Quinoline Yellow Research Articles

Combining ACE, PLS-R, and SVM-R for rapid detection of adulteration in saffron samples by diffuse reflectance infrared fourier transform spectroscopy

Accurate estimation of saffron purity is essential for ensuring product integrity, particularly in the presence of common chemical adulterants such as tartrazine, sunset yellow, and quinoline yellow. This study introduces the alternating conditional expectations (ACE) algorithm, coupled with diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), as an innovative chemometric approach to address this challenge. The ACE algorithm utilizes optimal transformations for both independent and dependent variables, revealing non-linear relationships and maximizing linear effects between transformed variables. To prepare the spectral data for ACE modeling, we will perform moving average smoothing and Standard Normal Variate (SNV) transformation for preprocessing. Subsequently, we will employ the duplex algorithm to select both calibration and prediction sets from the preprocessed data matrix. The effectiveness of the ACE model was evaluated using several metrics, including the coefficient of determination (R2), adjusted R-squared (R2adj), sum of squared errors (SSE), Regression Sum of Squares (SSR) and mean squared error (MSE). ACE model exhibited excellent performance in determining saffron content even in the presence of adulterants like tartrazine, sunset yellow, and quinoline yellow, on both calibration and prediction sets. Our model achieved excellent performance on both datasets. On the calibration set, a high R2 value (0.9951) indicates a strong correlation between predicted and observed saffron content in the model. The R2adj (0.9950) further strengthens this conclusion by accounting for model complexity, suggesting the model avoids overfitting. These findings are complemented by robustness measures. The statistical parameters of the ACE model, such as total sum of squares (SST) (1.103∗104), SSR (1.098∗104), SSE (54.414), and MSE (0.878), were calculated to compare the performance of the developed methods for determining Saffron's concentration in each mixed sample.

Quinoline yellow acts as a novel amyloid fibrillation probe by using surface-enhanced Raman spectroscopy

Protein amyloid fibrillation is linked to a wide range of neurodegenerative diseases. Protein oligomer is an intermediate substance in the process of fibrillation, which is neurotoxic and formed by the aggregation of protein molecules under physiological stress. Early detection of protein oligomers could make timely intervention of protein fibrillation related diseases. Therefore, it is crucial to develop efficient inhibitors and probes for monitoring amyloid fibril formation. In this study, we developed a novel amyloid inhibitor quinoline yellow (QY), which was proved to be effective in inhibiting insulin protein fibrillation as demonstrated by fluorescence, morphology characterization and circular dichroism. When QY binds to insulin, it exerts inhibitory effects on the nucleation process and effectively impedes the formation of fibrillar fibrils. In addition, we present the application of surface-enhanced Raman spectroscopy (SERS) as an extremely sensitive technique for identifying amyloid oligomers. The investigation employed the probe QY, which demonstrated a linear reaction for identifying oligomers in the concentration range of 1.0–58.0 μM. Impressively, it showcased an exceptionally sensitive detection threshold of 0.2 μM. And also illustrating the binding sites and interaction mechanisms between small molecules of QY and insulin by SERS. The aforementioned methodology was also employed for the identification of insulin oligomers in human serum samples. Thereby, the proposed approach presenting a promising avenue with extensive implications in the realms of pharmaceutical exploration and disease diagnosis.

Green Synthesis of CQDs via the Trunks of Bauhinia purpurea as Fluorescence Probes for Rapid and Accurate Detection of Quinoline Yellow.

Carbon quantum dots (CQDs) were greenly synthesized via a single-step hydrothermal method, using the trunks of Bauhinia purpurea as the carbon source. They exhibited good dispersibility, water solubility, high sensitivity, and great stability with a spherical form and a particle size of 2.68 ± 0.32 nm. By utilizing the inner filter effect and dynamic quenching effect, the fluorescence quenching of CQDs can be induced to detect quinoline yellow. Detailed experimental results showed that the change rate of fluorescence intensity of CQDshadagood linearrelationshipwith varying concentrations of quinoline yellow (2-128 µmol/L). It can be clearly observed that the fluorescence quenching occurred within 1 min, its correlation coefficient (R2) is 0.9912, and the detection limit (DL) is 1.7884 μmol/L, substantially lower than the maximum concentration stipulated by the national standard of 209.5 µmol/L. Furthermore, quinoline yellow had been successfully detected in real beverage samples using CQDs, with the recovery rates of 90.6%-110.4% and the relative standard deviation (RSD) ≤ 6.3% and it also showed great anti-interference and selectivity. These findings indicate that the detected quinoline yellow of CQDs possess substantial promise for a wide range of applications within the detected artificial food colors field.

Nitrogen-doped carbon quantum dots as dual mode fluorescence sensors for the determination of food colorant quinoline yellow

Quinoline yellow (QY), as a food coloring agent, will consume a large number of detoxifying substances in the body after being ingested by the human body, interfering with the normal metabolic functions of the human body, and may cause allergies, diarrhea and other symptoms, as well as a certain degree of carcinogenicity, posing a great threat to human health. As a result, it is critical to develop a fast, sensitive, and effective approach to determining quinoline yellow in food. In this study, carbon dots (N-CQDs) with high fluorescence quantum yield were prepared and used to determine the QY content using the dual mode of internal filtering effect and fluorescence emission shift detection. Both methods showed good linearity in the range of QY concentration of 0.3–3.2 μM, and the detection limits were classified as 2.6 nM and 0.18 μM. In addition, in order to achieve visual detection of QY, fluorescent test strips were constructed using the carbon dots and non-fluorescent qualitative filter paper to make the detection of QY more convenient. This probe presents a novel way for detecting quinoline yellow in food analysis.

Development, Validation, Identification and Estimation of Quinoline Yellow in the Levodopa and Carbidopa Pharmaceutical Combined dosage form by Ultra violet Visible Spectrophotometer

A simple, cost-effective, précised, accurate and robust Ultra Violet spectrophotometric method [1, 2 ] has been developed for the Identification and estimation of Quinoline Yellow in the Levodopa and Carbidopa tablet dosage forms. It is used as a colourant in the pharmaceutical tablet’s dosage form. UV scan of Quinoline yellow was taken from the entire UV range of 200 to 800 nm. From the spectrum, maximum absorption was observed at 414nm (λmax) for the Quinoline Yellow. Method was found to be specific with no interference due to blank and placebo, The method was linear with a correlation coefficient of more than 0.999, and Accuracy was in the range of 98.3 to 101.3, In the robustness study employed for standard and sample preparation showed no impact on the results, by deliberate changes proves method is robust and can be utilized for regular analysis. Method validation was performed with reference to ICH guidelines Q2R1.

Investigating the binding interaction of quinoline yellow with bovine serum albumin and anti-amyloidogenic behavior of ferulic acid on QY-induced BSA fibrils

Protein aggregation induces profound changes in the structure along with the conformation of the protein, and is responsible for the pathogenesis of a number of neurodegenerative conditions such as Huntington’s, Creutzfeldt–Jacob, Type II diabetes mellitus, Alzheimer’s, etc. Numerous multi-spectroscopic approaches and in-silico experiments were utilized to investigate BSA’s biomolecular interaction and aggregation in the presence of quinoline yellow. The present research investigation evaluated the interaction of BSA with the food colorant (QY) at two different pH (7.4 and 2.0). The development of the BSA-QY complex was established with UV visible and fluorescence spectroscopy. The quenching of fluorescence upon the interaction of BSA with QY revealed the static nature of quenching mechanism. The Kb value obtained from our result is 4. 54 × 10−4 M−1. The results from the competitive site marker study infer that quinoline yellow is binding with the sub-domain IB of bovine serum albumin, specifically on site III. Three-dimensional fluorescence and synchronous fluorescence spectroscopy were applied for monitoring the alterations in the microenvironment of BSA upon the addition of quinoline yellow. The results from turbidity and RLS studies showed that higher concentrations of QY (80–400 µM) triggered bovine serum albumin (BSA) aggregation at pH 2.0. At pH 7.4, QY couldn’t manage to trigger bovine serum albumin aggregation, perhaps because of the repulsion between negatively charged dye (QY) and anionic bovine serum albumin. The results from far-UV CD, Congo Red, and scanning electron microscopy implicate that the QY-induced aggregates exhibit amyloid fibril-like structures. Molecular docking results revealed that hydrophobic interactions, hydrogen bonding, and Pi-Sulfur interactions contribute to QY-induced aggregation of BSA. Further, the amyloid inhibitory potential of ferulic acid (FA), a phenolic acid on QY-induced aggregation of BSA, has also been assessed. The QY-induced amyloid fibrils are FA-soluble, as confirmed by turbidity, RLS, and far-UV CD studies. Far-UV CD results showed that FA retains α helix and inhibits cross β sheet formation when the BSA samples were pre-incubated with increasing concentrations of FA (0–500 µM). Our findings conclude that QY dye successfully stimulates BSA aggregation, but ferulic acid inhibits QY-induced aggregation of BSA. Thus, FA can serve as a therapeutic agent and can help in the treatment of various amyloid-related conditions.

Ag@MUT-16 nanocomposite as a Fenton-like and plasmonic photocatalyst for degradation of Quinoline Yellow under visible light.

A new cobalt-based metal-organic framework with the chemical formula of [Co2(DClTPA)2(DABCO)]·(DMF)4 (MUT-16) containing 1,4-diazabicyclo[2.2.2]octane (DABCO) and 2,5-dichloroterephthalic acid (DClTPA) has been designed and prepared through a solvothermal method. MUT-16 (MUT = Materials from University of Tehran) crystallized in a tetragonal system with I41/acd space group, based on single-crystal X-ray analysis. The Ag@MUT-16 nanocomposite was prepared using Ag nanoparticles (NPs) loaded into/onto porous MUT-16via photoreduction route (PR). The MUT-16 and Ag@MUT-16 were characterized using various techniques, such as PXRD, FT-IR, FE-SEM, TEM, EDX, N2 adsorption-desorption isotherms, TGA, DRS, PL, EIS, and Mott-Schottky measurements. The Ag@MUT-16 nanocomposite showed photocatalytic activity of 87.75% in the degradation of Quinoline Yellow (QY) after 30 min under visible light irradiation. The distinctive characteristics of the Ag@MUT-16 nanocomposite, such as the Fenton-like effect of Co2+ ions, surface plasmon resonance (SPR) of Ag NPs, Schottky junction at interfaces between Ag NPs and MUT-16, and reduction of electron-hole recombination through electron trapping by Ag NPs as co-catalyst, all play significant roles in the photocatalytic degradation of Quinoline Yellow (QY).

Synthesis of a coordination polymer based on Zn(DMF)(Tp) as a novel adsorbent for the simultaneous removal of quinoline yellow and azure B

In this study, a Zn(DMF)(Tp) coordination polymer was synthesized by solvothermal method using dimethylformamide (DMF) and terephthalic acid (TP). It was then characterized by single crystal X-ray diffraction (SCXRD), thermal gravimetric analysis (TGA), X-ray diffraction (XRD), and Fourier-transform infrared spectrometer (FT-IR). The polymer was used as an adsorbent for the simultaneous removal of quinoline yellow (QY) and azure B (AZB) dyes. Accordingly, the effects of four parameters, including pH, amount of adsorbent, contact time, and initial dye concentration, on removal efficiency were studied and optimized by response surface methodology based on the central composite design (RSM-CCD). The optimal conditions for maximum adsorption theoretically determined by RSM-CCD were as follows: 6 min contact time, 15 mg Zn(DMF)(Tp), pH of 3, 10 mg/L AZB, and 13 mg/L QY, with percentage removal values of 94.70 and 90.79 for QY and AZB, respectively. The monolayer adsorption capacity was 46.57 and 40.983 mg/g for QY and AZB, respectively. A kinetic study was performed under optimal conditions. In addition, all data corresponding to the process were fitted with pseudo-second-order model. The adsorbent provides fast adsorption due to its porous structure and high removal efficiency due to its high specific surface area.

Bacterial Cellulose Aerogels Derived from Pineapple Peel Waste for the Adsorption of Dyes.

Valorization of pineapple peel waste is an attractive research topic because of the huge quantities of this byproduct generated from pineapple processing industries. In this study, the extract from pineapple waste was collected to produce a hydrogel-like form containing bacterial cellulose fibers with a three-dimensional structure and nanoscale diameter by the Acetobacter xylinum fermentation process. The bacterial cellulose suspension was subsequently activated by freeze-drying, affording lightweight aerogels as potential adsorbents in wastewater treatment, in particular the adsorptive removal of organic dyes. Intensive tests were carried out with the adsorption of methylene blue, a typical cationic dye, to investigate the influence of adsorption conditions (temperature, pH, initial dye concentration, time, and experiment scale) and aerogel-preparation parameters (grinding time and bacterial cellulose concentration). The bacterial cellulose-based aerogels exhibited high adsorption capacity not only for methylene blue but also for other cationic dyes, including malachite green, rhodamine B, and crystal violet (28-49 mg/g). However, its activity was limited for most of the anionic dyes, such as methyl orange, sunset yellow, and quinoline yellow, due to the repulsion of these anionic dyes with the aerogel surface, except for the case of congo red. It is also an anionic dye but has two amine groups providing a strong interaction with the hydroxyl group of the aerogel via hydrogen bonding. Indeed, the aerogel has a substantially large congo red-trapping capacity of 101 mg/g. Notably, the adsorption process exhibited similar performances, upscaling the solution volume to 50 times. The utilization of abundant agricultural waste in the simple aerogel preparation to produce a highly efficient and biodegradable adsorbent is the highlight of this work.

Highly Sensitive Voltammetric Method for Quinoline Yellow Determination on Renewable Amalgam Film Electrode.

A novel electrochemical method for the determination of quinoline yellow (QY) was developed using the renewable amalgam film electrode (Hg(Ag)FE). The sensors used can be characterized by good stability and long lifespan. Irreversible QY reduction peaks were recorded in 0.05 mol L-1 HCl with a potential of about -630 mV. The use of the Hg(Ag)FE electrode with a regulated working surface allowed the QY limit of detection to be as low as 0.48 nmol L-1. The obtained result is the lowest in comparison to other voltammetric methods described in the literature. The effects of parameters such as the size of the working electrode surface, influence of the pH value, accumulation time, and potential were investigated to provide precision and high sensitivity of the performed measurements. This new procedure was applied for the highly sensitive determination of quinoline yellow in different beverages, pre-workout supplements, and throat lozenges. The process of sample preparation was relatively simple. Calculated recoveries (96-107%) suggest that the method can be considered accurate.

MoS2 quantum dots-based optical sensing platform for the analysis of synthetic colorants. Application to quinoline yellow determination

In this work, a novel fluorescence sensor has been designed to solve the actual need of new fast and inexpensive sensing platforms for the analysis of synthetic colorants. It is based on MoS2 quantum dots obtained by a hydrothermal method and incorporated as fluorophore into the matrix of PVC membranes, which are deposited on quartz substrates by spin-coating. It was proven, as in these conditions, MoS2 quantum dots maintain the fluorescent properties that they present in solution. Experiments carried out in solution displayed a maximum emission when they were excited under 310 nm. This initial fluorescence decreases linearly in presence of increasing concentrations of various synthetic colorants namely quinoline yellow, tartrazine, sunset yellow, allura red, ponceau 4R and carmoisine. The two possible mechanisms that can explain this quenching effect, colorants absorbing photons emitted by quantum dots and/or competing with the nanomaterial for photons coming from the excitation source, were evaluated. The most pronounced effect was observed with quinoline yellow, as a result of a mixed mechanism. The optimized methodology developed for the determination of quinoline yellow showed a linear concentration range between 5.4 and 55.0 µg with a limit of detection of 1.6 µg. The sensor was applied to the determination of quinoline yellow in a food colour paste obtaining results in good agreement with those obtained by HPLC-UV–vis measurements.

Consumption of commonly used artificial food dyes increases activity and oxidative stress in the animal model Caenorhabditis elegans

In recent decades, the consumption of artificial colorants in foods and beverages has increased despite of concerns in the general population raised by studies that have shown possible injurious effects. In this study, tartrazine, sunset yellow, quinoline yellow, ponceau 4R, carmoisine and allura red were employed as pure compounds to explore their effects in vivo in the animal model Caenorhabditis elegans. The exposition of C. elegans to these artificial dyes produced damage related with aging such as oxidative stress and lipofuscin accumulation, as well as a heavy shortening of lifespan, alterations in movement patterns and alterations in the production of dopamine receptors. Besides, microarray analysis performed with worms treated with tartrazine and ponceau 4R showed how the consumption of synthetic colorants is able to alter the expression of genes involved in resistance to oxidative stress and neurodegeneration.

Effects of two food colorants on catalase and trypsin: Binding evidences from experimental and computational analysis

Recently, growing concern has been paid to the toxicity of additives in food. The present study investigated the interaction of two commonly used food colorants, quinoline yellow (QY) and sunset yellow (SY), with catalase and trypsin under physiological conditions by fluorescence, isothermal titration calorimetry (ITC), ultraviolet-vis absorption, synchronous fluorescence techniques as well as molecular docking. Based on the fluorescence spectra and ITC data, both QY and SY could significantly quench the intrinsic fluorescence of catalase or trypsin spontaneously to form a moderate complex driven by different forces. Additionally, the thermodynamics results demonstrated QY bind more tightly to both catalase and trypsin than SY, suggesting QY poses more of a threat to two enzymes than SY. Furthermore, the binding of two colorants could not only lead to the conformational and microenvironmental alterations of both catalase and trypsin, but also inhibit the activity of two enzymes. This study provides an important reference for understanding the biological transportation of synthetic food colorants in vivo, and enhancing their risk assessment on food safety.

Synthesis and testing of polyacrylamide‐grafted waste sand derived composite adsorbent for water purification

AbstractIn this work, waste sand derived polyacrylamide grafted sand particles (PAGSPs) were developed as an effective adsorbent for the adsorption of organic and inorganic pollutants from water. The composite particles were characterized using FESEM, EDX, ATR‐FTIR, XRD, TGA, and BET analyses. The FESEM results revealed the sizes of composite particles were in the micrometer range and BET analysis showed specific surface area of 10 m2 g−1 with average pore radius of 1.22 nm. The adsorption isotherm and kinetics of dyes namely Methyl Orange (MO) and Quinoline Yellow (QY) and Ni(II) and Cr(VI) metal ions were analyzed. The adsorption capacities for dyes MO and QY were 32.25 and 55.55 mg g−1 and for metal ions Ni(II) and Cr(VI) were 75.18 and 125 mg g−1 respectively, at experimental pH conditions. Because of the excellent regeneration capacity, the functional polymer based composite particles exhibit great potential for the removal of any organic and inorganic pollutants from wastewater.

Synthesis of layered zinc-aluminium double hydroxides modified with metal ions as photocatalysts with enhanced sorption properties

In the article the process of Fe, Co, Ni and Cu hydroxides modified nanoparticles of layered double hydroxides (LDH) based on Zn and Al (Zn-Al LDH) was successfully presented. The precipitation method allowed to obtain nanoparticles of high crystallinity with lateral dimensions below 100 nm and thickness below 20 nm. The photocatalytic activity of the modified LDH in the degradation process of quinoline yellow was over 99%, while for the unmodified LDH the efficiency was only 30%. The study confirmed that modification of LDH with divalent ions had a significant effect on both photocatalytic and sorption properties. Furthermore, the study also investigated the effect of the nature of the type of light on the photodegradation efficiency.

Food additive dye–lysozyme complexation: Determination of binding constants and binding sites by fluorescence spectroscopy and modeling methods

The interaction mechanisms of QY with lysozyme were investigated using multispectral and molecular docking methods in the current study. Quinoline yellow (QY) is a synthetic dye that is widely used in the food industry. The interaction of QY with this proteinase was studied using fluorescence spectroscopy. The fluorescence quenching results demonstrated that QY could quench this proteinase's intrinsic fluorescence using a static quenching procedure. Through hydrogen bonding and van der Waals interactions, QY binds to lysozyme. The binding constant (Ka) and the number of binding sites (n) for this binding interaction were determined using associated fluorescence quenching data. The presence of QY dye reduced enzyme activity, according to kinetic technique analysis. The CD results confirmed the protein's conformational changes during the complexation process. Aside from the experimental studies, molecular docking revealed the precise binding location of QY within the lysozyme enzyme structure. Molecular dynamics simulation was also used to assess the stability of the lysozyme-QY complex.

Enhanced reactivity of the CuO-Fe2O3 intimate heterojunction for the oxidation of quinoline yellow dye (E104).

This research work describes the degradation of quinoline yellow (QY) in aqueous solutions by the heterogeneous Fenton and photo-Fenton processes in the presence of CuO/Fe2O3 photocatalyst. CuO/Fe2O3 derived from LDH structure was synthesized by the co-precipitation method. The physiochemical characteristics of CuO/Fe2O3 were described by XRD, TEM/SEM, BET surface area, and FTIR techniques. The effects of pH, H2O2concentration, dye concentration, catalyst dose, reaction temperature, and reusability of catalyst on the QY decolorization efficiency were studied. The results indicated that a complete removal of QY was achieved within 150 min, when the H2O2 and QY concentrations were 27.6 mM and 100 mg/L, respectively. The rate constants for QY removal by the heterogeneous Fenton system were calculated, and the experimental data were found to fit the pseudo-first order model. Under optimal conditions, the rate constants were, respectively, 0.02032 and 0.01715 min-1 for the photo-Fenton and Fenton systems; this means that the addition of light has not a noticeable effect.

Micellar extraction and spectrophotometric determination of quinoline yellow in drugs

A distinctive feature of modern drugs is a complex multicomponent composition, including both medicinal and auxiliary substances. The synthetic food dye Quinoline yellow (QY) is widely used for color correction, however, the determination of QY by the spectrophotometric method is impossible without separating the preparation from the matrix. Micellar extraction with polyoxyethylated alkylphenols Triton X-100 and OP-10 is proposed as an alternative to solid-phase extraction and traditional extraction with organic solvents. The phase separation of aqueous and aqueous-salt solutions of Triton X-100 and OP-10 with a con-centration of 1 to 10% is studied in various modes: polythermal (when heated to cloud point) and isothermal (salting out at 25°C). Sodium and ammonium sulfates and sodium carbonate are used as salting-out agents. Their salting-out ability decreases in the series Na2CO3 > Na2SO4 > (NH4)2SO4. The effect of the acidity of the medium and the nature of the electrolyte on the state of the QY in aqueous and aqueous micellar solutions is also studied. The form of the dye does not change within the pH range 1 – 8 and with the addition of Na2SO4, (NH4)2SO4. At higher pH values and in the presence of Na2CO3, structural changes occur in the molecule. The intensity and position of the maximum in the absorption spectrum change in the presence of surfactant micelles (bathochromic shift, Δλ = 8 nm). The dye distribution between the aqueous and micellar phases is studied in different modes of phase separation. It is shown that the systems with the addition of sodium and ammonium sulfates in the salting-out mode (R > 97%) have the best extraction characteristics. Optimal conditions for the maximum single extraction of the dye in the concentration range of 1 – 10 mg/liter in the aqueous solution C(surfactant) — 10%, solution volume — 10 ml, Na2SO4 — 0.84 g, temperature — 25°C, time — 30 min. A rapid and easy to use method of QY extraction concentration from orodispersible tablets (lozenges) is developed. The error of the method does not exceed 5%. The verification of the correctness of the method, carried out by HPLC, proved the absence of a systematic error.

Noncovalent interactions between Quinoline yellow and trypsin: In vitro and in silico methods

These days, synthetic colors are extensively used in many products, so it is essential to get more information about their side effects. We selected Quinoline yellow as an edible color and trypsin as one of the essential enzymes of our body in our study. Several techniques such as fluorescence spectrophotometry, UV–Vis spectroscopy, molecular dynamics simulation, and molecular docking were used to investigate the effects of Quinoline yellow on the structure and activity of trypsin. The results of UV– Vis spectroscopy and fluorescence spectrophotometry indicated that Quinoline yellow could result in a reduction in absorption and intrinsic fluorescence of the enzyme. The results obtained by fluorescence spectroscopy showed a hypochromism shift and a static form of quenching in the presence of this color. Furthermore, the thermal stability study illustrated that Quinoline yellow (until 0.056 mM) increases the Tm point of trypsin by about 5˚C. The kinetics study indicated that the Vmax value of trypsin in the presence of Quinoline yellow (0–0.0275 mM) increases from 0.0002 to 0.01 µmol.s−1. Finally, the computational study results confirmed that the trypsin could be more compact in the existence of Quinoline yellow.

A cationic surfactant-decorated liquid crystal-based sensor for sensitive detection of quinoline yellow

Quinoline yellow (QY) is one of the popular synthetic food colorants and in food industry greatly used. Developing accurate and simple QY detection procedures is of major considerable importance in ensuring food safety. Hence, it is important to detect this food colorant effectively to reduce risk. Herein, an innovative liquid crystal (LC)-based sensor was designed for the label-free and ultra-sensitive detecting of the QY by means of a cationic surfactant-decorated LC interface. The nematic liquid crystal in touch with CTAB revealed a homeotropic alignment, when QY was injected into the LC-cell, the homeotropic alignment consequently altered to a planar one by electrostatic interactions between QY and CTAB. The designed LC-based sensor detected QY at the too much trace level as low as 0.5 fM with analogous selectivity. The suggested LC-based sensor is a rapid, convenient and simple procedure for label-free detection of QY in food industrial and safety control application.