Query Terms Research Articles

Health Disparities and Inequities in the Utilization of Proton Therapy for Prostate Cancer

Our study sought to review and summarize the reported health disparities and inequities in the utilization of proton beam therapy (PBT) for prostate cancer. We queried the PubMed search engine through 12/2023 for original publications examining disparate utilization of PBT for prostate cancer. The query terms included the following: prostate cancer AND proton AND (disparities OR IMRT OR race OR insurance OR socioeconomic OR inequities)”. Studies were included if they involved United States patients, examined PBT in prostate cancer, and addressed health inequities. From this query, 22 studies met the inclusion criteria, comprising 13 population-based analyses, 5 single-institutional analyses, 3 cost/modeling investigations, and 1 survey-based study. The analyses revealed that in addition to age-related and insurance-related disparities, race and socioeconomic status played significant roles in the receipt of PBT. The likelihood of receiving PBT was lower for non-White patients in population-based and single-institution analyses. Socioeconomic metrics, such as higher median income and higher education level, portended an increased likelihood of receiving PBT. Conclusively, substantial age-based, racial, socioeconomic/insurance-related, and facility-associated disparities and inequities existed for PBT utilization in prostate cancer. The identification of these disparities provides a framework to better address these as the utility of PBT continues to expand across the US and globally.

Caregivers in implantable brain-computer interface research: a scoping review.

While the ethical significance of caregivers in neurological research has increasingly been recognized, the role of caregivers in brain-computer interface (BCI) research has received relatively less attention. This report investigates the extent to which caregivers are mentioned in publications describing implantable BCI (iBCI) research for individuals with motor dysfunction, communication impairment, and blindness. The scoping review was conducted in June 2024 using the PubMed and Web of Science bibliographic databases. The articles were systematically searched using query terms for caregivers, family members, and guardians, and the results were quantitatively and qualitatively analyzed. Our search yielded 315 unique studies, 78 of which were included in this scoping review. Thirty-four (43.6%) of the 78 articles mentioned the study participant's caregivers. We sorted these into 5 categories: Twenty-two (64.7%) of the 34 articles thanked caregivers in the acknowledgement section, 6 (17.6%) articles described the caregiver's role with regard to the consent process, 12 (35.3%) described the caregiver's role in the technical maintenance and upkeep of the BCI system or in other procedural aspects of the study, 9 (26.5%) discussed how the BCI enhanced participant communication and goal-directed behavior with the help of a caregiver, and 3 (8.8%) articles included general comments that did not fit into the other categories but still related to the importance of caregivers in the lives of the research participants. Caregivers were mentioned in less than half of BCI studies in this review. The studies that offered more robust discussions of caregivers provide valuable insight into the integral role that caregivers play in supporting the study participants and the research process. Attention to the role of caregivers in successful BCI research studies can help guide the responsible development of future BCI study protocols.

Context-Aware Search for Environmental Data Using Dense Retrieval

The search for environmental data typically involves lexical approaches, where query terms are matched with metadata records based on measures of term frequency. In contrast, dense retrieval approaches employ language models to comprehend the context and meaning of a query and provide relevant search results. However, for environmental data, this has not been researched and there are no corpora or evaluation datasets to fine-tune the models. This study demonstrates the adaptation of dense retrievers to the domain of climate-related scientific geodata. Four corpora containing text passages from various sources were used to train different dense retrievers. The domain-adapted dense retrievers are integrated into the search architecture of a standard metadata catalogue. To improve the search results further, we propose a spatial re-ranking stage after the initial retrieval phase to refine the results. The evaluation demonstrates superior performance compared to the baseline model commonly used in metadata catalogues (BM25). No clear trends in performance were discovered when comparing the results of the dense retrievers. Therefore, further investigation aspects are identified to finally enable a recommendation of the most suitable corpus composition.

Towards cross-application model-agnostic federated cohort discovery.

To demonstrate that 2 popular cohort discovery tools, Leaf and the Shared Health Research Information Network (SHRINE), are readily interoperable. Specifically, we adapted Leaf to interoperate and function as a node in a federated data network that uses SHRINE and dynamically generate queries for heterogeneous data models. SHRINE queries are designed to run on the Informatics for Integrating Biology & the Bedside (i2b2) data model. We created functionality in Leaf to interoperate with a SHRINE data network and dynamically translate SHRINE queries to other data models. We randomly selected 500 past queries from the SHRINE-based national Evolve to Next-Gen Accrual to Clinical Trials (ENACT) network for evaluation, and an additional 100 queries to refine and debug Leaf's translation functionality. We created a script for Leaf to convert the terms in the SHRINE queries into equivalent structured query language (SQL) concepts, which were then executed on 2 other data models. 91.1% of the generated queries for non-i2b2 models returned counts within 5% (or ±5 patients for counts under 100) of i2b2, with 91.3% recall. Of the 8.9% of queries that exceeded the 5% margin, 77 of 89 (86.5%) were due to errors introduced by the Python script or the extract-transform-load process, which are easily fixed in a production deployment. The remaining errors were due to Leaf's translation function, which was later fixed. Our results support that cohort discovery applications such as Leaf and SHRINE can interoperate in federated data networks with heterogeneous data models.

A Bibliometric Analysis of the 100 Most-Cited Articles on Otoplasty.

A bibliometric analysis was conducted in April 2024, to review the current trends in otoplasty. It involved literature search on Scopus database for original articles using the query term "otoplasty" and "pinnaplasty", without restricting publication dates or selecting journals in the database. The top 100 articles with the highest citations were reviewed. Bibliometric analysis was performed using Scimago journal impact factor. The screening was done using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA) guidelines to extract the top 100 most cited articles in otoplasty. We excluded articles not focused on otoplasty, those involving other surgical procedures, and non-English articles. Scopus and manual screening were used together to perform citation analysis of selected articles. Mean values were calculated for the number of citations and citations per year. Of the 951 studies identified, 100 (10.5%) were analyzed in detail. The studies were published between 1941-2024, with a mean of 36 ± 23.7 citations per paper. The journal "Plastic and Reconstructive Surgery" reported the highest number (23[23%]) of articles, followed by "Journal of Plastic, Reconstructive and Aesthetic Surgery" with 13% (n=13) articles. The highest number of articles originated from the United States (38%, n=38), followed by United Kingdom (15%, n=15). Our bibliometric analysis provides a comprehensive overview of the landscape of otoplasty research, highlighting key publications, authors, and journals. This study contributes to the understanding of the evolution and impact of otoplasty literature, laying the groundwork for further research and innovation in this field.

A novel query execution time prediction approach based on operator iterate-aware of the execution plan on the graph database

Query execution time prediction is essential for database query optimization tasks, such as query scheduling, progress monitoring, and resource allocation. In the query execution time prediction tasks, the query plan is often used as the modeling object of a prediction model. Although the learning-based prediction models have been proposed to capture plan features, there are two limitations need to be considered more. First, the parent–child dependencies between plan operators can be captured, but the operator’s branch independence cannot be distinguished. Second, each operator’s output row is its following operator input, but the data iterate transfer operations between operators are ignored. In this study, we propose a graph query execution time prediction model containing a plan module, a query module, a plan-query module, and a prediction module to improve prediction effectiveness. Specifically, the plan module is used to capture the data iterate transfer operations and distinguish independent of branch operators; the query module is used to learn features of query terms that have an influence on the composition of operators; the plan-query interaction module is used to learn the logical correlations of plan and query. The experiment on datasets proves the effectiveness of the operator iterate-aware and query-plan interaction method in our proposed graph query execution prediction model.

A modified Vector Space Model for semantic information retrieval

In this research, we present a modified Vector Space Model which focuses on the semantic relevance of words for retrieving documents. The modified VSM resolves the problem of the classical model performing only lexical matching of query terms to document terms for retrievals. This problem also restricts the classical model from retrieving documents that do not have exact match of query terms even if they are semantically relevant to the query. In the modified model, we introduced a Query Relevance Update technique, which pads the original query set with semantically relevant document terms for optimised semantic retrieval results. The modified model also includes a novel tf−p which replaces the tf−idf technique of the classical VSM, which is used to compute the Term Frequency weights. The replacement of the tf−idf resolves the problem of the classical model penalising terms that occur across documents with the assumption that they are stop words, which in practice, there are usually such words which carry relevant semantic information for documents’ retrieval. We also extended the cosine similarity function with a proportionality weight pqd, which moderates biases for high frequency of terms in longer documents. The pqd ensures that the frequency of query terms including the updated ones are accounted for in proportionality with documents size for the overall ranking of documents. The simulated results reveal that, the modified VSM does achieve semantic retrieval of documents beyond lexical matching of query and document terms.

A materials terminology knowledge graph automatically constructed from text corpus

A scalable, reusable, and broad-coverage unified material knowledge representation shows its importance and will bring great benefits to data sharing among materials communities. A knowledge graph (KG) for materials terminology, which is a formal collection of term entities and relationships, is conceptually important to achieve this goal. In this work, we propose a KG for materials terminology, named Materials Genome Engineering Database Knowledge Graph (MGED-KG), which is automatically constructed from text corpus via natural language processing. MGED-KG is the most comprehensive KG for materials terminology in both Chinese and English languages, consisting of 8,660 terms and their explanations. It encompasses 11 principal categories, such as Metals, Composites, Nanomaterials, each with two or three levels of subcategories, resulting in a total of 235 distinct category labels. For further application, a knowledge web system based on MGED-KG is developed and shows its great power in improving data sharing efficiency from the aspects of query expansion, term, and data recommendation.

Automatic text classification of drug-induced liver injury using document-term matrix and XGBoost.

Regulatory agencies generate a vast amount of textual data in the review process. For example, drug labeling serves as a valuable resource for regulatory agencies, such as U.S. Food and Drug Administration (FDA) and Europe Medical Agency (EMA), to communicate drug safety and effectiveness information to healthcare professionals and patients. Drug labeling also serves as a resource for pharmacovigilance and drug safety research. Automated text classification would significantly improve the analysis of drug labeling documents and conserve reviewer resources. We utilized artificial intelligence in this study to classify drug-induced liver injury (DILI)-related content from drug labeling documents based on FDA's DILIrank dataset. We employed text mining and XGBoost models and utilized the Preferred Terms of Medical queries for adverse event standards to simplify the elimination of common words and phrases while retaining medical standard terms for FDA and EMA drug label datasets. Then, we constructed a document term matrix using weights computed by Term Frequency-Inverse Document Frequency (TF-IDF) for each included word/term/token. The automatic text classification model exhibited robust performance in predicting DILI, achieving cross-validation AUC scores exceeding 0.90 for both drug labels from FDA and EMA and literature abstracts from the Critical Assessment of Massive Data Analysis (CAMDA). Moreover, the text mining and XGBoost functions demonstrated in this study can be applied to other text processing and classification tasks.

Using online search activity for earlier detection of gynaecological malignancy

BackgroundOvarian cancer is the most lethal and endometrial cancer the most common gynaecological cancer in the UK, yet neither have a screening program in place to facilitate early disease detection. The aim is to evaluate whether online search data can be used to differentiate between individuals with malignant and benign gynaecological diagnoses.MethodsThis is a prospective cohort study evaluating online search data in symptomatic individuals (Google user) referred from primary care (GP) with a suspected cancer to a London Hospital (UK) between December 2020 and June 2022. Informed written consent was obtained and online search data was extracted via Google takeout and anonymised. A health filter was applied to extract health-related terms for 24 months prior to GP referral. A predictive model (outcome: malignancy) was developed using (1) search queries (terms model) and (2) categorised search queries (categories model). Area under the ROC curve (AUC) was used to evaluate model performance. 844 women were approached, 652 were eligible to participate and 392 were recruited. Of those recruited, 108 did not complete enrollment, 12 withdrew and 37 were excluded as they did not track Google searches or had an empty search history, leaving a cohort of 235.ResultsThe cohort had a median age of 53 years old (range 20–81) and a malignancy rate of 26.0%. There was a difference in online search data between those with a benign and malignant diagnosis, noted as early as 360 days in advance of GP referral, when search queries were used directly, but only 60 days in advance, when queries were divided into health categories. A model using online search data from patients (n = 153) who performed health-related search and corrected for sample size, achieved its highest sample-corrected AUC of 0.82, 60 days prior to GP referral.ConclusionsOnline search data appears to be different between individuals with malignant and benign gynaecological conditions, with a signal observed in advance of GP referral date. Online search data needs to be evaluated in a larger dataset to determine its value as an early disease detection tool and whether its use leads to improved clinical outcomes.

EP-BoxE: A method for hypernym discovery based on extended patterns and box embeddings

Hypernym discovery aims to distinguish potential hypernyms for a query term. However, existing methods for hypernym discovery suffer from the following problems: (1) traditional unsupervised pattern-based methods suffer from low recall; (2) recent supervised box embedding methods are deficient in identifying specific hypernyms. To cope with the above problems, this paper presents a method for hypernym discovery based on Extended Patterns and Box Embeddings (EP-BoxE). Firstly, to acquire more hypernymy relation entity pairs, we identify co-hyponyms of a given term and use their hypernyms as the candidate hypernym set for the given term; Secondly, by analyzing the text corpus, we find that the language patterns also provide additional information for hypernym discovery, which also solves the deficiency of the box embedding methods in identifying specific hypernyms. Finally, experimentations on two domain-specific datasets reveal that EP-BoxE surpasses the performance of popular methods on the majority of evaluation metrics.

Lemierre’s syndrome in pediatric population

Introduction: Lemierre’s syndrome is a rare, potentially fatal complication of upper respiratory tract infections, occurring mainly in young, previously healthy individuals. It is defined as postanginal septicaemia accompanied by thrombosis of the internal jugular vein and formation of abscesses in distant organs. Characteristic symptoms include deterioration of patient’s condition on the 4th–7th day of the management of primary infection, with the recurrence of fever and unilateral swelling and painfulness of the neck. Aims: The analysis of pediatric cases of Lemierre’s syndrome as described in the literature over the last 30 years; presentation of own experience and clinical observations in pediatric patients receiving treatment for Lemierre’s syndrome. Material and methods: A search of the literature available through the PubMed platform was carried out using the query terms “Lemierre syndrome” and “children”. A total of 73 pediatric cases reported on in papers published in English literature within the time span of 1980 through 2023 were included in the analysis. Results: As shown by the analysis of the 73 pediatric cases of Lemierre’s syndrome, the most common causes of the disease were acute pharyngitis and acute otitis media. The presence of the bacterial species Fusobacterium necrophorum was established in the blood cultures of more than one half of the patient group. Distant complications were most frequently observed in the lungs while the most common locations of thrombosis included the internal jugular vein and the sigmoid sinus. Intravenous antibiotic therapy was delivered to all patients, many of whom required additional surgical intervention and/or anticoagulation treatment. Conclusions: In most cases, Lemierre’s syndrome is a complication of acute pharyngitis and acute otitis media. Despite the presence of severe distant organ complications and extensive thrombotic lesions within the venous vessels, complete recovery is achieved in most cases in the pediatric population. The treatment of Lemierre’s syndrome is based primarily on broad-spectrum antibiotic therapy, with surgical interventions and/or anticoagulant therapy being also required in some cases. As of the present, no uniform guidelines have been established for the use of anticoagulant therapy, particularly in the pediatric population.

Quantum algorithms to compute the neighbour list of N-body simulations

One of the strategies to reduce the complexity of N-body simulations is the computation of the neighbour list. However, this list needs to be updated from time to time, with a high computational cost. This paper focuses on the use of quantum computing to accelerate such a computation. Our proposal is based on a well-known oracular quantum algorithm (Grover). We introduce an efficient quantum circuit to build the oracle that marks pairs of closed bodies, and we provide three novel algorithms to calculate the neighbour list under several hypotheses which take into account a-priori information of the system. We also describe a decision methodology for the actual use of the proposed quantum algorithms. The performance of the algorithms is tested with a statistical simulation of the oracle, where a fixed number of pairs of bodies are set as neighbours. A statistical analysis of the number of oracle queries is carried out. The results obtained with our simulations indicate that when the density of bodies is low, our algorithms clearly outperform the best classical algorithm in terms of oracle queries.

Patients with floaters: Answers from virtual assistants and large language models.

"Floaters," a common complaint among patients of all ages, was used as a query term because it affects 30% of all people searching for eye care. The American Academy of Ophthalmology website's "floaters" section was used as a source for questions and answers (www.aao.org). Floaters is a visual obstruction that moves with the movement of the eye. They can be associated with retinal detachment, which can lead to vision loss. With the advent of large language model (LLM) chatbots ChatGPT, Bard versus virtual assistants (VA), Google Assistant, and Alexa, we analyzed their responses to "floaters." Using AAO.org, "Public & Patients," and its related subsection, "EyeHealth A-Z": Floaters and Flashes link, we asked four questions: (1) What are floaters? (2) What are flashes? (3) Flashes and Migraines? (4) Floaters and Flashes Treatment? to ChatGPT, Bard, Google Assistant, and Alexa. The American Academy of Ophthalmology (AAO) keywords were identified if they were highlighted. The "Flesch-Kincaid Grade Level" formula approved by the U.S. Department of Education, was used to evaluate the reading comprehension level for the responses. Of the chatbots and virtual assistants, Google Assistant is the only one that uses the term "ophthalmologist." There is no mention of the urgency or emergency nature of floaters. AAO.org shows a lower reading level vs the LLMs and VA (p = .11). The reading comprehension levels of ChatGPT, Bard, Google Assistant, and Alexa are higher (12.3, 9.7, 13.1, 8.1 grade) vs the AAO.org (7.3 grade). There is a higher word count for LLMs vs VA (p < .0286). Currently, ChatGPT, Bard, Google Assistant, and Alexa are similar. Factual information is present but all miss the urgency of the diagnosis of a retinal detachment. Translational relevance: Both the LLM and virtual assistants are free and our patients will use them to obtain "floaters" information. There may be errors of omission with ChatGPT and a lack of urgency to seek a physician's care.

A framework for approximate product search using faceted navigation and user preference ranking

One of the problems that e-commerce users face is that the desired products are sometimes not available and Web shops fail to provide similar products due to their exclusive reliance on Boolean faceted search. User preferences are also often not taken into account. In order to address these problems, we present a novel framework specifically geared towards approximate faceted search within the product catalog of a Web shop. It is based on adaptations to the p-norm extended Boolean model, to account for the domain-specific characteristics of faceted search in an e-commerce environment. These e-commerce specific characteristics are, for example, the use of quantitative properties and the presence of user preferences. Our approach explores the concept of facet similarity functions in order to better match products to queries. In addition, the user preferences are used to assign importance weights to the query terms. Using a large-scale experimental setup based on real-world data, we conclude that the proposed algorithm outperforms the considered benchmark algorithms. Last, we have performed a user-based study in which we found that users who use our approach find more relevant products with less effort.

The road from manual to automatic semantic indexing of biomedical literature: a 10 years journey.

Biomedical experts are facing challenges in keeping up with the vast amount of biomedical knowledge published daily. With millions of citations added to databases like MEDLINE/PubMed each year, efficiently accessing relevant information becomes crucial. Traditional term-based searches may lead to irrelevant or missed documents due to homonyms, synonyms, abbreviations, or term mismatch. To address this, semantic search approaches employing predefined concepts with associated synonyms and relations have been used to expand query terms and improve information retrieval. The National Library of Medicine (NLM) plays a significant role in this area, indexing citations in the MEDLINE database with topic descriptors from the Medical Subject Headings (MeSH) thesaurus, enabling advanced semantic search strategies to retrieve relevant citations, despite synonymy, and polysemy of biomedical terms. Over time, advancements in semantic indexing have been made, with Machine Learning facilitating the transition from manual to automatic semantic indexing in the biomedical literature. The paper highlights the journey of this transition, starting with manual semantic indexing and the initial efforts toward automatic indexing. The BioASQ challenge has served as a catalyst in revolutionizing the domain of semantic indexing, further pushing the boundaries of efficient knowledge retrieval in the biomedical field.

Context based diversification on keyword search by conceptualization of typed terms of the query

The human era is evolved and dominated through the ultimate intention to know about the Universe and its assets more and more. This in turn persuaded him to gather the immense information of need in the form of theory, tools, intuitions, visuals, and ultimately as the form of abstract objects. In modern Information practice, the art of Conceptualization and the induction of the data driven paradigm identifies the user query intention over a Conceptual network to mold a confident search segment of user choice. The proposed Conceptualization with Typed Terms of Query (CTTQ) approach derives a confident segment of the user query which is contextually measured by means of novel randomized Machine learning algorithms and its surrogates. The Normalized Discounted Cumulative Gain (nDCG) measures of the CTTQ show the usefulness of the query suggestions. It's efficiency improvements are represented with varying impact lexical feature indicator (θ) values.

Query-by-Example Spoken Term Detection for Zero-Resource Languages Using Heuristic Search

Query-by-Example spoken content retrieval is a demanding and challenging task when a large volume of spoken content is piled up in the repositories without annotation. In the absence of annotation, spoken content retrieval is achieved by capturing the similarities between the query and spoken terms from the acoustic feature representation itself. Dynamic Time Warping (DTW) centric techniques identify the optimal alignment between the acoustic feature representations and capture the similarities between query and spoken terms. Despite feasibility, the DTW-centric techniques produce a lot of false alarms due to the variabilities that exist in natural speech and degrade the performance. In the proposed approach, the variability challenges are addressed in two stages. At first, the speaker-independent acoustic feature representation was obtained from the deep convolutional neural networks that reduce the speaker variabilities. In the second stage, the similarities between the query and spoken term were captured using the heuristic search method. The proposed approach was compared with other state-of-the-art methods using Microsoft Low-Resource Language speech corpus. A 3% improvement and 32% reduction in the hit and false alarm ratio were achieved across languages.

Promoting Document Relevance Using Query Term Proximity for Exploratory Search

In the information retrieval system, relevance manifestation is pivotal and regularly based on document-term statistics, i.e., term frequency (tf), inverse document frequency (idf), etc. Query term proximity (QTP) within matched documents is mostly under-explored. In this article, a novel information retrieval framework is proposed to promote the documents among all relevant retrieved ones. The relevance estimation is a weighted combination of document statistics and query term statistics, and term-term proximity is simply aggregates of diverse user preferences aspects in query formation, thus adapted into the framework with conventional relevance measures. Intuitively, QTP is exploited to promote the documents for balanced exploitation-exploration, and eventually navigate a search towards goals. The evaluation asserts the usability of QTP measures to balance several seeking tradeoffs, e.g., relevance, novelty, result diversification (coverage, topicality), and overall retrieval. The assessment of user search trails indicates significant growth in a learning outcome (due to novelty).

Neural Language Model Based Attentive Term Dependence Model for Verbose Query (Student Abstract)

The query-document term matching plays an important role in information retrieval. However, the retrieval performance degrades when the documents get matched with the extraneous terms of the query which frequently arises in verbose queries. To address this problem, we generate the dense vector of the entire query and individual query terms using the pre-trained BERT (Bidirectional Encoder Representations from Transformers) model and subsequently analyze their relation to focus on the central terms. We then propose a context-aware attentive extension of unsupervised Markov Random Field-based sequential term dependence model that explicitly pays more attention to those contextually central terms. The proposed model utilizes the strengths of the pre-trained large language model for estimating the attention weight of terms and rank the documents in a single pass without any supervision.