This paper explores the emerging intersection of genomics, neuroscience, and entrepreneurship. Specifically, it examines if and how genetic factors and neurobiological processes influence entrepreneurial behaviors and success. The key questions addressed are: 1) Is there a genetic basis for the entrepreneurial mindset? 2) Can genetic markers and neuroimaging data predict entrepreneurial outcomes? 3) What challenges arise when combining genetic, neuroscientific, and business data? 4) How can entrepreneurs utilize insights from genomics and neuroscience? The paper argues that synchronizing molecular genetics with behavioral data can offer new causal explanations for entrepreneurial cognition under the umbrella of "genoeconomics." However, there are methodological difficulties in analyzing genetically informative data. It cautions against genetic determinism while highlighting opportunities from mapping genetic entrepreneurial proclivities. Entrepreneurship is an intricate phenotype. Are entrepreneurs born or made or developed or adopted? What makes an entrepreneur think outside the box and pursuing avant-garde paths to attain entrepreneurial goals? Alvin Toffler mentioned of various ‘Waves’ viz. Agrarian, Industrial and so on. Economics and Business Management, today, is experiencing inestimable waves viz. Heterodox Wave, Genetic Wave, Molecular Wave, Cellular Wave, Hereditary Wave, [‘Infoplosion’ or ‘Info-Tectonics’ Wave, Capability Approach Wave, Institutional Wave, Behavioral / Experimental Wave [Cognitive and Emotional dimensions / Develops and uses experiments typically with human subjects], Evolutionary Wave, Cognitive Wave, Information Wave , Artificial [Synthetic and / or Fabricated] Intelligence Wave and Neuro Wave, to list a few, from a rational perspective. Of central interest in this paper is Managerial Business - Economics Wave. It deals with, with complex, deep-rooted problems, gears and technique to dissect market demand, assess expenses, establish pricing strategies, assess risks, and appreciate competitive dynamics. Is entrepreneurship a genetic trait? Of recent origin is emergence of incorporating genetic and biological markers into entrepreneurship. Issue that confronts is, is there a need to sync molecular genetics and entrepreneurial business data to genomic entrepreneurship; under umbrella of ‘Genoeconomics’? Does this mean that entrepreneurship is in genes? Do genes determine entrepreneurial success? Can genetics or molecular genetics and entrepreneurial data predict response to multifarious behavioral intercession? Can genetics calculate retort to intricate behavioral interference? Are genetic markers of interest for entrepreneurship research? What challenges occur when analyzing genetically informative facts? How, if at all, should entrepreneurs use and combine molecular genetics and business data? What challenges arise when analyzing genetically informative data? The moot issue is, can entrepreneurship be genetic? Can an entrepreneur be ‘genetically-inclined’? One debatable question is why do entrepreneurial parents have entrepreneurial children? What kinds of opportunities will genetic mapping of entrepreneur offer business entities? Do the big Five Personality Traits [Openness, Conscientiousness, Extraversion, Agree-Ableness and Neuroticism] play a role? Do genetic factors influence tendency to acquire skills and develop attributes relevant to entrepreneurship? Is it crucial to emphasize that a genetic predisposition to entrepreneurship should definitely, unequivocally, not be confounded with genetic determinism? This paper aims to seek a conceptualistic conformation to the above issues