Racial Mixture Research Articles

Plasma Proteins Associated with COVID-19 Severity in Puerto Rico.

Viral strains, age, and host factors are associated with variable immune responses against SARS-CoV-2 and disease severity. Puerto Ricans have a genetic mixture of races: European, African, and Native American. We hypothesized that unique host proteins/pathways are associated with COVID-19 disease severity in Puerto Rico. Following IRB approval, a total of 95 unvaccinated men and women aged 21-71 years old were recruited in Puerto Rico from 2020-2021. Plasma samples were collected from COVID-19-positive subjects (n = 39) and COVID-19-negative individuals (n = 56) during acute disease. COVID-19-positive individuals were stratified based on symptomatology as follows: mild (n = 18), moderate (n = 13), and severe (n = 8). Quantitative proteomics was performed in plasma samples using tandem mass tag (TMT) labeling. Labeled peptides were subjected to LC/MS/MS and analyzed by Proteome Discoverer (version 2.5), Limma software (version 3.41.15), and Ingenuity Pathways Analysis (IPA, version 22.0.2). Cytokines were quantified using a human cytokine array. Proteomics analyses of severely affected COVID-19-positive individuals revealed 58 differentially expressed proteins. Cadherin-13, which participates in synaptogenesis, was downregulated in severe patients and validated by ELISA. Cytokine immunoassay showed that TNF-α levels decreased with disease severity. This study uncovers potential host predictors of COVID-19 severity and new avenues for treatment in Puerto Ricans.

Molecular and Cytological Identification of Wheat-Thinopyrum intermedium Partial Amphiploid Line 92048 with Resistance to Stripe Rust and Fusarium Head Blight.

Thinopyrum intermedium (2n = 6x = 42, EeEeEbEbStSt or JJJsJsStSt) contains a large number of genes that are highly adaptable to the environment and immune to a variety of wheat diseases, such as powdery mildew, rust, and yellow dwarf, making it an important gene source for the genetic improvement of common wheat. Currently, an important issue plaguing wheat production and breeding is the spread of pests and illnesses. Breeding disease-resistant wheat varieties using disease-resistant genes is currently the most effective measure to solve this problem. Moreover, alien resistance genes often have a stronger disease-resistant effect than the resistance genes found in common wheat. In this study, the wheat-Th. intermedium partial amphiploid line 92048 was developed through hybridization between Th. intermedium and common wheat. The chromosome structure and composition of 92048 were analyzed using ND-FISH and molecular marker analysis. The results showed that the chromosome composition of 92048 (Octoploid Trititrigia) was 56 = 42W + 6J + 4Js + 4St. In addition, we found that 92048 was highly resistant to a mixture of stripe rust races (CYR32, CYR33, and CYR34) during the seedling stage and fusarium head blight (FHB) in the field during the adult plant stage, suggesting that the alien or wheat chromosomes in 92048 had disease-resistant gene(s) to stripe rust and FHB. There is a high probability that the gene(s) for resistance to stripe rust and FHB are from the alien chromosomes. Therefore, 92048 shows promise as a bridge material for transferring superior genes from Th. intermedium to common wheat and improving disease resistance in common wheat.

Whiteness, Mestizaje, and social equity

This article discusses the relationship between Whiteness and Mestizaje–the idea of a ‘race made of the mixture of other races’–in the context of Mexican public administration. It argues that Mestizaje promotes a raceless or ‘color-evasive’ narrative that has historically prevented the discussion of race and ethnoracial inequalities in Mexico; sustains Whiteness in public organizations, and creates the conditions for White supremacy, as an uneven distribution of social privileges and penalties along ethnoracial lines benefitting White people. Ultimately, these three aspects of the Mestizaje ideology and its connection with Whiteness could be preventing the advancement of social equity in Mexico. Moreover, the reflections presented here are potentially insightful for other contexts in which raceless and/or color-evasive narratives are prevalent as well.

Saudi Population Nasal Anthropometric Study: Local and International Comparison.

Anthropometric measurements are essential for diagnosing and treating various craniofacial disorders during nasal reconstruction and esthetic surgery. Different people have unique individual esthetic features that are a mixture of different races and backgrounds. This study aimed to compare 12 different anthropometric measurements in the Saudi Arabian population with those in other local and international studies. This cross-sectional study was conducted with 420 volunteers from December 2022 to August 2023 in Riyadh, Saudi Arabia. Study samples were drawn from the general population, and 12 nasal anthropometric variables were measured, including 7 linear and 5 angular variables, by taking digital photographs from frontal and lateral views. Anthropometric landmarks and measurements were obtained as previously described by Farkas et al. Photographs were analyzed using Adobe Photoshop CS4 software, and facial landmarks were identified. Data were analyzed using an independent sample t test to assess the mean and SD with differences (P<0.05 indicated a significant value). After statistical analysis, the results were compared with previously published standards for other races. Exactly 420 Saudi Arabian volunteers were examined to compare nasal anthropometric variables. All 12 nasal anthropometric variables differed significantly between male and female individuals. Anthropometry of the nose has an enormous miscellaneous relationship between sexes and populations of different geographic areas. It is important to create average anthropometric measurements for different groups for successful plastic surgery and rhinoplasty.

Mestizo Urbanism: Enduring Racial Intersections in Latin American Cities

AbstractAcross Latin America, there continues to be strong resistance to the claim that racism plays a role in the production of urban space. Deemed antipatriotic, this issue remains widely unaddressed in urban planning and geography. Based on qualitative research in Bogotá and secondary literature on other Latin American cities, this article explores the afterlife of mestizaje (racial mixture) as a racial–colonial project from the viewpoint of its materialisation in the city and society–space relations. In particular, it illustrates how racism in the city is transfigured as ‘always something else’ (e.g., culture, class, regionalism, displacement) through a variety of normative, discursive and operational devices. Thus, the article confronts the need to divest from the racial hegemony of mestizaje in urban planning and geography, suggesting that it is hindering the path towards more equitable urban futures.

First Report of Puccinia striiformis F. Sp. Tritici Race ME2018 in Irrigated Wheat Production in Ethiopia

Stripe rust, caused by Puccinia striiformis f. sp. tritici, is a devastating disease of wheat in Ethiopia and the globe. The disease was dynamic and quite complex with the host (variety and plant spp), the environment, and with the pathogen genetic nature. The genetic alternation or change of a pathogen could affect the resistant population in the area. New race identification helps preparedness for the needs a rise to reduce the possible losses due to the problem. The race analysis dynamics identified three yellow rust races; namely, PstS11, PstS16 and ME2018 and one other unknown new race were the major in recent years but in the 2012-2016 Psts1 and PSTS2 were the dominant once. The new race ME2018 race mixture was increased the risk of stripe race epidemics in the area because it is Yr10-virulence race. So regular monitoring, for early detection and identification of new races was crucial.

Mapping of a Recessive Gene for All-Stage Resistance to Stripe Rust in a Wheat Line Derived from Cultivated Einkorn (Triticum monococcum).

Stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is one of the most destructive fungal diseases of wheat. Cultivated einkorn (Triticum monococcum L. ssp. monococcum, 2n = 2x = 14, AmAm), one of the founder crops of agriculture, harbors unexploited genetic sources for wheat improvement. An advanced wheat line, Z15-1949, with 42 chromosomes, selected from the hybrids of Pst-susceptible common wheat cultivar Crocus and resistant T. monococcum accession 10-1, exhibits high resistance to a mixture of the prevalent Chinese Pst races. Genetic analysis on F1, F2, and F2:3 generations of the cross between Z15-1949 and Pst-susceptible common wheat SY95-71 indicated that the resistance of Z15-1949 was conferred by a recessive gene, tentatively designated as YrZ15-1949. This gene was mapped to the short arm of chromosome 7D using the Wheat 55K single nucleotide polymorphism array, flanked by markers KASP-1949-2 and KASP-1949-10 within a 3.3-cM genetic interval corresponding to a 1.12-Mb physical region in the Chinese Spring reference genome V2.0. The gene differs from previously reported Yr genes on 7D based on their physical positions and is probably a novel gene. YrZ15-1949 would be a valuable resource for developing Pst-resistant wheat cultivars, and the linked markers could be used for marker-assisted selection.

‘Real National Work’: The Politics of Nazi Race Science in Upper Silesia, 1934–1942

Abstract This article analyses the political and scientific controversy surrounding a race science project undertaken by the anthropologist Egon Freiherr von Eickstedt under National Socialism. Beginning in 1934, Eickstedt and his team of assistants conducted a series of racial studies on the population of Upper Silesia, a contested borderland in East Prussia. Motivated by a nationalist desire to counter the work of Polish anthropologists in the region, Eickstedt argued that the population of Upper Silesia belonged predominantly to the so-called ‘Nordic race’ and that the territory was thus fundamentally German. Nazi officials, however, viewed the Silesian studies with alarm, since the results also appeared to show that people in the area were a racial mixture and that the ‘Nordic race’ made up less than 40 per cent of the population in some locales. They worried that Eickstedt’s studies could undermine Germany’s territorial claims in the region and threaten national unity. The ensuing controversy presents a case in which the anthropological concept of ‘race’, rather than serving its usual role in Nazi thinking as the biological underpinning of the Volk (or people), threatened to undermine its coherence. The reaction to Eickstedt’s Silesian studies demonstrates a lack of consensus on race within the Nazi system, suggesting that understandings of race in Nazi Germany were neither as coherent nor as uniform as the paradigm of the ‘racial state’ has assumed.

Música del Mariachi: Conservator of Mexican Culture and Heritage

Mariachi music, its profound texts, rhythms, and mestizaje (racial mixture) preserve Mexican culture and heritage. Mariachi music is synonymous with Mexico. Both birthed through a violent beginning of forced assimilation and mestizaje, mariachi is one of the foremost symbols of Mexican national pride. Mariachi’s lyrics and distinctive rhythms, share and preserve a story of survival, cradle ancestral epistemologies, all that is Mexico, its Indigenous, Spanish, and African roots and history pre and post 1821. And just as in the study of any other music, language, or culture, it is consequential that precise, literal, translations (scores) of mariachi music, research, and other scholarly, cultivated resources are accessible to all Mexican descent people, especially Chicana/x/o students and those who teach them. Culturally relevant curriculum fosters identity and inclusivity and promotes academic success. However, as it pertains to music education, western European music history, theory, notation, and praxes dominate. With over 62 million Hispanics living in the United States, 62% of Mexican descent, it is dire to create decolonized music spaces that offer more than a single narrative. And within these spaces, it is crucial that quality resources are provided equitably. Because of its popularity and adoption as core curriculum in schools around the United States, amassing quality mariachi educational resources, musical scores and transcriptions, and other curricular materials is central to Mexican descent student success. In this article, I describe common mariachi song forms, their region of origin, meter, text structure and offer rhythmic analyses and examples for notating them.

Real-time PCR assays for races of the spinach Fusarium wilt pathogen, Fusarium oxysporum f. sp. spinaciae.

Fusarium wilt of spinach, caused by Fusarium oxysporum f. sp. spinaciae, is a significant limitation for producers of vegetative spinach and spinach seed crops during warm temperatures and/or on acid soils. Identification of isolates of F. oxysporum f. sp. spinaciae, and distinction of isolates of the two known races entails time-intensive pathogenicity tests. In this study, two real-time PCR assays were developed: one for a candidate effector gene common to both races of F. oxysporum f. sp. spinaciae, and another for a candidate effector gene unique to isolates of race 2. The assays were specific to isolates of F. oxysporum f. sp. spinaciae (n = 44) and isolates of race 2 (n = 23), respectively. Neither assay amplified DNA from 10 avirulent isolates of F. oxysporum associated with spinach, 57 isolates of other formae speciales and Fusarium spp., or 7 isolates of other spinach pathogens. When the assays were used to detect DNA extracted from spinach plants infected with an isolate of race 1, race 2, or a 1:1 mixture of both races, the amount of target-DNA detected increased with increasing severity of wilt. Plants infected with one or both isolates could be distinguished based on the ratio in copy number for each target locus. The real-time PCR assays enable rapid diagnosis of Fusarium wilt of spinach and will facilitate research on the epidemiology and management of this disease, as well as surveys on the prevalence of this understudied pathogen in regions of spinach and/or spinach seed production.

Monuments to Mestizaje and the Commemoration of Racial Democracy in Puerto Rico

AbstractIn this paper, I argue that monuments to mestizaje (miscegenation) in Puerto Rico reaffirm the myth of a harmonious mixture between the White Spaniard, Black African, and Indigenous Taíno. This racial triad, originally conceived in the nineteenth century, was institutionalized in 1956 by the Institute of Puerto Rican Culture to legitimize the reformulation of Puerto Rico's colonial status. It was meant to foster a consensus‐driven nation‐building project through a depoliticized harmonious mixture of races. I analyze ten monuments to mestizaje that privilege the white European root of Puerto Rican identity and demonstrate how their visual discourse sustains the narratives of racial democracy in Puerto Rico.

The Boundaries of Freedom: Slavery, Abolition, and the Making of Modern Brazil Edited by Brodwyn Fischer and Keila Grinberg

With an introduction and a collection of fifteen chapters, Fischer and Grinberg have provided one of the most insightful and wide-ranging analyses of slavery, abolition, and its legacies in Brazil published to date. The editors’ introduction highlights three individuals who re-surface throughout the volume. Son of a wealthy landowner in the province (now state) of Pernambuco, Joaquim Nabuco (1813–1878) founded the Brazilian Anti-Slavery Society in September 1880. That Society and Nabuco’s book Abolitionism (1883) helped to foment a movement that brought Brazilian slavery to an end in 1888. Nabuco denounced slavery’s impact on all sectors of Brazilian society, highlighting how it corrupted the rule of law and harmed economic development.From the same state of Pernambuco, Gilberto Freyre (1900–1987) became one of Brazil’s most famous intellectuals of the twentieth century. Freyre’s depiction of beneficent slave owners and “racial democracy” in post-emancipation Brazil have been thoroughly debunked. Nevertheless, his descriptions of patriarchalism, family structure, sexuality, and race mixture remain hugely relevant.The third intellectual is Abdias do Nascimento (1914–2011), an African Brazilian from São Paulo. As activist, journalist, playwright, and professor, Nascimento relentlessly affirmed the contributions of Africans and their descendants to Brazilian society. By emphasizing Black resistance to enslavement and detailing the pervasive racism directed toward Blackness since the founding of the nation, Nascimento fueled controversial debates. Many of his initiatives became government policy, such as the revision of educational curricula to include diverse histories and affirmative action in employment. Nabuco’s critiques of institutions and economics, Freyre’s expansive social histories, and Nascimento’s studies of culture inspired research that is readily witnessed in The Boundaries of Freedom. Extended stays and experiences outside Brazil influenced all three of these men; several of the chapters address the theme of transnationalism.In a section entitled “On the Ethic of Silence,” Hebe Mattos comments on the book’s interdisciplinarity: “The theoretical references for this work [the collection of chapters] from E. P. Thompson’s cultural Marxism to the micro-historical methodologies of Fredrik Barth, emphasize the relational and political meanings of collective identity formation, as well as the relationship between normative structures and social agency” (317). Tying macro-histories (such as paternalism, plantation economies, class relations, and expanding capitalism) with micro-histories (such as slave flight, court appeals, day-by-day violence, labor conditions, and residential patterns), contributors shed light on silent histories and “precarious freedoms” during and after slavery. Quantitative methods provide evidence of the transport of enslaved children to the province of Pernambuco. Local legislation banned the purchase of goods produced by slaves and prevented access to taverns. “Subterranean structures” ensured the marginalization of female slaves and free Black women after emancipation. Free Black intellectuals, such as Teodoro Sampaio and André Rebouças, employed personal and professional skills to negotiate their way in hostile environments. Complex themes related to social agency and Black resistance emerge through contributors’ meticulous readings of original written documents and newspapers, as well as a close viewing of posters, paintings, and photographs located in archives large and small inside and outside Brazil.In a chapter describing relations between Brazil and Uruguay, Grinberg shows how tensions mounted pursuant to Uruguay’s emancipation decree of 1842. Slaves who crossed the border into Uruguay gained their freedom; they could not be re-enslaved if they returned to Brazil because of an 1831 Brazilian law that banned the importation of slaves to Brazil. Planters in the southernmost province of Rio Grande do Sul condemned their own government for failing to prevent slave flight and protect their property (ownership of slaves). Instead of following traditional approaches to the study of diplomacy, Grinberg points to the need to “forge a social history of international relations” (131). Such a plea, alongside the path-breaking insights shared in this volume, could not be more relevant.

Indian Time: Temporality, Gender, Mobility

Indian Time: Temporality, Gender, Mobility

The ruse of impurity: Paul Gilroy’s The Black Atlantic and the politics of hybridity

ABSTRACT Placing Paul Gilroy’s The Black Atlantic: Modernity and Double Consciousness (1993) within a larger historical and transnational context, this essay interrogates Gilroy’s uncritical deployment of mestizaje and hybridity to theorize Black subject formation and Black cultural productions. In doing so, it shows that the exclusion of Afro-Latin America and the Hispanophone Caribbean has crucial consequences for the work’s conceptualization of the Black Atlantic and its broader racial politics. While Gilroy seeks to repudiate what he calls ‘the dangerous obsessions with ‘racial’ purity which are circulating inside and outside black politics,’ I argue that the obsession with hybridity that animates Gilroy’s work is no less dangerous. Contrary to Gilroy’s assumption, ‘creolisation, métissage, mestizaje, and hybridity’ do not ‘exceed racial discourse,’ but are rather embedded in the history and logics of the Latin American eugenics movement. As it fails to contend with the material histories of racial mixture as a white supremacist technology, The Black Atlantic echoes some of these eugenicist logics, colluding with the anti-Black agenda that it seeks to contest. In the process, the book prefigures the racial disavowal of Gilroy's later work and leaves us with inadequate tools for understanding the workings of racial power.

Blood Count Parameters As Early Predictors of Clonal Cytopenia of Undetermined Significance (CCUS) Using a Diverse Ethnoracial Data Set

Background: Hematologic malignancies are a spectrum of disease that frequently have an insidious onset and may be difficult to diagnose. Improved screening using basic complete blood count parameters are needed to enhance early detection of these processes. Aging results in an expansion of hematopoietic clones that may predispose individuals to subsequent development of a hematologic malignancy. Recent studies with next generation sequencing (NGS) and whole-exome sequencing have identified certain somatic mutations known as DTA mutations that are associated with aging (e.g., DNMT3A, TET2, and ASXL1). These mutations, although more commonly seen in myeloid malignancies, are initially benign but may develop into overt hematologic malignancy and are collectively termed clonal hematopoiesis of indeterminate potential (CHIP). Similarly, individuals with cytopenia and clonal mutations are designated as clonal cytopenia of undetermined significance (CCUS). However, these mutations carry a risk of progression to hematologic malignancy. Animal models have shown that clonal hematopoiesis can accelerate cardiovascular mortality due to increased atherogenesis by causing inflammation and endothelial injury via upregulation of inflammasome pathways. Also, it has already been shown that clonal hematopoiesis with increasing number of clonal mutations, higher variant allele frequency and mutations in known driver genes have a higher risk of progression to hematopoietic malignancy (acute myeloid leukemia, AML). Certain acute phase reactants, like C-reactive protein (CRP) or erythrocyte sedimentation rate (ESR) have been used in prior studies as markers of inflammation and are strongly associated with variations in red cell size as determined by the red cell distribution width (RDW), reflecting chimeric clonal origins. We therefore propose that RDW and mean corpuscular volume (MCV) with or without other blood count parameters (red cell count, white blood cell count and platelet count) might be used as important predictors of progression of myeloid neoplasms, especially myelodysplastic syndromes (MDS), clonal cytopenias (CCUS) and acute myeloid leukemias (AML). Methods: Utilizing Epic's self-service reporting tool SlicerDicer, cohort discovery was performed on the Caboodle Patients data model. Cohort criteria included individuals with the cytopenia diagnostic grouper that had undergone blood or bone marrow myeloid panel next generation sequencing, that also had concurrent or historic complete blood count (CBC) results. Patients with known acute leukemias were excluded. Once the cohort was identified, a data pull was performed that captured CBC values, age, gender, race, and ethnicity, in addition to the NGS results. The NGS results were ranked into 3 classes from 0 to 2. Class 0 included results with no apparent disease, while class 2 results included high grade myeloid mutations (i.e. mutations in NRAS, KRAS, TP53, RUNX1 or ASKL1). Class 1 mutations were considered low grade and featured mutations not seen in class 2. The collated data was analyzed using SAS software. Results: Overall 72 patients met inclusion criteria. Patients ranged in age from 23 to 92 years, 48% identified as female and 52% identified as male with a mixture of race and ethnicity (Table 1). Abnormalities in several CBC components including MCH, MCHC, RBC count, and hemoglobin concentration were associated with increased odds of identifying those with malignant myeloid processes (Figure 1). It is notable that no mutations in FLT3 or KIT were observed in this cohort. Discussion: Based on our preliminary data, these cost-effective parameters can be added to an algorithm for risk assessment of hematologic neoplasms and better predict which patients will further benefit from targeted gene testing. Also, additional data will be helpful and applying this data to modern machine learning techniques will further the clinical application of these findings. Figure 1View largeDownload PPTFigure 1View largeDownload PPT Close modal

BoCAPS: Rapid screening of chemical races in Botryococcus braunii with direct PCR-CAPS

The colony-forming microalga Botryococcus braunii produces petroleum-like hydrocarbons and is a promising source for biofuel production. B. braunii is classified into three chemical races (A, B, L) plus a tentative class (S), based on the structure of its hydrocarbons. The determination of hydrocarbon structure in a newly isolated strain requires several months for culturing and analysis. As potential for biofuel production differs among races, a rapid method for estimating race is needed for the effective bioprospecting. This study aimed to develop a DNA-based rapid estimation method (BoCAPS) of the chemical races of B. braunii and to test the feasibility of direct PCR from a single colony. A total of 247 wild strains were isolated from 29 ponds in Japan and Indonesia, their 18S rRNA sequences determined, and a phylogenetic tree constructed based on the sequences of standard strains with known chemical races. Polymorphisms between clades of the phylogenetic tree corresponding to chemical races were mapped, and a cleaved amplified polymorphic sequence (CAPS) marker was developed for race discrimination. Direct PCR was tested on a single colony as a template. We demonstrated that HaeIII restriction of the PCR product enables race discrimination on agarose gels, and that direct PCR amplifies the 18S rRNA gene from a single colony without any pre-treatment. With BoCAPS, we investigated race compositions of the isolated strains and determined that the B-race was dominant (74 %). Neither the A-race nor S-race strains were isolated from tropical regions. In addition, we observed a few ponds in which minor races (L or A) were dominant and some ponds with a mixture of different races. The BoCAPS allows us to estimate chemical race without the time-consuming and expensive analysis of hydrocarbons and will be useful for high-throughput screening and ecological studies of wild populations.

Long-term Risk of Overdose or Mental Health Crisis After Opioid Dose Tapering

Patients prescribed long-term opioid therapy are increasingly undergoing dose tapering. Recent studies suggest that tapering is associated with short-term risks of substance misuse, overdose, and mental health crisis, although lower opioid dose could reduce risks of adverse events over the longer term. To assess the longer-term risks of overdose or mental health crisis associated with opioid dose tapering. This is a cohort study using an exposure-crossover analysis. Data were obtained from the OptumLabs Data Warehouse, which includes deidentified medical and pharmacy claims and enrollment records for commercial insurance and Medicare Advantage enrollees, representing a diverse mixture of ages, races, ethnicities, and geographical regions across the US. Participants were US adults who underwent opioid dose tapering from 2008 to 2017 after a 12-month baseline period of stable daily dosing of 50 morphine milligram equivalents or higher and who had at least 1 month of long-term follow-up during a postinduction period beginning 12 months after taper initiation. Data analysis was performed from October 2021 to April 2022. Opioid tapering, defined as 15% or more relative reduction in mean daily dose during any of 6 overlapping 60-day windows within a 7-month follow-up period after the stable baseline period. Emergency or hospital encounters for drug overdose or withdrawal and mental health crisis (depression, anxiety, or suicide attempt). Outcome counts were assessed in pretaper and postinduction periods (from 12 to 24 months after taper initiation). The study included 21 515 tapering events among 19 377 patients with a mean (SD) of 9.1 (2.7) months of postinduction follow-up per event (median [IQR], 10 [8-11] months). Patients had a mean (SD) age of 56.9 (11.2) years, 11 581 (53.8%) were female, and 8217 (38.2%) had commercial insurance (vs Medicare Advantage). In conditional negative binomial regression analyses, adjusted incidence rate ratios for the postinduction period compared with the pretaper period were 1.57 (95% CI, 1.42-1.74) for overdose or withdrawal and 1.52 (95% CI, 1.35-1.71) for mental health crisis. These findings suggest that opioid tapering was associated with increased rates of overdose, withdrawal, and mental health crisis extending up to 2 years after taper initiation.

Identification and Mapping of QTL for Stripe Rust Resistance in the Chinese Wheat Cultivar Shumai126.

Stripe rust, caused by Puccinia striiformis f. sp. tritici, is a damaging disease of wheat globally, and breeding resistant cultivars is the best control strategy. The Chinese winter wheat cultivar Shumai126 (SM126) exhibited strong resistance to P. striiformis f. sp. tritici in the field for more than 10 years. The objective of this study was to identify and map quantitative trait loci (QTL) for resistance to stripe rust in a population of 154 recombinant inbred lines (RILs) derived from a cross between cultivars Taichang29 (TC29) and SM126. The RILs were tested in six field environments with a mixture of the Chinese prevalent races (CYR32, CYR33, CYR34, Zhong4, and HY46) of P. striiformis f. sp. tritici and in growth chamber with race CYR34 and genotyped using the Wheat55K single nucleotide polymorphism (SNP) array. Six QTL were mapped on chromosomes 1BL, 2AS, 2AL, 6AS, 6BS, and 7BL, respectively. All QTL were contributed by SM126 except QYr.sicau-2AL. The QYr.sicau-1BL and QYr.sicau-2AS had major effects, explaining 27.00 to 39.91% and 11.89 to 17.11% of phenotypic variances, which may correspond to known resistance genes Yr29 and Yr69, respectively. The QYr.sicau-2AL, QYr.sicau-6AS, and QYr.sicau-6BS with minor effects are likely novel. QYr.sicau-7BL was only detected based on growth chamber seedling data. Additive effects were detected for the combination of QYr.sicau-1BL, QYr.sicau-2AS, and QYr.sicau-2AL. SNP markers linked to QYr.sicau-1BL (AX-111056129 and AX-108839316) and QYr.sicau-2AS (AX-111557864 and AX-110433540) were converted to breeder-friendly Kompetitive allele-specific PCR (KASP) markers that would facilitate the deployment of stripe rust resistance genes in wheat breeding.

Losses caused by stem rust (Puccinia graminis f.sp tritici) on durum wheat in Ethiopia

Stem rust caused by Puccinia graminis f.sp. tritici is one of the major biotic constraints of wheat production. The disease may cause substantial quantitative and qualitative yield losses but much of the work in Ethiopia on this pathosystem focuses on quantitative yield loss of durum wheat. This work was carried out at Debre Zeit Agriculture Research Centre during 2015/16 and 2016/17 main and off-seasons. Hence the current study was conducted with the objectives to quantify the amount of loss in grain yield due to stem rust and assess the relationship between disease parameters, grain yield, and physical quality parameters of improved durum wheat varieties grown in Ethiopia. Artificial inoculation was performed using a mixture of different dominant stem rust races. There were treated and untreated plots by fungicide that serves as protected and unprotected plots, respectively. Disease severity was recorded each 10 days interval and area under disease progress curve (AUDPC), terminal severity, and coefficient of infection were calculated. The tested cultivars exhibited different disease severity levels, having a mean value of 6.7-76%. High values of area under disease progress curve (AUDPC) were detected on Hitossa, Utuba (1225.7, 585.9). Whereas the lowest values of yield loss were recorded on CVS. Mangudo and Utuba have the mean value of yield loss of 40.2 and 44.8%, respectively. The highest yield loss was observed on susceptible variety Hitosa showing the mean value of 70%. Correlation coefficients were tested between yield losses and values of AUDPC, final stem rust severity, coefficient of infection, and rate of infection of the tested cultivars. There were strong correlation coefficients among disease parameters (r=0.72-0.99). There was also a moderately strong negative correlation coefficient among disease parameters and yield, hectoliter weight, and 1000-kernel weight of the test cultivars (r= -0.53 to -0.81). The current study indicated that the application of Rex Duo can be used in minimizing yield losses caused by the stem rust disease of durum wheat. Therefore, supporting the released durum wheat cultivars with fungicide application is the most pertinent issue in Ethiopia as most of the durum wheat cultivars in farmers' hands were moderately susceptible to susceptible cultivars Pgt races.

Introduction: Race science in the Latin world.

This essay outlines the various analytical frameworks related to the history of race science that contribute to a "Latin" intellectual culture and tradition. In addition to defining Latinity as applied to the history of science, this article examines the troubled relationship between Latin American history and histories of science characterized as global. Similarly, it explores intellectual linkages across the Global South regarding racial mixture and the legacy of colonialism. It concludes by considering how a Latin perspective can illuminate the continued hegemony of ideas and scientific practices originating in North America and northern Europe.