Radial Speed Of Sound Research Articles

Sex and Obesity-Specific Associations of Ultrasound-Assessed Radial Velocity of Sound with Body Composition

Background: This study aimed to investigate the association between body composition (BC) specific parameters such as fat mass (FM) and lean body mass (LBM) and bone quality in obese and non-obese young Slovak adults (18–30 years) using bioelectrical impedance analysis and quantitative ultrasound while considering the factors of sex and obesity status; Methods: BC was evaluated using bioelectrical impedance analysis (InBody 770) and bone quality by the speed of sound (SOS) in radius using QUS (Sunlight MiniOmni) in 774 young Slovak young adults aged 18–30 years, categorized by sex and obesity status (body fat %, PBF, ≥28% for men and ≥20% for women); Results: In non-obese individuals, radial SOS correlated positively with FM parameters. Significant positive correlations with LBM, including skeletal muscle mass (SMM), were observed in non-obese men but not in women. Conversely, SOS correlated negatively with FM parameters in obese individuals, significantly only in women. The correlation of SOS with LBM in obese individuals was insignificant in both sexes. Age, visceral FM, FM in the arm, and vitamin D intake were identified as the main predictors of radial SOS in young adults, except in obese men. Conclusions: Findings indicate FM benefits bone tissue in non-obese individuals, while excessive adiposity deteriorates bone quality in obese individuals, necessitating tailored evaluations and interventions based on sex, obesity status, and specific predictors.

Bone Health Status, Muscular Strength and Power, and Aerobic and Anaerobic Capacities of Malaysian Male Athletes Involved in Sports with Different Mechanical Loading on Bones.

BackgroundPhysical activity is beneficial for bone health. Bones respond and adapt to applied loads that can vary among physical activity. This study investigated differences in bone health status, muscular performance, and aerobic and anaerobic capacities of young male Malaysian athletes competing at the state level.MethodsA total of 44 participants (age: 17.1 ± 1.6 years old) were randomly divided into sedentary control, weightlifting, cycling or squash groups. The bone speed of sound (SOS), muscular performance, maximal oxygen uptake (VO2max) and anaerobic capacities of the participants were measured.ResultsAll athletes exhibited significantly higher tibial and radial bone SOS (P < 0.01) values than the sedentary group. Weightlifting athletes showed the highest radial bone SOS value in the arm, whereas cycling athletes exhibited the highest tibial bone SOS value in the leg among the groups. Weightlifting athletes also had significantly higher isokinetic knee extension, shoulder extension and shoulder flexion peak torque (PT) and average power (AVG.P) (P < 0.05) as well as significantly greater anaerobic peak power (P < 0.05) compared to cyclists and squash players. However, the aerobic capacity of cyclists and squash players was significantly higher (P < 0.001) than the weightlifters. The cyclists had significantly higher anaerobic capacity and power (P < 0.001) than weightlifters and squash players.ConclusionThe findings imply that the bone health and physiological profiles of athletes are influenced by the type of sporting activity they undertake.

Charged anisotropic compact star core-envelope model with polytropic core and linear envelope

This manuscript is related to the construction of relativistic core-envelope model for spherically symmetric charged anisotropic compact objects. The polytropic equation of state is considered for core, while it is linear in the case of envelope. We present that core, envelope and the Reissner Nordstrddot{o}m exterior regions of stars match smoothly. It has been verified that all physical parameters are well behaved in the core and envelope region for the compact stars SAX J1808.4-3658 and 4U1608-52. Various physical parameters inside star are discussed herein, non-singularity and continuity at the junction has been catered as well. Impact of charged compact object together with core-envelope model on the mass, radius and compactification factor is described by graphical representation in both core and envelop regions. The stability of the model is worked out with the help of Tolman–Oppenheimer–Volkoff equations and radial sound speed.

The effect of long-distance running on bone strength and bone biochemical markers.

It still remains controversial whether exercise will help or adversely affect the bone formation. The aim of this study was to evaluate the effect of common long-distance running on the magnitude of change in bone properties as measured by quantitative ultrasound (QUS) and bone biochemical markers. Subjects included 68 long-distance runners and 40 controls. Long-distance runners had been training in the marathon club for at least 6 months, the average period of exercise was 2 years, and running at 48.6±24.9 km per week. Otherwise, controls were people who had not experienced any specific sports before. Bone speed of sound (SOS) was measured by QUS at the distal one third radius and the mid-shaft of the tibia. Serum osteocalcin and urine deoxypyridinolin were measured in all groups. No significant differences were found in tibial and radial SOS between the two groups. Serum osteocalcin was higher in long-distance runners than control (P<0.05) in both the 30s and 40s of the participants, but urine deoxypyridinolin showed no significant difference between the two groups. It is concluded that long-distance running at the club level increases bone formation marker, but seems to do no harmful effect on bone properties as measured by QUS.

Physiological profiles and bone health status of Malay adolescent male boxing, Muay Thai and silat athletes

This study aimed to determine the differences in physiological profiles and bone health status of Malay adolescent male state boxing, Muay Thai and silat athletes. Forty participants with mean age 16.7 ± 1.5 years participated in this study. They were divided into four groups, i.e., sedentary control, boxing, Muay Thai and silat groups with 10 participants per group. Participants’ lung capacity, estimated maximal oxygen uptake (VO2max), Wingate anaerobic capacity, isokinetic muscular peak torque (strength) and power, hand-grip strength, back and leg strength, explosive power, agility, static balance and flexibility were measured. Bone sonometer was used to measure tibial and radial bone speed of sound (SOS). The research approach employed was purposive method and the duration for completing data collection was 3 months. The result of the present study showed that boxing athletes exhibited significantly (p < 0.05) greater arm isokinetic muscular strength and power than silat athletes, and greater arm isokinetic muscular power than Muay Thai athletes respectively. Boxing athletes also showed significantly (p < 0.05) higher estimated VO2max compared to silat athletes. Muay Thai athletes exhibited significantly (p < 0.05) greater radial bone SOS value compared to sedentary controls. The Malay male adolescent boxing athletes had greater arm isokinetic muscular performance than their silat and Muay Thai counterparts. Boxing athletes also showed better aerobic fitness compared to silat athletes. In addition, Muay Thai athletes had better bone health status than sedentary individuals. This study provides new scientific information on physiological profiles and bone health status of Malay adolescent male state boxing, Muay Thai and silat athletes in the field of martial arts.

Enhancing monochromatic multipole emission by a subwavelength enclosure of degenerate Mie resonances.

Sound emission is inefficient at low frequencies as limited by source size. This letter presents enhancing emission of monochromatic monopole and multipole sources by enclosing the source with a subwavelength circular enclosure filled of an anisotropic material of a low radial sound speed. The anisotropy is associated with an infinite tangential density along the azimuth. Numerical simulations show that emission gain is produced at frequencies surrounding degenerate Mie resonant frequencies of the enclosure, and meanwhile the radiation directivity pattern is well preserved. The degeneracy is theoretically analyzed. A realization of the material is suggested by using a space-coiling structure.

Porosity predicted from ultrasound backscatter using multivariate analysis can improve accuracy of cortical bone thickness assessment.

A rapidly growing area of interest in quantitative ultrasound assessment of bone is to determine cortical bone porosity from ultrasound backscatter. Current backscatter analyses are based on numerical simulations, while there are no published reports of successful experimental measurements. In this study, multivariate analysis is applied to ultrasound reflections and backscatter to predict cortical bone porosity. The porosity is then applied to estimate cortical bone radial speed of sound (SOS) and thickness using ultrasound backscatter signals obtained at 2.25 and 5 MHz center frequencies from cortical bone samples (n = 43) extracted from femoral diaphyses. The study shows that the partial least squares regression technique could be employed to successfully predict (R2 = 0.71-0.73) cortical porosity. It is found that this multivariate approach can reduce uncertainty in pulse-echo assessment of cortical bone thickness from 0.220 to 0.045 mm when porosity based radial SOS was applied, instead of a constant value from literature. Upon further validation, accurate estimation of cortical bone porosity and thickness may be applied as a financially viable option for fracture risk assessment of individuals.

Sex- and Maturity-Related Differences in Cortical Bone at the Distal Radius and Midshaft Tibia Evaluated by Quantitative Ultrasonography

Boys usually have higher values of bone mineral density measured by dual-energy X-ray absorptiometry than girls, but contradictorily also have a greater incidence of fractures during growth. The purpose of this study was to investigate sex- and maturity-related differences in bone speed of sound (SoS) at the radius and tibia in a sample of 625 healthy children aged 10–14 y and to analyze the contributions of physical activity (PA) to possible dissimilarities. Radial and tibial SoS was evaluated by quantitative ultrasound, maturity was estimated as the years of distance from the peak height velocity age, and PA was assessed by accelerometry. Comparisons between sexes and maturity groups (low: below average [<−2.5 y], high: average or above [≥−2.5 y]) were made by two-sample t-tests with unequal variances. Girls in the high-maturity group had higher SoS at the radius and tibia compared with girls in the low-maturity group (p < 0.001). There were no SoS differences at the radius or tibia between the high- and low-maturity groups in boys. Within high-maturity children, girls had higher SoS than boys at the radius and tibia (p < 0.001). There were no differences at the radius and tibia between girls and boys with low maturity. The results were not modified after controlling for PA. Regardless of PA, the results provide insight into sex- and maturity-related differences in bone SoS at the distal radius and midshaft tibia from maturity less than 2.5 y from the peak height velocity age, with boys having lower SoS.

Effect of porosity, tissue density, and mechanical properties on radial sound speed in human cortical bone.

The purpose of this study was to investigate the effect of simultaneous changes in cortical porosity, tissue mineral density, and elastic properties on radial speed of sound (SOS) in cortical bone. The authors applied quantitative pulse-echo (PE) ultrasound techniques that hold much potential especially for screening of osteoporosis at primary healthcare facilities. Currently, most PE measurements of cortical thickness, a well-known indicator of fracture risk, use a predefined estimate for SOS in bone to calculate thickness. Due to variation of cortical bone porosity, the use of a constant SOS value propagates to an unknown error in cortical thickness assessment by PE ultrasound. The authors conducted 2.25 and 5.00 MHz focused PE ultrasound time of flight measurements on femoral diaphyses of 18 cadavers in vitro. Cortical porosities of the samples were determined using microcomputed tomography and related to SOS in the samples. Additionally, the effect of cortical bone porosity and mechanical properties of the calcified matrix on SOS was investigated using numerical finite difference time domain simulations. Both experimental measurements and simulations demonstrated significant negative correlation between radial SOS and cortical porosity (R(2) ≥ 0.493, p < 0.01 and R(2) ≥ 0.989, p < 0.01, respectively). When a constant SOS was assumed for cortical bone, the error due to variation of cortical bone porosity (4.9%-16.4%) was about 6% in the cortical thickness assessment in vitro. Use of a predefined, constant value for radial SOS in cortical bone, i.e., neglecting the effect of measured variation in cortical porosity, propagated to an error of 6% in cortical thickness. This error can be critical as characteristic cortical thinning of 1.10% ± 1.06% per yr decreases bending strength of the distal radius and results in increased fragility in postmenopausal women. Provided that the cortical porosity can be estimated in vivo, the relationship between radial SOS and cortical porosity can be utilized and a porosity based radial SOS estimate could be implemented to determine cortical thickness. This would constitute a step toward individualized quantitative ultrasound diagnostics of osteoporosis.

A METHOD FOR THE ESTIMATION OF $p$-MODE PARAMETERS FROM AVERAGED SOLAR OSCILLATION POWER SPECTRA

A new fitting methodology is presented which is equally well suited for the estimation of low-, medium-, and high-degree mode parameters from $m$-averaged solar oscillation power spectra of widely differing spectral resolution. This method, which we call the "Windowed, MuLTiple-Peak, averaged spectrum", or WMLTP Method, constructs a theoretical profile by convolving the weighted sum of the profiles of the modes appearing in the fitting box with the power spectrum of the window function of the observing run using weights from a leakage matrix that takes into account both observational and physical effects, such as the distortion of modes by solar latitudinal differential rotation. We demonstrate that the WMLTP Method makes substantial improvements in the inferences of the properties of the solar oscillations in comparison with a previous method that employed a single profile to represent each spectral peak. We also present an inversion for the internal solar structure which is based upon 6,366 modes that we have computed using the WMLTP method on the 66-day long 2010 SOHO/MDI Dynamics Run. To improve both the numerical stability and reliability of the inversion we developed a new procedure for the identification and correction of outliers in a frequency data set. We present evidence for a pronounced departure of the sound speed in the outer half of the solar convection zone and in the subsurface shear layer from the radial sound speed profile contained in Model~S of Christensen-Dalsgaard and his collaborators that existed in the rising phase of Solar Cycle~24 during mid-2010.

Radial quantitative ultrasound and dual energy x-ray absorptiometry: intermethod agreement for bone status assessment in children.

Aim. To validate a radial quantitative ultrasound (QUS) system with dual energy X-ray absorptiometry (DXA), a criterion technique in bone status assessment among children. Methods. Bone health was evaluated using a radial QUS system (Sunlight Omnisense 8000P) to measure the speed of sound (SOS) at one-third distal radius of the nondominant hand and DXA (Hologic QDR) was used to assess whole body bone mineral density (BMD). Results. Some 29.9% of the children were grossly misclassified according to quartiles of BMD and radial SOS. Poor agreement was observed between Z-scores of radial SOS and whole-body BMD (mean difference = 0.6 ± 0.9; 95% limits of agreement = −1.4 to 2.6). With a cut-off value of −1.0, radial SOS yielded satisfactory sensitivity (80%) and specificity (93%) for the detection of children with low BMD. Conclusion. The observed poor agreement in the present study suggests that radial QUS and DXA are not comparable and hence are not interchangeable in evaluating bone status of the children.

Measurement Properties of Radial and Tibial Speed of Sound for Screening Bone Fragility in 10- to 12-Year-Old Boys and Girls

The objective of this study was to analyze measurement properties of the radial and tibial speed of sound (SoS) evaluated by quantitative ultrasound (QUS) for screening bone fragility. Bone fragility was defined as low whole body less head bone mineral density (WBLH BMD) measured by DXA (first tertile, 95% CI −1.1 to −0.9) and as past fractures evaluated by questionnaire. The sample included 319 nonobese boys and girls, ages 10–12 yr. All bone variables were standardized. The results revealed concordance coefficient correlations between WBLH BMD and radial and tibial SoS of 0.129 and 0.038, respectively. The regression lines between DXA and QUS variables were different from the identity lines. Cross-classification analysis by Kappa statistic showed that only 34% and 36% of the 113 participants categorized in the first tertile of WBLH BMD were also categorized in the first tertile of tibial and radial SoS, correspondingly. Logistic regression with gender and maturity adjustments demonstrates that radial SoS was the single significant variable in predicting OR for identifying participants with past fractures. In conclusion, the radial QUS revealed itself to be a valuable tool for screening bone fragility in youth of 10–12 yr, despite the absence of agreement with DXA WBLH BMD.

THU0375 Can Radial Speed of Sound Measurements Identify Osteoporosis at the Radius as Measured by DXA?

BackgroundOne-third radius (33% radius) bone mineral density (BMD) measurements of the non-dominant forearm using dual-energy X-ray absorptiometry (DXA) may be used for the diagnosis of osteoporosis in certain circumstances.ObjectivesThe aim...

Quantitative Ultrasound Densitometry in University Level Cricket Fast Bowlers and Nonathletes

ABSTRACT Background Fast bowling in cricket is an important skill that imparts mechanical loads on limbs. The differential loading patterns involved in bowling affect the peripheral limb bone status. Objective To evaluate bone properties using quantitative ultrasound densitometry (QUS), among fast cricket bowlers in comparison with nonathletes. A secondary objective was designed to find correlation between QUS parameters and bonespecific physical activity questionnaire (BPAQ). Methodology A total of 80 subject, 40 fast cricket bowlers of both gender (20 male and 20 female) and 40 nonathletes (20 male and 20 female) were included in our study and all are aged between 20 and 25 years. Bone speed of sound (SOS) was measured bilaterally at the distal radius and the mid tibia using Sunlight OmnisenseTM device. Results There was a significant difference between dominant side and nondominant side radial SOS (p &lt; 0.05) and tibial SOS (p &lt; 0.05) in cricket bowlers favoring dominant radial bone SOS and nondominant tibial bone SOS which was not found in nonathletes. Significant difference in dominant radial bone SOS values (p &lt; 0.05) and nondominant tibial bone SOS (p &lt; 0.05) values existed between cricket bowlers and controls. Positive correlation was found between tibial SOS and past BPAQ in all subjects. Conclusion QUS parameters were significantly higher in young cricket bowlers with greater values observed in the dominant arm and leading foot, thus reflecting the osteogenic effect that occurs due to the nature of the game. Further BPAQ is significantly correlated with lower limb bone properties as measured by QUS at mid shaft tibia. How to cite this article Shenoy S, Parthasarathy S, Sandhu JS. Quantitative Ultrasound Densitometry in University Level Cricket Fast Bowlers and Nonathletes. J Postgrad Med Edu Res 2013;47(2):83-89.

Reference Data for Bone Speed of Sound in Portuguese Girls and Boys Aged 9–13 Years

The objective of this study was to provide reference data for quantitative ultrasound (QUS, Sunlight Omnisense; BeamMed Ltd., Petach-Tikva, Israel) of the radius and tibia in Portuguese subjects. The evaluation was conducted with QUS in 430 healthy participants (213 girls and 217 boys) aged between 9 and 13 yr. The results indicate that 13-yr-old girls had higher radial and tibial speed of sound (SOS) than younger girls and higher tibial SOS than boys of the same age ( p < 0.05). Regression analysis revealed positive associations between radial and tibial SOS and skeletal maturity in girls and negative association between tibial SOS and fat mass in both sexes and average intensity of physical activity in girls ( p < 0.01). The young Portuguese subjects showed an age-related variation in SOS similar to that seen in some of the eastern Mediterranean countries. Children with a history of fracture of lower (n = 24) or upper limbs (n = 43) did not show a significant decrease of SOS values in any of the bone sites evaluated (tibia Z-score: −0.23 standard deviations [SDs]; radius Z-score: −0.21 SDs; p > 0.05).

Comparative study of quantitative ultrasonography and dual-energy X-ray absorptiometry for evaluating renal osteodystrophy in children with chronic kidney disease

Our aim was to assess bone parameters in children with chronic kidney disease (CKD) with both dual-energy X-ray absorptiometry (DXA) and quantitative ultrasonography (QUS) and additionally with biochemical markers of bone turnover. Twenty children (12 boys and 8 girls) with CKD and a mean decimal age of 9.47±4.44years were included in the study where anthropometric parameters (height and weight), pubertal status, bone mineral density (BMD) at lumbar spine, speed of sound (SOS) measured by QUS at radius and at tibia, and biochemical markers of bone metabolism were measured. Six patients (30%) had tibial SOS Z score <-1, and 52.7% had radial SOS Z score <-1, whereas only 16.67% had BMD Z score <-1. Patients had significantly increased levels of serum intact parathormone (p<0.001), serum bone alkaline phosphatase (BAP) (p<0.001) and serum N-terminal-mid fragment (aminoacids 1-43) of osteocalcin (p<0.001) compared to controls, whereas serum osteoprotegerin was significantly decreased in patients compared to controls (p=0.001). SOS was significantly correlated to BAP (r=-0.586, p=0.013 and r=-0.709, p=0.001, respectively, for radius and tibia). In conclusion no association between DXA and QUS measurements was documented in our study, whereas QUS was better correlated to biochemical indices of ROD.

Relative importance of body composition, osteoporosis-related behaviors, and parental income on bone speed of sound in adolescent females

Adolescence provides a unique opportunity to employ strategies aimed at optimizing peak bone mass yet there are limited studies on the relationship between specific social constructs, osteoporosis-related behaviors, and bone health status in adolescent females. The purpose of this study was to examine associations between bone speed of sound (SOS) and body composition, osteoporosis-related health behaviors, and parental income in adolescent females. Four hundred forty-two female students in grades 9-12 from schools in Southern Ontario, Canada were measured for height, body mass, and percent body fat and completed a battery of instruments to assess osteoporosis-related health behaviors. Bone SOS was measured by transaxial quantitative ultrasound at the distal radius and midtibia. Percent body fat was a negative correlate of tibial SOS. No significant correlation was found between physical activity and bone SOS yet physical activity was negatively related to adiposity. Hierarchical regression showed that age and percent body fat were the most important predictors of the variance in tibial SOS scores, with calcium intake having a weaker, yet significant, relationship. Age was the only statistically significant predictor of radial SOS. Users of oral contraceptives had higher radial SOS when controlling for age. Higher parental income was not associated with bone SOS but positive associations between parental income, daily calcium intake, and weekly physical activity were noted. Bone SOS is reduced in adolescent females with increased adiposity, whereas it is positively influenced by oral contraceptives and daily calcium intake.

Bone properties in child and adolescent male hockey and soccer players

Children and adolescents who train extensively in high-impact, weight-bearing activities have enhanced bone mineral density. The purpose of this study was to evaluate bone strength, as reflected by quantitative ultrasound (QUS, Sunlight Omniscence), of child (10–12 yrs old) and adolescent (14–16 yrs old) male soccer and hockey players in comparison with age-matched controls. The groups included 30 child (CH) and 31 adolescent (AH) hockey players, 26 child (CS) and 30 adolescent (AS) soccer players, as well as 34 child (CC) and 31 adolescent (AC) healthy, non-athletic, age-matched controls. All athletes trained at an elite level year-round, with no difference in training volume between groups. Ultrasound speed of sound (SOS) was measured at the distal-radius and mid-tibia. In both age groups, hockey players were the heaviest and had the highest fat-free mass. No differences were found among groups in total energy intake, calcium or vitamin D intake. Radial and tibial SOS increased with age. Hockey players had higher radial SOS in both age groups (children: CH:3763 ± 74, CS:3736 ± 77, CC:3721 ± 88 m/s; adolescents: AH:3809 ± 105, AS:3767 ± 85, AC:3760 ± 94 m/s). Tibial SOS was higher in soccer players compared with controls. In spite of the higher body mass and fat-free mass in hockey players, their tibial SOS was similar to the non-athletes in both age groups. These findings support previous suggestions of sport-specific effects on bone strength. However, they need to be corroborated with longitudinal or prospective intervention studies.

Assessment of cortical bone density and anisotropy in human femur using ultrasound and x‐ray

The purpose of this research is to investigate the contribution of the intrinsic properties of human bone to the ultrasound velocities in the axial, radial, and tangential directions. Samples of cortical bone were cut from 19 human medial femurs and polished to a rectangular parallelepiped shape. The orientation of apatite crystallites was assessed by microbeam x‐ray diffraction, the density with a densitometer using the Archimedes' principle. Bone mineral density (BMD) was also measured with peripheral quantitative computed tomography (pQCT) and dual‐x‐ray absorptiometry (DXA). The speed of sound (SOS) for each three directions was measured with 3 MHz ultrasonic broadband transducers. Radial and tangential SOS demonstrated a strong correlation with density (R=0.83,p<0.0001 and R=0.85,p<0.0001, respectively). In the axial direction, the correlation between density and SOS was moderate (R=0.59). However, a significant correlation was found by using density and apatite orientation of c‐axis in a multiple re...

Bone Development in Children Living on Houseboats on a River in Vietnam

BackgroundWith the rapid urbanization of Vietnam, living on boats has come to be associated with underprivileged socioeconomic status, and there are major concerns regarding the health of children living under such conditions. Bone development is a critical concern in children because the foundation for skeletal health is established early in life. We evaluated the bone properties of children living under underprivileged conditions on boats in Hue City, Vietnam, with respect to a number of household factors.MethodsOne hundred and twenty children aged 7-11 years selected randomly from households living on boats in Hue were included in this study. Tibial and radial speed of sound (SOS) were measured by non-invasive quantitative ultrasonometry. Socioeconomic profiles, health promotion proficiency, and nutritional intake of households were assessed by structured interview. The bone properties of 60 children aged 7-11 living on land were also assessed as controls.ResultsThe Z-scores of tibial and radial SOS of boat children were -0.16 ± 0.89 and -0.24 ± 0.75 (mean ± SD), respectively. Tibial SOS exhibited a significant correlation with radial SOS (r = 0.39, P < 0.01). Among the household factors examined, the educational level of fathers (P < 0.05) and the health promotion proficiency (P < 0.05) of households exhibited positive associations with the tibial bone properties of the children. The tibial and radial SOS of boat children were lower than those of children living on land (P = 0.001 and P = 0.086, respectively).ConclusionThe results of the present study revealed the underdevelopment of bone properties in children living on houseboats, which was correlated with their living conditions.