radiation therapy used to treat gynecological cancers such as cervical and endometrial cancers. Intracavitary brachytherapy is used to deliver a high dose of radiation directly to the tumor, while minimizing exposure to the surrounding normal tissue. Maintaining accurate reproducibility of radiation dose delivery during each treatment session is important. The proposed framework uses a C-arm-based integrated online imaging system for computed tomography (CT) and single-photon emission computed tomography (SPECT) to detect changes in the treatment conditions and improve treatment quality. The C-arm CT system acquires 3D images by obtaining two-dimensional image data at limited rotation angles, which are less than the complete 360° range of rotation. However, images obtained with limited angular rotation have poor image quality and many artifacts. To overcome this limitation, a deep learning technique was applied to eliminate these artifacts and improve image quality. This study evaluated the auto-segmentation performance of ground truth (GT) images, limited-angle C-arm cone-beam CT images, and C-arm CT images corrected using deep learning. We used the Dice similarity coefficient and Hausdorff distance to quantitatively evaluate the auto-segmentation performance of major organs in the pelvic region. Although slight differences were observed in certain areas, the auto-segmentation results demonstrated an overall high performance, similar to that of the GT image. The results showed that the proposed framework can establish an optimal treatment plan by quickly and accurately calculating the patient's internal radiation dose distribution. This study demonstrates the potential of deep learning-based high-quality CT imaging techniques and auto-contouring techniques for major organs within images to improve the treatment quality of intracavitary brachytherapy.

Comparative experimental performance research on parameter optimization of foam metal radiators

As a new type of plate fin radiator, foam metal radiators can be widely applied in the automobile and petrochemical industry field. The foam metal fin structure has great influence on the heat exchange performance. In this paper, a parameterized optimization method to optimize the airside heat exchange structure of foam metal has been presented. Comparative experimental performance research on the initial and optimized foam metal radiators have been carried out. Results showed the unit volume heat dissipation rate and airside heat transfer coefficient of the optimized foam metal radiator compared with the initial radiator has a maximum increase of 6.5 % and 1.43 %, respectively, under the airflow rate from 800 m3/h to 2800 m3/h at the ambient pressure of 58 kPa and room temperature. The optimized radiator has the better overall performance at higher airflow rate, where the comprehensive evaluation factor (i.e. JF) of optimized radiator is larger than that of the initial radiator. The optimized radiator has better heat dissipation performance and needs lower fan power consumption under the same gas side resistance. The effectiveness of the parameter optimization method has been validated by experimental results and can be used to optimize the structure of foam metal radiator.

The Transcriptomic Response of Cells of the Thermophilic Bacterium Geobacillus icigianus to Terahertz Irradiation.

As areas of application of terahertz (THz) radiation expand in science and practice, evidence is accumulating that this type of radiation can affect not only biological molecules directly, but also cellular processes as a whole. In this study, the transcriptome in cells of the thermophilic bacterium Geobacillus icigianus was analyzed immediately after THz irradiation (0.23 W/cm2, 130 μm, 15 min) and at 10 min after its completion. THz irradiation does not affect the activity of heat shock protein genes and diminishes the activity of genes whose products are involved in peptidoglycan recycling, participate in redox reactions, and protect DNA and proteins from damage, including genes of chaperone protein ClpB and of DNA repair protein RadA, as well as genes of catalase and kinase McsB. Gene systems responsible for the homeostasis of transition metals (copper, iron, and zinc) proved to be the most sensitive to THz irradiation; downregulation of these systems increased significantly 10 min after the end of the irradiation. It was also hypothesized that some negative effects of THz radiation on metabolism in G. icigianus cells are related to disturbances in activities of gene systems controlled by metal-sensitive transcription factors.

Sonochemical Synthesis of Ti1−x−yFexPbyO2 (with x and y = 0, 0.01, 0.03, 0.07): Structural Analysis, Influence of Radiation Type on Photocatalytic Activity and Assessment of Antimicrobial Properties

Sonochemical Synthesis of Ti1−x−yFexPbyO2 (with x and y = 0, 0.01, 0.03, 0.07): Structural Analysis, Influence of Radiation Type on Photocatalytic Activity and Assessment of Antimicrobial Properties

Design and Performance of an InAs Quantum Dot Scintillator with Integrated Photodetector.

A new scintillation material composed of InAs quantum dots (QDs) hosted within a GaAs matrix was developed, and its performance with different types of radiation is evaluated. A methodology for designing an integrated photodetector (PD) with a low defect density and that is optically matched to the QD's emission spectrum is introduced, utilizing an engineered epitaxial InAlGaAs metamorphic buffer layer. The photoluminescence (PL) collection efficiency of the integrated PD is examined using two-dimensional scanning laser excitation. The detector response to 5.5 MeV α-particles and 122 keV photons is presented. Yields of 13 electrons/keV for α-particles and 30-60 electrons/keV for photons were observed. The energy resolution of 12% observed with α-particles was mainly limited by noise- and geometry-related optical losses. The radiation hardness of an InAs QDs hosted within GaAs and a wider band gap AlGaAs ternary alloy was studied under a 1 MeV proton implantation up to a 1014 cm-2 dose. The integrated PL responses were compared to evaluate PL quenching due to non-radiative defects. The QDs embedded in the AlGaAs demonstrated improved radiation hardness compared to QDs in the GaAs matrix and in the InGaAs quantum wells.

Photoprotection and its implications for drug safety

Appropriate photoprotection plays a key role in the safety of using medicinal preparations whose active substances may induce photosensitivity reactions. This aspect applies not only to drugs applied topically to the skin, but also systemically. Drug-induced photosensitivity reactions to light depend on the active substance contained in the medicinal product and its dose, which translates into the concentration in the skin, the type of ultraviolet radiation, its intensity and exposure time. The chemical structure of phototoxic drugs contains unsaturated chemical bonds and aromatic groups, which are responsible for the absorption of radiation, the formation of degradation products and/or free radicals and hypersensitivity reactions. Therefore, in order to prevent hypersensitivity reactions, it is necessary to use appropriate sun protection and/or avoid exposure to solar radiation during pharmacotherapy with selected groups of drugs. The paper presents the latest research results on the impact of drug-induced photohypersensitivity on the increased likelihood of skin cancer. Drugs with the potential to induce photohypersensitivity reactions are discussed, including information on the relationship between their long-term use and the incidence of skin cancer. Based on the data contained in the Product Characteristics, exemplary indications regarding the appropriate photoprotection method to ensure the safe use of the medicinal product are presented. Med Pr Work Health Saf. 2024;75(5).

Radium levels in Brazil nuts: A review of the literature.

Brazil nuts are well known for their extraordinarily high selenium content. For this reason, they are frequently recommended as a kind of natural selenium 'supplement', particularly for certain population groups such as vegetarians and vegans in regions with low soil selenium levels. Typically, an intake of one or two Brazil nuts per day is recommended. Brazil nuts, however, also stand out from other nuts in terms of their high (albeit highly variable) radium content. The radium isotopes Ra-226 and Ra-228 emit alpha- and beta-radiation, with this type of radiation being particularly harmful when ingested. Consequently, it is important to consider radium levels in Brazil nuts before formulating recommendations for a long-term, daily intake of these nuts. To date, however, no comprehensive overview of radium levels in Brazil nuts has been published. Therefore, a literature review without time or language restrictions was conducted, including unpublished original data from Germany. The literature review (including the German data) indicated mean Ra-226 and Ra-228 levels of 49 (range: 17-205) mBq/g and 67 (range: 12-235) mBq/g, respectively. Assuming a consistent daily intake of one or two Brazil nuts, this would result in an effective dose of ~88-220 μSv/year. This level of exposure appears to be neither clearly harmful nor clearly harmless. As increased radioactivity exposure (at least at higher doses) is associated with increased cancer risk, randomised controlled trials assessing the effect of Brazil nuts on cancer risk biomarkers are needed.

Comparing the improvement of occupant thermal comfort with local heating devices in cold environments

Local heating can improve the thermal comfort of occupants and save energy in buildings in cold environments; however, few studies have investigated the effects of heat-transfer modes. Here, we aimed to evaluate different local heating measurements including five-sided enclosed radiant panel, heating plate, and fan heater using climate chamber experiments with 20 participants in cold environments (14 °C). Skin temperature and thermal perception votes under two radiation types with low and high power, one condition of conduction, and one condition of convection were collected and analyzed (RL, RH, CD, and CV). Under conditions RH, CD, and CV, the investigated parameters significantly improved by three local heating devices, with foot skin temperature rising by 0.46 °C, foot thermal sensation rising by 1.25 scores, and overall thermal comfort increasing by 0.36 score; however, their energy consumption varied greatly. In contrast, no significant improvement was observed in the RL group. Additionally, direct application of heat at sites of palpable cold discomfort was not always the optimal approach, and heating other parts of the body may provide significant alleviation. We recommend that the surface temperature of local heaters based on conduction and radiation for heat transfer should not be lower than 40.38 °C and 52.15 °C, respectively. To maintain thermal comfort, air outlet temperature should not be lower than 34.56 °C for convection type heaters. Our results provide technical and experimental basis for designing energy-saving buildings.

Wireless Data Transmission through Concrete Structures

Chloride ion presence in the concrete pore solution is an important factor in the initiation of rebar corrosion. Therefore, elevated chloride concentration in the pore solution needs to be detected as early as possible. For this early detection to be achieved, it is ideal to deploy sensors inside the concrete structure itself. This allows real time sampling of the pore solution which is closest to the rebar. To achieve this one needs to have a system based on wireless communication which allow the sensors to communicate within the structure. This would avoid wired communications methods, which impart fragility and implementation difficulties. This literature review paper endeavours to look at the various types of radiation which can be harnessed to penetrate through the opaque concrete structure. Potential data transmission methods utilising Radio Frequency Radiation, Ultrasonic Radiation, X-Ray Radiation and Neutron Beam Radiation physics were reviewed and evaluated against a set of parameters. The paper scores each radiation type against System Size, Power Supply Requirements, Transmission Range, Complexity of Circuits and Safety issues. Through these scores, each transmission technology was graded on its potential to act as the basis on which to build a micrometre sized intra-concrete data transmission system. The paper shows that ultrasonic radiation is the most promising radiation technology for use in this application.

Identification of conditions for ultrasonic effect on gas-dispersed medium and creation of radiators to increase the efficiency of coagulation in devices with swirling flow

Relevance. The presence and uncontrolled distribution of aerosols of various substances in the air, which have a negative impact on humans, flora and fauna. This problem is especially acute in the extraction, processing and combustion of georesources. The most effective way to solve the problem is the use of high-intensity ultrasonic vibrations, the effect of which on aerosols causes convergence and agglomeration of small particles into large ones. However, at low concentrations, the particle coagulation efficiency is not sufficient to increase the recovery rate of gas treatment equipment. Therefore, there is a need to find new ways to optimize ultrasonic equipment for coagulation of fine particles in order to increase its efficiency. Aim. To determine the optimal conditions for ultrasonic influence on a swirling gas-dispersed flow, ensuring maximum efficiency of agglomeration of highly dispersed particles. Carrying out comparative studies of coagulation of particles when exposed to ultrasonic fields generated by different types of radiators and their combined effects will make it possible to determine the effectiveness of ultrasonic coagulation and the optimal design scheme of ultrasonic exposure. Objects. Coagulation of particles under ultrasonic impact, formed by various types of radiators. Methods. Computer modeling of the generated ultrasonic field using the finite element method using harmonic acoustic analysis. Finite element modeling and design of disk radiators using modal analysis. To determine the characteristics of the aerosol, a Malvern Spraytec Particle Analyzer was used. Results. The results of calculations and experiments have shown that the use of an extended ultrasonic tubular radiator operating on a bending-diametric mode of vibration and forming a ring standing wave with a sound pressure level of 162–165 dB as the main source of ultrasonic impact for devices with swirling flows may be the most energy efficient. Further increase in the efficiency of coagulation can only be achieved by the combined action of a tubular radiator and a longitudinally oscillating radiator. This significantly modifies the field structure and provides not only an increase in the sound pressure level (up to 167 dB), but also in the number of formed nodal surfaces (up to 44).

Wireless Data Transmission through Concrete Structures

Chloride ion presence in the concrete pore solution is an important factor in the initiation of rebar corrosion. Therefore, elevated chloride concentration in the pore solution needs to be detected as early as possible. For this early detection to be achieved, it is ideal to deploy sensors inside the concrete structure itself. This allows real time sampling of the pore solution which is closest to the rebar. To achieve this one needs to have a system based on wireless communication which allow the sensors to communicate within the structure. This would avoid wired communications methods, which impart fragility and implementation difficulties. This literature review paper endeavours to look at the various types of radiation which can be harnessed to penetrate through the opaque concrete structure. Potential data transmission methods utilising Radio Frequency Radiation, Ultrasonic Radiation, X-Ray Radiation and Neutron Beam Radiation physics were reviewed and evaluated against a set of parameters. The paper scores each radiation type against System Size, Power Supply Requirements, Transmission Range, Complexity of Circuits and Safety issues. Through these scores, each transmission technology was graded on its potential to act as the basis on which to build a micrometre sized intra-concrete data transmission system. The paper shows that ultrasonic radiation is the most promising radiation technology for use in this application.

Radiation and DNA Origami Nanotechnology: Probing Structural Integrity at the Nanoscale.

DNA nanotechnology has emerged as a groundbreaking field, using DNA as a scaffold to create nanostructures with customizable properties. These DNA nanostructures hold potential across various domains, from biomedicine to studying ionizing radiation-matter interactions at the nanoscale. This review explores how the various types of radiation, covering a spectrum from electrons and photons at sub-excitation energies to ion beams with high-linear energy transfer influence the structural integrity of DNA origami nanostructures. We discuss both direct effects and those mediated by secondary species like low-energy electrons (LEEs) and reactive oxygen species (ROS). Further we discuss the possibilities for applying radiation in modulating and controlling structural changes. Based on experimental insights, we identify current challenges in characterizing the responses of DNA nanostructures to radiation and outline further areas for investigation. This review not only clarifies the complex dynamics between ionizing radiation and DNA origami but also suggests new strategies for designing DNA nanostructures optimized for applications exposed to various qualities of ionizing radiation and their resulting byproducts.

Development of empirical models for calculating global and diffuse erythemal weighted solar ultraviolet radiation under clear sky conditions in Thailand

This study introduced semi-empirical models for calculating hourly global and diffuse erythemal weighted ultraviolet (EUV) solar radiation under clear sky conditions in Thailand. To develop these models, global and diffuse erythemal ultraviolet data collected over a decade (2011–2020) from four solar monitoring stations situated in the main regions of Thailand were used. The data was classified into two groups. The first group (2011–2018) was used for modeling, while the second group (2019–2020) was reserved for model validation. The global and diffuse EUV radiation models revolve around semi-empirical functions. These functions express both types of EUV radiation in terms of normalized variables, specifically the total ozone column, aerosol optical depth, and air mass. To assess the accuracy of the proposed models, their outputs for hourly global and diffuse EUV radiation were calculated at the four monitoring stations. These outputs were then compared against actual measurements to validate the effectiveness of the models. The evaluation revealed a root mean square difference of 15.8% for global EUV radiation and 14.9% for diffuse EUV radiation when compared to the mean measured values.

Crime radiation theory: the co-production of crime patterns through opportunity creation and exploitation

AbstractConsiderable research shows that crime is concentrated at a few proprietary places: addresses and facilities. Emerging research suggests that proprietary places may radiate crime: activities at a place increase the risk of crime in the area around it. Weaknesses in the research create uncertainty about radiation, so we need more rigorous research. To conduct this research, we need a theory of crime radiation that operates at two spatial levels: the proprietary place and the area. This paper describes such a theory. Our theory states that crime radiation stems from the interaction between place management decisions at the place and offenders searching for opportunities in the area. Place managers create crime opportunities inside and outside their places. Offenders exploit place managers’ creations by deliberately searching for opportunities or by chancing upon the opportunities. The ways place managers and offenders interact gives rise to three types of crime radiation: hot dot, veiled dot, and cold dot. Finally, we propose questions crime scientists should answer to better understand crime radiation.

Unveiling the shielding potential: Exploring photon and neutron attenuation in a novel lead-free XCr2Se4 chalcogenide Spinals alloys with MCNP 4C code

The study covers shielding properties of three promising lead-free XCr2Se4 alloys, where X represents Mn, Cu, or Ag, across a spectrum of energies between 0.02 MeV and 15 MeV. MCNP4C was employed to simulate the mass attenuation coefficient (MAC) for the three selected alloys. After being prepared using the conventional solid-state reaction method, the samples displayed densities ranging from 5.45 g cm−3to 6.22 g cm−3. The simulated results obtained from the MCNP4C are then benchmarked with data obtained using different software such as Phy-X, Py-MLBUF, EPIXS, and GRASP. Upon comparing the acquired results with the Phy-X data, a notable correlation was observed with a relative difference ranging from 0.11% to 8.57%. The accuracy of the simulated data was additionally validated through the Kolmogorov-Smirnov test. From the simulated MAC, different ionizing radiation shielding properties including linear attenuation coefficient (LAC), half-value layer (HVL), mean-free path (MFP), transmission factor (TF), radiation protection efficiency (RPE), and fast neutron removal cross section (FNRCS) were calculated to provide a comprehensive analysis of the samples' efficacy in dealing with different types of radiation. The LAC for neutrons at different energies is also examined. HVL analysis indicates the radiation-blocking capacity of the samples. The TF shows the alloys’ ability to either permit or restrain the transfer of radiation. Additionally, RPE and FNRCS give indication of the shielding potential of the studied samples. This study is important for nuclear physicians and researchers and serves as useful data for the development of superior shielding materials.

A comprehensive review of radiation shielding concrete: Properties, design, evaluation, and applications

AbstractThis review paper provides a comprehensive analysis of radiation shielding concrete, covering its properties, design, evaluation, and applications. It begins with an introduction, stating the objective and scope. The paper explores radiation shielding basics, including ionizing radiation, shielding principles, and materials used for shielding. Concrete's properties relevant to shielding, radiation attenuation mechanisms, and factors affecting its efficiency are discussed. Different types of radiation shielding concrete are examined, along with their applications. The design and formulation of shielding concrete, including mix proportions, optimization techniques, and quality control, are presented. Evaluation methods and standards are discussed. Lastly, challenges, future directions, and emerging technologies are outlined. This review paper serves as a valuable resource for professionals involved in radiation shielding. The review on radiation shielding concrete highlighted its effectiveness in attenuating ionizing radiation, emphasizing material composition, density, and thickness as key design factors. Evaluation methods, such as gamma spectroscopy and Monte Carlo simulations, are discussed, demonstrating its versatile applications in nuclear facilities, healthcare, and space exploration.

CYRAD: a translational study assessing immune response to radiotherapy by photons or protons in postoperative head and neck cancer patients through circulating leukocyte subpopulations and cytokine levels

BackgroundRadiotherapy has both immunostimulant and immunosuppressive effects, particularly in radiation-induced lymphopenia. Proton therapy has demonstrated potential in mitigating this lymphopenia, yet the mechanisms by which different types of radiation affect the immune system function are not fully characterized. The Circulating Immunes Cells, Cytokines and Brain Radiotherapy (CYRAD) trial aims to compare the effects of postoperative X-ray and proton radiotherapy on circulating leukocyte subpopulations and cytokine levels in patients with head and neck (CNS and ear nose throat) cancer.MethodsCYRAD is a prospective, non-randomized, single-center non interventional study assessing changes in the circulating leukocyte subpopulations and cytokine levels in head and neck cancer patients receiving X-ray or proton radiotherapy following tumor resection. Dosimetry parameters, including dose deposited to organs-at-risk such as the blood and cervical lymph nodes, are computed. Participants undergo 29 to 35 radiotherapy sessions over 40 to 50 days, followed by a 3-month follow-up. Blood samples are collected before starting radiotherapy (baseline), before the 11th (D15) and 30th sessions (D40), and three months after completing radiotherapy. The study will be conducted with 40 patients, in 2 groups of 20 patients per modality of radiotherapy (proton therapy and photon therapy). Statistical analyses will assess the absolute and relative relationship between variations (depletion, recovery) in immune cells, biomarkers, dosimetry parameters and early outcomes.DiscussionPrevious research has primarily focused on radiation-induced lymphopenia, paying less attention to the specific impacts of radiation on different lymphoid and myeloid cell types. Early studies indicate that X-ray and proton irradiation may lead to divergent outcomes in leukocyte subpopulations within the bloodstream. Based on these preliminary findings, this study aims to refine our understanding of how proton therapy can better preserve immune function in postoperative (macroscopic tumor-free) head and neck cancer patients, potentially improving treatment outcomes.Protocol versionVersion 2.1 dated from January 18, 2023.Trial registrationThe CYRAD trial is registered from October 19, 2021, at the US National Library of Medicine, ClinicalTrials.gov ID NCT05082961.

Optimization of test methods and algorithms for assessing the resistance of field-effect transistors to various types of radiation using promising test equipment

Optimization of test methods and algorithms for assessing the resistance of field-effect transistors to various types of radiation using promising test equipment