Collaborative Networks Research Articles

How do network embeddedness and knowledge stock influence collaboration dynamics? Evidence from patents

Science, technology, and innovation are becoming increasingly collaborative, prompting concerted efforts to understand and measure the factors influencing these collaborations. This study aims to explore the driving factors and underlying mechanisms of collaboration dynamics based on patent data. Multilayer longitudinal networks are constructed to scrutinize interactions among organizations as well as the embedding of their knowledge elements in the network fabric. We then analyze the structures and characteristics of collaboration and knowledge networks from global and local perspectives, in which process topological indicators and graphlets are used to feature each organization's collaborative patterns and knowledge stock. Knowledge elements are extracted to present the core concepts of patents, overcoming the limitations of predefined categorizations, such as IPC, when representing technological content and context. By performing a longitudinal analysis using a stochastic actor-oriented model, we integrate network structures, node characteristics, and different dimensions of proximity to model collaboration dynamics and reveal the driving factors behind them. An empirical study in the field of lithography finds that organizations with a larger number of partners or a higher number of annular graphlets in their collaboration networks are less likely to collaborate with others. If an assignee has a more extensive range of knowledge elements and demonstrates a higher capability for knowledge combination, or if its local knowledge network exhibits weaker connectivity, its propensity to seek new collaborators increases. Both cognitive and organizational proximity play important roles in fostering collaboration.

Vitiligo is associated with an increased risk of cardiovascular diseases: a large-scale, propensity-matched, US-based retrospective study

Vitiligo is an autoimmune disease, characterized by specific destruction of melanocytes. While associations with numerous comorbid conditions, which potentially increase the risk of cardiovascular diseases have been described, data on the risk for cardiovascular disease is inconclusive. To address this relevant knowledge gap, this study aims to identify the risk of cardiovascular disease in vitiligo. The US Collaborative Network was accessed using the TriNetX platform, allowing retrospective data retrieval from electronic health records (EHRs) from 57 US based health care organizations (HCOs). Patients with vitiligo and controls were identified by their respective ICD10 codes. Risk of onset of several cardiovascular diseases was determined in patients within 15 years after diagnoses. A total of 94 diagnoses with a prevalence of ≥1% in both cohorts, which consisted of 96,581 individuals per group after propensity-score-matching, were identified. Of those, 54 displayed an increased risk in vitiligo. None of the cardiovascular diseases investigated were associated with a decreased risk in patients with vitiligo. Specifically, cerebral infarction occurred in 1.3% of patients with vitiligo, and 1.0% in controls. This difference translated into a hazard ratio (HR) of 1.21 (95% confidence interval [CI] 1.11-1.32, padj<0.001). Venous thromboembolism was recorded in 1.34% of cases and 1.02% of controls without vitiligo, resulting in an increased HR of 1.27 (95% CI 1.171-1.38, padj<0.001). Further, major adverse cardiovascular events (MACE) as a composite endpoint was evaluated. The risk for MACE was increased following a vitiligo diagnosis (HR 1.28, 95% CI 1.22-1.35, padj<0.001), which persisted in both sensitivity analyses. Patients with vitiligo display an increased risk of onset of cardiovascular diseases as compared to healthy individuals. Thus, vitiligo might require more precise monitoring and systemic treatment. This research was supported by the Schleswig-Holstein Excellence-Chair Program from the State of Schleswig Holstein, by the Excellence Cluster Precision Medicine in Chronic Inflammation (DFG, EXC 2167), and by DFG Individual Grant LU 877/25-1.

Review article: Prevention of inflammatory bowel disease-The path forward.

The possibility of preventing inflammatory bowel disease (IBD) is becoming more plausible due to advances in understanding preclinical disease and successful prevention trials in other immune-mediated diseases, such as type 1 diabetes and rheumatoid arthritis. However, before that possibility becomes reality, several efforts need to occur in parallel and in a coordinated way. To propose some critical steps necessary for advancing the field of IBD prediction and prevention. We reviewed the current literature to identify the necessary steps toward a preventive strategy for IBD. The first step should determine the most robust predictive biomarkers and validate them across independent cohorts, creating a multidimensional predictive tool. The second step is to gain a better understanding of the preferences of first-degree relatives and people at risk for IBD, informing the implementation of screening and preventive strategies. Third, these efforts should contribute to the development of high-risk clinics and establish the necessary networks for disease prevention trials. Advancing the field of IBD prediction and prevention will require a multifaceted approach, integrating biomarker discovery, understanding patient preferences, and establishing infrastructure for a collaborative network to support the practical implementation of IBD prevention strategies.

Hereditary Rickets: A Quick Guide for the Pediatrician.

With the increased discovery of genes implicated in vitamin D metabolism and the regulation of calcium and phosphate homeostasis, a growing number of genetic forms of rickets are now recognized. These are categorized into calciopenic and phosphopenic rickets. Calciopenic forms of hereditary rickets are caused by genetic mutations that alter the enzymatic activity in the vitamin D activation pathway or impair the vitamin D receptor action. Hereditary forms of phosphopenic rickets, on the other hand, are caused by genetic mutations that lead to increased expression of FGF23 hormone or that impair the absorptive capacity of phosphate at the proximal renal tubule. Due to the clinical overlap between acquired and genetic forms of rickets, identifying children with hereditary rickets can be challenging. A clear understanding of the molecular basis of hereditary forms of rickets and their associated biochemical patterns allow the health care provider to assign the correct diagnosis, avoid non-effective interventions and shorten the duration of the diagnostic journey in these children. In this mini-review, known forms of hereditary rickets listed on the Online Mendelian Inheritance in Man database are discussed. Further, a clinical approach to identify and diagnose children with hereditary forms of rickets is suggested.

Association between hidradenitis suppurativa and gout: a propensity-score-matched cohort study.

Introduction While an association between hidradenitis suppurativa (HS) and inflammatory arthritis has been reported in clinical studies, the potential link between HS and gout remains uncertain. As HS and gout share common immunological pathways, we conducted a retrospective cohort study to determine whether HS patients are at an increased risk of developing gout in the future. Methods This retrospective multicenter cohort study obtained information through the US collaborative network, a subset of the TriNetX research network. Patients diagnosed with HS between January 01, 2005, and December 31, 2017, were recruited, and a 1:1 propensity score matching was conducted to identify appropriate controls. The hazard ratio for the new-onset of gout in HS patients was subsequently calculated. Results Compared to individuals without HS, those with HS were associated with a 1.39-fold higher risk (95% CI, 1.20, 1.62) of developing new-onset gout within five years after the index date. This association remained significant in shorter follow-up times and sensitivity analyses utilizing different matching models. For both male and female HS patients, the risk of developing new-onset gout within 5 years after the index date was statistically significant, with respective hazard ratios of 1.61 (95% CI, 1.28,2.02) for males and 1.41 (95% CI, 1.11,1.78) for females. Conclusion HS patients are at a high risk of developing gout within five years after an HS diagnosis while comparing with non-HS controls.

Mapping the Path to Low-Carbon Behaviour: A Systematic Review of Trends, Gaps, and Future Directions

It is essential to conduct research on low-carbon behaviour in order to address global climate change and promote sustainable development. This study conducts a thorough examination of a bibliometric analysis of the existing literature in this field. We analysed 129 papers from the Web of Science Core Collection database to conduct a study on the concept of “low-carbon behaviour”. Review articles, proceedings papers, and editorial materials were all excluded. This investigation examines a diverse array of research environment factors, including the most highly ranked publications, publication trends, significant publishers, and patterns in citations and publications over time. The primary institutional contributors in the discipline and the most influential works worldwide are also mentioned. The application of advanced visualisation techniques, such as wordcloud representations, the spatial distribution of research output, and co-occurrence and overlay networks, is employed to generate maps of keyword relationships and collaboration networks using Bibliometrix Stable Version, VOSviewer 1.6.20, and Scimago Graphica Beta 1.0.45. This multi-modal methodology enables a comprehensive investigation of significant research issues and emerging directions in low-carbon behavioural studies. This study contributes to the ongoing endeavours to promote sustainable development and mitigate climate change by conducting a comprehensive evaluation of the current state of research and establishing a robust framework for future investigations into low-carbon behavioural patterns and behaviours.

How research contributions of professor Jiju Antony have influenced the field of quality management: an appraisal and critique

PurposeThe purpose of this study is to apply bibliometric techniques to critically examine the contributions of Professor (Dr) Jiju Antony in the domain of quality management research over a period close to 30 years (i.e. 1995 to 2023).Design/methodology/approachThe study incorporates a bibliometric analysis approach using VoSviewer software package to critically examine the contributions and trends in publications on Scopus indexed publications of Antony, followed by an industry wide evaluation of contributions made. Thematic analysis of the bibliographic data was imported in comma-separated values (CSV) format by selecting Antony (last name) and Jiju (first name) in the author search tab in Scopus. The search was made on September 09, 2023 and bibliographic records of 429 documents were considered for the analysis. The analysis was carried out in terms of most frequent keywords used, sources with most frequent publications, thematic analysis of most cited works and global collaborations.FindingsAntony has focused his research interest largely in the domain of quality management, publishing his research in top rated journals in the domain with a broad network of international collaborators. Antony has received 18,802 and 40,947 citations in Scopus and Google Scholar, respectively. This signifies the impact that Antony has created through his research publications. His major contributions are on the topics of six sigma, lean six sigma, continuous improvement, critical success factors and quality management practice implementations in various organizations. Diverse methodologies both qualitative and quantitative were utilized to conduct his research. However, his body of work is not without criticism. Such criticism includes the limited scope of work, with narrow focus on ISO 9001 and QMS standards, Total Quality Management (TQM). Critique also highlights the necessity for more depth, following insufficient exploration of distinctions between TQM and operational excellence (OPEX) methodologies like lean, six sigma, kaizen and agile. Antony’s work has yet to consider a diverse range of industry sectors, in terms of implementation of quality management principles, geographical location, the impact of national culture on corporate performance and explore data quality influence on decision-making. Notably, there is clear opportunity to consider the service sector in future research.Originality/valueTo best of the authors’ knowledge, there are few previous studies conducted using bibliometric analysis for analyzing the work of an individual. Therefore, the present study aims to set a trend whereby bibliometric analysis can be used to recognize and critically asses the contributions of other researchers in their respective domains.

Baseline characteristics and outcomes of patients admitted to intensive cardiovascular care unit

Abstract Background Intensive Cardiovascular Care Unit (ICCU) is a crucial element of care for critically ill patients suffering from cardiovascular disease. Therefore, we aimed to provide data on the characteristics and outcomes of patients admitted to ICCU. Methods Data was obtained from One Intensive Cardiovascular Care Unit (One ICCU) Registry, a collaborative multicentre research network of ICCU. A total of 10 centres participated in this registry, eight centres were ICCU level III and the remaining were ICCU level II. Each participating centre collected data of patients admitted to ICCU from August 2021 until August 2023. Data recorded were demographics, past medical history, diagnosis, treatment, complications, outcome, and 30-day follow up. Only first ICCU admission data from each patient was analysed to prevent outcome-related bias from readmission data. Results 12,950 patients were included in the analysis of which 9308 (71.9%) were male and the median age was 59 (51-66) years. Most common diagnosis on admission was acute coronary syndromes (69.8%) followed by acute heart failure (34.6%) and arrhythmias (25.8%). Cardiovascular complication most frequently during ICCU stay was cardiogenic shock (18.9%) while for non-cardiovascular complication was acute kidney injury (17.4%). Cardiac arrest (61.2%), respiratory failure (43%), and sepsis (38%) were among the highest case fatality rates for ICCU complications. Overall mortality was found to be approximately 11.4%, 14.3%, and 15.2% for intra ICCU, in-hospital and 30-day mortality, respectively. Non-cardiovascular variables which were independently associated with 30-day mortality were pre-existing asthma (OR 2.12, CI 1.315 – 3.411, p=0.002) and chronic kidney disease (OR 1.67, CI 1.308 – 2.139, p&amp;lt;0.001), initial diagnosis of respiratory failure (OR 4.01, CI 3.373 – 4.773, p&amp;lt;0.001), haemorrhagic stroke(OR 3.46, CI 1.396 – 8.574, p=0.007), ischaemic stroke (OR 3.12, CI 2.248 – 4.345, p&amp;lt;0.001), sepsis (OR 2.00, CI 1.715 – 2.334, p&amp;lt;0.001), urinary tract infection (OR 1.60, CI 1.228 – 2.226, p=0.001) and pneumonia (OR 1.29, CI 1.120 – 1.482, p&amp;lt;0.001), as well as complications during ICCU stay which consisted of haemorrhagic stroke (OR 3.91, CI 1.062 – 14.414, p=0.040), respiratory failure (OR 2.91, CI 2.081 – 4.070, p&amp;lt;0.001), sepsis (OR 2.17, CI 1.686 – 2.790, p&amp;lt;0.001), ischaemic stroke (OR 1.84, CI 1.074 – 3.139, p=0.026), and urinary tract infection (OR 1.39, CI 1.039 – 1.851, p=0.026). Conclusion Patients admitted to our ICCU were relatively younger and the cause for ICCU admission was still predominated by acute coronary syndrome. Despite that, non-cardiovascular condition also warrants clinicians attention due to its significant role as predictors of mortality. Non-cardiac complications that arise during ICCU care also emphasize the importance of collaboration with specialists in other disciplines to improve patient’s outcomes.Diagnosis (A) and Case Fatality (B)Mortality Predictors at 30 days

Cardiovascular and non-cardiovascular adverse events in patients with hematologic malignacies treated with BTK inhibitors: a real-world analysis

Abstract Background Bruton tyrosine kinase (BTK) inhibitors play an important role in targeted treatment of B-cell lymphoproliferative disorders. However, adverse events may limit the proper course of treatment in many patients. Purpose To compare the risk of cardiovascular and non-cardiovascular adverse events in patients with chronic lymphocytic leukemia (CLL) or small cell lymphocytic lymphoma (SLL) treated with first-generation BTK inhibitor ibrutinib versus second-generation acalabrutinib, using real-world data from electronic medical records. Methods We used data from a large collaborative multinational network ( TriNetX), that emcompasses more than 100 healthcare organizations worldwide. We queried the databank for patients aged ≥ 18 years with chronic lymphocytic leukemia or small-cell lymphomas treated with ibrutinib or acalabrutinib in the past 10 years before the analysis. We used propensity score matching to balance the cohorts. The 3-year cumulative incidences and hazard ratios for the following outcomes were calculated: atrial flutter or fibrillation, other arrhythmias, heart failure, ischemic stroke or peripheral embolism, acute coronary syndrome, bleeding, and sepsis. Results We compared 2,107 patients in each group. The 3-year incidences of atrial fibrillation or flutter in the acalabrutinib and ibrutinib groups were 7.11% and 14.78% respectively, with a lower ratio in patients treated with acalabrutinib than those treated with ibrutinib (hazard ratio, HR 0.68, 95% CI 0.55-0.84). New-onset hypertension occurred during the 3-year follow-up in 16.29% patients in the acalabrutinib group versus 27.8% patients in the ibrutinib group (HR 0,81, 95% CI 0.66-0.98). The incidence of sepsis was 6.49% in patients treated with acalabrutinib versus 11.37% in those treated with ibrutinib group (HR 0.77, 95% CI 0.60-0.98). Concerning the other adverse events, there were no significant differences between the two groups. Conclusions In this large real-world analysis, patients with CLL or SLL treated with acalabrutinib had a better cardiovascular and non-cardiovascular safety profile than those treated with ibrutinib, with lower incidence of atrial flutter or fibrillation, new-onset arterial hypertension, and sepsis.Figure 1.Cardiovascular outcomesFigure 2.Non-cardiovascular outcomes

New scheme of cooperative compressed spectrum sensing

Abstract This study addresses key challenges in sparse signal recovery and compressed spectrum sensing (CSS), focusing on low signal-to-noise ratios (SNR), and the computational complexity of cooperative systems. Motivated by the need for faster and more accurate recovery techniques, we first investigate and generalize the Reduced-Set Matching Pursuit (RMP) algorithm, which overcomes the speed and accuracy limitations of conventional greedy algorithms. Secondly, we propose a novel spatial averaging technique that enhances detection performance by exploiting data from multiple users to counteract low SNR. Lastly, we integrate cooperation into CSS, further improving the detection capabilities during the recovery process. Compared to existing techniques like Joint Sparse Recovery (JSR) and CoSaMP, which face computational and accuracy constraints in real-time applications, the RMP algorithm, combined with the Virtual method (data transformation) and AND fusion rule, delivers superior performance than JSR methods. Moreover, spatial averaging significantly increases the probability of cooperative detection Q d , with SNR increasing linearly by a factor of L − 1 per channel. The results are validated through the implementation of SDR. These findings demonstrate the potential of RMP and cooperation to overcome current limitations in CSS, advancing the state-of-the-art in spectrum sensing for collaborative networks.

Financial Development and Climate Change: A Detailed Bibliometric Investigation

This paper presents a detailed bibliometric analysis of the interaction between financial development and climate change, with the main aim of elucidating the current state of research in this area, identifying existing gaps, and guiding future researchers interested in this rapidly expanding field. The study used VOSviewer software version 1.6.18 to analyze the bibliometric data, facilitating the mapping of co-author networks, institutional collaborations, and the identification of main research directions. Through this tool, 730 papers from the Web of Science database covering the period 2010–2024 were extracted and analyzed. The study highlights the authors and institutions that have made significant contributions to the investigation of the relationship between financial development and climate change. The identification of key contributors and international collaborative networks provides a solid foundation for future research and policy initiatives. In addition, the study identifies the most prolific journals and assesses the quality and impact of the research. This allows for a deeper understanding of current research directions and potential future developments. The study not only clarifies the current state of research but also opens up new opportunities for investigating innovative and sustainable solutions aimed at improving the quality of life and protecting the environment.

Ten-year outcomes in patients with hypertension and primary hyperaldosteronism undergoing surgical adrenalectomy versus medical therapy: data from the multinational collaborative network TriNetX

Abstract Background Surgical adrenalectomy for resection of adenomas has been the standard approach for treating patients with secondary hypertension due to primary hyperaldosteronism. However, few studies explored long-term outcomes in patients treated with adrenalectomy when compared to patients treated with conservative management. Purpose To compare ten-year mortality and cardiovascular outcomes in patients with primary hyperaldosteronism treated with surgical adrenalectomy versus patients with primary hyperaldosteronism treated with medical therapy alone. Methods This retrospective cohort study used real-world data from healthcare organizations participating in the global health research collaborative network TriNetX. We performed propensity score matching for demographic and clinical characteristics and calculated hazard ratios, comparing 2.397 patients in each group. The outcomes were all-cause death, heart failure, and the composite endpoint ischemic stroke, hemorrhagic stroke, myocardial infarction, unstable angina, and aorta aneurysm or dissection (major adverse vascular events) during the 10-year follow-up. Results Patients undergoing surgical adrenalectomy had a lower incidence of all-cause death (3.0%) when compared with patients in medical therapy (5.0%) ( hazard ratio 0.60, 95% CI 0.45-0.81). Patients in the surgical group had a 4.6% incidence of heart failure and the medical therapy had an 8.6% incidence of heart failure (hazard ratio 0.54, 95% CI 0.42-0.69). The incidence of major adverse vascular events was lower in the surgical group (10.9%) compared to the medical therapy group (14. 1%) ( hazard ratio 0.76, 95% CI 0.65-0.90). Conclusion In patients with hypertension and primary hyperaldosteronism, surgical adrenalectomy was associated with lower 10-year mortality, heart failure, and major adverse vascular events compared to medical therapy alone.

Home and leisure accidents among children and young people up to 19 years old as an event observed in the EU-IDB surveillance system: 2012-2021 data

Abstract Paediatric injuries are widely acknowledged as a major public health issue among different medical disciplines. In the context of injuries and accidents, the surrounding environment of children and young people remains a major health concern. The present study was developed to extend current knowledge on the characteristics and magnitude of home and leisure accidents in this population. A descriptive, observational, cross-sectional study was developed under the EU-IDB (European Injury Database) collaborative network comprising up to 25 European countries and ten years of data collection (2012 to 2021). The methodology of the EU-IDB is a well consolidated standard for collecting injury data in Emergency departments, in compliance with the Eurostat methodological requirements for European health statistics. During the ten years of data collection in emergency departments, through EU-IDB surveillance 3 603 975 episodes of home and leisure accidents (HLA) were recorded at European level, involving people aged 0-19 years, constituting 34.5 % of hospital ED attendances due to HLA. Children and young people between 10 and 14 years old represented the major age group proportion of HLA(33.0%), the proportion of HLA increased across age groups until fourteen years old, being these differences statistically significant(p &amp;lt; 0,001). Falls were the most common cause of injuries among all age-groups, in the youngest group up to 4-years(54.4%), the 5-9years old (52.2%), the 10-14years old (46.1%) and in the oldest group between 15-19 years(37.5%), representing 47.2% of the total HLA mechanism. As regards to the treatment/follow-up, the vast majority of the HLA episodes were not admitted to hospital (92.9%). Hospital ED Injury data represent very useful information on the health burden of non-fatal injuries in this population of interest. These data could be used for the design of injury prevention policies and regulations for accidents that occur at home, school and outdoor spaces.

Safety and feasibility of nationwide invasive coronary function testing in patients with angina and no obstructive coronary artery disease (NL-CFT)

Abstract Background and purpose Patients with angina and no obstructive coronary artery disease (ANOCA) frequently have coronary vasomotor dysfunction (CVDys) as underlying pathophysiological mechanism, comprising epicardial spasm, microvascular spasm and/or microcirculatory dysfunction. These can be diagnosed by invasive coronary function testing (CFT), which has previously shown to be safe in tertiary and expert centres. The prevalence of CVDys and safety and feasibility of CFT is reported on in this first national collaboration network on CFT’s: NL-CFT. Methods NL-CFT is a prospective, observational registry of all consecutive patients undergoing clinically indicated CFT in 15 participating hospitals throughout the Netherlands. A complete CFT consisted of acetylcholine spasm provocation testing and assessment of microcirculatory function by either bolus thermodilution or Doppler flow velocity measurements. The prevalence of six different endotypes based on CFT results and overall safety were assessed and compared between tertiary (n=2) and non-tertiary centres (n=13). Tertiary was defined as having performed over 100 CFT’s prior to the start of NL-CFT and fulfilling a referral function with specialized ANOCA outpatient clinic. Results In total 1207 predominantly female (81%) patients with a mean age of 60±10 years were included. Traditional cardiovascular risk factors were frequently present. Almost all of the included 1207 patients underwent a complete CFT (93.4%) and prevalence of CVDys was high (77%, Fig. 1). There were 11 (0.9%) serious complications reported on, of which three were definitely related to CFT as depicted in Table 1. No procedural death, myocardial infarction or stroke was observed. Lastly, no differences were found in the occurrence of complications between tertiary an non-tertiary centres. Conclusions Coronary function testing is feasible and safe to perform nationally with a high diagnostic yield.Figure 1.Endotype distribution.Table 1.Side-effects&amp;complication rates.

Real-world analysis of transcatheter aortic valve replacement in patients with prostate cancer and severe aortic stenosis

Abstract Background Patients with prostate cancer have a high prevalence of cardiovascular disease, including degenerative heart valve diseases such as aortic stenosis. It is not uncommon in clinical practice to perform transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis and active prostate cancer. Still, the prognosis after this procedure in this population is not well known. Purpose To evaluate 1-year and 3-year survival rates after TAVR in patients with prostate cancer who have undergone TAVR when compared with patients without active cancer. Methods Data were extracted from electronic medical records of a large multinational collaborative network (TriNetX) that currently englobes 113 healthcare organizations worldwide with more than 100 million patients. Patients aged 18 years or older with prostate cancer documented up to 12 months before TAVR as well as controls undergoing TAVR without oncologic history before the proceeding were included. The survival analysis for 1 year and 3 years was performed with Kaplan Meier survival plots and log-rank test. Propensity score matching, using clinical and demographic variables, was performed to pair the cohorts. Results From a cohort of 26,656 men who had undergone TAVR, we identified 1,040 with prostate cancer diagnosed up to 1 year before TAVR ( prostate cancer group) and 20,231 patients without oncologic history before TAVI (control group). After propensity score matching, analyzing 1,040 patients in each group, the 1-year and 3-year survival probabilities were not different between the prostate cancer group versus the control group ( 89.5% vs 88.9%, log-rank test P=0.70 and 72.6% vs 68.7%, log-rank test P=0.22, respectively). Considering a subgroup of patients with metastatic prostate cancer ( n=229) under androgen deprivation therapy vs the control group ( n =229), we have also not observed a survival difference between the two groups at 1-year and 3-year follow-up ( 88.1 vs 89.1%, log-rank test P=0.69 and 58.7% vs 67.4%, log-rank test P=0.25). Conclusions In this real-world analysis, patients with prostate cancer and severe aortic stenosis who underwent TAVR, including patients with metastatic disease, the 1-year and 3-year survival rates were not significantly different when compared to patients without oncologic hystory who underwent TAVR.

SGLT2 inhibitors in patients with amyloidosis and heart failure: a worldwide retrospective cohort study

Abstract Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the combined risk of death and hospitalization in patients with heart failure with reduced or preserved left ventricular ejection fraction. However, evidence of their impact on patients with heart failure due to amyloidosis is lacking. Purpose To evaluate the effects of SGLT2 inhibitors on mortality and hospitalization in patients with amyloidosis and heart failure. Methods In this retrospective cohort study, we used real-world data from 108 healthcare organizations worldwide from the global health research collaborative network TriNetX. We identified 24,619 patients with amyloidosis and heart failure without exposure to SGLT2 inhibitors (control group) and 2,988 patients with amyloidosis and heart failure under treatment with SGLT2 inhibitors (SGLTi group). We performed propensity score matching for demographic and clinical characteristics and Kaplan–Meier plots, log-rank tests, and Cox proportional hazard models were calculated. The outcomes were 12-month all-cause death and 12-month hospitalization. Results After propensity score matching, 2,237 patients were analyzed in each group. During the 12-month follow-up, 198 (8.8%) patients died in the SGLT2i group, and 431 (19.2%) patients died in the control group (hazard ratio 0.51, 95% CI 0.43-0.61). In the SGLT2i group, 974 (44.5%) patients were hospitalized, and in the control group, 1508 (53.5%) patients were hospitalized (hazard ratio 0,79, 95% CI 0.72-0.86). The Kaplan-Meier curves are shown in Figure 1. Conclusions In conclusion, in this retrospective cohort study with a large number of patients with amyloidosis and heart failure, SGLT2 inhibitors were associated with a lower 12-month all-cause mortality and hospitalization. Further evidence from randomized controlled studies are needed to confirm the efficacy of SGLT2 inhibitors in patients with cardiac amyloidosis.Figure 1.Kaplan-Meier curves

Beyond the Ire of Flames: Work Experiences of Bureau of Fire Protection (BFP) Station Chiefs

Fire occurrences have significantly risen in recent years. These fires endanger lives, cause economic damage, and harm the environment. Uncontrolled fires are a major reason for building collapses and injuries. Building fires cause trauma due to the loss of belongings and the building itself. Existing fire safety systems are failing due to unaddressed factors causing building fires (Rathnayake et al., 2020). This study explored the experiences of the station chiefs of the Bureau of Fire Protection in Iloilo Province, Philippines, through a qualitative research method. The participants of this study were the selected ten (10) BFP station chiefs. All participants were subjected to an individual in-depth interview. The findings of this study are described in emergent themes. Six (6) emergent themes described the positive and negative experiences of the informants in the performance of their duties. For the positive experiences, two (2) emergent themes were developed, namely Personal Satisfaction Through Job Fulfillment and Workplace Camaraderie and Support. For the negative experiences, four (4) emergent themes were also developed, namely: Inadequate Resources and Financial Challenges, Complexity of Leadership and Personnel Management, Bombarded with Public Dissatisfaction, and Operational Delays and Equipment Failures. Meanwhile, three (3) emergent themes were formulated to explain how the participants address the challenges encountered in the performance of their duties, namely: Empowering Collaboration and Support Networks, Bolstering Preventive Measures and Education, and Embodying Resilience and Adaptability. Finally, three (3) emergent themes were created to express the aspirations of participants to improve the quality of their services, namely Continuous Training and Professional Development, Adequate Fiscal Allocation and Service Facilities, and Improvement of Personnel and Staffing Issues. Based on the emergent themes identified, it is recommended that the fire station chiefs be enhanced by providing them with specialized training and career development programs. This can be accomplished by the successful integration of the latest firefighting technologies in the specialized training to enhance the response effectiveness of their station.

A New Approach to Measuring Institutional and Researcher Contributions to the SDGs: Combining Data from Elsevier SciVal and VOSviewer

The Sustainable Development Goals (SDGs), established by the United Nations in 2015, are a comprehensive global framework that addresses social, economic, and environmental challenges through sustainable development. This study examines the role of universities, specifically focusing on the Department of Mechanical Engineering at Universitas Muhammadiyah Magelang (UNIMMA), in contributing to the SDGs. The study utilized data from Elsevier’s SciVal to analyze the department’s contribution to the SDGs through scientific publications in the Scopus database. A total of 97 out of 156 articles published by nine researchers from the department were found to contribute to various SDGs, with a significant focus on Goals 7 (affordable and clean energy), 17 (partnerships for the goals), 9 (industry, innovation, and infrastructure), and 12 (responsible consumption and production). The study highlights the department’s collaborative efforts and alignment with global sustainability goals. In addition, VOSviewer was used to map the research collaboration network within the department, revealing strong contributions to energy efficiency, sustainable technologies, and climate action. However, the department's research shows limited contribution to social SDGs such as poverty alleviation and gender equality. By mapping the university’s contributions to the SDGs, this study helps faculty members identify opportunities for targeted research collaborations, address gaps in SDG contributions, and enhance partnerships with researchers from other institutions, thus broadening the university’s impact on global sustainable development goals.

The Epidemiology of Pediatric Shoulder Dislocations in the United States.

Shoulder dislocations are the most common of all major joint dislocations and are a frequent cause of emergency department (ED) presentations. While the epidemiology of shoulder dislocations has been characterized in adults, it has not yet been done for children in the United States. The primary goal of this study was to calculate the incidence rate of pediatric shoulder dislocations in the United States. Secondary goals were to characterize the demographic information of children with shoulder dislocations as well as trends in management. The US Collaborative Network in TriNetX, a network of clinical data repositories containing patient data from over 100,000,000 unique individuals within the United States, was queried for patients younger than 18 years old diagnosed with shoulder dislocation from 2014 to 2024 using ICD codes. The demographic details were then extracted from the data set, and treatment approaches were determined by CPT coding. Over the past 10 years, there were 16,460 pediatric and adolescent patients diagnosed with a first-time shoulder dislocation in either an ED or ambulatory clinic. The overall incidence rate was 60.31 per 100,000 patients, while the incidence rate was 116.61 per 100,000 patients presenting in the ED and 33.95 per 100,000 patients presenting in ambulatory clinics that were under the age of 18 years. Most patients were male (73%), White (59%), and came from the southeastern region of the United States (36%). The most common treatment was a closed reduction (25%), followed by arthroscopic surgery (17%). The number of annual shoulder dislocations has increased over the past decade without an increase in the number of patients undergoing surgical treatment. There remains a high incidence rate of shoulder dislocations in the pediatric population of the United States. Despite evidence that early surgical treatment of shoulder dislocations offers improved outcomes, nonoperative treatment continues to be the most common modality without any increase in the percentage of patients undergoing surgical treatment. Level IV-descriptive epidemiological analysis.

How urban renewal affects the sustainable development of public spaces: trends, challenges, and opportunities

The process of urbanization has spurred economic growth and social challenges, necessitating research on public spaces in urban renewal to optimize design, enhance functionality, promote sustainable urban development, and improve residents’ quality of life. However, existing studies lack in-depth discussions on development trends and research focal points. This study addresses the gap in existing literature, by conducting a bibliometric analysis using data from the Web of Science Core Collection database from 1 January 2000, to 1 April 2024. Using visualization tools such as VOSviewer and CiteSpace, the study examines publication trends, collaborative networks among countries, institutions, and authors, co-citation relationships among key journals and articles, and emerging research hotspots through keyword analysis. A total of 393 papers were analyzed, with China contributing the highest number (65), followed by the United States (51). Leading contributors include Zazzi Michele and Anguelovski Isabelle. The top three journals for publications are Sustainability, Cities, and Land. Key research trends highlight themes such as space syntax, nature-based solutions, and sustainable transportation. These findings have significant implications for urban planning and policy, suggesting that future urban development strategies should increasingly incorporate sustainable design practices and nature-based solutions to address both environmental and social challenges. By identifying global research trends and highlighting future challenges, this study provides a comprehensive overview that will help policymakers and practitioners in urban planning align their efforts with cutting-edge research and emerging best practices for more sustainable and resilient cities.