The article examines the contradictions that arose in the political leadership of the independent state of Greater Colombia after liberation of Latin America territory from Spain. After Simon Bolivar, the leader of revolution movement, organized the administration of Greater Colombia, disagreements began among the regional leaders of the federation, backed by local landowning and trading elites and caudillos, mainly due to contradictions between personal interests and attempts at state centralization of land question by the new power. Also the leaders of Venezuela and Columbia didn’t agree with the Bolivar wishes to unite all newly free territories in one confederate state – And confederation – following the United States of America. The main struggle unfolded between the appointed Vice-President of the Great Columbia Francisco de Paula Santander and Venezuelan military leader Jose Antonio Paez. This led Paez to a request sent to Bolivar to assume, as the leader of the nation and the entire liberation movement, full power in Greater Colombia, and as a result of this Bolivar reconciled rival powers.